TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 750.745 | Formula: C45H34O11
H donors: 2 H acceptors: 8 LogP: 6.33 Rotable bonds: 2
Rule of 5 violations (Lipinski): 2
SMILES: O=C1c2c(ccc3c2C=CC(O3)(C)C)C(=O)C(=C1O)C1=C(C(=O)c2c(C1=O)c1CCC(Oc1cc2)(C)C)C1=C(O)C(=O)c2c(C1=O)ccc1c2C=CC(O1)(C)C
InChi: 1S/C45H34O11/c1-43(2)16-13-19-25(54-43)10-7-22-28(19)38(49)32(34-37(48)24-9-12-27-21(15-18-45(5,6)56-27)30(24)40(51)42(34)53)31(35(22)46)33-36(47)23-8-11-26-20(14-17-44(3,4)55-26)29(23)39(50)41(33)52/h7-12,14-15,17-18,52-53H,13,16H2,1-6H3
InChiKey: UIVVAUBNXGNWQF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Human immunodeficiency virus 1	Integrase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_139608	All targets in OG5_139608
Plasmodium yoelii	integrase-related	Get druggable targets OG5_139608	All targets in OG5_139608
Trypanosoma congolense	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608
Trypanosoma brucei	RNA helicase, putative	Get druggable targets OG5_139608	All targets in OG5_139608

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0068	0.0096
Echinococcus multilocularis	geminin	0.0348	0.2597	0.3686
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0068	0.0091
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.0306	0.0276
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0365	0.2739	0.3831
Schistosoma mansoni	hypothetical protein	0.0033	0.0045	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Schistosoma mansoni	serine/threonine protein kinase	0.0101	0.06	0.0847
Trypanosoma cruzi	polo-like protein kinase, putative	0.0101	0.06	0.0535
Onchocerca volvulus	Alhambra homolog	0.0031	0.0032	0.0039
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0101	0.06	0.8782
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0102	0.0609	0.0859
Schistosoma mansoni	hypothetical protein	0.0045	0.0146	0.0201
Schistosoma mansoni	hypothetical protein	0.0045	0.0146	0.0201
Schistosoma mansoni	hypothetical protein	0.0045	0.0146	0.0201
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0045	0.0064
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0112	0.0044
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0306	0.0342
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0068	0.0096
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0306	0.0342
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0426	0.3232	0.3186
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0045	0.0058
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0306	0.0429
Echinococcus multilocularis	protein dispatched 1	0.0054	0.0214	0.0298
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0142	0.0925	0.1309
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0068	0.0091
Echinococcus granulosus	geminin	0.0348	0.2597	0.3686
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.016	0.029
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0085	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.0426	0.3232	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0157	0.1049	0.1485
Echinococcus granulosus	peregrin	0.0031	0.0032	0.0039
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0185	0.0369
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0258	0.0192
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.1261	1	1
Loa Loa (eye worm)	inositol-1	0.0041	0.0112	0.0159
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0306	0.0429
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0045	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Trypanosoma brucei	RNA helicase, putative	0.0125	0.0791	0.0728
Echinococcus multilocularis	sterol regulatory element binding protein	0.0047	0.016	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0213	0.0302
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0041	0.0112	0.0063
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0045	0.0058
Schistosoma mansoni	hypothetical protein	0.0071	0.0355	0.0499
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.06	0.1681
Mycobacterium ulcerans	thymidylate synthase	0.0896	0.7039	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.011	0.0667	1
Brugia malayi	PHD-finger family protein	0.0031	0.0032	0.0039
Echinococcus granulosus	Niemann Pick C1 protein	0.011	0.0667	0.0943
Onchocerca volvulus		0.0896	0.7039	1
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0112	0.0153
Schistosoma mansoni	hypothetical protein	0.0033	0.0045	0.0058
Echinococcus granulosus	GPCR family 2	0.0033	0.0045	0.0058
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.06	0.1681
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0085	0.0121
Trypanosoma cruzi	cruzipain precursor, putative	0.0065	0.0304	0.0238
Echinococcus multilocularis	thymidylate synthase	0.0896	0.7039	1
Loa Loa (eye worm)	dihydrofolate reductase	0.0365	0.2739	0.3891
Schistosoma mansoni	dihydrofolate reductase	0.0365	0.2739	0.3887
Brugia malayi	jmjC domain containing protein	0.0038	0.0085	0.0115
