Detailed information for compound 91573

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 550.666 | Formula: C30H34N2O6S
  • H donors: 1 H acceptors: 3 LogP: 5.08 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C[C@H]1NS(=O)(=O)c1ccccc1)C(=O)OCc1ccccc1
  • InChi: 1S/C30H34N2O6S/c1-36-28-17-16-23(18-29(28)38-24-12-8-9-13-24)26-19-32(30(33)37-21-22-10-4-2-5-11-22)20-27(26)31-39(34,35)25-14-6-3-7-15-25/h2-7,10-11,14-18,24,26-27,31H,8-9,12-13,19-21H2,1H3/t26-,27+/m0/s1
  • InChiKey: TZJPMCZVQHEUFW-RRPNLBNLSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4B, cAMP-specific Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0147 0.0144
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0003 0.0003
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0109 0.0107
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0147 0.0144
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.1027 0.5439 0.5437
Echinococcus granulosus hexokinase 0.0257 0.1332 0.1332
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0012 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0012 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0295 0.0295
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0014 0.0032 0.0032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0012 0.0009
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Plasmodium falciparum phosphodiesterase delta, putative 0.0014 0.0032 0.0029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0012 0.0012
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0012 0.0009
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Mycobacterium ulcerans hypothetical protein 0.0035 0.0147 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0012 0.0009
Loa Loa (eye worm) PDE1B protein 0.0014 0.0032 0.0029
Loa Loa (eye worm) histone methyltransferase 0.001 0.001 0.0007
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0014 0.0032 0.0032
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.0555 0.0555
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0012 0.0012
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus granulosus tar DNA binding protein 0.0063 0.0295 0.0295
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0012 0.0012
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0099 0.0096
Loa Loa (eye worm) inositol-1 0.0026 0.0099 0.0096
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1882 1 1
Trypanosoma cruzi polyprenyl synthase, putative 0.1027 0.5439 0.5437
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0014 0.0032 0.0032
Trypanosoma brucei squalene synthase, putative 0.0611 0.3216 0.3214
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1882 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0197 0.0197
Leishmania major hypothetical protein, conserved 0.0025 0.0093 0.009
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Loa Loa (eye worm) hexokinase 0.0161 0.082 0.0818
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1882 1 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus multilocularis hexokinase 0.0257 0.1332 0.1332
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Loa Loa (eye worm) RNA binding protein 0.0063 0.0295 0.0292
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0147 0.0144
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0326 0.1701 0.1698
Schistosoma mansoni hypothetical protein 0.0182 0.0928 0.0928
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0012 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.0144
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0014 0.0032 0.0029
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0109 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0295 0.0295
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0014 0.0032 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0012 0.0009
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Schistosoma mansoni hypothetical protein 0.0182 0.0928 0.0928
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0147 0.0144
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0098 0.0482 0.0479
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0197
Echinococcus granulosus hypothetical protein 0.0008 0.0003 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0012 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Brugia malayi Hexokinase family protein 0.0161 0.082 0.0818
Trypanosoma brucei hexokinase 0.0257 0.1332 0.1329
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0014 0.0032 0.0032
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0003 0.0003
Brugia malayi Hexokinase family protein 0.008 0.0384 0.0381
Onchocerca volvulus 0.0257 0.1332 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0583 0.3069 0.3067
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0093 0.009
Entamoeba histolytica hexokinase 2 0.0257 0.1332 0.4335
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Plasmodium falciparum hexokinase 0.0257 0.1332 0.1329
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Schistosoma mansoni carbonyl reductase 0.0008 0.0003 0.0003
Onchocerca volvulus Hexokinase homolog 0.0161 0.082 0.6151
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0147 0.0147
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0012 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0003 0.0003
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0014 0.0032 0.0029
Loa Loa (eye worm) hexokinase type II 0.0257 0.1332 0.1329
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0147 0.0144
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0112 0.0555 0.0552
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0093 0.009
Trypanosoma brucei hexokinase 0.0257 0.1332 0.1329
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0026 0.0099 0.0096
Echinococcus granulosus importin subunit beta 1 0.0028 0.0109 0.0109
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0583 0.3069 0.3069
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0014 0.0032 0.0032
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Plasmodium vivax phosphodiesterase gamma, putative 0.0014 0.0032 0.0029
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0012 0.0009
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.0555 0.0555
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.1027 0.5439 0.5439
Entamoeba histolytica hypothetical protein 0.0023 0.0081 0.0255
Brugia malayi Inositol-1 0.0026 0.0099 0.0096
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0014 0.0032 0.0029
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1882 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Entamoeba histolytica hypothetical protein 0.0036 0.015 0.0479
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0035 0.0147 0.0144
Leishmania major hypothetical protein, conserved 0.019 0.0974 0.0972
