Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0415 | 0.0404 |
Echinococcus multilocularis | allatostatin A receptor | 0.0012 | 0.0112 | 0.0133 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0301 | 0.5578 | 1 |
Echinococcus granulosus | neuropeptide receptor | 0.0012 | 0.0112 | 0.0133 |
Plasmodium vivax | elongation of very long chain fatty acids protein 3, putative | 0.0061 | 0.1029 | 0.1423 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | serotonin receptor | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0417 | 0.0375 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0061 | 0.1029 | 0.1019 |
Brugia malayi | fatty acid elongation protein 3 | 0.0061 | 0.1029 | 0.0991 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0012 | 0.0112 | 0.01 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0539 | 0.0527 |
Schistosoma mansoni | amine GPCR | 0.0012 | 0.0112 | 0.01 |
Echinococcus granulosus | g protein coupled receptor | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0061 | 0.1029 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | snurportin 1 | 0.0304 | 0.5632 | 0.7482 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0417 | 0.0406 |
Schistosoma mansoni | glutaminase | 0.0535 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0301 | 0.5578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0462 | 0.06 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.052 | 0.0461 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0012 | 0.0112 | 0.0133 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0417 | 0.0268 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | sex peptide receptor | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | G-protein coupled receptor | 0.0012 | 0.0112 | 0.007 |
Schistosoma mansoni | amine GPCR | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1724 | 0.1687 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0539 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Schistosoma mansoni | amine GPCR | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0301 | 0.5578 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Echinococcus granulosus | somatostatin receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | opsin-like receptor | 0.0012 | 0.0112 | 0.01 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Toxoplasma gondii | fatty acid elongase | 0.0061 | 0.1029 | 0.1423 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0012 | 0.0112 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0112 | 0.01 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0462 | 0.06 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0012 | 0.0112 | 0.01 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Onchocerca volvulus | 0.0035 | 0.0539 | 0.4649 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.0061 | 0.1029 | 0.0991 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0539 | 0.0498 |
Schistosoma mansoni | biogenic amine receptor | 0.0012 | 0.0112 | 0.01 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.114 | 0.1101 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0539 | 0.0496 |
Echinococcus granulosus | neuropeptide receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0061 | 0.1029 | 0.0989 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0275 | 0.0232 |
Onchocerca volvulus | 0.0028 | 0.0415 | 0.3305 | |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0462 | 0.06 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0539 | 0.0701 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | Dopamine receptor | 0.0012 | 0.0112 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.052 | 0.0461 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | Augmenter of liver regeneration | 0.0034 | 0.052 | 0.0479 |
Brugia malayi | GnHR receptor homolog | 0.0012 | 0.0112 | 0.007 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0539 | 0.0497 |
Echinococcus multilocularis | g protein coupled receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0112 | 0.01 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Trypanosoma brucei | Fatty acid elongase | 0.0061 | 0.1029 | 0.1423 |
Echinococcus granulosus | g protein coupled receptor | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | follicle stimulating hormone receptor | 0.0012 | 0.0112 | 0.007 |
Schistosoma mansoni | histamine h1 receptor | 0.0012 | 0.0112 | 0.01 |
Schistosoma mansoni | neuropeptide receptor | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0034 | 0.052 | 0.0477 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0012 | 0.0112 | 0.0133 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0301 | 0.5578 | 1 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0012 | 0.0112 | 0.007 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0539 | 0.0498 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0301 | 0.5578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0539 | 0.0496 |
Schistosoma mansoni | neuropeptide receptor | 0.0012 | 0.0112 | 0.01 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.114 | 0.113 |
Echinococcus granulosus | serotonin receptor | 0.0012 | 0.0112 | 0.0133 |
Trypanosoma brucei | Long chain fatty acyl elongase | 0.0061 | 0.1029 | 0.1423 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0012 | 0.0112 | 0.007 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0112 | 0.01 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0301 | 0.5578 | 1 |
Echinococcus granulosus | g protein coupled receptor | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0012 | 0.0112 | 0.01 |
