Detailed information for compound 916612

Basic information

Technical information
  • TDR Targets ID: 916612
  • Name: (E)-3-(3,4-dihydroxyphenyl)-1-[4-[di(phenyl)m ethyl]piperazin-1-yl]prop-2-en-1-one
  • MW: 414.496 | Formula: C26H26N2O3
  • H donors: 2 H acceptors: 3 LogP: 4.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)C(c1ccccc1)c1ccccc1)/C=C/c1ccc(c(c1)O)O
  • InChi: 1S/C26H26N2O3/c29-23-13-11-20(19-24(23)30)12-14-25(31)27-15-17-28(18-16-27)26(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-14,19,26,29-30H,15-18H2/b14-12+
  • InChiKey: YETJQMBJCJCZFG-WYMLVPIESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(3,4-dihydroxyphenyl)-1-[4-[di(phenyl)methyl]-1-piperazinyl]prop-2-en-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Tubulin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium berghei tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Leishmania braziliensis epsilon tubulin, putative Tubulin   445 aa 465 aa 30.1 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin   445 aa 445 aa 29.4 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.3 %
Onchocerca volvulus Tubulin   445 aa 433 aa 39.0 %
Onchocerca volvulus Tubulin   445 aa 427 aa 49.9 %
Plasmodium vivax tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Leishmania infantum epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin   445 aa 434 aa 38.2 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin   445 aa 426 aa 49.8 %
Leishmania donovani epsilon tubulin, putative Tubulin   445 aa 475 aa 30.3 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin   445 aa 430 aa 91.4 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Plasmodium falciparum tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Onchocerca volvulus 1D304 homolog Tubulin   445 aa 433 aa 40.4 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.2 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Plasmodium yoelii tubulin gamma chain Tubulin   445 aa 438 aa 33.1 %
Echinococcus multilocularis tubulin delta chain Tubulin   445 aa 461 aa 25.8 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Echinococcus multilocularis tubulin alpha Tubulin   445 aa 443 aa 30.5 %
Neospora caninum Beta-tubulin, related Tubulin   445 aa 446 aa 35.2 %
Schistosoma mansoni tubulin subunit epsilon Tubulin   445 aa 464 aa 31.7 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 85.8 %
Onchocerca volvulus Tubulin   445 aa 427 aa 82.4 %
Leishmania mexicana gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin   445 aa 444 aa 28.6 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.2 %
Trypanosoma brucei epsilon tubulin Tubulin   445 aa 443 aa 29.1 %
Trypanosoma brucei gambiense gamma tubulin Tubulin   445 aa 436 aa 33.5 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin   445 aa 438 aa 33.3 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Trypanosoma congolense epsilon tubulin Tubulin   445 aa 464 aa 29.1 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin   445 aa 456 aa 31.4 %
Onchocerca volvulus Tubulin   445 aa 433 aa 40.0 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.3 %
Babesia bovis tubulin gamma chain Tubulin   445 aa 441 aa 34.0 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.0 %
Trypanosoma congolense tubulin gamma chain Tubulin   445 aa 436 aa 33.3 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Theileria parva tubulin gamma chain, putative Tubulin   445 aa 420 aa 34.5 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin   445 aa 429 aa 87.4 %
Onchocerca volvulus Tubulin   445 aa 441 aa 31.7 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 75.7 %
Giardia lamblia Gamma tubulin Tubulin   445 aa 460 aa 32.4 %
Neospora caninum tubulin alpha chain, putative Tubulin   445 aa 433 aa 30.9 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   445 aa 415 aa 33.3 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 93.7 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin   445 aa 433 aa 30.7 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.4 %
Cryptosporidium parvum gamma tubulin Tubulin   445 aa 436 aa 37.6 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 90.6 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin   445 aa 440 aa 38.4 %
Leishmania major gamma-tubulin Tubulin   445 aa 438 aa 34.0 %
Trypanosoma brucei tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.5 %
Entamoeba histolytica tubulin gamma chain Tubulin   445 aa 428 aa 33.2 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin   445 aa 441 aa 29.0 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Giardia lamblia Epsilon tubulin Tubulin   445 aa 442 aa 27.6 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Schistosoma mansoni tubulin subunit gamma Tubulin   445 aa 436 aa 33.7 %
Leishmania donovani tubulin gamma chain Tubulin   445 aa 438 aa 34.2 %
Onchocerca volvulus Tubulin   445 aa 445 aa 36.2 %
Leishmania infantum gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin   445 aa 436 aa 34.2 %
Leishmania mexicana epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.4 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Babesia bovis tubulin, putative Tubulin   445 aa 459 aa 21.1 %