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0326 0.1701 0.1698
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Loa Loa (eye worm) polyprenyl synthetase 0.1882 1 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0014 0.0032 0.0032
Schistosoma mansoni importin beta-1 0.0028 0.0109 0.0109
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0583 0.3069 1
Echinococcus granulosus hexokinase type 2 0.0257 0.1332 0.1332
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0014 0.0032 0.0032
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0014 0.0032 0.0029
Schistosoma mansoni hypothetical protein 0.019 0.0974 0.0974
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0012 0.0009
Schistosoma mansoni cpg binding protein 0.0033 0.0133 0.0133
Plasmodium falciparum importin beta, putative 0.0028 0.0109 0.0107
Schistosoma mansoni trans-prenyltransferase 0.0583 0.3069 0.3069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0032 0.0032
Loa Loa (eye worm) hexokinase 0.0257 0.1332 0.1329
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0093 0.009
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0032 0.0032
Onchocerca volvulus 0.0161 0.082 0.6151
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1191 0.1191
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0035 0.0147 0.0144
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0147 0.0144
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1882 1 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0003 0.0003
Onchocerca volvulus 0.001 0.0012 0.0067
Leishmania major cAMP-specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0003 0.0003
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0181 0.0178
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0295 0.0292
Leishmania major farnesyl pyrophosphate synthase 0.1882 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0197 0.0197
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Brugia malayi glutaminase DH11.1 0.0276 0.143 0.1427
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0099 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0032 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0012 0.0009
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.0144
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0583 0.3069 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0014 0.0032 0.0032
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Leishmania major importin beta-1 subunit, putative 0.0023 0.0081 0.0078
Entamoeba histolytica hexokinase 1 0.0257 0.1332 0.4335
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.1027 0.5439 0.5439
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0032 0.0029
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0003 0.0003
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0003 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.2297 0.2297
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0099 0.0096
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0012 0.0009
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0014 0.0032 0.0032
Brugia malayi steroid hormone receptor 0.001 0.0012 0.0009
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0012 0.0067
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0326 0.1701 0.1698
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0003 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0112 0.0555 0.0552
Schistosoma mansoni glutaminase 0.0276 0.143 0.143
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0032 0.0029
Onchocerca volvulus 0.0047 0.0211 0.1562
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0326 0.1701 0.1698
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0003 0.0003
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus granulosus snurportin 1 0.0301 0.1563 0.1563
Echinococcus granulosus cpg binding protein 0.0033 0.0133 0.0133
Schistosoma mansoni carbonyl reductase 0.0008 0.0003 0.0003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Loa Loa (eye worm) glutaminase 0.0276 0.143 0.1427
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Plasmodium vivax hexokinase, putative 0.0257 0.1332 0.1329
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0003 0.0003
Brugia malayi Importin beta-1 subunit 0.0028 0.0109 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0032 0.0029
Brugia malayi RNA, U transporter 1 0.008 0.0386 0.0384
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.007 0.0067
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Entamoeba histolytica hypothetical protein 0.0036 0.015 0.0479
Schistosoma mansoni inositol monophosphatase 0.0026 0.0099 0.0099
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0012 0.0067
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1882 1 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0109 0.0107
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1191 0.1191
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0147 0.0144
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1882 1 1
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1882 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0331 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0295 0.0295
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0032 0.0032
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0147 0.0147
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0714 0.0711
Trichomonas vaginalis inositol monophosphatase, putative 0.0026 0.0099 0.0096
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0014 0.0032 0.0029
Schistosoma mansoni nuclear hormone receptor 0.001 0.0012 0.0012
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0163 0.0521
Brugia malayi hypothetical protein 0.0036 0.015 0.0147
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0147 0.0144
Trypanosoma cruzi squalene synthase, putative 0.0611 0.3216 0.3214
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0295 0.0295
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0326 0.1701 0.1698
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0003 0.0003
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0583 0.3069 0.3069
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1882 1 1
Loa Loa (eye worm) acetyltransferase 0.0142 0.0714 0.0711
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0098 0.0482 0.0482
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.0144
Echinococcus multilocularis Squalene phytoene synthase 0.019 0.0974 0.0974
Echinococcus granulosus oxidoreductase 0.0008 0.0003 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0003 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0019 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0012 0.0009
Giardia lamblia hypothetical protein 0.0014 0.0032 0.0029
