Detailed information for compound 917162

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.769 | Formula: C13H12ClN3O5S
  • H donors: 3 H acceptors: 6 LogP: 2.48 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(O)cc(c(c1CCC(=O)Nc1ncns1)Cl)O
  • InChi: 1S/C13H12ClN3O5S/c1-22-12(21)10-6(11(14)8(19)4-7(10)18)2-3-9(20)17-13-15-5-16-23-13/h4-5,18-19H,2-3H2,1H3,(H,15,16,17,20)
  • InChiKey: FOCUSGAUNXAGEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni neuropeptide receptor 0.0732 0.7585 1
Schistosoma mansoni amine GPCR 0.0732 0.7585 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0267 0.0352
Schistosoma mansoni opsin-like receptor 0.0732 0.7585 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0732 0.7585 1
Loa Loa (eye worm) neuropeptide F receptor 0.0732 0.7585 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0732 0.7585 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0732 0.7585 1
Schistosoma mansoni opsin-like receptor 0.0732 0.7585 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0732 0.7585 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0732 0.7585 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0334 0.0415
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0334 0.0417
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0732 0.7585 1
Schistosoma mansoni alpha-glucosidase 0.0154 0.1532 0.202
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.002 0.0027
Echinococcus multilocularis orexin receptor type 2 0.0732 0.7585 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0334 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0732 0.7585 1
Schistosoma mansoni hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni amine GPCR 0.0732 0.7585 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0732 0.7585 1
Echinococcus granulosus S formylglutathione hydrolase 0.0041 0.0346 0.0456
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0732 0.7585 1
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0962 1 1
Echinococcus granulosus somatostatin receptor 0.0732 0.7585 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Brugia malayi neuropeptide F receptor 0.0732 0.7585 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0334 0.044
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.1794 0.2365
Loa Loa (eye worm) neuropeptide F receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0732 0.7585 1
Echinococcus granulosus neuropeptide receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis serotonin receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0732 0.7585 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0073 0.007
Schistosoma mansoni neuropeptide F-like receptor 0.0732 0.7585 1
Schistosoma mansoni neuropeptide F-like receptor 0.0732 0.7585 1
Brugia malayi sulfakinin receptor protein 0.0732 0.7585 1
Brugia malayi RE15519p 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus fmrfamide receptor 0.0732 0.7585 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0732 0.7585 1
Brugia malayi putative neuropeptide receptor 0.0732 0.7585 1
Echinococcus granulosus neuropeptide receptor A26 0.0732 0.7585 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0732 0.7585 1
Brugia malayi putative neuropeptide receptor NPR1 0.0732 0.7585 1
Brugia malayi GnHR receptor homolog 0.0732 0.7585 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0334 1
Schistosoma mansoni amine GPCR 0.0732 0.7585 1
Schistosoma mansoni biogenic amine receptor 0.0732 0.7585 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0732 0.7585 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.1794 0.2346
Onchocerca volvulus 0.0732 0.7585 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1794 0.2365
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1794 0.2365
Schistosoma mansoni hypothetical protein 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Brugia malayi Serotonin receptor 0.0732 0.7585 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni opsin-like receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni cpg binding protein 0.0033 0.0267 0.0352
Brugia malayi Dopamine receptor protein 1 0.0732 0.7585 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0732 0.7585 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Echinococcus granulosus neuropeptides capa receptor 0.0732 0.7585 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0732 0.7585 1
Echinococcus granulosus tm gpcr rhodopsin 0.0732 0.7585 1
Schistosoma mansoni cpg binding protein 0.0033 0.0267 0.0352
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0041 0.0346 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0073 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Echinococcus multilocularis g protein coupled receptor 0.0732 0.7585 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0732 0.7585 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Onchocerca volvulus 0.0032 0.0249 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0732 0.7585 1
Brugia malayi Dopamine receptor 0.0732 0.7585 1
Echinococcus granulosus sex peptide receptor 0.0732 0.7585 1
Schistosoma mansoni neuropeptide receptor 0.0732 0.7585 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0732 0.7585 1
Echinococcus granulosus neuropeptide Y receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus orexin receptor type 2 0.0732 0.7585 1
Schistosoma mansoni alpha-glucosidase 0.0154 0.1532 0.202
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Trypanosoma brucei glucosidase, putative 0.004 0.0334 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0619 0.0816
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0249 0.0302
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0732 0.7585 1
Echinococcus granulosus tm gpcr rhodopsin 0.0732 0.7585 1
Brugia malayi hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0732 0.7585 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0732 0.7585 1
Echinococcus granulosus hypothetical protein 0.0732 0.7585 1
Brugia malayi Serotonin receptor 0.0732 0.7585 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0334 0.9558
Echinococcus multilocularis G protein coupled receptor 139 0.0732 0.7585 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Brugia malayi Melatonin receptor type 1A 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis neuropeptide s receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni adenoreceptor 0.0732 0.7585 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0732 0.7585 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0732 0.7585 1
Echinococcus granulosus serotonin receptor 0.0732 0.7585 1
Brugia malayi hypothetical protein 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Brugia malayi hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni alpha glucosidase 0.004 0.0334 0.044
Echinococcus granulosus dro:myosuppressin receptor 0.0732 0.7585 1
Echinococcus multilocularis g protein coupled receptor 0.0732 0.7585 1
Schistosoma mansoni neuropeptide receptor 0.0732 0.7585 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0732 0.7585 1
Brugia malayi hypothetical protein 0.0732 0.7585 1
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0334 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0732 0.7585 1
Onchocerca volvulus 0.0104 0.1003 0.1238
