Detailed information for compound 916002

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 943.516 | Formula: C44H46ClF3N6O6S3
  • H donors: 2 H acceptors: 6 LogP: 8.22 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)c1cnccc1CN1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(c(c1)S(=O)(=O)C(F)(F)F)N[C@@H](CSc1ccccc1)CCN1CCOCC1
  • InChi: 1S/C44H46ClF3N6O6S3/c45-35-10-6-32(7-11-35)40-29-49-18-16-34(40)30-53-20-22-54(23-21-53)37-12-8-33(9-13-37)43(55)51-63(58,59)39-14-15-41(42(28-39)62(56,57)44(46,47)48)50-36(17-19-52-24-26-60-27-25-52)31-61-38-4-2-1-3-5-38/h1-16,18,28-29,36,50H,17,19-27,30-31H2,(H,51,55)/t36-/m1/s1
  • InChiKey: XFXJPZKDEQAKJU-PSXMRANNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens B-cell CLL/lymphoma 2 Starlite/ChEMBL References
Homo sapiens BCL2-like 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus EGFP:Bcl2 fusion protein Get druggable targets OG5_139665 All targets in OG5_139665
Echinococcus multilocularis EGFP:Bcl2 fusion protein Get druggable targets OG5_139665 All targets in OG5_139665
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0049 0.0034
Schistosoma mansoni glutaminase 0.027 0.0859 0.0846
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0032 0.0021 0.0076
Brugia malayi ecdysteroid receptor 0.0042 0.0055 0.0179
Plasmodium falciparum DNA topoisomerase 3, putative 0.0032 0.002 0.0071
Brugia malayi Bromodomain containing protein 0.0041 0.0053 0.0171
Echinococcus granulosus carboxylesterase 5A 0.0897 0.3063 0.3063
Chlamydia trachomatis DNA gyrase subunit A 0.0127 0.0353 0.3045
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0036 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0033 0.0023 0.0031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0134 0.0134
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.0076 0.0143
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0055 0.0055
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0102 0.0381
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0043 0.0081
Brugia malayi ThiF family protein 0.0032 0.0021 0.0066
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0308 0.1149
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0184 0.0686
Loa Loa (eye worm) hypothetical protein 0.024 0.0751 0.2451
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0071 0.0071
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0344 0.1116 0.209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0071 0.0071
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.001 0.001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0003 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0055 0.0179
Loa Loa (eye worm) Ulp1 protease 0.0067 0.0144 0.0471
Echinococcus granulosus dna polymerase eta 0.004 0.0049 0.0049
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0016 0.003
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0016 0.0057
Echinococcus multilocularis musashi 0.0085 0.0206 0.0206
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0067
Brugia malayi cytochrome P450 0.0033 0.0023 0.0075
Loa Loa (eye worm) acetylcholinesterase 1 0.0897 0.3063 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0181
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0173 0.0159
Mycobacterium ulcerans carboxylesterase, LipT 0.0152 0.0441 0.1689
Loa Loa (eye worm) hypothetical protein 0.0046 0.0069 0.0227
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0016 0.003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0079 0.0257
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0031 0.0016 0.0057
Toxoplasma gondii RNA-directed DNA polymerase 0.0085 0.0208 0.0776
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0032 0.002 0.0064
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0173 0.0623
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0055 0.0055
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0152 0.0441 0.0835
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0076 0.0144
Giardia lamblia DNA topoisomerase III 0.0032 0.002 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0055 0.0041
Echinococcus granulosus flap endonuclease 1 0.0026 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0055 0.0179
Mycobacterium leprae Conserved hypothetical protein 0.0033 0.0023 0.0093
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0016 0.0057
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0589 0.198 0.198
Mycobacterium ulcerans lipase LipD 0.0075 0.0173 0.0623
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0339 0.1099 0.3588
Loa Loa (eye worm) DNA topoisomerase I 0.0788 0.2679 0.8749
Chlamydia trachomatis DNA gyrase subunit B 0.0271 0.0863 0.7687
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0788 0.2679 1
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.007 0.0156 0.0156
Brugia malayi Bromodomain containing protein 0.0081 0.0192 0.0626
Mycobacterium leprae Probable lipase LipE 0.0075 0.0173 0.0681
Echinococcus granulosus neuropeptide receptor A26 0.0486 0.1618 0.1618
Loa Loa (eye worm) hypothetical protein 0.0081 0.0193 0.0629
Echinococcus granulosus dna polymerase kappa 0.004 0.0049 0.0049
Treponema pallidum cell division protein FtsZ 0.0307 0.0987 0.1844
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0033 0.0023 0.0031
Mycobacterium ulcerans glutaminase 0.027 0.0859 0.3348
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0173 0.0623
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Echinococcus multilocularis acetylcholinesterase 0.0897 0.3063 0.3063
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0173 0.0564
Schistosoma mansoni survival motor neuron protein 0.0149 0.043 0.0417
Schistosoma mansoni neuroligin 3 (S09 family) 0.0152 0.0441 0.0427
Loa Loa (eye worm) hypothetical protein 0.0152 0.0441 0.1439
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0079 0.0079
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0032 0.002 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0071 0.0071
Loa Loa (eye worm) glutaminase 0.027 0.0859 0.2803
Trichomonas vaginalis Sentrin-specific protease, putative 0.0067 0.0144 0.0273
Plasmodium falciparum DNA topoisomerase 2 0.0589 0.198 0.739
Loa Loa (eye worm) hypothetical protein 0.0152 0.0441 0.1439
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0032 0.002 0.002
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0032 0.0021 0.0021
Brugia malayi jmjC domain containing protein 0.0062 0.0127 0.0414
Brugia malayi MAP kinase sur-1 0.0055 0.0102 0.0332
Trichomonas vaginalis sensor histidine kinase, putative 0.0031 0.0016 0.003
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0102 0.0266 0.0994
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0036 0.0036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0044 0.0044
