Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.2164 | 0.2772 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.7251 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.2144 | 0.257 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.2164 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0377 | 0.0233 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0891 | 0.0748 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2594 | 0.2303 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0891 | 0.0963 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0548 | 0.0249 |
Trypanosoma brucei | ISWI complex protein | 0.0017 | 0.0213 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2372 | 0.2073 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0891 | 0.0748 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0548 | 0.2535 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0548 | 0.0178 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0712 | 0.0709 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.4703 | 0.638 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.2164 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.2164 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0548 | 0.0249 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.2164 | 0.2599 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.2164 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.7251 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.01 | 0.7251 | 0.7091 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.2164 | 0.2772 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.01 | 0.7251 | 0.7143 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.7251 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.0548 | 0.172 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 0.0548 | 0.172 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.2164 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0548 | 0.0178 |
Brugia malayi | Inositol-1 | 0.004 | 0.2164 | 0.1709 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.2164 | 0.1856 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0548 | 0.0249 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 1 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0548 | 0.0477 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.2164 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.7251 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.2164 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0712 | 0.0348 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0548 | 0.0477 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.9714 | 0.9702 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.1809 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0548 | 0.2535 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0613 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0613 | 0.0569 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.2164 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.2366 | 0.1922 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.2164 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.0548 | 0.172 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0377 | 0.0233 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0377 | 0.0233 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0548 | 0.2535 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.58 | 0.5556 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2772 | 0.2489 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.54 | 0.5219 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.2144 | 0.257 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.2164 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.1809 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.4368 | 0.5807 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0548 | 0.0249 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0435 | 0.006 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.2164 | 0.2599 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0548 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0613 | 0.0344 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0548 | 0.0249 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.1113 | 0.0597 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.7251 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0548 | 0.0477 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0548 | 0.2535 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0548 | 0.2535 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.2164 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.4368 | 0.5807 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0377 | 0.0233 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0548 | 0.0249 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.7251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.9714 | 0.9697 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.9714 | 0.9702 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.7251 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 4000 uM | Activation of chloride ion uptake into mouse brain synaptoneurosomes, no net uptake at 4 nM | ChEMBL. | 12113824 |
Emax (functional) | 0 | Agonistic activity against GABA-A receptor chloride uptake (ND = no data) | ChEMBL. | 12113824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.