Detailed information for compound 916222

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.266 | Formula: C20H17IN2O2
  • H donors: 1 H acceptors: 2 LogP: 4.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc2c(c1)c(=O)c(cn2C1CC1)C(=O)NCc1ccccc1
  • InChi: 1S/C20H17IN2O2/c21-14-6-9-18-16(10-14)19(24)17(12-23(18)15-7-8-15)20(25)22-11-13-4-2-1-3-5-13/h1-6,9-10,12,15H,7-8,11H2,(H,22,25)
  • InChiKey: MARZTTVUVADRPV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0022 0.007
Leishmania major telomerase reverse transcriptase, putative 0.0087 0.0215 0.08
Echinococcus multilocularis musashi 0.0087 0.0215 0.0213
Plasmodium falciparum heat shock protein 90 0.0031 0.0024 0.0078
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0034 0.0032 0.0126
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0762 0.2539 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0031 0.0024 0.003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.0317 0.117
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0762 0.2539 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0157 0.0157
Plasmodium vivax DNA gyrase subunit B, putative 0.035 0.1121 0.4177
Plasmodium vivax telomerase reverse transcriptase, putative 0.0536 0.1762 0.6573
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0116 0.0317 0.0584
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0009 0.003
Brugia malayi hypothetical protein 0.0025 0.0004 0.0009
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0252 0.0476
Mycobacterium tuberculosis Probable two component sensor kinase 0.0031 0.0024 0.0094
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0156 0.0453 0.1784
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.018 0.0178
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0111 0.0109
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0165 0.0485 0.1908
Trypanosoma brucei heat shock protein, putative 0.0031 0.0024 0.0078
Schistosoma mansoni acetylcholinesterase 0.0165 0.0485 0.0485
Echinococcus multilocularis para nitrobenzyl esterase 0.0165 0.0485 0.0483
Loa Loa (eye worm) hypothetical protein 0.0077 0.018 0.0549
Mycobacterium leprae Conserved hypothetical protein 0.0034 0.0032 0.0126
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0378 0.1218 0.4541
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.156 0.5285 1
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.0178 0.0176
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0184
Loa Loa (eye worm) hypothetical protein 0.0077 0.018 0.0549
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0031 0.0024 0.0094
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0191
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0063 0.0061
Trypanosoma brucei polo-like protein kinase 0.0098 0.0252 0.093
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.005 0.0087 0.0085
Echinococcus granulosus tar DNA binding protein 0.007 0.0157 0.0155
Schistosoma mansoni alpha glucosidase 0.004 0.0054 0.0054
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0009 0.0007
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0009 0.002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0058 0.0056
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0147 0.0145
Echinococcus multilocularis heat shock protein 0.0031 0.0024 0.0022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.018 0.0549
Plasmodium falciparum DNA gyrase subunit B 0.035 0.1121 0.4177
Brugia malayi Cytochrome P450 family protein 0.0034 0.0032 0.0097
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.0534 0.0531
Schistosoma mansoni heat shock protein 0.0031 0.0024 0.0024
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0024 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0063 0.0191
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0063 0.0191
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0061 0.0059
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.06 0.1982 0.198
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0093 0.0282
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0093 0.0282
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0009 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0034 0.0032 0.0126
Mycobacterium ulcerans two component sensor kinase MprB 0.0031 0.0024 0.0094
Plasmodium falciparum DNA topoisomerase 2 0.06 0.1982 0.7396
Schistosoma mansoni inositol monophosphatase 0.0116 0.0317 0.0317
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0031 0.0024 0.003
Echinococcus granulosus dna polymerase kappa 0.0041 0.0058 0.0056
Brugia malayi PHD-finger family protein 0.0027 0.0011 0.0032
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.0151 0.0286
Onchocerca volvulus 0.0043 0.0063 0.0478
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0024 0.0078
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Echinococcus multilocularis heat shock protein 90 0.0031 0.0024 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0252 0.0462
Loa Loa (eye worm) hypothetical protein 0.0077 0.018 0.0549
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0058 0.0204
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0152 0.0439 0.1337
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0034 0.0032 0.0126
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0191
Loa Loa (eye worm) hypothetical protein 0.0165 0.0485 0.1477
Chlamydia trachomatis DNA gyrase subunit A 0.0129 0.0361 0.3045
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0111 0.0402
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0031 0.0024 0.0078
Trypanosoma brucei unspecified product 0.0028 0.0014 0.004
Onchocerca volvulus 0.0087 0.0215 0.1638
Schistosoma mansoni intermediate filament proteins 0.0087 0.0215 0.0215
Schistosoma mansoni neuroligin 3 (S09 family) 0.0165 0.0485 0.0485
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.018 0.0709
Brugia malayi kinase, mitochondrial precursor 0.0031 0.0024 0.0073
Onchocerca volvulus Huntingtin homolog 0.0126 0.035 0.2662
Trypanosoma brucei heat shock protein, putative 0.0031 0.0024 0.0078
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.018 0.0709
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0147 0.0147
Echinococcus multilocularis acetylcholinesterase 0.0977 0.3279 0.3278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0063 0.0191
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0104 0.0275 0.108
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0034 0.0032 0.0126
Brugia malayi beta-lactamase family protein 0.0077 0.018 0.0549
Brugia malayi Cytochrome P450 family protein 0.0034 0.0032 0.0097
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0063 0.0061
Toxoplasma gondii DNA topoisomerase I, putative 0.0803 0.2678 1
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0054 0.0187
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.018 0.0709
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0013 0.0036