Echinococcus multilocularis carboxylesterase 5A 0.0897 0.3063 0.3063
Plasmodium vivax DNA gyrase subunit A, putative 0.0127 0.0353 0.1317
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0134 0.0134
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0039 0.0046 0.0151
Mycobacterium ulcerans hypothetical protein 0.0075 0.0173 0.0623
Mycobacterium ulcerans DNA gyrase subunit A 0.0127 0.0353 0.1342
Plasmodium falciparum heat shock protein 90 0.0031 0.0016 0.0057
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.0051
Loa Loa (eye worm) inositol-1 0.0114 0.0308 0.1005
Loa Loa (eye worm) hypothetical protein 0.0075 0.0173 0.0564
Trichomonas vaginalis endoplasmin, putative 0.0031 0.0016 0.003
Leishmania major C-8 sterol isomerase-like protein 0.0373 0.122 0.4553
Brugia malayi hypoxia-induced factor 1 0.0312 0.1007 0.3285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0079 0.0065
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0184 0.0686
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0071 0.0231
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0043 0.008
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Schistosoma mansoni lamin 0.0085 0.0206 0.0192
Schistosoma mansoni BC026374 protein (S09 family) 0.0152 0.0441 0.0427
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0057
Onchocerca volvulus 0.0152 0.0441 0.3369
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0033 0.0023 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0055 0.0179
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0032 0.002 0.002
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0153 0.0446 0.1762
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Echinococcus granulosus lamin dm0 0.0085 0.0206 0.0206
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0152 0.0441 0.0441
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0055 0.0055
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0033 0.0023 0.0031
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0067 0.0144 0.0273
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0033 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0152 0.0441 0.1439
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0071 0.0229
Loa Loa (eye worm) ThiF family protein 0.0032 0.0021 0.0068
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0181
Echinococcus granulosus sentrin specific protease 8 0.0067 0.0144 0.0144
Plasmodium vivax topoisomerase I, putative 0.0788 0.2679 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0246 0.0804
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0516 0.0516
Schistosoma mansoni DNA topoisomerase type I 0.0788 0.2679 0.2669
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0055 0.0179
Mycobacterium ulcerans DNA gyrase subunit B 0.0344 0.1116 0.4372
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0033 0.0023 0.0031
Brugia malayi beta-lactamase family protein 0.0075 0.0173 0.0562
Trypanosoma brucei protein kinase, putative 0.0055 0.0102 0.0379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0055 0.0181
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Echinococcus granulosus intermediate filament protein 0.0085 0.0206 0.0206
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0003 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0085 0.0277
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0081
Brugia malayi nuclear receptor NHR-88 0.0042 0.0055 0.0179
Leishmania major DNA topoisomerase III, putative 0.0032 0.002 0.0073
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0043 0.0159
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0067 0.0142 0.0128
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0055 0.0041
Treponema pallidum fructose-bisphosphate aldolase 0.1528 0.5282 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0835 0.2845 0.2845
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0134 0.0439
Loa Loa (eye worm) DNA topoisomerase III 0.0032 0.002 0.0064
Brugia malayi hypothetical protein 0.0728 0.2469 0.8062
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0067 0.0219
Schistosoma mansoni cytochrome P450 0.0033 0.0023 0.0009
Toxoplasma gondii DNA topoisomerase family protein 0.0032 0.002 0.0071
Leishmania major cytochrome p450-like protein 0.0078 0.0184 0.0686
Schistosoma mansoni hypothetical protein 0.0035 0.0029 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0033 0.0023 0.0031
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0055 0.0041
Loa Loa (eye worm) hypothetical protein 0.0152 0.0441 0.1439
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0055 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0055 0.0424
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0033 0.0023 0.0031
Brugia malayi RNA binding protein 0.0068 0.0148 0.0482
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0206 0.0673
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0044 0.0044
Trypanosoma brucei DNA topoisomerase III, putative 0.0032 0.002 0.0071
Loa Loa (eye worm) RNA binding protein 0.0068 0.0148 0.0483
Echinococcus multilocularis survival motor neuron protein 1 0.0728 0.2469 0.2469
Plasmodium vivax DNA topoisomerase 3, putative 0.0032 0.002 0.0071
Loa Loa (eye worm) hypothetical protein 0.007 0.0156 0.0508
Leishmania major DNA polymerase kappa, putative 0.004 0.0049 0.0181
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0246 0.0919
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0032 0.0021 0.0021
Trypanosoma brucei DNA topoisomerase III, putative 0.0032 0.002 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0055 0.0055
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0127 0.0127
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0102 0.0088
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0589 0.198 0.6465
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1528 0.5282 1
Echinococcus multilocularis rho GTPase activating protein 20 0.0032 0.002 0.002
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0055 0.0041
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0181
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0055 0.0055
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0049 0.0179
Leishmania major mitochondrial DNA topoisomerase II 0.0661 0.2234 0.8337
Echinococcus multilocularis dnaJ subfamily C 6 0.0065 0.0136 0.0136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0055 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0055 0.0179
Loa Loa (eye worm) carboxylesterase 0.0897 0.3063 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0173 0.0564
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0246 0.0466
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0067 0.0144 0.0273
