Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0067 | 0.1487 | 0.3805 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0137 | 0.3908 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0137 | 0.3908 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0137 | 0.3908 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.3908 | 0.5542 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.3908 | 0.5542 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.3908 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0086 | 0.2154 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0086 | 0.2154 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0137 | 0.3908 | 1 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0097 | 0.254 | 0.65 |
Giardia lamblia | Telomerase catalytic subunit | 0.0086 | 0.2154 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0086 | 0.2154 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0067 | 0.1487 | 0.3805 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0101 | 0.2655 | 0.6794 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0101 | 0.2655 | 0.6794 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0067 | 0.1487 | 0.3805 |
Echinococcus multilocularis | acetylcholinesterase | 0.0137 | 0.3908 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0086 | 0.2154 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0097 | 0.254 | 0.65 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0086 | 0.2154 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0086 | 0.2154 | 0.5 |
Brugia malayi | Transient-receptor-potential like protein | 0.0037 | 0.0488 | 0.0693 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0067 | 0.1487 | 0.3805 |
Schistosoma mansoni | transient receptor potential channel | 0.0067 | 0.1487 | 0.3805 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.3908 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1372 | 0.3511 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2655 | 0.6794 |
Echinococcus granulosus | acetylcholinesterase | 0.0137 | 0.3908 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0137 | 0.3908 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.3908 | 1 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0037 | 0.0488 | 0.125 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0101 | 0.2655 | 0.6794 |
Brugia malayi | Telomerase reverse transcriptase | 0.0229 | 0.7052 | 1 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0037 | 0.0488 | 0.125 |
Schistosoma mansoni | transient receptor potential channel | 0.0101 | 0.2655 | 0.6794 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0067 | 0.1487 | 0.3805 |
Loa Loa (eye worm) | carboxylesterase | 0.0137 | 0.3908 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0373 | 0.0956 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0086 | 0.2154 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0488 | 0.125 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | >= 100 uM | Cytotoxicity against human MCF7 cells assessed as cell viability after 24 hrs incubation by MTT assay | ChEMBL. | 24890655 |
IZ (functional) | = 0 mm | Antimicrobial activity against Saccharomyces cerevisiae assessed as inhibition at 20 ug/6 mm disk after 1 to 2 days by agar diffusion assay | ChEMBL. | 24890655 |
IZ (functional) | = 0 mm | Antimicrobial activity against Candida albicans assessed as inhibition at 20 ug/6 mm disk after 1 to 2 days by agar diffusion assay | ChEMBL. | 24890655 |
IZ (functional) | = 0 mm | Antimicrobial activity against Escherichia coli tolC assessed as inhibition at 20 ug/6 mm disk after 1 to 2 days by agar diffusion assay | ChEMBL. | 24890655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.