Loa Loa (eye worm) hypothetical protein 0.0344 0.1101 0.3358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0063 0.0191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0078 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Brugia malayi Cytochrome P450 family protein 0.008 0.0194 0.0589
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0054 0.01
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0034 0.0032 0.0126
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.156 0.5285 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0111 0.0109
Brugia malayi Pre-SET motif family protein 0.0214 0.0652 0.1988
Loa Loa (eye worm) hypothetical protein 0.0077 0.018 0.0549
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0031 0.0024 0.0094
Plasmodium falciparum flap endonuclease 1 0.0027 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0077 0.018 0.0549
Onchocerca volvulus 0.0032 0.0028 0.0211
Brugia malayi Cytochrome P450 family protein 0.008 0.0194 0.0589
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0034 0.0032 0.0126
Chlamydia trachomatis DNA gyrase subunit B 0.035 0.1121 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0031 0.0024 0.0094
Schistosoma mansoni aryl hydrocarbon receptor 0.0103 0.027 0.027
Brugia malayi hypothetical protein 0.0037 0.0044 0.0132
Loa Loa (eye worm) hypothetical protein 0.0193 0.0582 0.1773
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0087 0.0087
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0754 0.1413
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0157 0.0476
Brugia malayi PAS domain containing protein 0.0103 0.027 0.0821
Loa Loa (eye worm) DnaJ domain-containing protein 0.0067 0.0149 0.0452
Brugia malayi heat shock protein 90 0.0031 0.0024 0.0073
Echinococcus multilocularis dna polymerase eta 0.0041 0.0058 0.0056
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0031 0.0024 0.0094
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.018 0.0709
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0034 0.0032 0.0126
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0175
Giardia lamblia Telomerase catalytic subunit 0.0087 0.0215 0.039
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0031 0.0024 0.0078
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0054 0.01
Loa Loa (eye worm) hypothetical protein 0.0165 0.0485 0.1477
Brugia malayi DNA topoisomerase III beta-1 0.0032 0.0028 0.0084
Brugia malayi DNA topoisomerase III 0.0032 0.0028 0.0084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.018 0.0709
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0058 0.0226
Leishmania major DNA topoisomerase III, putative 0.0032 0.0028 0.0103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0058 0.0175
Chlamydia trachomatis DNA gyrase subunit B 0.0277 0.0868 0.7687
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0024 0.0073
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Mycobacterium tuberculosis Possible two component sensor kinase 0.0031 0.0024 0.0094
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0104 0.0275 0.108
Brugia malayi Pre-SET motif family protein 0.0031 0.0022 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0054 0.0085
Echinococcus multilocularis survival motor neuron protein 1 0.0744 0.2476 0.2474
Onchocerca volvulus 0.0104 0.0274 0.2081
Brugia malayi Muscleblind-like protein 0.0318 0.101 0.3079
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0111 0.0111
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0032 0.0097
Loa Loa (eye worm) carboxylesterase 0.0165 0.0485 0.1477
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0116 0.0317 0.0584
Schistosoma mansoni DNA polymerase eta 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0674 0.2234 0.8341
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0034 0.0032 0.0126
Schistosoma mansoni bromodomain containing protein 0.007 0.0157 0.0157
Echinococcus multilocularis carboxylesterase 5A 0.0977 0.3279 0.3278
Schistosoma mansoni cell polarity protein 0.0147 0.0423 0.0423
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.005 0.0087 0.0313
Trypanosoma brucei unspecified product 0.0028 0.0014 0.004
Schistosoma mansoni tar DNA-binding protein 0.007 0.0157 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0058 0.0204
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.035 0.1121 0.4177
Echinococcus granulosus heat shock protein 0.0031 0.0024 0.0022
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0031 0.0024 0.0094
Brugia malayi Cell division protein ftsZ 0.0149 0.043 0.131
Echinococcus granulosus ras gtpase 0.0147 0.0423 0.0421
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0034 0.0032 0.0126
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0031 0.0024 0.003
Brugia malayi DNA topoisomerase I 0.0803 0.2678 0.8167
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0054 0.0085
Mycobacterium ulcerans putative regultory protein 0.0031 0.0024 0.0094
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.018 0.0709
Echinococcus granulosus lamin 0.0087 0.0215 0.0213
Brugia malayi Carboxylesterase family protein 0.0165 0.0485 0.1477
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0063 0.0191
Echinococcus multilocularis rho GTPase activating protein 20 0.0032 0.0028 0.0026
Mycobacterium leprae Possible regulatory protein 0.0027 0.0009 0.0031
Entamoeba histolytica DNA topoisomerase II, putative 0.06 0.1982 0.3749
Echinococcus multilocularis lamin dm0 0.0087 0.0215 0.0213
Leishmania major protein kinase, putative 0.0027 0.0011 0.004
Brugia malayi glutaminase DH11.1 0.0273 0.0857 0.2614
Schistosoma mansoni endoplasmin 0.0031 0.0024 0.0024
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0167
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.156 0.5285 1
Plasmodium vivax topoisomerase I, putative 0.0803 0.2678 1
Echinococcus multilocularis ras gtpase 0.0147 0.0423 0.0421
Mycobacterium tuberculosis Carboxylesterase LipT 0.0165 0.0485 0.1908
Trichomonas vaginalis hypothetical protein 0.0035 0.0037 0.0053
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0031 0.0024 0.0094
Trichomonas vaginalis protein kinase inhibitor, putative 0.0067 0.0149 0.0266
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.0317 0.117
Brugia malayi beta-lactamase family protein 0.0077 0.018 0.0549
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Trypanosoma brucei DNA topoisomerase ii 0.0674 0.2234 0.8341
Schistosoma mansoni tar DNA-binding protein 0.007 0.0157 0.0157
Entamoeba histolytica DNA topoisomerase III, putative 0.0032 0.0028 0.0052
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0032 0.0028 0.0037
Leishmania major cytochrome p450-like protein 0.0034 0.0032 0.0119
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.018 0.0326
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0034 0.0032 0.0126
Leishmania major DNA polymerase kappa, putative 0.0041 0.0058 0.0215
Trypanosoma brucei unspecified product 0.0041 0.0058 0.0204
Trypanosoma brucei glucosidase, putative 0.004 0.0054 0.0187