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.0441 0.0427
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0043 0.0159
Mycobacterium leprae putative cytochrome p450 0.0033 0.0023 0.0093
Schistosoma mansoni heat shock protein 0.0031 0.0016 0.0002
Leishmania major cytochrome p450-like protein 0.0033 0.0023 0.0087
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0043 0.0138
Brugia malayi Carboxylesterase family protein 0.0152 0.0441 0.1438
Brugia malayi hypothetical protein 0.0152 0.0441 0.1438
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0134 0.0134
Echinococcus multilocularis dna polymerase eta 0.004 0.0049 0.0049
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0055 0.0055
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0055 0.0041
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0032 0.002 0.0077
Leishmania major DNA topoisomerase III, putative 0.0032 0.002 0.0073
Trichomonas vaginalis spcc417.12 protein, putative 0.0152 0.0441 0.0835
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0043 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0173 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0032 0.0021 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0052 0.0052
Onchocerca volvulus 0.0085 0.0206 0.1574
Plasmodium vivax SET domain protein, putative 0.003 0.0014 0.0051
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0043 0.0081
Onchocerca volvulus 0.01 0.0259 0.1983
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0746 0.2533 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0312 0.1007 0.3287
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0102 0.0102
Mycobacterium tuberculosis Cell division protein FtsZ 0.0307 0.0987 0.3858
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0016 0.0057
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0031 0.0016 0.003
Brugia malayi Pre-SET motif family protein 0.003 0.0014 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0246 0.0466
Leishmania major hypothetical protein, conserved 0.0075 0.0173 0.0644
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0033 0.0023 0.0031
Onchocerca volvulus 0.0075 0.0173 0.1319
Leishmania major ubiquitin-activating enzyme-like protein 0.0032 0.0021 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0246 0.0466
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0344 0.1116 1
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0173 0.0644
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0001 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0246 0.0232
Loa Loa (eye worm) apoptosis regulator protein 0.0067 0.0142 0.0465
Brugia malayi TAR-binding protein 0.0068 0.0148 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0016 0.003
Echinococcus granulosus single minded 2 0.0075 0.017 0.017
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0005 0.0019
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0033 0.0023 0.0031
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0081
Onchocerca volvulus 0.024 0.0752 0.5748
Plasmodium vivax ubiquitin activating enzyme, putative 0.0049 0.008 0.0295
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0649 0.2121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0055 0.0179
Echinococcus multilocularis DNA topoisomerase 1 0.0788 0.2679 0.2679
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0067
Chlamydia trachomatis DNA gyrase subunit A 0.0127 0.0353 0.3045
Echinococcus granulosus neuroligin 0.0152 0.0441 0.0441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1528 0.5282 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.0308 0.0583
Trichomonas vaginalis protein kinase inhibitor, putative 0.0065 0.0136 0.0258
Brugia malayi PHD-finger family protein 0.0027 0.0002 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0049 0.0157
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0173 0.0623
Leishmania major DNA topoisomerase 1A 0.0032 0.002 0.0073
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0206 0.0673
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0589 0.198 0.6465
Schistosoma mansoni heat shock protein 0.0031 0.0016 0.0002
Brugia malayi glutaminase DH11.1 0.027 0.0859 0.2802
Giardia lamblia DINP protein human, muc B family 0.004 0.0049 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0055 0.0179
Schistosoma mansoni hypothetical protein 0.0033 0.0023 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0049 0.013
Loa Loa (eye worm) hypothetical protein 0.0081 0.0193 0.0629
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0043 0.0139
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0049 0.0181
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0055 0.0041
Trypanosoma brucei cytochrome P450, putative 0.0078 0.0184 0.0684
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0049 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0148 0.0134
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0661 0.2234 0.8337
Trypanosoma cruzi DNA topoisomerase III, putative 0.0032 0.002 0.0073
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0032 0.002 0.0005
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0033 0.0023 0.0031
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0173 0.0623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0079 0.0065
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0127 0.0353 0.1342
Echinococcus granulosus acetylcholinesterase 0.0897 0.3063 0.3063
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0049 0.0181
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0148 0.0483
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0344 0.1116 0.4372
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0033 0.0023 0.0031
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.0441 0.0427
Echinococcus multilocularis conserved hypothetical protein 0.0699 0.2367 0.2367
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0023 0.0077
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0114 0.0308 0.116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.0169
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0049 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0148 0.0134
Loa Loa (eye worm) hypothetical protein 0.0075 0.0173 0.0564
Onchocerca volvulus 0.0085 0.0206 0.1574
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0044 0.0064 0.005
Brugia malayi Carboxylesterase family protein 0.0152 0.0441 0.1438
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0149 0.043 0.1403
Echinococcus multilocularis heat shock protein 90 0.0031 0.0016 0.0016
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0057
Schistosoma mansoni alpha-glucosidase 0.0149 0.0431 0.0418
Echinococcus multilocularis 0.0033 0.0023 0.0023
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0822 0.2798 0.2798
