Detailed information for compound 917372

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 267.365 | Formula: C18H21NO
  • H donors: 1 H acceptors: 0 LogP: 3.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1OC(c1ccccc1)CC1CNC1
  • InChi: 1S/C18H21NO/c1-14-7-5-6-10-17(14)20-18(11-15-12-19-13-15)16-8-3-2-4-9-16/h2-10,15,18-19H,11-13H2,1H3
  • InChiKey: UJWNMDBIDDUPKQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0344
Loa Loa (eye worm) dihydrofolate reductase 0.0131 0.1585 0.3468
Loa Loa (eye worm) beta-lactamase 0.004 0.0173 0.0344
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.013 0.5
Echinococcus granulosus dihydrofolate reductase 0.0131 0.1585 0.1585
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0069 0.0031
Schistosoma mansoni kinase 0.0052 0.0364 0.0767
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0507 0.1084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0395 0.0836
Mycobacterium tuberculosis Probable reductase 0.0107 0.1206 0.2567
Loa Loa (eye worm) inositol-1 0.0037 0.013 0.0249
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0579 0.1169
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0045 0.0042
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.115 0.2505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1016 0.2208
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.115 0.2505
Brugia malayi jmjC domain containing protein 0.0038 0.0149 0.0291
Plasmodium falciparum glutathione reductase 0.0047 0.0277 0.0355
Leishmania major trypanothione reductase 0.0047 0.0277 0.034
Loa Loa (eye worm) hypothetical protein 0.0032 0.0045 0.0061
Loa Loa (eye worm) RNA binding protein 0.0062 0.0507 0.1084
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0213 0.0213
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0173 0.0156
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0045 0.0042
Plasmodium vivax glutathione reductase, putative 0.0047 0.0277 0.0396
Echinococcus multilocularis protein patched 0.0043 0.0213 0.0197
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0045 0.0042
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.115 0.115
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.013 0.013
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0173 0.0344
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3245 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0452 0.6571 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0173 0.0263
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.139 0.2979
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0173 0.0344
Mycobacterium ulcerans thymidylate synthase 0.0321 0.4538 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.115 0.3432
Schistosoma mansoni hypothetical protein 0.0041 0.0189 0.038
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0055 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0507 0.1084
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.115 0.3432
Echinococcus granulosus thymidylate synthase 0.0321 0.4538 0.4538
Brugia malayi beta-lactamase family protein 0.004 0.0173 0.0344
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0131 0.1585 0.3413
Schistosoma mansoni hypothetical protein 0.0037 0.0128 0.0246
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.1167 0.1167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1016 0.1004
Echinococcus granulosus pyruvate kinase 0.0032 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0213 0.0495
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0055 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0507 0.1084
Schistosoma mansoni hypothetical protein 0.0166 0.2135 0.4686
Toxoplasma gondii ABC1 family protein 0.004 0.0173 0.0237
Brugia malayi Dihydrofolate reductase 0.0131 0.1585 0.3468
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0173 0.0369
Onchocerca volvulus 0.004 0.0173 0.0344
Echinococcus granulosus pyruvate kinase 0.0032 0.0055 0.0055
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0173 0.0181
Schistosoma mansoni hypothetical protein 0.0032 0.0045 0.0061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1016 0.2208
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0055 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0507 0.1084
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0579 0.0804
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.013 0.0113
Plasmodium falciparum thioredoxin reductase 0.0047 0.0277 0.0355
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.013 0.0115
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0579 0.1243
Loa Loa (eye worm) hypothetical protein 0.0052 0.0361 0.0762
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.115 0.3432
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0173 0.0369
Brugia malayi jmjC domain containing protein 0.0104 0.1167 0.2544
Loa Loa (eye worm) hypothetical protein 0.0099 0.1092 0.2378
Echinococcus multilocularis protein dispatched 1 0.0049 0.0306 0.0291
Echinococcus multilocularis thymidylate synthase 0.0321 0.4538 0.4545
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.139 0.2979
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.013 0.0172
Plasmodium falciparum pyruvate kinase 0.0032 0.0055 0.0015
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.115 0.2505
Loa Loa (eye worm) hypothetical protein 0.0037 0.0128 0.0246
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.139 0.2979
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0579 0.1169