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.0215 0.079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Brugia malayi Bromodomain containing protein 0.0042 0.0062 0.0187
Brugia malayi Bromodomain containing protein 0.0083 0.0201 0.0611
Entamoeba histolytica hypothetical protein 0.0037 0.0044 0.0082
Mycobacterium ulcerans DNA topoisomerase I 0.0032 0.0028 0.0109
Schistosoma mansoni coup transcription factor 0.0043 0.0063 0.0063
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0151 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.156 0.5285 1
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0054 0.0198
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0191
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0034 0.0032 0.0126
Echinococcus multilocularis 0.0034 0.0032 0.003
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0009 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0063 0.0191
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0143 0.0141
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0031 0.0024 0.0094
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0833 0.2783 0.2781
Leishmania major ubiquitin-activating enzyme-like protein 0.0033 0.0029 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0063 0.0191
Echinococcus granulosus survival motor neuron protein 1 0.0744 0.2476 0.2474
Loa Loa (eye worm) CYP4Cod1 0.008 0.0194 0.0589
Loa Loa (eye worm) DNA topoisomerase III 0.0032 0.0028 0.0084
Echinococcus granulosus intermediate filament protein 0.0087 0.0215 0.0213
Trichomonas vaginalis endoplasmin, putative 0.0031 0.0024 0.003
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0034 0.0032 0.0108
Echinococcus granulosus dnaJ subfamily C 6 0.0067 0.0149 0.0147
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0191
Loa Loa (eye worm) hypothetical protein 0.0165 0.0485 0.1477
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0034 0.0032 0.0126
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0063 0.0061
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0032 0.0028 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0078 0.0076
Onchocerca volvulus 0.0165 0.0485 0.3693
Onchocerca volvulus 0.0165 0.0485 0.3693
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0063 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0034 0.0032 0.0126
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0009 0.0006
Plasmodium vivax DNA topoisomerase 3, putative 0.0032 0.0028 0.0092
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0165 0.0485 0.1908
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.018 0.0709
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0034 0.0032 0.0126
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0063 0.0061
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.035 0.1121 0.2084
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0111 0.0402
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0063 0.0191
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0031 0.0024 0.0022
Schistosoma mansoni kinase 0.005 0.0088 0.0088
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0031 0.0024 0.0094
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0252 0.0462
Loa Loa (eye worm) Ulp1 protease 0.0068 0.0151 0.046
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0252 0.0462
Schistosoma mansoni DNA topoisomerase type I 0.0803 0.2678 0.2678
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.0534 0.1626
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0803 0.2678 1
Mycobacterium tuberculosis Conserved protein 0.0077 0.018 0.0709
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0674 0.2234 0.8341
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0063 0.0063
Giardia lamblia DINP protein human, muc B family 0.0041 0.0058 0.0093
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0063 0.0061
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0063 0.0478
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0147 0.0147
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0061 0.0059
Echinococcus granulosus acetylcholinesterase 0.0977 0.3279 0.3278
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0063 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0014 0.004
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0139 0.0137
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0165 0.0485 0.0485
Leishmania major DNA polymerase eta, putative 0.0041 0.0058 0.0215
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0188
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0063 0.0478
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0068 0.0151 0.0151
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0024 0.003
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0252 0.093
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0011 0.0029
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0009 0.002
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0165 0.0485 0.0483
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0034 0.0032 0.0126
Plasmodium vivax SET domain protein, putative 0.0031 0.0022 0.007
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0034 0.0032 0.0126
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0044 0.0042
Onchocerca volvulus 0.0165 0.0485 0.3693
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0167
Leishmania major developmentally regulated phosphoprotein-like protein 0.0031 0.0024 0.0089
Loa Loa (eye worm) RNA binding protein 0.007 0.0157 0.0476
Trypanosoma brucei DNA topoisomerase IA, putative 0.0032 0.0028 0.0092
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0053 0.0051
Echinococcus multilocularis conserved hypothetical protein 0.0709 0.2356 0.2354
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0032 0.0028 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Mycobacterium ulcerans putative regulatory protein 0.0076 0.0178 0.0699
Brugia malayi Flap endonuclease-1 0.0027 0.0009 0.0025
Onchocerca volvulus 0.0027 0.0009 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0063 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0063 0.0061
Trichomonas vaginalis spcc417.12 protein, putative 0.0165 0.0485 0.0903
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0034 0.0032 0.0126
Echinococcus multilocularis lamin 0.0087 0.0215 0.0213
Brugia malayi hypothetical protein 0.0071 0.0163 0.0494
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0111 0.0194
Toxoplasma gondii DNA topoisomerase 2, putative 0.06 0.1982 0.7396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.156 0.5285 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0009 0.0006
Toxoplasma gondii ThiF family protein 0.0033 0.0029 0.0095
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0031 0.0024 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0252 0.0462
Treponema pallidum DNA topoisomerase I (topA) 0.0032 0.0028 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0063 0.0191