Brugia malayi | Dopamine receptor protein 2 | 0.0012 | 0.0112 | 0.007 |
Brugia malayi | G-protein coupled receptor | 0.0012 | 0.0112 | 0.007 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0446 | 0.0578 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0112 | 0.01 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | opsin-like receptor | 0.0012 | 0.0112 | 0.01 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1029 | 0.0989 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0462 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0061 | 0.1029 | 1 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0012 | 0.0112 | 0.01 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Leishmania major | fatty acid elongase, putative | 0.0301 | 0.5578 | 1 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | sulfakinin receptor protein | 0.0012 | 0.0112 | 0.007 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.1017 | 0.1006 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Loa Loa (eye worm) | glutaminase | 0.0535 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0044 | 0.0044 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.052 | 0.0461 |
Brugia malayi | GNS1/SUR4 family protein | 0.0061 | 0.1029 | 0.0991 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Brugia malayi | fatty acid elongation protein 3 | 0.0061 | 0.1029 | 0.0991 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0315 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0462 | 0.042 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0539 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0539 | 0.0496 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0539 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0012 | 0.0112 | 0.01 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0539 | 0.0498 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0012 | 0.0112 | 0.01 |
Schistosoma mansoni | hypothetical protein | 0.0404 | 0.7524 | 0.7521 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0012 | 0.0112 | 0.01 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0539 | 0.0539 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0446 | 0.0435 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0446 | 0.0435 |
Echinococcus multilocularis | fmrfamide receptor | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0462 | 0.06 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0275 | 0.0234 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0539 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Brugia malayi | larval opioid receptor | 0.0012 | 0.0112 | 0.007 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0061 | 0.1029 | 0.1019 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0061 | 0.1029 | 0.1355 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.5632 | 0.5627 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | hypothetical protein | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0417 | 0.0377 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0275 | 0.0275 |
Brugia malayi | neuropeptide F receptor | 0.0012 | 0.0112 | 0.007 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0012 | 0.0112 | 0.01 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0275 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0417 | 0.0268 |
Schistosoma mansoni | amine GPCR | 0.0012 | 0.0112 | 0.01 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0275 | 0.0351 |
Plasmodium falciparum | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0061 | 0.1029 | 0.1423 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0315 | 0.0076 |
Loa Loa (eye worm) | glutaminase 2 | 0.0535 | 1 | 1 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.052 | 0.0461 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0012 | 0.0112 | 0.0133 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0539 | 0.0539 |
Brugia malayi | fatty acid elongation protein 3 | 0.0061 | 0.1029 | 0.0991 |
Schistosoma mansoni | neuropeptide receptor | 0.0012 | 0.0112 | 0.01 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0012 | 0.0112 | 0.01 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.1724 | 0.1689 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.052 | 0.0676 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.114 | 0.1102 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0012 | 0.0112 | 0.007 |
Onchocerca volvulus | 0.0035 | 0.0539 | 0.4649 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | fmrfamide receptor | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | GNS1/SUR4 family protein | 0.0301 | 0.5578 | 0.5559 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0539 | 0.0496 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.052 | 0.0461 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.052 | 0.0461 |
Brugia malayi | putative neuropeptide receptor | 0.0012 | 0.0112 | 0.007 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0012 | 0.0112 | 0.0133 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0061 | 0.1029 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Echinococcus multilocularis | somatostatin receptor | 0.0012 | 0.0112 | 0.0133 |
Onchocerca volvulus | 0.0035 | 0.0539 | 0.4649 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0539 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0539 | 0.0497 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0417 | 0.054 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0462 | 0.0422 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0012 | 0.0112 | 0.0068 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.0061 | 0.1029 | 0.1019 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0417 | 0.0268 |