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1092 0.1081
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0238 0.0222
Onchocerca volvulus 0.004 0.0173 0.0344
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0173 0.0263
Trichomonas vaginalis esterase, putative 0.004 0.0173 0.0369
Schistosoma mansoni patched 1 0.0043 0.0213 0.0433
Schistosoma mansoni hypothetical protein 0.0041 0.0189 0.038
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0579 0.0565
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0321 0.4538 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.013 0.0249
Schistosoma mansoni hypothetical protein 0.0041 0.0189 0.038
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0055 0.0058
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.013 0.0167
Schistosoma mansoni hypothetical protein 0.0166 0.2135 0.4686
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0069 0.0031
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.115 0.168
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0131 0.1585 0.3413
Onchocerca volvulus 0.0321 0.4538 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0173 0.0344
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0277 0.034
Brugia malayi RNA binding protein 0.0062 0.0507 0.1084
Echinococcus multilocularis geminin 0.0166 0.2135 0.213
Loa Loa (eye worm) hypothetical protein 0.0054 0.0395 0.0836
Echinococcus multilocularis expressed conserved protein 0.0093 0.0999 0.0987
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0149 0.0132
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.115 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.013 0.0115
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0452 0.6571 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1092 0.2378
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.3519 0.7728
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0045 0.0045
Mycobacterium leprae Probable lipase LipE 0.004 0.0173 0.0263
Mycobacterium tuberculosis Conserved protein 0.004 0.0173 0.0263
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0238 0.0238
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1206 0.2567
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.115 0.168
Brugia malayi PHD-finger family protein 0.0032 0.0045 0.0061
Schistosoma mansoni inositol monophosphatase 0.0037 0.013 0.0249
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0173 0.0263
Brugia malayi Pre-SET motif family protein 0.0209 0.2797 0.6148
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1753 0.1753
Brugia malayi Thioredoxin reductase 0.0047 0.0277 0.0574
Loa Loa (eye worm) hypothetical protein 0.0054 0.0397 0.0841
Echinococcus granulosus tar DNA binding protein 0.0062 0.0507 0.0507
Onchocerca volvulus Alhambra homolog 0.0032 0.0045 0.0061
Onchocerca volvulus 0.0238 0.3245 0.714
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0055 0.0084
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0507 0.1084
Echinococcus multilocularis pyruvate kinase 0.0032 0.0055 0.0038
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0173 0.0263
Echinococcus multilocularis conserved hypothetical protein 0.0671 0.9964 1
Schistosoma mansoni pyruvate kinase 0.0032 0.0055 0.0084
Brugia malayi glutathione reductase 0.0047 0.0277 0.0574
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0277 0.0261
Brugia malayi TAR-binding protein 0.0062 0.0507 0.1084
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0173 0.0369
Chlamydia trachomatis dihydrofolate reductase 0.0131 0.1585 1
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0173 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0507 0.1084
Onchocerca volvulus 0.004 0.0173 0.0344
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0045 0.0028
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0153 0.1924 0.2868
Mycobacterium tuberculosis Conserved protein 0.004 0.0173 0.0263
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.013 0.0234
Schistosoma mansoni pyruvate kinase 0.0032 0.0055 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.115 0.3432
Trypanosoma brucei polo-like protein kinase 0.0103 0.115 0.168
Trypanosoma brucei trypanothione reductase 0.0047 0.0277 0.034
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0173 0.0344
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0045 0.0061
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0507 0.0493
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0277 0.0277
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0395 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.1924 0.5859
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1016 0.1016
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.115 0.3432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1016 0.1004
Toxoplasma gondii thioredoxin reductase 0.0047 0.0277 0.0396
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1092 0.1092
Brugia malayi Inositol-1 0.0037 0.013 0.0249
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0507 0.1084
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0055 0.0058
Schistosoma mansoni dihydrofolate reductase 0.0131 0.1585 0.3468
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0343 0.0902
Echinococcus multilocularis dihydrofolate reductase 0.0131 0.1585 0.1576
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0452 0.6571 1
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0277 0.0396
Brugia malayi beta-lactamase 0.004 0.0173 0.0344
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0344