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0111 0.0402
Leishmania major hypothetical protein, conserved 0.0031 0.0024 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.018 0.0326
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0063 0.0061
Schistosoma mansoni alpha-glucosidase 0.0154 0.0448 0.0448
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0078 0.0238
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0031 0.0024 0.0094
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0063 0.0061
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0033 0.0029 0.0095
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0191
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Brugia malayi cytochrome P450 0.0034 0.0032 0.0097
Loa Loa (eye worm) hypothetical protein 0.0078 0.0185 0.0562
Trichomonas vaginalis DNA topoisomerase II, putative 0.06 0.1982 0.374
Giardia lamblia Kinase, PLK 0.0098 0.0252 0.0462
Giardia lamblia Pms1-like protein 0.0031 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0087 0.0263
Leishmania major DNA topoisomerase III, putative 0.0032 0.0028 0.0103
Brugia malayi nuclear hormone receptor 0.0043 0.0063 0.0191
Brugia malayi Carboxylesterase family protein 0.0165 0.0485 0.1477
Brugia malayi beta-lactamase 0.0077 0.018 0.0549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0078 0.0076
Trypanosoma brucei heat shock protein, putative 0.0031 0.0024 0.0078
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0032 0.0028 0.0028
Brugia malayi Inositol-1 0.0116 0.0317 0.0964
Leishmania major protein kinase, putative 0.0027 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0201 0.061
Trypanosoma brucei heat shock protein, putative 0.0031 0.0024 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Loa Loa (eye worm) hypothetical protein 0.0244 0.0757 0.2306
Toxoplasma gondii DNA topoisomerase family protein 0.0032 0.0028 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0032 0.0028 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0063 0.0191
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0034 0.0032 0.0126
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0037
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0977 0.3279 0.3279
Schistosoma mansoni cell polarity protein 0.0147 0.0423 0.0423
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0078 0.0076
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0139 0.0137
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0054 0.0187
Trypanosoma brucei protein kinase, putative 0.0056 0.0111 0.0402
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0063 0.0063
Echinococcus multilocularis sentrin specific protease 8 0.0068 0.0151 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0252 0.0462
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0058 0.0056
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0031 0.0024 0.0094
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0031 0.0024 0.0094
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0037 0.0112
Brugia malayi Carboxylesterase family protein 0.0977 0.3279 1
Brugia malayi ThiF family protein 0.0033 0.0029 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0078 0.0078
Onchocerca volvulus 0.0243 0.0754 0.5744
Brugia malayi hypothetical protein 0.0344 0.1101 0.3358
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0078 0.0238
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0031 0.0024 0.0094
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0031 0.0024 0.0094
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0063 0.0191
Mycobacterium tuberculosis Conserved protein 0.0077 0.018 0.0709
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0009 0.0001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0139 0.0137
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.018 0.018
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0054 0.0051
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0031 0.0024 0.0094
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0129 0.0361 0.1336
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0024 0.003
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0116 0.0317 0.0598
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.0534 0.0531
Plasmodium falciparum DNA topoisomerase 3, putative 0.0032 0.0028 0.0092
Schistosoma mansoni tsg101-related 0.0059 0.0121 0.0121
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0116 0.0317 0.2665
Trypanosoma brucei developmentally regulated phosphoprotein 0.0031 0.0024 0.0078
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0093 0.0282
Echinococcus granulosus carboxylesterase 5A 0.0977 0.3279 0.3278
Entamoeba histolytica hypothetical protein 0.0037 0.0044 0.0082
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0053 0.0051
Brugia malayi GTP-binding protein, identical 0.0147 0.0423 0.129
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0024 0.0078
Onchocerca volvulus 0.0165 0.0485 0.3693
Trypanosoma brucei telomerase reverse transcriptase 0.0087 0.0215 0.079
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0002 0.0002
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0024 0.0078
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.018 0.0661
Echinococcus granulosus muscleblind protein 0.0318 0.101 0.1008
Loa Loa (eye worm) hypothetical protein 0.0378 0.1218 0.3714
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0194 0.0589
Plasmodium vivax ubiquitin activating enzyme, putative 0.005 0.0087 0.0313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0078 0.0078
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0054 0.0085
Schistosoma mansoni lamin 0.0087 0.0215 0.0215
Trichomonas vaginalis glutaminase, putative 0.0273 0.0857 0.1609
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0311 0.0987 0.8779
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0034 0.0032 0.0126
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0058 0.0109
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.018 0.0326
Plasmodium vivax hypothetical protein, conserved 0.0077 0.018 0.0661
Loa Loa (eye worm) hypothetical protein 0.0977 0.3279 1
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0319 0.1016 0.1921
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0252 0.0768
Echinococcus granulosus DNA topoisomerase 1 0.0803 0.2678 0.2677
Loa Loa (eye worm) glutaminase 2 0.0273 0.0857 0.2614
Echinococcus multilocularis DNA topoisomerase 1 0.0803 0.2678 0.2677
Onchocerca volvulus 0.0087 0.0215 0.1638
Echinococcus granulosus single minded 2 0.0076 0.0178 0.0176
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.1613 0.1611
Onchocerca volvulus 0.0077 0.018 0.1371
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0047 0.0078 0.0236
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0033 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0244 0.0757 0.2306
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0032 0.0028 0.0092
Loa Loa (eye worm) hypothetical protein 0.0165 0.0485 0.1477