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0016 0.0059
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0014 0.0014
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0043 0.008
Echinococcus multilocularis sentrin specific protease 8 0.0067 0.0144 0.0144
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0016 0.0057
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0049 0.0034
Plasmodium vivax DNA gyrase subunit B, putative 0.0344 0.1116 0.4165
Toxoplasma gondii ABC1 family protein 0.0075 0.0173 0.0642
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0057
Loa Loa (eye worm) hypothetical protein 0.0191 0.0578 0.1889
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0033 0.0023 0.0031
Schistosoma mansoni hypothetical protein 0.0052 0.0091 0.0077
Echinococcus multilocularis lamin 0.0085 0.0206 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0148 0.0134
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0043 0.0157
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0102 0.0379
Brugia malayi Cytochrome P450 family protein 0.0033 0.0023 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0055 0.0179
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0055 0.0041
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0016 0.0059
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0055 0.0041
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0102 0.0381
Trypanosoma brucei DNA topoisomerase ii 0.0661 0.2234 0.8337
Loa Loa (eye worm) hypothetical protein 0.0067 0.0142 0.0465
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0031 0.0016 0.0059
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0102 0.0266 0.105
Schistosoma mansoni DNA topoisomerase type I 0.0788 0.2679 0.2669
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0557 0.1868 0.6973
Schistosoma mansoni hypothetical protein 0.0354 0.1154 0.1142
Schistosoma mansoni single-minded 0.0101 0.0263 0.0249
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0246 0.0802
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0083 0.0201 0.0655
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0206 0.0671
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0005 0.0016
Plasmodium falciparum topoisomerase I 0.0788 0.2679 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0033 0.0023 0.0031
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0173 0.0681
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0152 0.0441 0.0441
Echinococcus multilocularis BC026374 protein (S09 family) 0.0152 0.0441 0.0441
Schistosoma mansoni coup transcription factor 0.0042 0.0055 0.0041
Brugia malayi hypothetical protein 0.007 0.0156 0.0506
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1528 0.5282 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0033 0.0023 0.0031
Trypanosoma brucei C-8 sterol isomerase, putative 0.0373 0.122 0.4552
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0055 0.0181
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0031 0.0016 0.0062
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0173 0.0623
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0181
Trypanosoma brucei developmentally regulated phosphoprotein 0.0031 0.0016 0.0057
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0102 0.0381
Schistosoma mansoni gliotactin 0.0152 0.0441 0.0427
Mycobacterium tuberculosis Conserved protein 0.0075 0.0173 0.0623
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.0516 0.1684
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0057
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0067 0.0144 0.0273
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0173 0.0327
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0055 0.0181
Brugia malayi Carboxylesterase family protein 0.0897 0.3063 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0246 0.0466
Loa Loa (eye worm) hypothetical protein 0.0075 0.0173 0.0564
Trypanosoma brucei telomerase reverse transcriptase 0.0085 0.0208 0.0776
Echinococcus granulosus para nitrobenzyl esterase 0.0152 0.0441 0.0441
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0085 0.0208 0.1593
Leishmania major protein kinase, putative 0.0027 0.0003 0.0011
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0031 0.0016 0.0016
Schistosoma mansoni inositol monophosphatase 0.0114 0.0308 0.0294
Plasmodium falciparum DNA gyrase subunit B 0.0344 0.1116 0.4165
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0043 0.0043
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0049 0.0179
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0173 0.0623
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0055 0.0179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0071 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0033 0.0023 0.0031
Trichomonas vaginalis set domain proteins, putative 0.024 0.0752 0.1424
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0102 0.0381
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1528 0.5282 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0173 0.0562
Toxoplasma gondii cytochrome p450 superfamily protein 0.0033 0.0023 0.0085
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0788 0.2679 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0033 0.0023 0.0087
Loa Loa (eye worm) hypothetical protein 0.0044 0.0062 0.0203
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0173 0.0623
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0049 0.013
Plasmodium falciparum endoplasmin, putative 0.0031 0.0016 0.0057
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0067 0.0142 0.0463
Brugia malayi steroid hormone receptor 0.0042 0.0055 0.0179
Trypanosoma brucei unspecified product 0.0028 0.0005 0.0016
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0661 0.2234 0.8337
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0308 0.1147
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0016 0.0059
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0516 0.0516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0055 0.0181
Onchocerca volvulus Huntingtin homolog 0.0124 0.0344 0.2632
Brugia malayi Cytochrome P450 family protein 0.0033 0.0023 0.0075
Onchocerca volvulus 0.0149 0.043 0.3288
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0049 0.0181
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0102 0.0102
Loa Loa (eye worm) endoplasmin 0.0031 0.0016 0.0051
Leishmania major developmentally regulated phosphoprotein-like protein 0.0031 0.0016 0.0059
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0246 0.0466
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0031 0.0016 0.0016
Echinococcus multilocularis transfer RNA-Lys 0.0075 0.017 0.017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0055 0.0179
