Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | pantoate--beta-alanine ligase | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Neospora caninum | pantoate--beta-alanine ligase, putative | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Toxoplasma gondii | pantoate-beta-alanine ligase | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | Get druggable targets OG5_129569 | All targets in OG5_129569 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.002 | 0.004 | 0.004 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0725 | 0.3926 | 0.5 |
Loa Loa (eye worm) | PEK/HRI protein kinase | 0.1827 | 1 | 1 |
Trypanosoma brucei | eukaryotic translation initiation factor 2-alpha kinase 1, putative | 0.1827 | 1 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0023 | 0.0056 | 0.0056 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0448 | 0.2398 | 0.2398 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0448 | 0.2398 | 0.2398 |
Schistosoma mansoni | tyrosine kinase | 0.0438 | 0.2341 | 0.9764 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1827 | 1 | 1 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Trypanosoma brucei | protein kinase, putative | 0.1827 | 1 | 0.5 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0725 | 0.3926 | 0.5 |
Echinococcus multilocularis | eukaryotic translation initiation factor 2 alpha | 0.1827 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.1827 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0448 | 0.2398 | 1 |
Echinococcus granulosus | eukaryotic translation initiation factor 2 alpha | 0.1827 | 1 | 1 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0725 | 0.3926 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0725 | 0.3926 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.002 | 0.004 | 0.004 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1827 | 1 | 1 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.7 uM | Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) by spectrophotometry | ChEMBL. | 24953948 |
Inhibition (ADMET) | = 31.67 % | Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell viability at 50 uM after 72 hrs by MTT assay | ChEMBL. | 24953948 |
MIC (functional) | = 10.38 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition after 28 days by agar dilution method | ChEMBL. | 24953948 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.