Schistosoma mansoni	hypothetical protein	0.0033	0.0045	0.0058
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0365	0.2739	0.3831
Schistosoma mansoni	hypothetical protein	0.0348	0.2597	0.3686
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0045	0.0058
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0112	0.0153
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0037	0.0077	0.0012
Schistosoma mansoni	hypothetical protein	0.0033	0.0045	0.0058
Toxoplasma gondii	ABC1 family protein	0.0036	0.0068	0.0036
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0065	0.0306	0.0342
Loa Loa (eye worm)	jmjC domain-containing protein	0.0065	0.0302	0.0429
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Echinococcus granulosus	dihydrofolate reductase	0.0365	0.2739	0.3887
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.0191	0.0124
Echinococcus granulosus	inositol monophosphatase 1	0.0041	0.0112	0.0153
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0047	0.016	0.0227
Echinococcus granulosus	Protein patched homolog 1	0.0047	0.016	0.0221
Brugia malayi	CHE-14 protein	0.0047	0.016	0.0221
Echinococcus granulosus	expressed conserved protein	0.0103	0.0613	0.0866
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0101	0.06	0.0847
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.06	0.1681
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0102	0.0609	0.0859
Giardia lamblia	Kinase, PLK	0.0101	0.06	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0045	0.0058
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.0925	0.1309
Loa Loa (eye worm)	thymidylate synthase	0.0896	0.7039	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0047	0.016	0.0221
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.0085	0.0115
Schistosoma mansoni	hypothetical protein	0.0348	0.2597	0.3686
Echinococcus granulosus	Niemann Pick C1 protein	0.0157	0.1049	0.1485
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.1261	1	1
Mycobacterium tuberculosis	Hypothetical protein	0.0426	0.3232	0.4539
Echinococcus multilocularis	peregrin	0.0031	0.0032	0.0039
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0304	0.0238
Brugia malayi	beta-lactamase family protein	0.0036	0.0068	0.0091
Trypanosoma brucei	polo-like protein kinase	0.0101	0.06	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0068	0.0096
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0085	0.0115
Schistosoma mansoni	patched 1	0.0047	0.016	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0068	0.0096
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.1261	1	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0101	0.06	0.0847
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0104	0.0623	0.0885
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0068	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0068	0.0096
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0068	0.0091
Onchocerca volvulus		0.0036	0.0068	0.0091
Echinococcus multilocularis	conserved hypothetical protein	0.067	0.5206	0.7394
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0045	0.0058
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0142	0.0925	0.1314
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0142	0.0925	0.1309
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.1261	1	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0896	0.7039	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0306	0.0342
Leishmania major	cathepsin L-like protease	0.0065	0.0304	0.0238
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0101	0.06	0.0535
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0142	0.0925	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0355	0.0505
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.06	0.1681
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0304	0.0238
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0101	0.06	0.0852
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.0925	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0045	0.0064
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0112	0.0044
Brugia malayi	beta-lactamase family protein	0.0036	0.0068	0.0091
Loa Loa (eye worm)	PHD-finger family protein	0.0031	0.0032	0.0045
Loa Loa (eye worm)	hypothetical protein	0.011	0.0667	0.0948
Brugia malayi	thymidylate synthase	0.0896	0.7039	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.0306	0.024
Chlamydia trachomatis	dihydrofolate reductase	0.0365	0.2739	0.5
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0041	0.0112	0.008
Echinococcus multilocularis	protein patched	0.0047	0.016	0.0221
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.0112	0.0138
Brugia malayi	jmjC domain containing protein	0.0102	0.0609	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0068	0.0096
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0068	0.0036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Brugia malayi	Inositol-1	0.0041	0.0112	0.0153