Schistosoma mansoni DNA topoisomerase II 0.06 0.1982 0.1982
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0151 0.0271
Schistosoma mansoni hypothetical protein 0.0152 0.0439 0.0439
Echinococcus granulosus para nitrobenzyl esterase 0.0165 0.0485 0.0483
Brugia malayi hypothetical protein 0.0165 0.0485 0.1477
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Brugia malayi MAP kinase sur-1 0.0056 0.0111 0.0337
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.156 0.5285 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0058 0.0226
Echinococcus granulosus DNA topoisomerase 2 alpha 0.06 0.1982 0.198
Schistosoma mansoni tar DNA-binding protein 0.007 0.0157 0.0157
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0024 0.0029
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0058 0.0215
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0024 0.0078
Echinococcus multilocularis dnaJ subfamily C 6 0.0067 0.0149 0.0147
Trypanosoma brucei heat shock protein, putative 0.0031 0.0024 0.0078
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.008 0.0194 0.0761
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0034 0.0032 0.0126
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0032 0.0028 0.0035
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0087 0.0085
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0032 0.0028 0.0092
Loa Loa (eye worm) hypothetical protein 0.0082 0.0201 0.061
Onchocerca volvulus 0.0152 0.0439 0.3341
Mycobacterium leprae Probable two-component sensor kinase 0.0031 0.0024 0.0094
Schistosoma mansoni cytochrome P450 0.0034 0.0032 0.0032
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0077 0.0232
Plasmodium vivax DNA gyrase subunit A, putative 0.0129 0.0361 0.1336
Brugia malayi hypoxia-induced factor 1 0.0318 0.101 0.3078
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0033 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.0025 0.0004 0.0011
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0406 0.1312 1
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0034 0.0032 0.0126
Loa Loa (eye worm) hypothetical protein 0.0085 0.021 0.0639
Brugia malayi ThiF family protein 0.005 0.0087 0.0264
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0116 0.0317 0.117
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.035 0.1121 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0058 0.0204
Mycobacterium tuberculosis Cell division protein FtsZ 0.0311 0.0987 0.3886
Schistosoma mansoni hypothetical protein 0.0037 0.0044 0.0044
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0009 0.0019
Echinococcus granulosus inositol monophosphatase 1 0.0116 0.0317 0.0314
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0054 0.0187
Echinococcus granulosus neuroligin 0.0165 0.0485 0.0483
Mycobacterium leprae putative cytochrome p450 0.0034 0.0032 0.0126
Leishmania major mitochondrial DNA topoisomerase II 0.0674 0.2234 0.8342
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0063 0.0478
Trypanosoma brucei cytochrome P450, putative 0.008 0.0194 0.0711
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.1613 0.1611
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0087 0.0085
Loa Loa (eye worm) glutaminase 0.0273 0.0857 0.2614
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0063 0.0191
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Schistosoma mansoni microtubule-associated protein tau 0.2931 1 1
Plasmodium falciparum DNA gyrase subunit A 0.0129 0.0361 0.1336
Trypanosoma brucei C-8 sterol isomerase, putative 0.0378 0.1218 0.4541
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0063 0.0191
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0063 0.0061
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0054 0.0162
Schistosoma mansoni tsg101-related 0.0059 0.0121 0.0121
Schistosoma mansoni tar DNA-binding protein 0.007 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0051 0.0093 0.0282
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0032 0.0028 0.0092
Schistosoma mansoni sumo-1-activating enzyme E1a 0.005 0.0087 0.0087
Loa Loa (eye worm) TAR-binding protein 0.007 0.0157 0.0476
Loa Loa (eye worm) hypothetical protein 0.0977 0.3279 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0031 0.0024 0.0094
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0034 0.0032 0.0108
Loa Loa (eye worm) hypothetical protein 0.0071 0.0163 0.0494
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.1613 0.1611
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0024 0.0045
Loa Loa (eye worm) endoplasmin 0.0031 0.0024 0.0073
Brugia malayi hypothetical protein 0.0744 0.2476 0.755
Trichomonas vaginalis Sentrin-specific protease, putative 0.0068 0.0151 0.0271
Brugia malayi Probable DNA topoisomerase II 0.06 0.1982 0.6042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0034 0.0032 0.0126
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0063 0.0063
Brugia malayi GRF zinc finger family protein 0.0032 0.0028 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0034 0.0032 0.0126
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0111 0.0402
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0111 0.0402
Trypanosoma brucei heat shock protein, putative 0.0031 0.0024 0.0078
Schistosoma mansoni inositol monophosphatase 0.0116 0.0317 0.0317
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0077 0.018 0.0709
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0024 0.003
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0031 0.0024 0.0022
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0054 0.0162
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0022 0.002
Echinococcus granulosus dna polymerase eta 0.0041 0.0058 0.0056
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0058 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0014 0.004
Brugia malayi jmjC domain containing protein 0.0065 0.0139 0.0424
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0063 0.0063
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.0163 0.016
Giardia lamblia DNA topoisomerase III 0.0032 0.0028 0.0037
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0024 0.0078
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0568 0.187 0.6979
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.018 0.018
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0111 0.0194
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0063 0.0063
Loa Loa (eye worm) cytochrome P450 0.0034 0.0032 0.0097
Brugia malayi Carboxylesterase family protein 0.0977 0.3279 1
Treponema pallidum cell division protein FtsZ 0.0311 0.0987 0.183
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0033 0.0029 0.0027
Trypanosoma brucei heat shock protein, putative 0.0031 0.0024 0.0078
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0129 0.0361 0.064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0022 0.0022
Trypanosoma cruzi DNA topoisomerase III, putative 0.0032 0.0028 0.0092
