TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 308.335 | Formula: C17H16N4O2
H donors: 1 H acceptors: 2 LogP: 3.38 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)/C=N/NC(=O)c1c(C)nc2n1cccc2
InChi: 1S/C17H16N4O2/c1-12-16(21-10-4-3-5-15(21)19-12)17(22)20-18-11-13-6-8-14(23-2)9-7-13/h3-11H,1-2H3,(H,20,22)/b18-11+
InChiKey: RAFFUWXAZKHSRT-WOJGMQOQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	pantoate-beta-alanine ligase	Get druggable targets OG5_129569	All targets in OG5_129569
Mycobacterium tuberculosis	Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	Get druggable targets OG5_129569	All targets in OG5_129569
Neospora caninum	pantoate--beta-alanine ligase, putative	Get druggable targets OG5_129569	All targets in OG5_129569
Mycobacterium ulcerans	pantoate--beta-alanine ligase	Get druggable targets OG5_129569	All targets in OG5_129569
Mycobacterium leprae	Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	Get druggable targets OG5_129569	All targets in OG5_129569

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	expressed conserved protein	0.0135	0.0478	0.0478
Brugia malayi	CHE-14 protein	0.0126	0.0439	0.3857
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0122	0.0414
Echinococcus multilocularis	Niemann Pick C1 protein	0.0294	0.1138	0.1138
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0002	0.5
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0002	0.0666
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0011	0.0543
Plasmodium falciparum	metacaspase-like protein	0.0027	0.0025	0.1835
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0107	0.0361	0.217
Echinococcus multilocularis	caspase 3	0.0073	0.0218	0.0218
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.0025	0.0084
Echinococcus granulosus	caspase 2	0.0027	0.0025	0.0148
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0025	0.0559
Trypanosoma cruzi	metacaspase 5, putative	0.0027	0.0025	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0053	0.0134	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0134	0.1113
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0025	0.0559
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0034	0.0205
Echinococcus granulosus	sentrin specific protease 7	0.0148	0.0532	0.3197
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0025	0.0559
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0148	0.0532	0.4424
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0025	1
Brugia malayi	RNA binding protein	0.0064	0.0181	0.1591
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0122	0.0414
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.1506
Schistosoma mansoni	ran	0.0021	0.0002	0.0019
Toxoplasma gondii	pantoate-beta-alanine ligase	0.0725	0.2937	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0208	0.1733
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.1506
Schistosoma mansoni	ran	0.0021	0.0002	0.0019
Brugia malayi	RNA, U transporter 1	0.0082	0.0257	0.2256
Mycobacterium ulcerans	pantoate--beta-alanine ligase	0.0725	0.2937	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0098	0.0098
Trypanosoma brucei	metacaspase MCA2	0.0027	0.0025	0.7189
Schistosoma mansoni	importin beta-1	0.0029	0.0034	0.0284
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0025	0.0559
Mycobacterium leprae	Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	0.0725	0.2937	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0098	0.0587
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0053	0.0134	0.0455
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0148	0.0532	0.4674
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0122	0.0414
Echinococcus multilocularis	caspase 2	0.0027	0.0025	0.0025
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0071	0.0208	0.183
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0034	0.0034
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0002	0.0019
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.1506
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0071	0.0208	0.183
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0204
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0002	0.0927
Brugia malayi	Importin beta-1 subunit	0.0029	0.0034	0.03
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0309	0.1202	1
Loa Loa (eye worm)	hypothetical protein	0.0294	0.1138	0.9465
Schistosoma mansoni	hypothetical protein	0.0122	0.042	0.3493
Brugia malayi	TAR-binding protein	0.0064	0.0181	0.1591
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0098	0.0812
Brugia malayi	hypothetical protein	0.0107	0.0361	0.3171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0098	0.0812
Echinococcus multilocularis	caspase	0.01	0.0329	0.0329
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0181	0.1506
Brugia malayi	Niemann-Pick C1 protein precursor	0.0294	0.1138	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0025	0.0559
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0098	0.0812
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0025	1
Echinococcus granulosus	Niemann Pick C1 protein	0.042	0.1664	1
Entamoeba histolytica	Ran family GTPase	0.0021	0.0002	0.002
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0027	0.0025	0.0216
Plasmodium falciparum	acyl-CoA synthetase	0.0053	0.0134	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0126	0.0439	0.0439
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0025	0.0559
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0208	0.0709
Echinococcus granulosus	sterol regulatory element binding protein	0.0126	0.0439	0.2639
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0025	0.0559
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0208	1
Onchocerca volvulus	Cell death protein 3 homolog	0.0027	0.0025	0.1178
Schistosoma mansoni	caspase-7 (C14 family)	0.0027	0.0025	0.0204
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0011	0.0258
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0208	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0098	0.0812
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0208	0.183
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0122	0.0414
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0002	0.0002
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0025	0.0559
Echinococcus granulosus	expressed conserved protein	0.0276	0.1064	0.6395
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0025	0.0559
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0071	0.0208	0.0709
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0208	0.183
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0034	0.0284
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0027	0.0025	0.0204
Entamoeba histolytica	acyl-coA synthetase, putative	0.0071	0.0208	0.183
Leishmania major	GTP-binding protein, putative	0.0021	0.0002	0.0109
Echinococcus multilocularis	expressed conserved protein	0.0276	0.1064	0.1064
Echinococcus multilocularis	snurportin 1	0.0309	0.1202	0.1202
Entamoeba histolytica	hypothetical protein	0.0107	0.0361	0.3171
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0071	0.0208	0.0709
Trypanosoma cruzi	metacaspase 5, putative	0.0027	0.0025	1
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0002	0.017