Brugia malayi kinase, mitochondrial precursor 0.0031 0.0016 0.0049
Schistosoma mansoni kinase 0.0049 0.0081 0.0067
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0835 0.2845 0.2845
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0033 0.0023 0.0031
Brugia malayi hypothetical protein 0.0339 0.1099 0.3587
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0031 0.0016 0.003
Echinococcus multilocularis muscleblind protein 1 0.031 0.0998 0.0998
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0033 0.0023 0.0031
Mycobacterium ulcerans putative regulatory protein 0.0075 0.017 0.0615
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0246 0.0465
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0033 0.0023 0.0031
Leishmania major hypothetical protein, conserved 0.0031 0.0016 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0173 0.0642
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0005 0.0016
Trypanosoma cruzi DNA topoisomerase III, putative 0.0032 0.002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0076 0.0176 0.0575
Brugia malayi Cell division protein ftsZ 0.0151 0.044 0.1436
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Mycobacterium tuberculosis Conserved protein 0.0075 0.0173 0.0623
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0246 0.1881
Toxoplasma gondii ThiF family protein 0.0032 0.0021 0.0076
Onchocerca volvulus 0.0075 0.0173 0.1319
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.0516 0.1683
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0057 0.0108 0.0806
Plasmodium falciparum DNA gyrase subunit A 0.0127 0.0353 0.1317
Echinococcus multilocularis muscleblind protein 0.031 0.0998 0.0998
Schistosoma mansoni microtubule-associated protein tau 0.2869 1 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0049 0.013
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0246 0.0466
Loa Loa (eye worm) beta-lactamase 0.0075 0.0173 0.0564
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0246 0.0919
Brugia malayi beta-lactamase 0.0075 0.0173 0.0562
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0049 0.0092
Schistosoma mansoni lamin 0.0085 0.0206 0.0192
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0308 0.1149
Loa Loa (eye worm) hypothetical protein 0.0085 0.0206 0.0673
Brugia malayi Carboxylesterase family protein 0.0897 0.3063 1
Echinococcus granulosus dnaJ subfamily C 6 0.0065 0.0136 0.0136
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0055 0.0179
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0055 0.0055
Onchocerca volvulus 0.0152 0.0441 0.3369
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0031 0.0016 0.0057
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0049 0.0092
Echinococcus granulosus muscleblind protein 0.031 0.0998 0.0998
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0033 0.0023 0.0031
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.0441 0.0427
Schistosoma mansoni DNA topoisomerase type I 0.0788 0.2679 0.2669
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0055 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0312 0.1005 0.1901
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0049 0.008 0.0295
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0033 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.024 0.0751 0.2451
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0557 0.1868 0.6973
Brugia malayi jmjC domain containing protein 0.0064 0.0134 0.0437
Schistosoma mansoni hypothetical protein 0.0067 0.0142 0.0128
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0102 0.0381
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.0308 0.0583
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Trypanosoma brucei glucosidase, putative 0.0038 0.0043 0.0157
Echinococcus multilocularis neuropeptide s receptor 0.0486 0.1618 0.1618
Echinococcus multilocularis neuropeptide receptor A26 0.0486 0.1618 0.1618
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0589 0.198 0.198
Echinococcus granulosus lamin 0.0085 0.0206 0.0206
Giardia lamblia DNA topoisomerase III 0.0032 0.002 0.0036
Trichomonas vaginalis glutaminase, putative 0.027 0.0859 0.1626
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0001 0.0002
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0001 0.0002
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0031 0.0016 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0134 0.0121
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0055 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0184 0.06
Loa Loa (eye worm) carboxylesterase 0.0152 0.0441 0.1439
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0373 0.122 0.3983
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0127 0.0127
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0043 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1528 0.5282 1
Loa Loa (eye worm) carboxylesterase 0.0152 0.0441 0.1439
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0055 0.0179
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0173 0.0327
Echinococcus multilocularis para nitrobenzyl esterase 0.0152 0.0441 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0055 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0055 0.0179
Mycobacterium leprae Probable two-component sensor kinase 0.0031 0.0016 0.0062
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0055 0.0055
Echinococcus granulosus BC026374 protein S09 family 0.0152 0.0441 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0055 0.0181
Loa Loa (eye worm) hypothetical protein 0.0897 0.3063 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1528 0.5282 1
Schistosoma mansoni pyruvate dehydrogenase 0.0031 0.0016 0.0002
Schistosoma mansoni tsg101-related 0.0048 0.0076 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0033 0.0023 0.0031
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Trypanosoma cruzi DNA topoisomerase II, putative 0.0557 0.1868 0.6973
Brugia malayi Carboxylesterase family protein 0.0152 0.0441 0.1438
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0032 0.002 0.0073
Schistosoma mansoni hypothetical protein 0.0149 0.043 0.0417
Trypanosoma brucei DNA topoisomerase IA, putative 0.0032 0.002 0.0071
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1528 0.5282 1
Echinococcus granulosus survival motor neuron protein 1 0.0728 0.2469 0.2469
Brugia malayi Cell division protein ftsZ 0.0147 0.0426 0.1388
Plasmodium vivax endoplasmin, putative 0.0031 0.0016 0.0057
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0016 0.003
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0016 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1528 0.5282 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0557 0.1868 0.6973
