Detailed information for compound 916760

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 236.31 | Formula: C13H20N2O2
  • H donors: 2 H acceptors: 3 LogP: 2.4 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(=O)Nc1nc(C)c(c(c1C)C)O)C
  • InChi: 1S/C13H20N2O2/c1-7(2)6-11(16)15-13-9(4)8(3)12(17)10(5)14-13/h7,17H,6H2,1-5H3,(H,14,15,16)
  • InChiKey: SOFZAHSTVCWREC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0434 0.1132
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0356 0.2232
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1479 0.1863
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.1489 0.3883
Loa Loa (eye worm) hypothetical protein 0.0035 0.0884 0.0764
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0434 0.2754
Brugia malayi Pre-SET motif family protein 0.003 0.0724 0.0873
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0395 0.181
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0024 0.0431
Brugia malayi TAR-binding protein 0.0133 0.4282 0.6098
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0395 0.0343
Mycobacterium ulcerans hypothetical protein 0.0074 0.224 0.584
Echinococcus granulosus importin subunit beta 1 0.0028 0.065 0.065
Brugia malayi Pre-SET motif family protein 0.0211 0.6938 1
Echinococcus granulosus endoplasmin 0.0025 0.0551 0.0551
Leishmania major hypothetical protein, conserved 0.0053 0.1513 0.3908
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0724 0.0724
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0773 0.5029
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0773 0.371
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0504 0.0504
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.4282 0.4206
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.3835 1
Schistosoma mansoni hypothetical protein 0.0165 0.5362 0.5362
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Loa Loa (eye worm) hypothetical protein 0.0053 0.1513 0.1402
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0686 0.0686
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1479 0.1863
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Echinococcus multilocularis heat shock protein 0.0032 0.0773 0.0773
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 1 1
Echinococcus granulosus heat shock protein 90 0.0032 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0055 0.1594 0.1483
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0803 0.0682
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0773 0.5029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.003 0.0724 0.0602
Echinococcus multilocularis heat shock protein 90 0.0032 0.0773 0.0773
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0434 0.1132
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0773 0.5029
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.1479 0.3818
Loa Loa (eye worm) hypothetical protein 0.0055 0.1594 0.1483
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0434 0.0447
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1479 0.9771
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0022 0.0434 0.1937
Schistosoma mansoni endoplasmin 0.0032 0.0773 0.0773
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0773 0.1965
Loa Loa (eye worm) endoplasmin 0.0032 0.0773 0.0651
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0356 0.0356
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.3835 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0395 0.0389
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.144 0.1925
Echinococcus multilocularis heat shock protein 90 0.0025 0.0551 0.0551
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0434 0.1132
Brugia malayi AMP-binding enzyme family protein 0.0074 0.224 0.3099
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.3835 0.3835
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0776 0.1975
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0434 0.1937
Echinococcus granulosus dna polymerase kappa 0.002 0.0356 0.0356
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.1513 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0773 0.5029
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0147 0.083
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.1513 0.945
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0434 0.1132
Loa Loa (eye worm) hypothetical protein 0.0055 0.1594 0.1483
Schistosoma mansoni hypothetical protein 0.0016 0.0239 0.0239
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0434 0.0308
Schistosoma mansoni hypothetical protein 0.0035 0.0884 0.0884
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0803 0.0989
Entamoeba histolytica Ran family GTPase 0.0021 0.0395 0.1255
Trypanosoma brucei heat shock protein, putative 0.0032 0.0773 0.5029
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.3835 0.3835
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0773 0.0973
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0551 0.0694
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0434 0.1076
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0395 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0147 0.083
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.3835 0.3835
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0434 0.1132
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0724 0.0724
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0776 0.5054
Echinococcus granulosus GPCR family 2 0.0016 0.0239 0.0239
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0434 0.1132
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0356 0.0356
Echinococcus multilocularis snurportin 1 0.0299 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.065 0.4203
Trypanosoma brucei heat shock protein, putative 0.0032 0.0773 0.5029
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0434 0.0308
Onchocerca volvulus 0.0022 0.0434 0.039
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0356 0.0872
Schistosoma mansoni tar DNA-binding protein 0.0133 0.4282 0.4282