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0034	1
Schistosoma mansoni	patched 1	0.0126	0.0439	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0208	0.1733
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0114	0.1003
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0181	0.0181
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0098	0.0587
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0294	0.1138	1
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0025	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0439	0.3651
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0025	0.0559
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0002	0.0008
Echinococcus granulosus	caspase 8	0.0027	0.0025	0.0148
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0025	0.0559
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0071	0.0208	0.0709
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0208	1
Echinococcus granulosus	caspase	0.01	0.0329	0.1978
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0025	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0557	0.4634
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0053	0.0134	0.5
Plasmodium vivax	acyl-CoA synthetase, putative	0.0053	0.0134	1
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0208	0.0709
Echinococcus granulosus	expressed conserved protein	0.0135	0.0478	0.2873
Echinococcus granulosus	snurportin 1	0.0309	0.1202	0.7227
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0107	0.0361	0.0361
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0181	0.1088
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0034	0.2553
Schistosoma mansoni	caspase-3 (C14 family)	0.01	0.0329	0.2737
Echinococcus multilocularis	protein patched	0.0126	0.0439	0.0439
Echinococcus granulosus	Protein patched homolog 1	0.0126	0.0439	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0208	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0025	0.0204
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0098	0.0858
Trypanosoma brucei	metacaspase 5, putative	0.0027	0.0025	0.7189
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0181	0.1591
Plasmodium vivax	hypothetical protein, conserved	0.0027	0.0025	0.1835
Echinococcus multilocularis	Niemann Pick C1 protein	0.042	0.1664	0.1664
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0181	0.1506
Entamoeba histolytica	hypothetical protein	0.0023	0.0011	0.0099
Entamoeba histolytica	hypothetical protein	0.0107	0.0361	0.3171
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0098	0.0098
Schistosoma mansoni	hypothetical protein	0.0122	0.042	0.3493
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.0025	0.0084
Plasmodium falciparum	importin beta, putative	0.0029	0.0034	0.2553
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0114	0.0949
Trypanosoma brucei	metacaspase MCA3	0.0027	0.0025	0.7189
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0181	0.1506
Entamoeba histolytica	hypothetical protein	0.0107	0.0361	0.3171
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0114	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0134	0.1113
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.01	0.0329	0.1978
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0025	0.0559
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0208	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0134	0.1113
Echinococcus multilocularis	protein dispatched 1	0.0144	0.0513	0.0513
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0011	0.461
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.1506
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0071	0.0208	0.0709
Echinococcus multilocularis	caspase 8	0.0027	0.0025	0.0025
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0208	0.0709
Trichomonas vaginalis	conserved hypothetical protein	0.0126	0.0439	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0051	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0134	0.1113
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.1506
Entamoeba histolytica	hypothetical protein	0.0107	0.0361	0.3171
Schistosoma mansoni	hypothetical protein	0.0107	0.0361	0.3002
Schistosoma mansoni	hypothetical protein	0.0033	0.0051	0.0421
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0034	0.0116
Echinococcus granulosus	Niemann Pick C1 protein	0.0294	0.1138	0.6841
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0002	0.002
Leishmania major	metacaspase, putative	0.0027	0.0025	0.1178
Schistosoma mansoni	caspase-7 (C14 family)	0.01	0.0329	0.2737
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0114	0.1003
Trypanosoma brucei	metacaspase	0.0027	0.0025	0.7189
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0025	0.0559
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0126	0.0439	0.3651
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0071	0.0208	0.0709
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0051	0.0445
Echinococcus multilocularis	sentrin specific protease 7	0.0148	0.0532	0.0532
Schistosoma mansoni	hypothetical protein	0.0122	0.042	0.3493
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0011	0.0258
Onchocerca volvulus		0.0071	0.0208	1
Schistosoma mansoni	hypothetical protein	0.0309	0.1202	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0011	0.0258
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0002	0.0927
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0025	0.0559
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0002	0.0014
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0025	1
Mycobacterium tuberculosis	Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	0.0725	0.2937	1
Trypanosoma brucei	Metacaspase-4	0.0027	0.0025	0.7189
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0071	0.0208	0.0709
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0208	0.183
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0071	0.0208	0.0709
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.0025	0.0084
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0002	0.017
Schistosoma mansoni	transcription factor LCR-F1	0.0107	0.0361	0.3002
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.01	0.0329	0.0329
Brugia malayi	Cell death protein 3 precursor	0.0027	0.0025	0.0216
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0071	0.0208	0.0709
Echinococcus granulosus	caspase 3	0.0073	0.0218	0.131
Plasmodium vivax	metacaspase 1, putative	0.0027	0.0025	0.1835
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0134	0.1113
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0034	1
Plasmodium falciparum	metacaspase 1	0.0027	0.0025	0.1835
Trichomonas vaginalis	ran, putative	0.0021	0.0002	0.0052
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0298	0.1157	0.9623
Schistosoma mansoni	hypothetical protein	0.0122	0.042	0.3493

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.37 uM	Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) by spectrophotometry	ChEMBL.	24953948
MIC (functional)	= 80.91 uM	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition after 28 days by agar dilution method	ChEMBL.	24953948

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3310308

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 916670