Echinococcus multilocularis | snurportin 1 | 0.0304 | 0.5632 | 0.7482 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0301 | 0.5578 | 0.5558 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0301 | 0.5578 | 0.5558 |
Brugia malayi | neuropeptide F receptor | 0.0012 | 0.0112 | 0.007 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0415 | 0.0372 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0462 | 0.0451 |
Brugia malayi | G protein-coupled receptor | 0.0012 | 0.0112 | 0.007 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0061 | 0.1029 | 0.1019 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0404 | 0.7524 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | ELO-9 protein | 0.0061 | 0.1029 | 0.0989 |
Leishmania major | fatty acid elongase, putative | 0.0301 | 0.5578 | 1 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0012 | 0.0112 | 0.01 |
Echinococcus granulosus | sex peptide receptor | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0462 | 0.042 |
Echinococcus multilocularis | g protein coupled receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0539 | 0.0497 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.052 | 0.0676 |
Brugia malayi | Fatty acid elongation protein 3 | 0.0301 | 0.5578 | 0.5559 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | orexin receptor type 2 | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0539 | 0.0496 |
Trichomonas vaginalis | glutaminase, putative | 0.0535 | 1 | 1 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0012 | 0.0112 | 0.007 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0012 | 0.0112 | 0.0068 |
Schistosoma mansoni | myosin xvIII | 0.0012 | 0.0112 | 0.01 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0012 | 0.0112 | 0.01 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0012 | 0.0112 | 0.01 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0012 | 0.0112 | 0.01 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0301 | 0.5578 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0012 | 0.0112 | 0.007 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0539 | 0.0496 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0539 | 0.0497 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.1724 | 0.1689 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.052 | 0.0461 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0012 | 0.0112 | 0.01 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | biogenic amine receptor | 0.0012 | 0.0112 | 0.01 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0315 | 0.0315 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0539 | 0.0497 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Leishmania major | long chain polyunsaturated fatty acid elongation enzyme-like protein | 0.0061 | 0.1029 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | g protein coupled receptor | 0.0012 | 0.0112 | 0.0133 |
Trypanosoma brucei | elongation of very long chain fatty acids protein, putative | 0.0061 | 0.1029 | 0.1423 |
Brugia malayi | ORL1-like opioid receptor | 0.0012 | 0.0112 | 0.007 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.052 | 0.0461 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0275 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0012 | 0.0112 | 0.0133 |
Trypanosoma brucei | Fatty acid elongase | 0.0301 | 0.5578 | 1 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0012 | 0.0112 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0012 | 0.0112 | 0.01 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.1724 | 0.1687 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0539 | 0.0498 |
Schistosoma mansoni | amine GPCR | 0.0012 | 0.0112 | 0.01 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0446 | 0.0578 |
Onchocerca volvulus | 0.0061 | 0.1029 | 1 | |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | opsin-like receptor | 0.0012 | 0.0112 | 0.01 |
Schistosoma mansoni | ran | 0.0021 | 0.0275 | 0.0264 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0304 | 0.5632 | 0.5613 |
Trypanosoma brucei | Fatty acid elongase | 0.0061 | 0.1029 | 0.1423 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Brugia malayi | Serotonin receptor | 0.0012 | 0.0112 | 0.007 |
Brugia malayi | Melatonin receptor type 1A | 0.0012 | 0.0112 | 0.007 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0012 | 0.0112 | 0.01 |
Echinococcus multilocularis | fmrfamide receptor | 0.0012 | 0.0112 | 0.0133 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0301 | 0.5578 | 1 |
Schistosoma mansoni | biogenic amine receptor | 0.0012 | 0.0112 | 0.01 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0417 | 0.0268 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0539 | 0.0496 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0012 | 0.0112 | 0.01 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0012 | 0.0112 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0061 | 0.1029 | 0.0989 |
Schistosoma mansoni | adenoreceptor | 0.0012 | 0.0112 | 0.01 |
Schistosoma mansoni | ran | 0.0021 | 0.0275 | 0.0264 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0539 | 0.0539 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0301 | 0.5578 | 1 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.052 | 0.0461 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0462 | 0.06 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | serotonin receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0012 | 0.0112 | 0.0133 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.0895 | 0.117 |