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0012 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1158 0.1155
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0003 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0012 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0012 0.0009
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0326 0.1701 0.1698
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0012 0.0009
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0583 0.3069 0.3067
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0081 0.0078
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Trypanosoma brucei hexokinase, putative 0.0257 0.1332 0.1329
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0093 0.009
Echinococcus multilocularis cpg binding protein 0.0033 0.0133 0.0133
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0032 0.0029
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.007 0.0067
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0093 0.009
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0583 0.3069 0.3067
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0032 0.0029
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1882 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0026 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0176 0.0896 0.0893
Schistosoma mansoni ran 0.0021 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0012 0.0009
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.007 0.0067
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0014 0.0032 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0197
Brugia malayi nuclear receptor NHR-88 0.001 0.0012 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0331 0.0328
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0012 0.0009
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0014 0.0032 0.0029
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0081 0.0078
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0003 0.0003
Trichomonas vaginalis ran, putative 0.0021 0.007 0.0067
Onchocerca volvulus 0.0035 0.0147 0.1082
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0295 0.0292
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.0144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0307 0.0307
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0032 0.0029
Schistosoma mansoni cpg binding protein 0.0031 0.0123 0.0123
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1882 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.1027 0.5439 0.5439
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0012 0.0012
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1882 1 1
Mycobacterium ulcerans phytoene synthase, CrtB 0.019 0.0974 0.0972
Echinococcus granulosus hexokinase 0.0257 0.1332 0.1332
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0331 0.0331
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.0393
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0009 0.0006
Mycobacterium tuberculosis Conserved protein 0.0035 0.0147 0.0144
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.007 0.0067
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0098 0.0482 0.0482
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0331 0.0328
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0003 0.0003
Trypanosoma cruzi hexokinase, putative 0.0257 0.1332 0.1329
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0012 0.0012
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0032 0.0032
Schistosoma mansoni thyroid hormone receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0217 0.0214
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Schistosoma mansoni survival motor neuron protein 0.0047 0.0211 0.0211
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0012 0.0012
Schistosoma mansoni thyroid hormone receptor 0.001 0.0012 0.0012
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0583 0.3069 0.3067
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0003 0.0003
Loa Loa (eye worm) polyprenyl synthetase 0.0583 0.3069 0.3067
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0003 0.0003
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0012 0.0012
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1882 1 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0163 0.016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0012 0.0009
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0014 0.0032 0.0032
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.007 0.007
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0003 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.007 0.0067
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0014 0.0032 0.0032
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0081 0.0078
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0181 0.0178
Onchocerca volvulus 0.0031 0.0123 0.0906
Treponema pallidum octaprenyl-diphosphate synthase 0.1027 0.5439 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0147 0.0144
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0331 0.0328
Schistosoma mansoni inositol monophosphatase 0.0026 0.0099 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0147 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Mycobacterium leprae Probable lipase LipE 0.0035 0.0147 0.0469
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0003 0.0003
Brugia malayi hypothetical protein 0.0231 0.1191 0.1189
Loa Loa (eye worm) hypothetical protein 0.0025 0.0093 0.009
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0099 0.0096
Brugia malayi RNA binding protein 0.0063 0.0295 0.0292
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0012 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0032 0.0029
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0014 0.0032 0.0032
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0003 0.0003
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0714 0.0714
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0583 0.3069 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Leishmania major hexokinase, putative 0.0257 0.1332 0.1329
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0583 0.3069 0.3067
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0012 0.0012
Leishmania major GTP-binding protein, putative 0.0021 0.007 0.0067
Schistosoma mansoni hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0123 0.012
Schistosoma mansoni cpg binding protein 0.0033 0.0133 0.0133
Trypanosoma cruzi squalene synthase, putative 0.0611 0.3216 0.3214
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0032 0.0029
Giardia lamblia Farnesyl diphosphate synthase 0.1882 1 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0014 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.019 0.0974 0.0972