Trypanosoma cruzi tubulin gamma chain Tubulin   445 aa 436 aa 33.5 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin   445 aa 461 aa 27.8 %
Onchocerca volvulus Tubulin   445 aa 435 aa 39.5 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin   445 aa 439 aa 34.6 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Onchocerca volvulus Tubulin   445 aa 434 aa 39.9 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin   445 aa 443 aa 29.3 %
Cryptosporidium hominis gamma-tubulin Tubulin   445 aa 436 aa 37.6 %
Echinococcus granulosus tubulin alpha Tubulin   445 aa 440 aa 30.2 %
Leishmania braziliensis gamma-tubulin Tubulin   445 aa 438 aa 34.2 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Leishmania major epsilon tubulin, putative Tubulin   445 aa 469 aa 30.9 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Plasmodium yoelii tubulin beta chain Tubulin   445 aa 445 aa 29.7 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Dictyostelium discoideum gamma tubulin Tubulin   445 aa 429 aa 34.0 %
Brugia malayi Tubulin gamma chain Tubulin   445 aa 440 aa 31.8 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin   445 aa 436 aa 34.4 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) tubulin beta-2A chain 0.0012 0.0115 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0142 0.9189 1
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0808 0.0702
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0457 0.0457
Echinococcus granulosus tubulin subunit TubB 0.0022 0.0808 0.0764
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0808 1
Loa Loa (eye worm) tubulin gamma chain 0.0012 0.0115 0.0115
Echinococcus granulosus tubulin alpha chain 0.0022 0.0808 0.0764
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.269 0.2605
Leishmania major alpha tubulin 0.0022 0.0808 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0808 0.0764
Schistosoma mansoni hypothetical protein 0.0049 0.269 0.2838
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.269 0.2838
Loa Loa (eye worm) tubulin beta chain 0.0012 0.0115 0.0115
Leishmania major alpha tubulin 0.0022 0.0808 1
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0808 1
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0808 1
Leishmania major alpha tubulin 0.0022 0.0808 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.7443 0.7443
Loa Loa (eye worm) RNA binding protein 0.0142 0.9189 0.9189
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0808 0.0764
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.269 0.2838
Loa Loa (eye worm) BEN-1 protein 0.0012 0.0115 0.0115
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0457 0.0457
Toxoplasma gondii alpha-tubulin I, putative 0.0022 0.0808 1
Brugia malayi Latrophilin receptor protein 2 0.0049 0.269 0.2605
Brugia malayi RNA binding protein 0.0142 0.9189 0.9179
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.4453 0.4781
Echinococcus granulosus tubulin alpha chain 0.0022 0.0808 0.0764
Echinococcus multilocularis tubulin subunit TubB 0.0022 0.0808 0.0764
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.4453 0.4781
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0808 0.0808
Leishmania major alpha tubulin 0.0022 0.0808 1
Entamoeba histolytica hypothetical protein 0.0074 0.4453 1
Schistosoma mansoni tar DNA-binding protein 0.0142 0.9189 1
Brugia malayi RNA recognition motif domain containing protein 0.0142 0.9189 0.9179
Echinococcus multilocularis hypothetical protein 0.0022 0.0808 0.0764
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.0808 0.0808
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0808 0.0764
Schistosoma mansoni hypothetical protein 0.0049 0.269 0.2838
Brugia malayi hypothetical protein 0.0074 0.4453 0.4388
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0808 0.0764
Echinococcus granulosus GPCR family 2 0.0049 0.269 0.2838
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0808 0.0764
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0808 0.0764
Loa Loa (eye worm) tubulin alpha-2 chain 0.0022 0.0808 0.0808
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0017 0.0457 0.494
Leishmania major alpha tubulin 0.0022 0.0808 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.269 0.2838
Echinococcus multilocularis tar DNA binding protein 0.0142 0.9189 1
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0808 0.0808
Echinococcus multilocularis GPCR, family 2 0.0049 0.269 0.2838
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0808 1
Toxoplasma gondii alpha tubulin TUBA1 0.0022 0.0808 1
Leishmania major alpha tubulin 0.0022 0.0808 1
Echinococcus granulosus tubulin alpha chain 0.0022 0.0808 0.0764
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.4453 0.4781
Trypanosoma cruzi alpha tubulin, putative 0.0022 0.0808 1
Leishmania major alpha tubulin 0.0022 0.0808 1
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0808 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.269 0.269
Leishmania major alpha tubulin 0.0022 0.0808 1
Echinococcus granulosus peroxisome assembly protein 26 0.0022 0.0808 0.0764
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0017 0.0457 0.0457
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0022 0.0808 1