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0434 0.1132
Schistosoma mansoni rotamase 0.0032 0.0803 0.0803
Trichomonas vaginalis ran, putative 0.0021 0.0395 0.0497
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.144 0.1328
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0724 0.0724
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0434 0.0434
Onchocerca volvulus 0.0022 0.0434 0.039
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0434 0.1132
Echinococcus granulosus heat shock protein 90 0.0025 0.0551 0.0551
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0434 0.1132
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0356 0.2232
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.3835 1
Schistosoma mansoni endoplasmin 0.0032 0.0773 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0803 0.1011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.144 0.1925
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0724 0.0724
Schistosoma mansoni tar DNA-binding protein 0.0133 0.4282 0.4282
Trypanosoma cruzi heat shock protein, putative 0.0013 0.013 0.0712
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0434 0.2754
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.013 0.0278
Brugia malayi Endoplasmin precursor 0.0032 0.0773 0.0944
Giardia lamblia Grp94/Hsp90 0.0025 0.0551 0.1734
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.1489 0.3883
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0434 0.1937
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0434 0.0434
Echinococcus multilocularis GPCR, family 2 0.0016 0.0239 0.0239
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0239 0.0239
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Trypanosoma brucei heat shock protein, putative 0.0032 0.0773 0.5029
Echinococcus multilocularis tar DNA binding protein 0.0133 0.4282 0.4282
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.1479 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0776 0.5054
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0551 0.0551
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Plasmodium falciparum heat shock protein 90 0.0032 0.0773 0.4392
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0434 0.1442
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.224 0.584
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0776 0.3065
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.224 0.5815
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0434 0.0447
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.013 0.0712
Echinococcus granulosus tar DNA binding protein 0.0133 0.4282 0.4282
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.6938 0.6898
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0551 0.1734
Loa Loa (eye worm) hypothetical protein 0.0074 0.224 0.2138
Trypanosoma brucei unspecified product 0.0013 0.0147 0.083
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.1513 1
Echinococcus granulosus geminin 0.0165 0.5362 0.5362
Onchocerca volvulus 0.003 0.0724 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0434 0.1132
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1479 0.1863
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0356 0.1073
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0551 0.0694
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.224 0.584
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0551 0.1436
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0434 0.1132
Loa Loa (eye worm) hypothetical protein 0.0074 0.224 0.2138
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0773 0.4392
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0776 0.5054
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0356 0.2232
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0434 0.0447
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.3835 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0356 0.0448
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0434 0.1132
Schistosoma mansoni heat shock protein 0.0032 0.0773 0.0773
Trypanosoma brucei unspecified product 0.0013 0.0147 0.083
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.3835 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.033 0.086
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0356 0.0929
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.224 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0434 0.2754
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0434 0.1132
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0395 0.0973
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0239 0.0111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.1489 0.3883
Treponema pallidum heat shock protein 90 0.0025 0.0551 1
Trichomonas vaginalis set domain proteins, putative 0.024 0.7941 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0434 0.1132
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.1479 0.9771
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0239 0.0161
Brugia malayi AMP-binding enzyme family protein 0.0074 0.224 0.3099
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.1594 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.1479 0.9771
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0434 0.1076
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.1489 0.3883
Brugia malayi MAP kinase sur-1 0.0052 0.1479 0.1982
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Loa Loa (eye worm) hypothetical protein 0.0028 0.065 0.0527
Loa Loa (eye worm) hypothetical protein 0.0022 0.0434 0.0308
Schistosoma mansoni hypothetical protein 0.0016 0.0239 0.0239
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0434 0.1132
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.224 0.5815
Brugia malayi RNA, U transporter 1 0.008 0.2431 0.3381
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0551 0.2459
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0434 0.0434
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.1479 0.1479