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.0555 0.0555
Leishmania major hexokinase, putative 0.0257 0.1332 0.1329
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Leishmania major squalene synthase, putative 0.0611 0.3216 0.3214
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0147 0.0144
Schistosoma mansoni hypothetical protein 0.0036 0.015 0.015
Brugia malayi CXXC zinc finger family protein 0.0031 0.0123 0.012
Echinococcus granulosus dnaJ subfamily B 0.0438 0.2297 0.2297
Echinococcus multilocularis oxidoreductase 0.0008 0.0003 0.0003
Brugia malayi hypothetical protein 0.0016 0.0045 0.0042
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0163 0.016
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Schistosoma mansoni carbonyl reductase 0.0008 0.0003 0.0003
Echinococcus granulosus tumor protein p63 0.033 0.172 0.172
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0014 0.0032 0.0029
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Brugia malayi Polyprenyl synthetase family protein 0.0583 0.3069 0.3067
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0029
Mycobacterium ulcerans lipase LipD 0.0035 0.0147 0.0144
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0331 0.0331
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0217 0.0217
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0147 0.0147
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0029
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0008 0.0003 0.0003
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0029
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0032 0.0029
Trypanosoma cruzi polyprenyl synthase, putative 0.1027 0.5439 0.5437
Onchocerca volvulus 0.0035 0.0147 0.1082
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0583 0.3069 0.3069
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0583 0.3069 0.3067
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0032 0.0029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0147 0.0144
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0197 0.0195
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0026 0.0099 0.0313
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Brugia malayi TAR-binding protein 0.0063 0.0295 0.0292
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.015 0.015
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0014 0.0032 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0012 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0147 0.0144
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0012 0.0012
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0003 0.0003
Echinococcus multilocularis hexokinase 0.0257 0.1332 0.1332
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0147 0.0144
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0012 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0012 0.0012
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0295 0.0295
Onchocerca volvulus 0.0048 0.0217 0.161
Giardia lamblia Hypothetical protein 0.0014 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0295 0.0295
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0583 0.3069 0.3069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0197 0.0197
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0583 0.3069 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0081 0.0078
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.019 0.0974 0.0972
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0197 0.0195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0197 0.0197
Brugia malayi hexokinase 0.0257 0.1332 0.1329
Echinococcus multilocularis tumor protein p63 0.033 0.172 0.172
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0026 0.0099 0.0313
Schistosoma mansoni hypothetical protein 0.0301 0.1563 0.1563
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Loa Loa (eye worm) hexokinase 0.0257 0.1332 0.1329
Leishmania major hypothetical protein, conserved 0.0014 0.0032 0.0029
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0003 0.0003
Echinococcus granulosus geminin 0.0182 0.0928 0.0928
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0003 0.0003
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0583 0.3069 0.3067
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0147 0.0144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0012 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0147 0.0144
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0583 0.3069 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.0144
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0012 0.0012
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0326 0.1701 0.1698
Trichomonas vaginalis glutaminase, putative 0.0276 0.143 0.1427
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0583 0.3069 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0147 0.0144
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0147 0.0469
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0098 0.0482 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0012 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0012 0.0012
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0181 0.0178
Echinococcus granulosus hexokinase 0.0257 0.1332 0.1332
Entamoeba histolytica hypothetical protein 0.0036 0.015 0.0479
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0099 0.0096
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1882 1 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.0555 0.0555
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0331 0.0328
Brugia malayi hypothetical protein 0.0025 0.0093 0.009
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0326 0.1701 0.1698
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0012 0.0012
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0326 0.1701 0.1698
Brugia malayi beta-lactamase family protein 0.0035 0.0147 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0147 0.0144
Brugia malayi beta-lactamase family protein 0.0035 0.0147 0.0144
Brugia malayi follicle stimulating hormone receptor 0.023 0.1186 0.1183
Onchocerca volvulus 0.0257 0.1332 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0331 0.0328
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0583 0.3069 0.3067
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0147 0.0144
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.019 0.0974 0.7309
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.007 0.0067
Echinococcus granulosus FTZ F1 alpha 0.001 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0047 0.0211 0.0211
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1597 0.8479 0.8479
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Schistosoma mansoni glutathione synthetase 0.0583 0.3069 0.3069
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0032 0.0032