Trypanosoma brucei alpha tubulin 0.0022 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0808 0.0808
Leishmania major alpha tubulin 0.0022 0.0808 1
Entamoeba histolytica hypothetical protein 0.0074 0.4453 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0012 0.0115 0.0115
Echinococcus granulosus alpha tubulin 0.0022 0.0808 0.0764
Loa Loa (eye worm) alpha-tubulin 0.0022 0.0808 0.0808
Echinococcus granulosus tar DNA binding protein 0.0142 0.9189 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0808 0.0764
Trypanosoma brucei alpha tubulin 0.0022 0.0808 1
Leishmania major alpha tubulin 0.0022 0.0808 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.0808 0.0764
Giardia lamblia Alpha-tubulin 0.0022 0.0808 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0015 0.0351 0.3406
Schistosoma mansoni alpha tubulin 0.0022 0.0808 0.0764
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0808 0.0764
Brugia malayi alpha-tubulin 0.0022 0.0808 0.0702
Schistosoma mansoni alpha tubulin 0.0022 0.0808 0.0764
Schistosoma mansoni tar DNA-binding protein 0.0142 0.9189 1
Brugia malayi TAR-binding protein 0.0142 0.9189 0.9179
Brugia malayi Tubulin alpha chain 0.0022 0.0808 0.0702
Schistosoma mansoni hypothetical protein 0.0049 0.269 0.2838
Loa Loa (eye worm) hypothetical protein 0.0105 0.6617 0.6617
Entamoeba histolytica tubulin alpha-1 chain 0.0022 0.0808 0.1599
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0808 0.0764
Loa Loa (eye worm) beta-tubulin 0.0012 0.0115 0.0115
Brugia malayi Tubulin alpha-2 chain 0.0022 0.0808 0.0702
Giardia lamblia Alpha-tubulin 0.0022 0.0808 1
Entamoeba histolytica hypothetical protein 0.0074 0.4453 1
Entamoeba histolytica hypothetical protein 0.0074 0.4453 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0142 0.9189 0.9189
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0808 0.0764
Loa Loa (eye worm) hypothetical protein 0.0049 0.269 0.269
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.6617 0.6577
Brugia malayi tubulin alpha chain - mouse 0.0022 0.0808 0.0702
Loa Loa (eye worm) BEN-1 protein 0.0012 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0153 1 1
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0808 0.0764
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.0808 1
Leishmania major alpha tubulin 0.0022 0.0808 1
Trypanosoma brucei alpha tubulin 0.0022 0.0808 1
Leishmania major alpha tubulin 0.0022 0.0808 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0012 0.0115 0.0115
Loa Loa (eye worm) tubulin alpha-3 chain 0.0015 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.0105 0.6617 0.7165
Entamoeba histolytica tubulin alpha chain, putative 0.0022 0.0808 0.1599
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.0808 0.0764
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.7443 0.7443
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0457 0.0457
Plasmodium falciparum alpha tubulin 2 0.0022 0.0808 1
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0808 0.0764
Echinococcus multilocularis tubulin alpha chain 0.0022 0.0808 0.0764
Schistosoma mansoni alpha tubulin 0.0022 0.0808 0.0764
Echinococcus multilocularis peroxisome assembly protein 26 0.0022 0.0808 0.0764
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0808 0.0764
Schistosoma mansoni tubulin subunit alpha 0.0022 0.0808 0.0764
Schistosoma mansoni hypothetical protein 0.0049 0.269 0.2838
Plasmodium falciparum alpha tubulin 1 0.0022 0.0808 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0808 0.0764
Echinococcus granulosus tubulin alpha chain 0.0022 0.0808 0.0764
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.0808 0.0764
Brugia malayi MH2 domain containing protein 0.0117 0.7443 0.7414
Loa Loa (eye worm) TAR-binding protein 0.0142 0.9189 0.9189
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.0808 0.0764
Schistosoma mansoni tar DNA-binding protein 0.0142 0.9189 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0808 1
Echinococcus granulosus tubulin alpha chain 0.0022 0.0808 0.0764
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.0808 0.0764
Schistosoma mansoni tar DNA-binding protein 0.0142 0.9189 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0808 1
Brugia malayi tubulin alpha-2 chain 0.0022 0.0808 0.0702
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.269 0.2838
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.0808 0.0764
Loa Loa (eye worm) hypothetical protein 0.0015 0.0351 0.0351
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0808 1
Trypanosoma brucei alpha tubulin 0.0022 0.0808 1
Schistosoma mansoni hypothetical protein 0.0074 0.4453 0.4781

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 18.33 % Cell cycle arrest in human MCF7 cells assessed as accumulation at G0/G1 phase at 1 ug/ml after 24 hrs by flow cytometry (Rvb = 62.34 %) ChEMBL. 24916028
IC50 (functional) = 0.54 ug ml-1 Antiproliferative activity against human A549 cells after 48 hrs by MTT assay ChEMBL. 24916028
IC50 (binding) = 0.92 uM Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric method ChEMBL. 24916028

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 24916028

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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