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0016 0.0057
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0033 0.0023 0.0031
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0016 0.003
Echinococcus multilocularis geminin 0.0354 0.1154 0.1154
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0032 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0085 0.0279
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0033 0.0023 0.0031
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0152 0.0441 0.1689
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0076 0.0144
Brugia malayi DNA topoisomerase III 0.0032 0.002 0.0062
Plasmodium falciparum telomerase reverse transcriptase 0.0529 0.177 0.6603
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0033 0.0023 0.0031
Trypanosoma cruzi hypothetical protein 0.0067 0.0144 0.0539
Leishmania major DNA polymerase eta, putative 0.004 0.0049 0.0181
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0078 0.0184 0.0668
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0181
Loa Loa (eye worm) TOPoisomerase family member 0.0589 0.198 0.6466
Brugia malayi bHLH-PAS transcription factor 0.0075 0.017 0.0555
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0022
Echinococcus multilocularis heat shock protein 0.0031 0.0016 0.0016
Trichomonas vaginalis inositol monophosphatase, putative 0.0114 0.0308 0.0583
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0102 0.0102
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0055 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0173 0.0159
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0373 0.122 0.4553
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0181
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.16 0.6294
Brugia malayi Carboxylesterase family protein 0.0152 0.0441 0.1438
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0127 0.0353 0.1317
Echinococcus granulosus cytochrome P450 2K1 0.0033 0.0023 0.0023
Brugia malayi follicle stimulating hormone receptor 0.0484 0.1611 0.526
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0016 0.0057
Trypanosoma brucei unspecified product 0.0028 0.0005 0.0016
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0085 0.0208 0.0778
Brugia malayi Probable DNA topoisomerase II 0.0589 0.198 0.6465
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0016 0.0029
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0067 0.0144 0.0272
Leishmania major DNA topoisomerase IB, large subunit 0.0788 0.2679 1
Leishmania major telomerase reverse transcriptase, putative 0.0085 0.0208 0.0778
Echinococcus granulosus geminin 0.0354 0.1154 0.1154
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0102 0.0192
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0102 0.0102
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0173 0.0173
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0398 0.1308 1
Giardia lamblia Kinase, PLK 0.0096 0.0246 0.0465
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0036 0.0036
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0114 0.0308 0.2654
Mycobacterium leprae Probable two component sensor kinase MprB 0.0031 0.0016 0.0062
Mycobacterium ulcerans cell division protein FtsZ 0.0307 0.0987 0.3858
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0067
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0043 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0173 0.0327
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0067 0.0144 0.047
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0173 0.0327
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0102 0.0333
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0049 0.0158
Schistosoma mansoni intermediate filament proteins 0.0085 0.0206 0.0192
Brugia malayi ThiF family protein 0.0049 0.008 0.0258
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0055 0.0055
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0016 0.0029
Loa Loa (eye worm) cytochrome P450 0.0033 0.0023 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0173 0.0644
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0033 0.0023 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0033 0.0023 0.0031
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0016 0.0059
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0897 0.3063 0.3053
Echinococcus multilocularis dna polymerase kappa 0.004 0.0049 0.0049
Echinococcus multilocularis inositol monophosphatase 1 0.0114 0.0308 0.0308
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0067 0.022
Brugia malayi Inositol-1 0.0114 0.0308 0.1003
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0746 0.2533 1
Loa Loa (eye worm) hypothetical protein 0.031 0.0998 0.3258
Schistosoma mansoni endoplasmin 0.0031 0.0016 0.0002
Giardia lamblia Telomerase catalytic subunit 0.0085 0.0208 0.0394
Trichomonas vaginalis esterase, putative 0.0075 0.0173 0.0327
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0484 0.1611 0.5261
Trichomonas vaginalis hypothetical protein 0.0034 0.0028 0.0054
Leishmania major protein kinase, putative 0.0027 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0152 0.0441 0.1439
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Schistosoma mansoni inositol monophosphatase 0.0114 0.0308 0.0294
Brugia malayi Endoplasmin precursor 0.0031 0.0016 0.0049
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0081
Brugia malayi DnaJ domain containing protein 0.0065 0.0136 0.0444
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0055 0.0424
Leishmania major DNA topoisomerase ii 0.0557 0.1868 0.6973
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Onchocerca volvulus 0.0152 0.0441 0.3369
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0029 0.0094
Echinococcus granulosus heat shock protein 90 0.0031 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0067
Brugia malayi intermediate filament protein 0.0085 0.0206 0.0671
Giardia lamblia Fructose-bisphosphate aldolase 0.1528 0.5282 1
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0049 0.008 0.0066
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0033 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.1124
Brugia malayi Cytochrome P450 family protein 0.0078 0.0184 0.0598
Mycobacterium tuberculosis Carboxylesterase LipT 0.0152 0.0441 0.1689
Schistosoma mansoni acetylcholinesterase 0.0152 0.0441 0.0427
Loa Loa (eye worm) hypothetical protein 0.0728 0.2469 0.8062
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0067 0.0144 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0055 0.0181
Brugia malayi Pre-SET motif family protein 0.0211 0.0649 0.2119
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0033 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0095