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.0131	0.018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.06	0.1681
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0068	0.0096
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0185	0.0369
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.0306	0.0429
Brugia malayi	Niemann-Pick C1 protein precursor	0.011	0.0667	0.0943
Echinococcus granulosus	PHD finger protein rhinoceros	0.0031	0.0032	0.0039
Onchocerca volvulus		0.0036	0.0068	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0623	0.0885
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0041	0.0112	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.0355	0.0499
Leishmania major	cathepsin L-like protease	0.0065	0.0304	0.0238
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.1631	0.2242
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0142	0.0925	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0047	0.016	0.0227
Echinococcus multilocularis	inositol monophosphatase 1	0.0041	0.0112	0.0153
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.06	0.1681
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0112	0.0044
Schistosoma mansoni	hypothetical protein	0.0031	0.0032	0.0039
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0111	0.0681	0.0962
Leishmania major	cathepsin L-like protease	0.0065	0.0304	0.0238
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0037	0.0077	0.0012
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.1261	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0104	0.0623	0.0879
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0031	0.0032	0.0039
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0896	0.7039	1
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0365	0.2739	0.3831
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0104	0.0623	0.0879
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.0306	0.0429
Brugia malayi	serine/threonine-protein kinase plk-2	0.0101	0.06	0.0847
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0004	0.0006
Brugia malayi	hypothetical protein	0.0426	0.3232	0.4589
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0068	0.0091
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0304	0.0238
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0068	0.0096
Echinococcus granulosus	hypothetical protein	0.0672	0.5224	0.742
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.0131	0.018
Trypanosoma cruzi	polo-like protein kinase, putative	0.0101	0.06	0.0535
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0112	0.0044
Schistosoma mansoni	hypothetical protein	0.0125	0.0791	0.1119
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.0112	0.0138
Brugia malayi	Bromodomain containing protein	0.0031	0.0032	0.0039
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0045	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0246	0.0349
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.0925	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0004	0.0006
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0031	0.0032	0.0039
Echinococcus multilocularis	Niemann Pick C1 protein	0.011	0.0667	0.0943
Trichomonas vaginalis	inositol monophosphatase, putative	0.0041	0.0112	0.0138
Echinococcus multilocularis	dihydrofolate reductase	0.0365	0.2739	0.3887
Brugia malayi	dihydrofolate reductase family protein	0.0365	0.2739	0.3887
Brugia malayi	beta-lactamase	0.0036	0.0068	0.0091
Onchocerca volvulus		0.0036	0.0068	0.0091
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0896	0.7039	1
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.06	0.1681
Echinococcus multilocularis	expressed conserved protein	0.0103	0.0613	0.0866
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0142	0.0925	0.1309
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0004	0.0006
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0101	0.06	0.0847
Schistosoma mansoni	hypothetical protein	0.0045	0.0146	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0032	0.0045
Echinococcus granulosus	thymidylate synthase	0.0896	0.7039	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.0085	0.0115
Schistosoma mansoni	kinase	0.0052	0.0196	0.0272
Schistosoma mansoni	jumonji domain containing protein	0.0081	0.0438	0.0617
Brugia malayi	Dihydrofolate reductase	0.0365	0.2739	0.3887
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0304	0.0238

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (functional)	> 20 uM	Cytotoxicity against human CEM cells	ChEMBL.	20685126
IC50 (binding)	= 1.8 uM	Inhibition of HIV1 integrase 3' processing activity	ChEMBL.	20685126
IC50 (binding)	= 6 uM	Inhibition of HIV1 integrase 3' strand transfer activity	ChEMBL.	20685126

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1223980

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 916074