Detailed information for compound 91647

Basic information

Technical information
  • TDR Targets ID: 91647
  • Name: 9-methyl-1,2,3,4,4a,6-hexahydropyrazino[1,2-a ]quinoxalin-5-one
  • MW: 217.267 | Formula: C12H15N3O
  • H donors: 2 H acceptors: 1 LogP: 0.77 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2ccc(cc2N2C1CNCC2)C
  • InChi: 1S/C12H15N3O/c1-8-2-3-9-10(6-8)15-5-4-13-7-11(15)12(16)14-9/h2-3,6,11,13H,4-5,7H2,1H3,(H,14,16)
  • InChiKey: XCMDBWQOUOFRED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-methyl-1,2,3,4,4a,6-hexahydropyrazino[2,1-c]quinoxalin-5-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0271 0.1875 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0135 0.0135
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0343 0.2411 0.2342
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0808 0.584 0.5833
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0204 0.0204
Leishmania major hypothetical protein, conserved 0.0029 0.0093 0.0004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0204 0.0188
Brugia malayi Hexokinase family protein 0.0271 0.1875 0.1861
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.1529 0.1526
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0316 0.0316
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0436 0.3099 0.3099
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0093 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0004 0.0004
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.1719 0.1716
Brugia malayi Glycosyl hydrolases family 31 protein 0.0077 0.0444 0.0428
Brugia malayi follicle stimulating hormone receptor 0.0224 0.1529 0.1515
Mycobacterium ulcerans phytoene synthase, CrtB 0.0069 0.0385 0.0246
Onchocerca volvulus 0.0036 0.0142 0.0326
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0051 0.0051
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Loa Loa (eye worm) hypothetical protein 0.0086 0.0513 0.0509
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0343 0.2411 0.2342
Echinococcus granulosus lysosomal alpha glucosidase 0.0345 0.2427 0.2427
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0343 0.2411 0.2339
Brugia malayi beta-lactamase 0.0036 0.0142 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0204 0.0204
Schistosoma mansoni glutathione synthetase 0.0436 0.3099 0.3099
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0444 0.0358
Brugia malayi Polyprenyl synthetase family protein 0.0436 0.3099 0.3087
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Schistosoma mansoni cpg binding protein 0.0031 0.0108 0.0108
Trypanosoma brucei squalene synthase, putative 0.022 0.1502 0.1426
Onchocerca volvulus 0.0036 0.0142 0.0326
Leishmania major polyprenyl synthase, putative 0.0808 0.584 0.5803
Trichomonas vaginalis esterase, putative 0.0036 0.0142 0.0053
Schistosoma mansoni cpg binding protein 0.0028 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Leishmania major squalene synthase, putative 0.022 0.1502 0.1426
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0204 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.0093 0.0089
Leishmania major solanesyl-diphosphate synthase, putative 0.0436 0.3099 0.3037
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Schistosoma mansoni hypothetical protein 0.002 0.0026 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Brugia malayi Hexokinase family protein 0.0084 0.0496 0.048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0004 0.0004
Trypanosoma cruzi squalene synthase, putative 0.022 0.1502 0.1426
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1372 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1151 0.1072
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0142 0.0053
Brugia malayi PHD-finger family protein 0.0026 0.0068 0.0051
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0051 0.0051
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0436 0.3099 0.5
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0808 0.584 0.584
Brugia malayi hypothetical protein 0.0029 0.0093 0.0076
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0808 0.584 0.5839
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0142 0.0137
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0077 0.0444 0.0354
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0808 0.584 0.584
Echinococcus multilocularis cpg binding protein 0.0031 0.0108 0.0108
Giardia lamblia Farnesyl diphosphate synthase 0.1372 1 0.5
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0436 0.3099 0.5
Onchocerca volvulus 0.0036 0.0142 0.0326
Schistosoma mansoni alpha-glucosidase 0.0297 0.2072 0.2072
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0093 0.0004
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0444 0.1179
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Loa Loa (eye worm) hypothetical protein 0.0039 0.0169 0.0165
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1372 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0142 0.0142
Schistosoma mansoni trans-prenyltransferase 0.0436 0.3099 0.3099
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0436 0.3099 0.3037
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0142 0.0053
Loa Loa (eye worm) hexokinase 0.0084 0.0496 0.0492
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0142 0.0142
Onchocerca volvulus 0.0271 0.1875 1
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1372 1 1
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0343 0.2411 0.2342
