Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0098 | 0.1024 | 0.3249 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0275 | 0.0275 |
Echinococcus granulosus | tumor protein p63 | 0.0347 | 0.3793 | 0.4844 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0644 | 0.7109 | 0.8986 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0148 | 0.0172 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0148 | 0.0501 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0644 | 0.7109 | 0.8986 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0644 | 0.7109 | 0.8986 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0716 | 0.791 | 1 |
Plasmodium vivax | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0079 | 0.0809 | 0.2384 |
Loa Loa (eye worm) | glutathione reductase | 0.0283 | 0.3079 | 1 |
Mycobacterium tuberculosis | Possible dehydrogenase/reductase | 0.0026 | 0.0223 | 0.0264 |
Chlamydia trachomatis | endonuclease IV | 0.0079 | 0.0809 | 0.732 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0708 | 0.7815 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0017 | 0.0017 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0056 | 0.0134 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0275 | 0.0591 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0056 | 0.0053 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0098 | 0.1024 | 0.3293 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1869 | 0.1869 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0082 | 0.0087 |
Mycobacterium leprae | Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) | 0.0026 | 0.0223 | 0.0264 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0098 | 0.1024 | 0.1294 |
Giardia lamblia | Thioredoxin reductase | 0.0026 | 0.0223 | 0.1907 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0098 | 0.1024 | 0.1024 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprA | 0.0026 | 0.0223 | 0.2066 |
Trypanosoma brucei | 2,4-dienoyl-coa reductase-like protein | 0.0026 | 0.0223 | 0.068 |
Brugia malayi | NADPH:adrenodoxin oxidoreductase, mitochondrial precursor | 0.0026 | 0.0223 | 0.068 |
Schistosoma mansoni | glutamate synthase | 0.0026 | 0.0223 | 0.0223 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0644 | 0.7109 | 0.8986 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0009 | 0.0034 | 0.0064 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0099 | 0.0275 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase fadh1, putative | 0.0026 | 0.0223 | 0.068 |
Schistosoma mansoni | netrin receptor unc5 | 0.0015 | 0.0098 | 0.0098 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0148 | 0.0437 |
Plasmodium falciparum | thioredoxin reductase | 0.0283 | 0.3079 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0327 | 0.1183 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Mycobacterium tuberculosis | Probable thioredoxin reductase TrxB2 (TRXR) (TR) | 0.0026 | 0.0223 | 0.0264 |
Mycobacterium tuberculosis | Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) | 0.0079 | 0.0809 | 0.1006 |
Plasmodium falciparum | glutathione reductase | 0.0098 | 0.1024 | 0.3249 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0026 | 0.0223 | 0.0786 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0148 | 0.0501 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0098 | 0.1024 | 0.3839 |
Echinococcus granulosus | death domain containing protein | 0.0015 | 0.0098 | 0.0107 |
Leishmania major | cytochrome p450-like protein | 0.0016 | 0.0114 | 0.0327 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0026 | 0.0223 | 0.068 |
Echinococcus multilocularis | geminin | 0.0174 | 0.1869 | 0.2377 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0015 | 0.0098 | 0.0272 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0026 | 0.0223 | 0.068 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0076 | 0.0775 | 0.0975 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0098 | 0.1024 | 0.3293 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0627 | 0.0785 |
Schistosoma mansoni | hypothetical protein | 0.0007 | 0.0014 | 0.0014 |
Leishmania major | 2,4-dienoyl-coa reductase-like protein | 0.0026 | 0.0223 | 0.068 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0007 | 0.0017 | 0.0003 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0098 | 0.1024 | 0.3293 |
Mycobacterium tuberculosis | Probable reductase | 0.0644 | 0.7109 | 0.8986 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprB | 0.0026 | 0.0223 | 0.2066 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0114 | 0.0327 |
Loa Loa (eye worm) | RecQ helicase | 0.0022 | 0.0177 | 0.0531 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0026 | 0.0223 | 0.0267 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.0355 | 0.1111 |
Trypanosoma brucei | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0026 | 0.0223 | 0.068 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0098 | 0.1024 | 0.3249 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0082 | 0.0221 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0242 | 0.0291 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0026 | 0.0223 | 0.0267 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0283 | 0.3079 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0223 | 0.0223 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0708 | 0.7815 | 0.7815 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0644 | 0.7109 | 0.8986 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0064 | 0.0161 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0026 | 0.0223 | 0.0786 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0009 | 0.0034 | 0.0025 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0026 | 0.0223 | 0.068 |