Echinococcus multilocularis tar DNA binding protein 0.007 0.0157 0.0155
Brugia malayi steroid hormone receptor 0.0043 0.0063 0.0191
Mycobacterium tuberculosis Conserved protein 0.0077 0.018 0.0709
Leishmania major DNA topoisomerase ii 0.0568 0.187 0.6982
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0406 0.1314 0.4006
Toxoplasma gondii ABC1 family protein 0.0077 0.018 0.0661
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0063 0.0061
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0045 0.0072 0.0072
Echinococcus granulosus sentrin specific protease 8 0.0068 0.0151 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0252 0.0462
Plasmodium vivax DNA topoisomerase II, putative 0.06 0.1982 0.7396
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Onchocerca volvulus Huntingtin homolog 0.0126 0.035 0.2662
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0058 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0034 0.0032 0.0126
Mycobacterium ulcerans two component regulator - sensor kinase 0.0031 0.0024 0.0094
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0318 0.101 0.3079
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0031 0.0024 0.0094
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0165 0.0485 0.0903
Loa Loa (eye worm) GTP-binding protein 0.0147 0.0423 0.129
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.018 0.0661
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0024 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0063 0.0191
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0063 0.0061
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0044 0.0044
Onchocerca volvulus 0.0031 0.0022 0.0166
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0024
Schistosoma mansoni DNA topoisomerase type I 0.0803 0.2678 0.2678
Loa Loa (eye worm) hypothetical protein 0.0165 0.0485 0.1477
Trichomonas vaginalis inositol monophosphatase, putative 0.0116 0.0317 0.0584
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0009 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0054 0.0085
Loa Loa (eye worm) beta-lactamase 0.0077 0.018 0.0549
Loa Loa (eye worm) DNA topoisomerase I 0.0803 0.2678 0.8167
Onchocerca volvulus 0.0076 0.0178 0.1354
Brugia malayi TAR-binding protein 0.007 0.0157 0.0476
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0063 0.0063
Mycobacterium ulcerans cell division protein FtsZ 0.0311 0.0987 0.3886
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0009 0.002
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0032 0.0028 0.0026
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0058 0.0094
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0147 0.0446
Mycobacterium tuberculosis Conserved protein 0.0031 0.0024 0.0094
Mycobacterium ulcerans lipase LipD 0.0077 0.018 0.0709
Loa Loa (eye worm) hypothetical protein 0.0077 0.018 0.0549
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0024 0.0078
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0029 0.0095
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.0163 0.016
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0032 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0406 0.1314 0.4006
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0111 0.0109
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0034 0.0032 0.0126
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0034 0.0032 0.0126
Brugia malayi Endoplasmin precursor 0.0031 0.0024 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0014 0.004
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0024 0.003
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0034 0.0032 0.0126
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0252 0.192
Mycobacterium leprae Probable lipase LipE 0.0077 0.018 0.0709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0063 0.0191
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0058 0.0175
Brugia malayi RNA binding protein 0.007 0.0157 0.0476
Entamoeba histolytica DNA topoisomerase III, putative 0.0032 0.0028 0.0052
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0252 0.0768
Loa Loa (eye worm) hypothetical protein 0.0087 0.0215 0.0655
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0058 0.0204
Trypanosoma brucei DNA topoisomerase III, putative 0.0032 0.0028 0.0092
Toxoplasma gondii cytochrome p450 superfamily protein 0.0034 0.0032 0.0108
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0165 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0047 0.0078 0.0237
Mycobacterium ulcerans DNA gyrase subunit A 0.0129 0.0361 0.1419
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Echinococcus granulosus acetylcholinesterase 0.0977 0.3279 0.3278
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.156 0.5285 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0018 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0084 0.0143
Brugia malayi bHLH-PAS transcription factor 0.0076 0.0178 0.0542
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.035 0.1121 0.4413
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0009 0.0025
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0054 0.0085
Schistosoma mansoni hypothetical protein 0.0053 0.0098 0.0098
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0063 0.0061
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0024 0.003
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0034 0.0032 0.0126
Giardia lamblia DNA topoisomerase II 0.0569 0.1874 0.3535
Loa Loa (eye worm) hypothetical protein 0.0165 0.0485 0.1477
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0252 0.093
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0044 0.0042
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0803 0.2678 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0111 0.0412
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0058 0.0226
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1123 0.3779 0.7149
Echinococcus granulosus BC026374 protein S09 family 0.0165 0.0485 0.0483
Leishmania major DNA topoisomerase 1A 0.0032 0.0028 0.0103
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0034 0.0032 0.0126
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0111 0.0194
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0111 0.0337
Entamoeba histolytica hypothetical protein 0.0037 0.0044 0.0082
Schistosoma mansoni single-minded 0.0103 0.027 0.027
Leishmania major C-8 sterol isomerase-like protein 0.0378 0.1218 0.4547
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.018 0.0709
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.0317 0.117
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0034 0.0032 0.0126
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0031 0.0024 0.0094
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0215 0.0655
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0031 0.0024 0.0094
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0406 0.1312 1
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0024 0.0078