Brugia malayi | AKH receptor | 0.0012 | 0.0112 | 0.007 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0415 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | dnaJ subfamily B | 0.0404 | 0.7524 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0301 | 0.5578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0012 | 0.0112 | 0.0133 |
Plasmodium vivax | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0061 | 0.1029 | 0.1423 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0462 | 0.0451 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0061 | 0.1029 | 0.0989 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0112 | 0.007 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0417 | 0.054 |
Schistosoma mansoni | neuropeptide receptor | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0012 | 0.0112 | 0.0068 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0539 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0012 | 0.0112 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.1411 | 0.1375 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0061 | 0.1029 | 0.0989 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0462 | 0.0422 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0012 | 0.0112 | 0.01 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0462 | 0.0451 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0012 | 0.0112 | 0.01 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.0061 | 0.1029 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0539 | 0.0539 |
Echinococcus granulosus | g-protein coupled receptor | 0.0012 | 0.0112 | 0.0133 |
Brugia malayi | Serotonin receptor | 0.0012 | 0.0112 | 0.007 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0462 | 0.0451 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0315 | 0.0315 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0061 | 0.1029 | 0.1019 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0012 | 0.0112 | 0.0133 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0315 | 0.0076 |
Brugia malayi | RE15519p | 0.0012 | 0.0112 | 0.007 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0417 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0012 | 0.0112 | 0.007 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | allatostatin A receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0012 | 0.0112 | 0.0133 |
Onchocerca volvulus | 0.0061 | 0.1029 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0012 | 0.0112 | 0.01 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.4096 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0539 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0012 | 0.0112 | 0.0133 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0012 | 0.0112 | 0.0133 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0539 | 0.0496 |
Leishmania major | fatty acid elongase, putative | 0.0061 | 0.1029 | 0.1423 |
Brugia malayi | fatty acid elongation protein 3 | 0.0061 | 0.1029 | 0.0991 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0061 | 0.1029 | 0.1355 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0012 | 0.0112 | 0.0133 |
Mycobacterium ulcerans | glutaminase | 0.0535 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Echinococcus granulosus | neuropeptide s receptor | 0.0012 | 0.0112 | 0.0133 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0061 | 0.1029 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0112 | 0.0068 |
Brugia malayi | Dopamine receptor protein 1 | 0.0012 | 0.0112 | 0.007 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0012 | 0.0112 | 0.0133 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0012 | 0.0112 | 0.01 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Competitive binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) assessed as inhibition of eIF4E/eIF4G interaction by fluorescence polarization assay relative to parent compound | ChEMBL. | 24675136 | |
Inhibition (binding) | Inhibition of eIF4E/eIF4G interaction in human CRL2813 cells assessed as downregulation of survivin protein expression at 15 to 30 uM after 6 hrs by Western blotting analysis | ChEMBL. | 24675136 | |
Inhibition (binding) | Inhibition of eIF4E/eIF4G interaction in human CRL2813 cells assessed as downregulation of cyclin D1 protein expression at 15 to 30 uM after 6 hrs by Western blotting analysis | ChEMBL. | 24675136 | |
Inhibition (binding) | Inhibition of eIF4E/eIF4G interaction in human CRL2813 cells assessed as downregulation of survivin mRNA expression at 30 uM after 6 hrs by RT-PCR analysis | ChEMBL. | 24675136 | |
Inhibition (binding) | Inhibition of eIF4E/eIF4G interaction in human CRL2813 cells assessed as downregulation of cyclin E mRNA expression at 30 uM after 6 hrs by RT-PCR analysis | ChEMBL. | 24675136 | |
Inhibition (binding) | Inhibition of eIF4E/eIF4G interaction in human CRL2813 cells assessed as downregulation of cyclin E protein expression at 15 to 30 uM after 6 hrs by Western blotting analysis | ChEMBL. | 24675136 | |
Inhibition (binding) | Inhibition of eIF4E/eIF4G interaction in human CRL2813 cells assessed as downregulation of cyclin D1 mRNA expression at 30 uM after 6 hrs by RT-PCR analysis | ChEMBL. | 24675136 | |
Kd (binding) | = 36.6 mM | Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenching method | ChEMBL. | 24675136 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.