Toxoplasma gondii | non-proton pumping type-II NADH dehydrogenase I | 0.0026 | 0.0223 | 0.068 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0098 | 0.1024 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0283 | 0.3079 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0283 | 0.3079 | 1 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0026 | 0.0223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0242 | 0.0741 |
Wolbachia endosymbiont of Brugia malayi | NADPH-dependent glutamate synthase beta chain | 0.0026 | 0.0223 | 0.0851 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0394 | 0.0394 |
Trypanosoma brucei | NADH dehydrogenase | 0.0026 | 0.0223 | 0.068 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0026 | 0.0223 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0009 | 0.0034 | 0.0025 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0007 | 0.0017 | 0.0003 |
Plasmodium falciparum | ferrodoxin reductase-like protein | 0.0026 | 0.0223 | 0.062 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0026 | 0.0223 | 0.068 |
Brugia malayi | Hypothetical 29.7 kDa protein C05D11.5 in chromosome III | 0.0021 | 0.0164 | 0.0487 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0007 | 0.0017 | 0.0008 |
Leishmania major | trypanothione reductase | 0.0283 | 0.3079 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1869 | 0.1869 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0056 | 0.0056 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0099 | 0.0275 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0015 | 0.0098 | 0.0098 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0098 | 0.1024 | 0.3293 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0026 | 0.0223 | 0.0267 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0007 | 0.0017 | 0.0017 |
Trypanosoma brucei | cytochrome P450, putative | 0.0016 | 0.0114 | 0.0327 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0098 | 0.1024 | 0.3839 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0627 | 0.6071 |
Mycobacterium ulcerans | sugar phosphate isomerases/epimerases | 0.0021 | 0.0164 | 0.148 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0098 | 0.1024 | 0.1278 |
Plasmodium falciparum | apurinic/apyrimidinic endonuclease Apn1, putative | 0.0079 | 0.0809 | 0.2545 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0007 | 0.0017 | 0.0003 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0148 | 0.1327 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0007 | 0.0017 | 0.0008 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0498 | 0.1579 |
Leishmania major | 2,4-dienoyl-coa reductase fadh1, putative | 0.0026 | 0.0223 | 0.068 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0098 | 0.0272 |
Mycobacterium ulcerans | glutamate synthase subunit beta | 0.0026 | 0.0223 | 0.2066 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0026 | 0.0223 | 0.0786 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0716 | 0.791 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0098 | 0.1024 | 1 |
Trypanosoma cruzi | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0026 | 0.0223 | 0.068 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0275 | 0.0333 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0015 | 0.0098 | 0.0107 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.0148 | 0.0373 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.0098 | 0.0272 |
Brugia malayi | glutathione reductase | 0.0283 | 0.3079 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.0242 | 0.0291 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0026 | 0.0223 | 0.0786 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0015 | 0.0098 | 0.0107 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0026 | 0.0223 | 1 |
Onchocerca volvulus | 0.0031 | 0.0275 | 0.0695 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0077 | 0.0203 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0034 | 0.0064 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.024 | 0.2606 | 0.8457 |
Brugia malayi | Uncoordinated protein 44 | 0.0015 | 0.0098 | 0.0272 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0012 | 0.0064 | 0.0179 |
Schistosoma mansoni | DNA helicase recq1 | 0.0009 | 0.0034 | 0.0034 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0275 | 0.0275 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0223 | 0.068 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0026 | 0.0223 | 1 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0015 | 0.0099 | 0.0099 |
Schistosoma mansoni | lamin | 0.0028 | 0.0242 | 0.0242 |
Onchocerca volvulus | 0.0028 | 0.0242 | 0.0566 | |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0148 | 0.1154 |
Mycobacterium ulcerans | dehydrogenase | 0.0026 | 0.0223 | 0.2066 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0498 | 0.0498 |
Onchocerca volvulus | 0.0028 | 0.0242 | 0.0566 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0056 | 0.0053 |
Schistosoma mansoni | disulfide oxidoreductase | 0.0026 | 0.0223 | 0.0223 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0082 | 0.0087 |
Toxoplasma gondii | endonuclease IV APN | 0.0079 | 0.0809 | 0.2593 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0148 | 0.0437 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0098 | 0.1024 | 1 |