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0068 0.0151 0.0271
Leishmania major DNA topoisomerase IB, large subunit 0.0803 0.2678 1
Loa Loa (eye worm) TOPoisomerase family member 0.06 0.1982 0.6042
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0011 0.0029
Echinococcus granulosus geminin 0.0361 0.1158 0.1156
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0215 0.0655
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.0084 0.0158
Toxoplasma gondii RNA-directed DNA polymerase 0.0087 0.0215 0.079
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0063 0.0061
Plasmodium vivax endoplasmin, putative 0.0031 0.0024 0.0078
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0054 0.0085
Mycobacterium ulcerans glutaminase 0.0273 0.0857 0.3376
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0112
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.018 0.0549
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0157 0.0476
Mycobacterium leprae conserved hypothetical protein 0.0077 0.018 0.0709
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0111 0.0412
Loa Loa (eye worm) hypothetical protein 0.0082 0.0201 0.061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0063 0.0191
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0009 0.0006
Onchocerca volvulus 0.0077 0.018 0.1371
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.06 0.1982 0.6042
Echinococcus granulosus neuropeptide s receptor 0.0493 0.1613 0.1611
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0011 0.0029
Brugia malayi DnaJ domain containing protein 0.0067 0.0149 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0032 0.0108
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0406 0.1312 1
Echinococcus multilocularis neuroligin 0.0165 0.0485 0.0483
Chlamydia trachomatis DNA gyrase subunit A 0.0129 0.0361 0.3045
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0009 0.0006
Entamoeba histolytica hypothetical protein 0.0037 0.0044 0.0082
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0063 0.0061
Loa Loa (eye worm) inositol-1 0.0116 0.0317 0.0964
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0024 0.0078
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0111 0.0194
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.018 0.0326
Echinococcus multilocularis geminin 0.0361 0.1158 0.1156
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0063 0.0191
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0129 0.0361 0.3069
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0034 0.0032 0.0126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0165 0.0485 0.0485
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0194 0.0589
Loa Loa (eye worm) hypothetical protein 0.0744 0.2476 0.755
Loa Loa (eye worm) hypothetical protein 0.0165 0.0485 0.1477
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0024 0.0078
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0034 0.0032 0.0126
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0034 0.0032 0.0126
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0087 0.0215 0.079
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0264
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.156 0.5285 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.035 0.1065
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0031 0.0024 0.0094
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0111 0.0109
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0378 0.1218 0.3714
Schistosoma mansoni lamin 0.0087 0.0215 0.0215
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0084 0.0143
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0063 0.0063
Trypanosoma cruzi hypothetical protein 0.0068 0.0151 0.0553
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0032 0.0108
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0034 0.0032 0.0119
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.0534 0.0531
Mycobacterium ulcerans DNA gyrase subunit B 0.035 0.1121 0.4413
Brugia malayi ecdysteroid receptor 0.0043 0.0063 0.0191
Giardia lamblia DNA repair protein RAD52 0.1123 0.3779 0.7145
Echinococcus multilocularis inositol monophosphatase 1 0.0116 0.0317 0.0314
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0058 0.0204
Loa Loa (eye worm) hypothetical protein 0.0126 0.035 0.1065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0063 0.0191
Echinococcus granulosus lamin dm0 0.0087 0.0215 0.0213
Trypanosoma brucei heat shock protein, putative 0.0031 0.0024 0.0078
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0762 0.2539 1
Loa Loa (eye worm) hypothetical protein 0.0318 0.101 0.3079
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0033 0.0029 0.0095
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.018 0.0709
Schistosoma mansoni pyruvate dehydrogenase 0.0031 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0034 0.0032 0.0126
Loa Loa (eye worm) ThiF family protein 0.0033 0.0029 0.0086
Echinococcus multilocularis acetylcholinesterase 0.0977 0.3279 0.3278
Brugia malayi hypothetical protein 0.0126 0.035 0.1065
Schistosoma mansoni hypothetical protein 0.0067 0.0149 0.0149
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0054 0.0051
Trichomonas vaginalis sensor histidine kinase, putative 0.0031 0.0024 0.003
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0568 0.187 0.6979
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0191
Brugia malayi Cell division protein ftsZ 0.0154 0.0445 0.1355
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0058 0.0175
Trichomonas vaginalis esterase, putative 0.0077 0.018 0.0326
Mycobacterium leprae Probable two component sensor kinase MprB 0.0031 0.0024 0.0094
Echinococcus granulosus cytochrome P450 2K1 0.0034 0.0032 0.003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.1601 0.6305
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Brugia malayi Carboxylesterase family protein 0.0165 0.0485 0.1477
Echinococcus granulosus flap endonuclease 1 0.0027 0.0009 0.0007
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0058 0.0094
Echinococcus multilocularis muscleblind protein 0.0318 0.101 0.1008
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0034 0.0032 0.0126
Schistosoma mansoni DNA topoisomerase type I 0.0803 0.2678 0.2678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0063 0.0191
Loa Loa (eye worm) carboxylesterase 0.0165 0.0485 0.1477
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0116 0.0317 0.118
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0087 0.0215 0.1633
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0063 0.0191
Brugia malayi nuclear receptor NHR-88 0.0043 0.0063 0.0191
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0215 0.0655
Brugia malayi jmjC domain containing protein 0.0067 0.0147 0.0446
Loa Loa (eye worm) carboxylesterase 0.0977 0.3279 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0165 0.0485 0.1908
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0652 0.1988