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0135 0.0135
Echinococcus multilocularis zinc finger protein 0.002 0.003 0.003
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.1719 0.1705
Loa Loa (eye worm) hexokinase type II 0.0271 0.1875 0.1871
Entamoeba histolytica hexokinase 2 0.0271 0.1875 0.5933
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0069 0.0385 0.0246
Brugia malayi Bromodomain containing protein 0.0037 0.0151 0.0135
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0444 0.1179
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Loa Loa (eye worm) polyprenyl synthetase 0.0436 0.3099 0.3096
Toxoplasma gondii ABC1 family protein 0.0036 0.0142 0.0049
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0089 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0142 0.0053
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0436 0.3099 0.3099
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1372 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Loa Loa (eye worm) hexokinase 0.017 0.1131 0.1127
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0436 0.3099 0.3034
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0436 0.3099 0.3034
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1372 1 1
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1372 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Trypanosoma cruzi hexokinase, putative 0.0271 0.1875 0.1802
Trypanosoma brucei hexokinase, putative 0.0271 0.1875 0.1802
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0345 0.2427 0.2423
Trypanosoma cruzi hexokinase, putative 0.0271 0.1875 0.1802
Onchocerca volvulus Hexokinase homolog 0.017 0.1131 0.5848
Echinococcus multilocularis lysosomal alpha glucosidase 0.0345 0.2427 0.2427
Trichomonas vaginalis maltase-glucoamylase, putative 0.0077 0.0444 0.0358
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Loa Loa (eye worm) hypothetical protein 0.0185 0.124 0.1236
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0436 0.3099 0.3099
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0436 0.3099 0.3
Loa Loa (eye worm) hypothetical protein 0.0043 0.0194 0.019
Echinococcus granulosus Squalene phytoene synthase 0.0069 0.0385 0.0385
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0283 0.0192
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1372 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0385 0.038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0395 0.2794 0.2794
Echinococcus multilocularis hexokinase 0.0271 0.1875 0.1875
Brugia malayi hexokinase 0.0271 0.1875 0.1861
Loa Loa (eye worm) hypothetical protein 0.0068 0.0383 0.0378
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1372 1 1
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.1086 0.5599
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0343 0.2411 0.2339
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0069 0.0385 0.0298
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0316 0.0316
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0343 0.2411 0.2339
Leishmania major alpha glucosidase II subunit, putative 0.0077 0.0444 0.0358
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0436 0.3099 1
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0343 0.2411 0.2339
Echinococcus granulosus cpg binding protein 0.0031 0.0108 0.0108
Entamoeba histolytica hexokinase 1 0.0271 0.1875 0.5933
Echinococcus multilocularis hexokinase 0.0271 0.1875 0.1875
Trypanosoma brucei hexokinase 0.0271 0.1875 0.1802
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0343 0.2411 0.2339
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0093 0.0004
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0436 0.3099 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0026 0.0021
Onchocerca volvulus 0.0271 0.1875 1
Plasmodium falciparum hexokinase 0.0271 0.1875 0.1798
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0089 0.0033
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1372 1 1
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0436 0.3099 0.3037
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0142 0.0053
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1372 1 1
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0436 0.3099 0.3037
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0444 0.0358
Echinococcus granulosus neutral alpha glucosidase AB 0.0077 0.0444 0.0444
Onchocerca volvulus 0.017 0.1131 0.5848
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1372 1 1
Leishmania major hexokinase, putative 0.0271 0.1875 0.1802
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0436 0.3099 0.3
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0142 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0037 0.0152 0.0148
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Echinococcus multilocularis hexokinase 0.0271 0.1875 0.1875
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0142 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0313 0.0313
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1151 0.1072
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Plasmodium vivax hexokinase, putative 0.0271 0.1875 0.1798
Echinococcus granulosus hexokinase 0.0271 0.1875 0.1875
Brugia malayi hexokinase type II 0.0086 0.0513 0.0497
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0444 0.0358
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0004 0.0004
Echinococcus multilocularis Squalene phytoene synthase 0.0069 0.0385 0.0385
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.156 0.1439