Brugia malayi ORL1-like opioid receptor 0.0732 0.7585 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Brugia malayi neuropeptide F receptor 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Schistosoma mansoni myosin xvIII 0.0732 0.7585 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0732 0.7585 1
Brugia malayi hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0732 0.7585 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0732 0.7585 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0334 1
Onchocerca volvulus 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis S formylglutathione hydrolase 0.0041 0.0346 0.0456
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0732 0.7585 1
Loa Loa (eye worm) esterase D 0.0041 0.0346 0.0431
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis allatostatin A receptor 0.0732 0.7585 1
Loa Loa (eye worm) TYRA-2 protein 0.0732 0.7585 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0732 0.7585 1
Brugia malayi AKH receptor 0.0732 0.7585 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0334 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0732 0.7585 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus tm gpcr rhodopsin 0.0732 0.7585 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.1794 0.2344
Brugia malayi Tachykinin-like peptides receptor 99D 0.0732 0.7585 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0732 0.7585 1
Brugia malayi hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus neuropeptide receptor 0.0732 0.7585 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0732 0.7585 1
Brugia malayi G protein-coupled receptor 0.0732 0.7585 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus g protein coupled receptor 0.0732 0.7585 1
Brugia malayi larval opioid receptor 0.0732 0.7585 1
Schistosoma mansoni hypothetical protein 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni amine GPCR 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Echinococcus multilocularis fmrfamide receptor 0.0732 0.7585 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Brugia malayi G-protein coupled receptor 0.0732 0.7585 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0732 0.7585 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0732 0.7585 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0544 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0732 0.7585 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0334 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0732 0.7585 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0732 0.7585 1
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0962 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Echinococcus multilocularis neuropeptide receptor A26 0.0732 0.7585 1
Schistosoma mansoni neuropeptide receptor 0.0732 0.7585 1
Echinococcus multilocularis g-protein coupled receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis neuropeptide Y receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus neuropeptide Y receptor 0.0732 0.7585 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0732 0.7585 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0334 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0732 0.7585 1
Schistosoma mansoni histamine h1 receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0732 0.7585 1
Brugia malayi hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus G protein coupled receptor 139 0.0732 0.7585 1
Echinococcus granulosus cpg binding protein 0.0033 0.0267 0.0352
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.002 0.0027
Schistosoma mansoni amine GPCR 0.0732 0.7585 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0732 0.7585 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0334 0.9558
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0732 0.7585 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0732 0.7585 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0732 0.7585 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0732 0.7585 1
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0334 0.044
Echinococcus multilocularis neuropeptide Y receptor 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Echinococcus multilocularis fmrfamide receptor 0.0732 0.7585 1
Brugia malayi hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis serotonin receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Brugia malayi G-protein coupled receptor 0.0732 0.7585 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0732 0.7585 1
Echinococcus granulosus neuropeptides capa receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0249 0.0304
Brugia malayi Esterase D 0.0041 0.0346 0.0433
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Onchocerca volvulus 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis somatostatin receptor 0.0732 0.7585 1
Schistosoma mansoni cpg binding protein 0.0032 0.0249 0.0328
Brugia malayi hypothetical protein 0.0732 0.7585 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus g protein coupled receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0732 0.7585 1
Echinococcus granulosus allatostatin A receptor 0.0732 0.7585 1
Echinococcus granulosus g-protein coupled receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0732 0.7585 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0732 0.7585 1
Brugia malayi Dopamine receptor protein 2 0.0732 0.7585 1
Loa Loa (eye worm) G-protein coupled receptor 0.0732 0.7585 1
Echinococcus multilocularis sex peptide receptor 0.0732 0.7585 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0334 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0732 0.7585 1
Echinococcus granulosus g protein coupled receptor 0.0732 0.7585 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0732 0.7585 1
Schistosoma mansoni biogenic amine receptor 0.0732 0.7585 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Brugia malayi hypothetical protein 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus neuropeptide s receptor 0.0732 0.7585 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0732 0.7585 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0732 0.7585 1
Schistosoma mansoni biogenic amine receptor 0.0732 0.7585 1
Loa Loa (eye worm) G-protein coupled receptor 0.0732 0.7585 1
Echinococcus multilocularis neuropeptide receptor 0.0732 0.7585 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0334 1
Onchocerca volvulus 0.0732 0.7585 1
Echinococcus multilocularis neuropeptides capa receptor 0.0732 0.7585 1
Schistosoma mansoni hypothetical protein 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0732 0.7585 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Echinococcus multilocularis neuropeptide receptor 0.0732 0.7585 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0732 0.7585 1
Brugia malayi follicle stimulating hormone receptor 0.0732 0.7585 1
Echinococcus multilocularis g protein coupled receptor 0.0732 0.7585 1
Loa Loa (eye worm) hypothetical protein 0.0732 0.7585 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0334 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0732 0.7585 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0732 0.7585 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 10.2 % Inhibition of recombinant Grp94 (unknown origin) assessed as tracer bound at 25 uM after 24 hrs by fluorescence polarization assay relative to control ChEMBL. 25027801

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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