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0034 0.0032 0.0126
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0143 0.0141
Trypanosoma cruzi DNA topoisomerase II, putative 0.0568 0.187 0.6979
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0068 0.0151 0.046
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0054 0.0085
Loa Loa (eye worm) hypoxia-induced factor 1 0.0318 0.101 0.3078
Schistosoma mansoni tsg101-related 0.0049 0.0084 0.0084
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0252 0.094
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0009 0.002
Echinococcus granulosus heat shock protein 90 0.0031 0.0024 0.0022
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0034 0.0032 0.0126
Leishmania major hypothetical protein, conserved 0.0077 0.018 0.0672
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0031 0.0024 0.0094
Plasmodium falciparum topoisomerase I 0.0803 0.2678 1
Toxoplasma gondii hypothetical protein 0.005 0.0087 0.0313
Schistosoma mansoni heat shock protein 0.0031 0.0024 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0063 0.0191
Mycobacterium leprae cell division protein FtsZ 0.0311 0.0987 0.3886
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Leishmania major cytochrome p450-like protein 0.0034 0.0032 0.0119
Entamoeba histolytica hypothetical protein 0.0319 0.1016 0.1921
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0034 0.0032 0.0126
Mycobacterium ulcerans beta-lactamase 0.0077 0.018 0.0709
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0111 0.0402
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0252 0.025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0058 0.0226
Onchocerca volvulus 0.0077 0.018 0.1371
Echinococcus multilocularis microtubule associated protein 2 0.2931 1 1
Echinococcus multilocularis muscleblind protein 1 0.0318 0.101 0.1008
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0129 0.0361 0.1419
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.018 0.0178
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0024 0.0078
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0252 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0058 0.0204
Trypanosoma cruzi DNA topoisomerase III, putative 0.0032 0.0028 0.0092
Trypanosoma cruzi cytochrome P450, putative 0.008 0.0194 0.0711
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.018 0.0326
Plasmodium falciparum endoplasmin, putative 0.0031 0.0024 0.0078
Schistosoma mansoni alpha-glucosidase 0.0154 0.0448 0.0448
Leishmania major cytochrome p450-like protein 0.008 0.0194 0.0721
Trypanosoma cruzi DNA topoisomerase III, putative 0.0032 0.0028 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0252 0.0462
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.0534 0.1626
Schistosoma mansoni survival motor neuron protein 0.0152 0.0439 0.0439
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.156 0.5285 1
Giardia lamblia DNA topoisomerase III 0.0032 0.0028 0.0037
Echinococcus granulosus hypothetical protein 0.0729 0.2426 0.2424
Schistosoma mansoni endoplasmin 0.0031 0.0024 0.0024
Treponema pallidum fructose-bisphosphate aldolase 0.156 0.5285 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0568 0.187 0.6979
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0031 0.0024 0.0022
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Brugia malayi GTP-binding protein 0.0147 0.0423 0.129
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0063 0.0191
Schistosoma mansoni BC026374 protein (S09 family) 0.0165 0.0485 0.0485
Loa Loa (eye worm) acetylcholinesterase 1 0.0977 0.3279 1
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0024 0.0045
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0034 0.0032 0.0126
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0024 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.156 0.5285 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0077 0.0232
Trypanosoma brucei DNA topoisomerase III, putative 0.0032 0.0028 0.0092
Brugia malayi Carboxylesterase family protein 0.0165 0.0485 0.1477
Plasmodium falciparum telomerase reverse transcriptase 0.0536 0.1762 0.6573
Schistosoma mansoni hypothetical protein 0.0034 0.0032 0.0032
Schistosoma mansoni gliotactin 0.0165 0.0485 0.0485
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0078 0.0078
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0032 0.0028 0.0109
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0034 0.0032 0.0126
Leishmania major heat shock protein 83-1 0.0031 0.0024 0.0089
Schistosoma mansoni hypothetical protein 0.0361 0.1158 0.1158
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0031 0.0024 0.0078
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0032 0.0028 0.0026
Echinococcus granulosus SUMO activating enzyme subunit 1 0.005 0.0087 0.0085
Brugia malayi intermediate filament protein 0.0087 0.0215 0.0655
Brugia malayi follicle stimulating hormone receptor 0.0491 0.1606 0.4895
Brugia malayi DNA topoisomerase II, alpha isozyme 0.06 0.1982 0.6042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0491 0.1606 0.4895
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0024 0.0078
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0033 0.0029 0.0095
Schistosoma mansoni glutaminase 0.0273 0.0857 0.0857
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0024 0.0078
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0073
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0116 0.0317 0.1245
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0111 0.0194
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0058 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0054 0.0085
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0009 0.0031
Schistosoma mansoni hypothetical protein 0.0361 0.1158 0.1158
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0054 0.0085
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0058 0.0116 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0063 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.018 0.0661
Echinococcus multilocularis BC026374 protein (S09 family) 0.0165 0.0485 0.0483
Giardia lamblia Fructose-bisphosphate aldolase 0.156 0.5285 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0024 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0063 0.0063
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0165 0.0485 0.0483
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0191
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0139 0.0139
Onchocerca volvulus 0.0165 0.0485 0.3693
Trypanosoma cruzi cytochrome P450, putative 0.008 0.0194 0.0711
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0063 0.0191

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 6.1 % Inhibition of PTP1B (unknown origin) using pNPP as substrate at 20 ug/ml by colorimetric assay ChEMBL. 24906513

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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