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0434 0.1132
Trichomonas vaginalis rotamase, putative 0.0032 0.0776 0.0978
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0434 0.2078
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0147 0.083
Echinococcus granulosus heat shock protein 0.0032 0.0773 0.0773
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0356 0.0929
Loa Loa (eye worm) hypothetical protein 0.0055 0.1594 0.1483
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0773 0.3047
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.1513 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0773 0.5029
Leishmania major heat shock protein, putative 0.0013 0.013 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0724 0.0724
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0356 0.0448
Plasmodium vivax SET domain protein, putative 0.003 0.0724 0.406
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.3835 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0434 0.1132
Loa Loa (eye worm) hypothetical protein 0.002 0.0356 0.0229
Loa Loa (eye worm) oxidoreductase 0.0022 0.0434 0.0308
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0434 0.1076
Echinococcus multilocularis expressed protein 0.0032 0.0803 0.0803
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0395 0.181
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0356 0.0229
Echinococcus multilocularis endoplasmin 0.0025 0.0551 0.0551
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.224 0.584
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0356 0.2232
Loa Loa (eye worm) hypothetical protein 0.0022 0.0434 0.0308
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.1479 0.9771
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.065 0.4203
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.3835 0.3835
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0356 0.2232
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.1479 0.3818
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0434 0.1132
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0356 0.2232
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.1479 0.1479
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.224 1
Plasmodium falciparum endoplasmin, putative 0.0019 0.0352 0.1516
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.1594 0.4155
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0776 0.1975
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0434 0.1132
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0434 0.0547
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.224 0.5815
Schistosoma mansoni tar DNA-binding protein 0.0133 0.4282 0.4282
Brugia malayi heat shock protein 90 0.0032 0.0773 0.0944
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0434 0.0447
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0434 0.1076
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.224 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0434 0.2754
Trichomonas vaginalis rotamase, putative 0.0032 0.0803 0.1011
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Schistosoma mansoni importin beta-1 0.0028 0.065 0.065
Schistosoma mansoni tar DNA-binding protein 0.0133 0.4282 0.4282
Onchocerca volvulus 0.024 0.7941 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.065 0.065
Loa Loa (eye worm) RNA binding protein 0.0133 0.4282 0.4206
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Onchocerca volvulus 0.0074 0.224 0.2701
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.013 0.0278
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0551 0.3539
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0395 0.249
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0356 0.0356
Trypanosoma brucei heat shock protein, putative 0.0032 0.0773 0.5029
Schistosoma mansoni hypothetical protein 0.0016 0.0239 0.0239
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0434 0.1132
Trypanosoma brucei heat shock protein, putative 0.0032 0.0773 0.5029
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.1594 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0551 0.1383
Echinococcus granulosus dna polymerase eta 0.002 0.0356 0.0356
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0467 0.0588
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.013 0.013
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0356 0.2232
Trypanosoma brucei heat shock protein, putative 0.0032 0.0773 0.5029
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.065 0.1643
Leishmania major DNA polymerase eta, putative 0.002 0.0356 0.0872
Schistosoma mansoni DNA polymerase eta 0.002 0.0356 0.0356
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0434 0.1132
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.1513 0.945
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0395 0.0395
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.1479 0.1479
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0356 0.0929
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0434 0.1132
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1479 0.9771
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0434 0.1132
Schistosoma mansoni ran 0.0021 0.0395 0.0395
Schistosoma mansoni heat shock protein 0.0032 0.0773 0.0773
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.224 0.584
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0467 0.0588
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0352 0.0443
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0356 0.0356
Echinococcus granulosus expressed protein 0.0032 0.0803 0.0803
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.224 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0467 0.2976
Trichomonas vaginalis heat shock protein, putative 0.0013 0.013 0.0163
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0884 0.1108
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0356 0.2232
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0434 0.1076