Mycobacterium leprae | Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate | 0.0026 | 0.0223 | 0.0264 |
Mycobacterium tuberculosis | Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) | 0.0026 | 0.0223 | 0.0264 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0242 | 0.0741 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0148 | 0.0437 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0026 | 0.0223 | 0.068 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0148 | 0.0437 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.2311 | 0.7493 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0114 | 0.0327 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0026 | 0.0223 | 0.0267 |
Mycobacterium ulcerans | NADH dehydrogenase Ndh1 | 0.0026 | 0.0223 | 0.2066 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0275 | 0.0849 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0644 | 0.7109 | 0.8986 |
Mycobacterium ulcerans | thioredoxin reductase TrxB2 | 0.0026 | 0.0223 | 0.2066 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0148 | 0.017 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0026 | 0.0223 | 0.0267 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0007 | 0.0017 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0128 | 0.0371 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0627 | 0.6071 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0627 | 0.1999 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0148 | 0.0437 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0148 | 0.0148 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0072 | 0.0734 | 0.2349 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0038 | 0.0355 | 0.1111 |
Mycobacterium ulcerans | endonuclease IV | 0.0079 | 0.0809 | 0.7874 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0223 | 0.068 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0056 | 0.0134 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0286 | 0.3114 | 0.3973 |
Mycobacterium leprae | conserved hypothetical protein | 0.0021 | 0.0164 | 0.0189 |
Giardia lamblia | Glutamate synthase | 0.0026 | 0.0223 | 0.1907 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0022 | 0.0177 | 0.0612 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0286 | 0.3114 | 0.3973 |
Mycobacterium leprae | PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) | 0.0079 | 0.0809 | 0.1006 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0034 | 0.0064 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0022 | 0.0177 | 0.0612 |
Plasmodium vivax | type II NADH:ubiquinone oxidoreductase, putative | 0.0026 | 0.0223 | 0.0418 |
Treponema pallidum | thioredoxin reductase (trxB) | 0.0026 | 0.0223 | 0.0851 |
Mycobacterium tuberculosis | NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) | 0.0026 | 0.0223 | 0.0264 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0275 | 0.0333 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0275 | 0.0849 |
Treponema pallidum | oxidoreductase | 0.0026 | 0.0223 | 0.0851 |
Onchocerca volvulus | 0.0243 | 0.264 | 1 | |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0098 | 0.1024 | 0.3293 |
Mycobacterium ulcerans | epimerase | 0.0021 | 0.0164 | 0.148 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0148 | 0.0148 |
Echinococcus granulosus | geminin | 0.0174 | 0.1869 | 0.2377 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0148 | 0.5317 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0007 | 0.0017 | 0.0003 |
Plasmodium falciparum | type II NADH:ubiquinone oxidoreductase | 0.0026 | 0.0223 | 0.062 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0098 | 0.1024 | 0.3293 |
Echinococcus granulosus | Ankyrin | 0.0015 | 0.0099 | 0.0109 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0026 | 0.0223 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0242 | 0.0242 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0026 | 0.0223 | 0.1907 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0076 | 0.0775 | 0.0975 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0026 | 0.0223 | 0.0267 |
Plasmodium vivax | NAD(P)H-dependent glutamate synthase, putative | 0.0026 | 0.0223 | 0.0418 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0026 | 0.0223 | 0.068 |
Toxoplasma gondii | NADH dehydrogenase (NDH2-II) | 0.0026 | 0.0223 | 0.068 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0223 | 0.2066 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0026 | 0.0223 | 0.0786 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0098 | 0.1024 | 0.1294 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0007 | 0.0017 | 0.0003 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0098 | 0.1024 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0283 | 0.3079 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0098 | 0.1024 | 1 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0026 | 0.0223 | 0.0267 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0098 | 0.1024 | 0.3293 |
Mycobacterium ulcerans | NADPH dependent 2,4-dienoyl-CoA reductase FadH | 0.0026 | 0.0223 | 0.2066 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase-like protein, putative | 0.0026 | 0.0223 | 0.068 |
Echinococcus granulosus | glutamate synthase | 0.0026 | 0.0223 | 0.0267 |
Mycobacterium ulcerans | NADH dehydrogenase | 0.0026 | 0.0223 | 0.2066 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0034 | 0.0063 |
