Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0079 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.22 uM | Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins | ChEMBL. | 24938495 |
IC50 (binding) | = 9.12 uM | Inhibition of human recombinant COX2 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins | ChEMBL. | 24938495 |
IC50 (binding) | = 38.26 uM | Inhibition of soybean lipoxygenase after 5 mins by colorimetric assay | ChEMBL. | 24938495 |
Inhibition (binding) | = 65 % | Inhibition of soybean lipoxygenase after 5 mins by colorimetric assay | ChEMBL. | 24938495 |
Inhibition (binding) | = 81.79 % | Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 mins | ChEMBL. | 24938495 |
Inhibition (functional) | = 91 % | Inhibition of TNFalpha expression in mouse RAW264.7 cells at 10 uM per-treated with compound for 2 hrs before LPS challenge for 22 hrs by ELISA method | ChEMBL. | 24938495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.