Echinococcus multilocularis inositol monophosphatase 1 0.0026 0.0099 0.0099
Trypanosoma cruzi phytoene synthase, putative 0.019 0.0974 0.0972
Loa Loa (eye worm) hypothetical protein 0.0231 0.1191 0.1189
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0181 0.0178
Toxoplasma gondii hexokinase 0.0257 0.1332 0.1329
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0289 0.0286
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0014 0.0032 0.0029
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.0393
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0012 0.0009
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0014 0.0032 0.0029
Leishmania major polyprenyl synthase, putative 0.1027 0.5439 0.5437
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.007 0.0067
Brugia malayi beta-lactamase 0.0035 0.0147 0.0144
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0295 0.0292
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.007 0.007
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0003 0.0003
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0014 0.0032 0.0029
Echinococcus multilocularis hexokinase 0.0257 0.1332 0.1332
Brugia malayi ecdysteroid receptor 0.001 0.0012 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0012 0.0012
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0147 0.0144
Mycobacterium ulcerans beta-lactamase 0.0035 0.0147 0.0144
Onchocerca volvulus 0.0035 0.0147 0.1082
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0112 0.0555 0.0555
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0211 0.0208
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0012 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0003 0.0003
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0003 0.0003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0012 0.0012
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1882 1 1
Leishmania major hypothetical protein, conserved 0.0035 0.0147 0.0144
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0583 0.3069 0.3067
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0014 0.0032 0.0029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Onchocerca volvulus 0.0257 0.1332 1
Schistosoma mansoni ran 0.0021 0.007 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0012 0.0012
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0693 0.0693
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Echinococcus multilocularis snurportin 1 0.0301 0.1563 0.1563
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0023 0.0084 0.0266
Echinococcus granulosus Squalene phytoene synthase 0.019 0.0974 0.0974
Plasmodium falciparum phosphodiesterase gamma, putative 0.0014 0.0032 0.0029
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0583 0.3069 0.3067
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0714 0.0714
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0109 0.0107
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0326 0.1701 0.1698
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Entamoeba histolytica Ran family GTPase 0.0021 0.007 0.0218
Schistosoma mansoni hypothetical protein 0.0438 0.2297 0.2297
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0181 0.0178
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0023 0.0084 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0012 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0012 0.0012
Leishmania major solanesyl-diphosphate synthase, putative 0.0583 0.3069 0.3067
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0099 0.0096
Brugia malayi hexokinase type II 0.0082 0.0396 0.0393
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0026 0.0099 0.0096
Echinococcus multilocularis hexokinase type 2 0.0257 0.1332 0.1332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0012 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0093 0.009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Loa Loa (eye worm) beta-lactamase 0.0035 0.0147 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Entamoeba histolytica hypothetical protein 0.0036 0.015 0.0479
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0003 0.0003
Trypanosoma cruzi hexokinase, putative 0.0257 0.1332 0.1329
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0331 0.0328
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0014 0.0032 0.0032
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0093 0.009
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0181 0.0181
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0032 0.0029
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0583 0.3069 0.3067
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.015 0.015
Toxoplasma gondii ABC1 family protein 0.0035 0.0147 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0012 0.0009
Loa Loa (eye worm) glutaminase 2 0.0276 0.143 0.1427
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0032 0.0029
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0109 0.0107
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0032 0.0029
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0112 0.0555 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0032 0.0029
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.1027 0.5439 0.5437
Schistosoma mansoni coup transcription factor 0.001 0.0012 0.0012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.015 0.015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0147 0.0147
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0003 0.0003
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0583 0.3069 0.3067
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.1186 0.1183
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0014 0.0032 0.0032
Schistosoma mansoni hexokinase 0.0257 0.1332 0.1332
Mycobacterium ulcerans glutaminase 0.0276 0.143 0.1427
Trichomonas vaginalis esterase, putative 0.0035 0.0147 0.0144
Brugia malayi Hexokinase family protein 0.0257 0.1332 0.1329
Brugia malayi nuclear hormone receptor 0.001 0.0012 0.0009
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0014 0.0032 0.0032
Echinococcus granulosus hypothetical protein 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0019 0.0019
Echinococcus multilocularis geminin 0.0182 0.0928 0.0928
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.1563 0.1561
Loa Loa (eye worm) hexokinase 0.008 0.0384 0.0381
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0583 0.3069 0.5

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4.42 uM Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) ChEMBL. No reference
Ki (binding) = 4.42 uM Ability to inhibit the catalytic activity of human Phosphodiesterase 4B (PDE IVB) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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