Trypanosoma brucei | trypanothione reductase | 0.0283 | 0.3079 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0009 | 0.0034 | 0.0025 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0056 | 0.0056 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0026 | 0.0223 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0026 | 0.0223 | 0.0267 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0007 | 0.0017 | 0.0003 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0164 | 0.0189 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0148 | 0.0375 |
Plasmodium falciparum | NAD(P)H-dependent glutamate synthase, putative | 0.0026 | 0.0223 | 0.062 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0098 | 0.1024 | 0.3104 |
Schistosoma mansoni | sulfide quinone reductase | 0.0026 | 0.0223 | 0.0223 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0223 | 0.068 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0098 | 0.1024 | 0.3104 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0015 | 0.0098 | 0.0107 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0072 | 0.0734 | 0.2349 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0022 | 0.0177 | 0.0531 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0009 | 0.0034 | 0.0025 |
Mycobacterium ulcerans | hypothetical protein | 0.0021 | 0.0164 | 0.148 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0275 | 0.0849 |
Schistosoma mansoni | cytochrome P450 | 0.0007 | 0.0014 | 0.0014 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0394 | 0.0394 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.0026 | 0.0223 | 0.0786 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0716 | 0.791 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0708 | 0.7815 | 1 |
Plasmodium vivax | ferrodoxin reductase, putative | 0.0026 | 0.0223 | 0.0418 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0034 | 0.0064 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0015 | 0.0096 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0098 | 0.0272 |
Mycobacterium ulcerans | NADH dehydrogenase Ndh | 0.0026 | 0.0223 | 0.2066 |
Toxoplasma gondii | selenide, water dikinase | 0.0026 | 0.0223 | 0.068 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0026 | 0.0223 | 0.068 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.0114 | 0.0327 |
Schistosoma mansoni | glutamate synthase | 0.0026 | 0.0223 | 0.0223 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0026 | 0.0223 | 0.0786 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0007 | 0.0017 | 0.0003 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0007 | 0.0017 | 0.0003 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0026 | 0.0223 | 0.068 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0064 | 0.0161 |
Plasmodium falciparum | glutathione reductase | 0.0283 | 0.3079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0164 | 0.0487 |
Schistosoma mansoni | lamin | 0.0028 | 0.0242 | 0.0242 |
Echinococcus multilocularis | bloom syndrome protein | 0.0022 | 0.0177 | 0.0209 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0026 | 0.0223 | 0.0267 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0098 | 0.1024 | 0.3293 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.0355 | 0.0436 |
Brugia malayi | glutamate synthase | 0.0026 | 0.0223 | 0.068 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0275 | 0.0333 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0148 | 0.0437 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0275 | 0.0275 |
Onchocerca volvulus | 0.0026 | 0.0223 | 0.0492 | |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0017 | 0.0017 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0026 | 0.0223 | 0.068 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0056 | 0.0053 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0148 | 0.0437 |
Echinococcus granulosus | bloom syndrome protein | 0.0022 | 0.0177 | 0.0209 |
Toxoplasma gondii | thioredoxin reductase | 0.0283 | 0.3079 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0242 | 0.0741 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0017 | 0.0126 | 0.0126 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0627 | 0.6071 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0098 | 0.1024 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0077 | 0.0203 |
Echinococcus multilocularis | Ankyrin | 0.0015 | 0.0099 | 0.0109 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0026 | 0.0223 | 0.0786 |
Schistosoma mansoni | DNA helicase recq5 | 0.0009 | 0.0034 | 0.0034 |
Onchocerca volvulus | Putative hydroxypyruvate isomerase | 0.0021 | 0.0164 | 0.026 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0026 | 0.0223 | 0.0851 |
Echinococcus multilocularis | glutamate synthase | 0.0026 | 0.0223 | 0.0267 |
Schistosoma mansoni | glutamate synthase | 0.0026 | 0.0223 | 0.0223 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0627 | 0.0776 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0098 | 0.1024 | 0.3293 |
Onchocerca volvulus | 0.0051 | 0.0498 | 0.1576 | |
Mycobacterium ulcerans | monoxygenase | 0.0026 | 0.0223 | 0.2066 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0098 | 0.1024 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0007 | 0.0017 | 0.0008 |
Leishmania major | NADH dehydrogenase, putative | 0.0026 | 0.0223 | 0.068 |
Mycobacterium leprae | THIOREDOXIN TRXC (TRX) (MPT46) | 0.0026 | 0.0223 | 0.0264 |