Leishmania major DNA polymerase kappa, putative 0.002 0.0356 0.0872
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Brugia malayi AMP-binding enzyme family protein 0.0074 0.224 0.3099
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0773 0.3047
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0504 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.4282 0.6098
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0239 0.0239
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0434 0.1132
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0356 0.2232
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.1513 0.3908
Leishmania major GTP-binding protein, putative 0.0021 0.0395 0.0973
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0724 0.0724
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0773 0.5029
Plasmodium vivax importin-beta 2, putative 0.0028 0.065 0.3553
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.224 0.584
Loa Loa (eye worm) hypothetical protein 0.0055 0.1594 0.1483
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0239 0.0239
Schistosoma mansoni hypothetical protein 0.0299 1 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0551 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.224 0.584
Onchocerca volvulus 0.0026 0.0569 0.0562
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.1479 0.1479
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0239 0.0161
Loa Loa (eye worm) hypothetical protein 0.0016 0.0239 0.0111
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.1594 0.5
Echinococcus multilocularis dna polymerase eta 0.002 0.0356 0.0356
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.224 0.584
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0395 0.249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0434 0.1132
Loa Loa (eye worm) hypothetical protein 0.0051 0.144 0.1328
Schistosoma mansoni tar DNA-binding protein 0.0133 0.4282 0.4282
Trypanosoma brucei heat shock protein, putative 0.0032 0.0773 0.5029
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0434 0.2754
Plasmodium falciparum importin beta, putative 0.0028 0.065 0.3553
Brugia malayi RNA binding protein 0.0133 0.4282 0.6098
Trypanosoma brucei heat shock protein, putative 0.0032 0.0773 0.5029
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0434 0.1132
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0434 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Entamoeba histolytica hypothetical protein 0.0023 0.0467 0.1598
Schistosoma mansoni ran 0.0021 0.0395 0.0395
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0551 0.1436
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0356 0.2232
Schistosoma mansoni heat shock protein 0.0013 0.013 0.013
Loa Loa (eye worm) TAR-binding protein 0.0133 0.4282 0.4206
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0356 0.0332
Leishmania major importin beta-1 subunit, putative 0.0023 0.0467 0.1163
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0434 0.1132
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0724 0.0724
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0395 0.249
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0773 0.5029
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0434 0.2754
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0724 0.1837
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Leishmania major heat shock protein 83-1 0.0032 0.0773 0.1965
Echinococcus multilocularis dna polymerase kappa 0.002 0.0356 0.0356
Trypanosoma brucei protein kinase, putative 0.0052 0.1479 0.9771
Schistosoma mansoni hypothetical protein 0.0165 0.5362 0.5362
Trypanosoma brucei unspecified product 0.002 0.0356 0.2232
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0395 0.0268
Brugia malayi Importin beta-1 subunit 0.0028 0.065 0.0764
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0434 0.0447
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0434 0.0447
Echinococcus multilocularis geminin 0.0165 0.5362 0.5362
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.224 0.584
Schistosoma mansoni hypothetical protein 0.0024 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0074 0.224 0.2138
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.1594 0.4155
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0352 0.0443
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0326 0.2032
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1479 0.1863
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.1513 0.945
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0467 0.0588
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.013 0.013
Onchocerca volvulus 0.0022 0.0434 0.039
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.224 0.584
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0773 0.5029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.224 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0434 0.2078
Brugia malayi hypothetical protein 0.0053 0.1513 0.2032
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0773 0.1965
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0434 0.1132
Brugia malayi hypothetical protein 0.0034 0.0865 0.1079
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.1479 0.1479
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0356 0.0332
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0434 0.1076
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0551 0.0694
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.1479 0.3818
Schistosoma mansoni hypothetical protein 0.0016 0.0239 0.0239
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0773 0.0651
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0356 0.0929
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.1479 0.1367
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0551 0.3539
Plasmodium vivax endoplasmin, putative 0.0032 0.0773 0.4392

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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