Schistosoma mansoni hypothetical protein 0.0354 0.1154 0.1142
Loa Loa (eye worm) hypothetical protein 0.0046 0.0068 0.0222
Giardia lamblia DNA repair protein RAD52 0.1096 0.3763 0.7124
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0308 0.1149
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0014 0.0051
Loa Loa (eye worm) hypothetical protein 0.0081 0.0193 0.0629
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0049 0.008 0.008
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0102 0.0193
Loa Loa (eye worm) hypothetical protein 0.0373 0.122 0.3984
Echinococcus granulosus DNA topoisomerase 1 0.0788 0.2679 0.2679
Loa Loa (eye worm) hypothetical protein 0.0152 0.0441 0.1439
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0049 0.0181
Schistosoma mansoni aryl hydrocarbon receptor 0.0101 0.0263 0.0249
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0173 0.0623
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0016 0.003
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0031 0.0016 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0181
Schistosoma mansoni alpha glucosidase 0.0038 0.0043 0.0029
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0055 0.0055
Brugia malayi Muscleblind-like protein 0.031 0.0998 0.3256
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0032 0.002 0.0071
Trypanosoma brucei unspecified product 0.004 0.0049 0.0179
Schistosoma mansoni hypothetical protein 0.0065 0.0136 0.0122
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0016 0.0057
Loa Loa (eye worm) hypothetical protein 0.0075 0.0173 0.0564
Mycobacterium tuberculosis Conserved protein 0.0075 0.0173 0.0623
Toxoplasma gondii DNA topoisomerase I, putative 0.0788 0.2679 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0148 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0055 0.0181
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0148 0.0482
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0398 0.1308 1
Giardia lamblia DNA topoisomerase II 0.0558 0.1872 0.3544
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0075 0.0173 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0055 0.0179
Schistosoma mansoni bromodomain containing protein 0.0068 0.0148 0.0134
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0032 0.0021 0.0076
Loa Loa (eye worm) hypothetical protein 0.0042 0.0055 0.0181
Onchocerca volvulus 0.0075 0.0173 0.1319
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0055 0.0041
Echinococcus multilocularis neuroligin 0.0152 0.0441 0.0441
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Loa Loa (eye worm) hypothetical protein 0.031 0.0998 0.3258
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0127 0.0353 0.3069
Echinococcus granulosus heat shock protein 0.0031 0.0016 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0071 0.0071
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0246 0.0919
Schistosoma mansoni hypothetical protein 0.0067 0.0142 0.0128
Schistosoma mansoni DNA topoisomerase II 0.0589 0.198 0.1969
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0052 0.0052
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0033 0.0023 0.0031
Onchocerca volvulus 0.003 0.0014 0.0108
Echinococcus granulosus inositol monophosphatase 1 0.0114 0.0308 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Onchocerca volvulus Huntingtin homolog 0.0124 0.0344 0.2632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1528 0.5282 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.3063 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0053 0.0174
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0049 0.008 0.008
Echinococcus granulosus tumor susceptibility gene 101 protein 0.007 0.0156 0.0156
Trypanosoma cruzi DNA topoisomerase III, putative 0.0032 0.002 0.0073
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0152 0.0441 0.1689
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0023 0.0087
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0079 0.0079
Brugia malayi DNA topoisomerase I 0.0788 0.2679 0.8749
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0049 0.0049
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0127 0.0127
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0032 0.002 0.0035
Onchocerca volvulus 0.0152 0.0441 0.3369
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1096 0.3763 0.7124
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0033 0.0023 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0043 0.0159
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0102 0.0381
Chlamydia trachomatis DNA gyrase subunit B 0.0344 0.1116 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0033 0.0023 0.0087
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0055 0.0179
Trichomonas vaginalis DNA topoisomerase II, putative 0.0589 0.198 0.3749
Brugia malayi hypothetical protein 0.0036 0.0036 0.0116
Trypanosoma brucei polo-like protein kinase 0.0096 0.0246 0.0917
Onchocerca volvulus 0.0152 0.0441 0.3369
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0033 0.0023 0.0031
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0031 0.0016 0.0059
Brugia malayi beta-lactamase family protein 0.0075 0.0173 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0246 0.0466
Entamoeba histolytica DNA topoisomerase III, putative 0.0032 0.002 0.0036
Onchocerca volvulus 0.0075 0.017 0.1303
Entamoeba histolytica DNA topoisomerase III, putative 0.0032 0.002 0.0036
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0148 0.0148
Onchocerca volvulus 0.0032 0.002 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0005 0.0016
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0023 0.0087
Loa Loa (eye worm) hypothetical protein 0.0399 0.131 0.4278
Schistosoma mansoni tsg101-related 0.0059 0.0114 0.01
Leishmania major cytochrome p450-like protein 0.0033 0.0023 0.0087
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0246 0.0246
Brugia malayi DNA topoisomerase III beta-1 0.0032 0.002 0.0062
Echinococcus multilocularis lamin dm0 0.0085 0.0206 0.0206
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0049 0.0157
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0085 0.0208 0.0778
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0055 0.0424
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0148 0.0134
Loa Loa (eye worm) hypothetical protein 0.004 0.0049 0.0158
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0344 0.1116 0.4165
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0049 0.0049
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0114 0.0308 0.1147
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0081
Mycobacterium leprae cell division protein FtsZ 0.0307 0.0987 0.3896
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0114 0.0308 0.0582