Brugia malayi | follicle stimulating hormone receptor | 0.024 | 0.2606 | 0.8457 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0242 | 0.0741 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0026 | 0.0223 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0007 | 0.0017 | 0.0003 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0026 | 0.0223 | 0.068 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0056 | 0.0053 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0242 | 0.0291 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0017 | 0.0017 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0114 | 0.0327 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0015 | 0.0098 | 0.0107 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0283 | 0.3079 | 0.3882 |
Treponema pallidum | NADH oxidase | 0.0098 | 0.1024 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0017 | 0.0008 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0012 | 0.0064 | 0.0161 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0026 | 0.0223 | 0.068 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0283 | 0.3079 | 1 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0026 | 0.0223 | 0.068 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0627 | 0.0627 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0026 | 0.0223 | 0.0786 |
Echinococcus multilocularis | tumor protein p63 | 0.0347 | 0.3793 | 0.4844 |
Mycobacterium tuberculosis | Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate | 0.0026 | 0.0223 | 0.0264 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0026 | 0.0223 | 0.0851 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0148 | 0.0172 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0034 | 0.0064 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0275 | 0.0275 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0242 | 0.0741 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0026 | 0.0223 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0809 | 0.2593 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0242 | 0.0291 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Trichomonas vaginalis | set domain proteins, putative | 0.0243 | 0.2639 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0016 | 0.0114 | 0.0327 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.0355 | 0.0436 |
Brugia malayi | DNA-(Apurinic or apyrimidinic site) lyase | 0.0079 | 0.0809 | 0.2593 |
Brugia malayi | Death domain containing protein | 0.0015 | 0.0098 | 0.0272 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0016 | 0.0114 | 0.0992 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0026 | 0.0223 | 0.068 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0026 | 0.0223 | 0.068 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0223 | 0.068 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0627 | 0.0785 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0114 | 0.0327 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0114 | 0.0327 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0007 | 0.0017 | 0.0003 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0148 | 0.0168 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0026 | 0.0223 | 0.0786 |
Schistosoma mansoni | sulfide quinone reductase | 0.0026 | 0.0223 | 0.0223 |
Mycobacterium ulcerans | ferredoxin reductase | 0.0026 | 0.0223 | 0.2066 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0026 | 0.0223 | 0.0786 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0026 | 0.0223 | 0.068 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0299 | 0.0929 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprA | 0.0026 | 0.0223 | 0.2066 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0034 | 0.0064 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.0627 | 0.1999 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0026 | 0.0223 | 0.068 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0242 | 0.0291 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0026 | 0.0223 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0099 | 0.0277 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0327 | 0.1183 |
Mycobacterium tuberculosis | Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) | 0.0026 | 0.0223 | 0.0264 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0627 | 0.0627 |
Mycobacterium leprae | PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) | 0.0026 | 0.0223 | 0.0264 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Plasmodium falciparum | thioredoxin reductase | 0.0098 | 0.1024 | 0.3249 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0026 | 0.0223 | 0.0267 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0262 | 0.0317 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0098 | 0.1024 | 0.3293 |
Trichomonas vaginalis | apoptosis inducing factor, putative | 0.0026 | 0.0223 | 0.0786 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0716 | 0.791 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0242 | 0.0291 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0098 | 0.1024 | 0.3293 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0026 | 0.0223 | 0.0267 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.2311 | 0.7493 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0236 | 0.0723 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio IC50 (binding) | = 0.8 | Competitive binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) assessed as inhibition of eIF4E/eIF4G interaction by fluorescence polarization assay relative to parent compound | ChEMBL. | 24675136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.