Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0193 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 30.6 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS challenge measured after 24 hrs by Griess method | ChEMBL. | 24909081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.