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0069 0.0385 0.1682
Leishmania major hexokinase, putative 0.0271 0.1875 0.1802
Echinococcus multilocularis lysosomal alpha glucosidase 0.0345 0.2427 0.2427
Echinococcus granulosus hexokinase 0.0271 0.1875 0.1875
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0077 0.0444 0.044
Schistosoma mansoni zinc finger protein 0.002 0.003 0.003
Brugia malayi Hexokinase family protein 0.017 0.1131 0.1116
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0436 0.3099 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0436 0.3099 1
Echinococcus granulosus hexokinase 0.0271 0.1875 0.1875
Toxoplasma gondii hexokinase 0.0271 0.1875 0.1798
Loa Loa (eye worm) hexokinase 0.0271 0.1875 0.1871
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0444 0.0358
Schistosoma mansoni bromodomain containing protein 0.0063 0.0341 0.0341
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2794 0.2794
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0436 0.3099 0.3099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0036 0.0142 0.0053
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0436 0.3099 0.3
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1372 1 1
Trypanosoma cruzi polyprenyl synthase, putative 0.0808 0.584 0.5803
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0142 0.0125
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2794 0.2794
Leishmania major farnesyl pyrophosphate synthase 0.1372 1 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0142 0.0137
Brugia malayi Bromodomain containing protein 0.0074 0.0425 0.0408
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0444 0.0358
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0436 0.3099 0.3
Echinococcus granulosus hexokinase type 2 0.0271 0.1875 0.1875
Brugia malayi beta-lactamase family protein 0.0036 0.0142 0.0125
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0142 0.0049
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0083 0.0079
Trichomonas vaginalis sucrase-isomaltase, putative 0.0077 0.0444 0.0358
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0204 0.0204
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0343 0.2411 0.2342
Trypanosoma brucei glucosidase, putative 0.0077 0.0444 0.0358
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0436 0.3099 0.3
Loa Loa (eye worm) hypothetical protein 0.0086 0.0513 0.0509
Loa Loa (eye worm) hexokinase 0.0271 0.1875 0.1871
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0204 0.0204
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1372 1 1
Loa Loa (eye worm) polyprenyl synthetase 0.1372 1 1
Schistosoma mansoni hypothetical protein 0.0069 0.0385 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.0053
Brugia malayi CXXC zinc finger family protein 0.0028 0.0083 0.0066
Echinococcus multilocularis hexokinase type 2 0.0271 0.1875 0.1875
Trypanosoma brucei hexokinase 0.0271 0.1875 0.1802
Trypanosoma cruzi phytoene synthase, putative 0.0069 0.0385 0.0298
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0808 0.584 0.584
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0085
Treponema pallidum octaprenyl-diphosphate synthase 0.0808 0.584 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0142 0.0137
Schistosoma mansoni cpg binding protein 0.0031 0.0108 0.0108
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0436 0.3099 0.3037
Echinococcus multilocularis neutral alpha glucosidase AB 0.0077 0.0444 0.0444
Brugia malayi beta-lactamase family protein 0.0036 0.0142 0.0125
Trypanosoma cruzi squalene synthase, putative 0.022 0.1502 0.1426
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0436 0.3099 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0142 0.0053
Echinococcus granulosus zinc finger protein 0.002 0.003 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1719 0.1645
Onchocerca volvulus 0.02 0.1352 0.7084
Schistosoma mansoni hexokinase 0.0271 0.1875 0.1875
Trypanosoma cruzi polyprenyl synthase, putative 0.0808 0.584 0.5803
Schistosoma mansoni alpha glucosidase 0.0077 0.0444 0.0444
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1086 0.1006
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0142 0.0142
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1372 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.0053
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0343 0.2411 0.2342
Brugia malayi Glycosyl hydrolases family 31 protein 0.0345 0.2427 0.2414
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0436 0.3099 0.3034
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1372 1 1
Schistosoma mansoni alpha-glucosidase 0.0297 0.2072 0.2072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0204 0.0204

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Inhibitory activity using [3H]-mesulergine as radioligand with receptor membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptamine 2C receptor at a concentration of 1 microM ChEMBL. 10987434
Inhibition (binding) = 0 % Inhibitory activity using [3H]-mesulergine as radioligand with receptor membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptamine 2C receptor at a concentration of 1 microM ChEMBL. 10987434
ND (binding) 0 nM Binding affinity using [125I]-DOI as radioligand with membranes isolated from a CHO-k cell line expressing the human 5-hydroxytryptamine 2C receptor; Not determined ChEMBL. 10987434

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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