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0049 0.013
Entamoeba histolytica hypothetical protein 0.0312 0.1005 0.1901
Treponema pallidum DNA topoisomerase I (topA) 0.0032 0.002 0.0007
Brugia malayi GRF zinc finger family protein 0.0032 0.002 0.0062
Loa Loa (eye worm) hypothetical protein 0.0399 0.131 0.4278
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0033 0.0023 0.0085
Brugia malayi Cytochrome P450 family protein 0.0078 0.0184 0.0598
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0085 0.0277
Toxoplasma gondii hypothetical protein 0.0049 0.008 0.0295
Loa Loa (eye worm) CYP4Cod1 0.0078 0.0184 0.06
Plasmodium vivax telomerase reverse transcriptase, putative 0.0529 0.177 0.6603
Brugia malayi nuclear hormone receptor 0.0042 0.0055 0.0179
Loa Loa (eye worm) glutaminase 2 0.027 0.0859 0.2803
Onchocerca volvulus 0.0042 0.0055 0.0424
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0016 0.0057
Loa Loa (eye worm) hypothetical protein 0.0152 0.0441 0.1439
Echinococcus granulosus hypothetical protein 0.0719 0.2438 0.2438
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0033 0.0023 0.0031
Schistosoma mansoni apoptosis regulator bax 0.0067 0.0142 0.0128
Entamoeba histolytica DNA topoisomerase II, putative 0.0589 0.198 0.3748
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0049 0.0091
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0057
Loa Loa (eye worm) DnaJ domain-containing protein 0.0065 0.0136 0.0445
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0016 0.0057
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0031 0.0016 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0102 0.0193
Schistosoma mansoni DNA polymerase eta 0.004 0.0049 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1528 0.5282 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0033 0.0023 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0071 0.0057
Loa Loa (eye worm) hypothetical protein 0.0124 0.0344 0.1124
Mycobacterium ulcerans beta-lactamase 0.0075 0.0173 0.0623
Loa Loa (eye worm) hypothetical protein 0.0049 0.008 0.026
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0033 0.0023 0.0031
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0032 0.002 0.0037
Schistosoma mansoni alpha-glucosidase 0.0149 0.0431 0.0418
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0184 0.06
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0021 0.0078
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0003 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0049 0.0181
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0055 0.0055
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0134 0.0121
Mycobacterium ulcerans DNA topoisomerase I 0.0032 0.002 0.0015
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0049 0.0179
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0032 0.002 0.0073
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0148 0.0483
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0003 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0033 0.0023 0.0031
Schistosoma mansoni tsg101-related 0.0059 0.0114 0.01
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0032 0.002 0.002
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0055 0.0041
Brugia malayi PAS domain containing protein 0.0101 0.0263 0.0856
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0016 0.0059
Giardia lamblia Pms1-like protein 0.0031 0.0016 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0102 0.0193
Brugia malayi heat shock protein 90 0.0031 0.0016 0.0049
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0173 0.0642
Loa Loa (eye worm) hypothetical protein 0.0039 0.0046 0.0151
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0055 0.0055
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0307 0.0987 0.8825
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0033 0.0023 0.0031
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0033 0.0023 0.0031
Echinococcus granulosus acetylcholinesterase 0.0897 0.3063 0.3063
Schistosoma mansoni endoplasmin 0.0031 0.0016 0.0002
Trypanosoma brucei heat shock protein, putative 0.0031 0.0016 0.0057
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0127 0.0353 0.0641
Toxoplasma gondii DNA topoisomerase 2, putative 0.0589 0.198 0.739
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0102 0.0193
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0173 0.0623
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0127 0.0113
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0043 0.0081
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0055 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0055 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0071 0.0057
Schistosoma mansoni hypothetical protein 0.0067 0.0142 0.0128
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0085 0.0279
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0032 0.0021 0.0076
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0102 0.0379
Echinococcus multilocularis microtubule associated protein 2 0.2869 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0055 0.0179
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0398 0.1308 1
Brugia malayi hypothetical protein 0.0124 0.0344 0.1123
Leishmania major heat shock protein 83-1 0.0031 0.0016 0.0059
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0016 0.0051
Plasmodium vivax DNA topoisomerase II, putative 0.0589 0.198 0.739
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0067 0.0142 0.0142
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0746 0.2533 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0033 0.0023 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0049 0.0179
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0067 0.0142 0.0142
Echinococcus multilocularis acetylcholinesterase 0.0897 0.3063 0.3063
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0016 0.0059
Echinococcus granulosus neuropeptide s receptor 0.0486 0.1618 0.1618
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0033 0.0023 0.0031
Echinococcus granulosus tar DNA binding protein 0.0068 0.0148 0.0148

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) < 0.01 uM Inhibition of c-terminal 6xHis-tagged Bcl-2 (amino acids 1 to 204) (unknown origin) preincubated for 1 hr prior to substrate addition measured after 20 mins by fluorescence polarization assay ChEMBL. 24881567
IC50 (binding) = 0.015 uM Inhibition of c-terminal 6xHis-tagged Bcl-xL (amino acids 1 to 209) (unknown origin) preincubated for 1 hr prior to substrate addition measured after 20 mins by fluorescence polarization assay ChEMBL. 24881567

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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