Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0128 | 0.2561 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0044 | 0.0313 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.1129 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.1142 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0044 | 0.0313 | 0.1142 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0044 | 0.0313 | 0.1142 |
Plasmodium falciparum | thioredoxin reductase | 0.0127 | 0.2533 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0127 | 0.2533 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0033 | 0.0026 | 0.0104 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0044 | 0.0313 | 0.1142 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0033 | 0.0026 | 0.0104 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0044 | 0.0313 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0127 | 0.2533 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0044 | 0.0313 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0044 | 0.0313 | 0.1142 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0044 | 0.0313 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0044 | 0.0313 | 0.1142 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Plasmodium falciparum | glutathione reductase | 0.0127 | 0.2533 | 1 |
Onchocerca volvulus | 0.0033 | 0.0026 | 0.5 | |
Leishmania major | trypanothione reductase | 0.0127 | 0.2533 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0127 | 0.2533 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0128 | 0.2561 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0127 | 0.2533 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0033 | 0.0026 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0044 | 0.0313 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0044 | 0.0313 | 0.1142 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0321 | 0.7751 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0289 | 0.6886 | 0.888 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0044 | 0.0313 | 0.0371 |
Mycobacterium tuberculosis | Probable reductase | 0.0289 | 0.6886 | 0.888 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0033 | 0.0026 | 0.0104 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.1142 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Onchocerca volvulus | 0.0033 | 0.0026 | 0.5 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0321 | 0.7751 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0044 | 0.0313 | 0.1234 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0127 | 0.2533 | 0.3245 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.1129 |
Entamoeba histolytica | aldose reductase, putative | 0.0033 | 0.0026 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0127 | 0.2533 | 1 |
Onchocerca volvulus | 0.0033 | 0.0026 | 0.5 | |
Entamoeba histolytica | aldose reductase, putative | 0.0033 | 0.0026 | 0.5 |
Brugia malayi | glutathione reductase | 0.0127 | 0.2533 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0127 | 0.2533 | 1 |
Onchocerca volvulus | 0.0033 | 0.0026 | 0.5 | |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0044 | 0.0313 | 0.5 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0127 | 0.2533 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0044 | 0.0313 | 0.1142 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0321 | 0.7751 | 1 |
Treponema pallidum | NADH oxidase | 0.0044 | 0.0313 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0026 | 0.5 | |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0044 | 0.0313 | 0.0287 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0044 | 0.0313 | 0.1142 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0289 | 0.6886 | 0.888 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0033 | 0.0026 | 0.0104 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0127 | 0.2533 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0044 | 0.0313 | 1 |
Onchocerca volvulus | 0.0033 | 0.0026 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0044 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0289 | 0.6886 | 0.888 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0289 | 0.6886 | 0.888 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0289 | 0.6886 | 0.888 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0289 | 0.6886 | 0.888 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0321 | 0.7751 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 25 uM | Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) by spectrophotometry | ChEMBL. | 24953948 |
MIC (functional) | = 42.23 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition after 28 days by agar dilution method | ChEMBL. | 24953948 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.