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.115 0.168
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0173 0.0263
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.057 0.1223
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0173 0.0181
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0173 0.0181
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0344
Mycobacterium leprae conserved hypothetical protein 0.004 0.0173 0.0263
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1206 0.2567
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0173 0.0263
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0452 0.6571 1
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.115 0.3432
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.013 0.0234
Brugia malayi beta-lactamase family protein 0.004 0.0173 0.0344
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0277 0.0495
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0173 0.0369
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0321 0.4538 1
Mycobacterium tuberculosis Hypothetical protein 0.0153 0.1924 0.4169
Loa Loa (eye worm) thymidylate synthase 0.0321 0.4538 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0344
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0173 0.0263
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1116 0.243
Echinococcus granulosus geminin 0.0166 0.2135 0.2135
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0344
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0128 0.0246
Leishmania major hypothetical protein, conserved 0.004 0.0173 0.0181
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0213 0.0433
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0055 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0579 0.1169
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0835 0.1809
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0507 0.1084
Mycobacterium ulcerans beta-lactamase 0.004 0.0173 0.0263
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.115 0.3432
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0055 0.0084
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0344
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1092 0.9435
Brugia malayi CHE-14 protein 0.0043 0.0213 0.0433
Mycobacterium ulcerans hypothetical protein 0.004 0.0173 0.0263
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0173 0.0263
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1016 0.1016
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0579 0.0857
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0213 0.0213
Brugia malayi dihydrofolate reductase family protein 0.0131 0.1585 0.3468
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.013 0.0234
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0579 0.1169
Loa Loa (eye worm) glutathione reductase 0.0047 0.0277 0.0574
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0131 0.1585 0.3413
Giardia lamblia Pyruvate kinase 0.0032 0.0055 0.0091
Brugia malayi Bromodomain containing protein 0.0032 0.0045 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1016 0.2208
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.013 0.0115
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0452 0.6571 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.139 0.2979
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.115 0.1139
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0579 0.0579
Echinococcus multilocularis peregrin 0.0032 0.0045 0.0028
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0045 0.0061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1016 0.2208
Echinococcus multilocularis pyruvate kinase 0.0032 0.0055 0.0038
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1206 0.2567
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0343 0.0902
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1753 0.1745
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0149 0.0291
Echinococcus granulosus peregrin 0.0032 0.0045 0.0045
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1206 0.2567
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0395 0.0836
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.013 0.0115
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1206 0.2567
Brugia malayi hypothetical protein 0.0153 0.1924 0.4218
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0173 0.0263
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.115 0.2505
Brugia malayi thymidylate synthase 0.0321 0.4538 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0173 0.0369
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0149 0.0291
Giardia lamblia Kinase, PLK 0.0103 0.115 1
Schistosoma mansoni hypothetical protein 0.0041 0.0189 0.038
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0055 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1016 0.2208
Plasmodium vivax hypothetical protein, conserved 0.004 0.0173 0.0237
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1206 0.2567
Loa Loa (eye worm) hypothetical protein 0.0043 0.0213 0.0433
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0149 0.0291
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2797 0.6148
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0452 0.6571 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.1167 0.1156
Echinococcus granulosus expressed conserved protein 0.0093 0.0999 0.0999
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0149 0.0149
Mycobacterium ulcerans lipase LipD 0.004 0.0173 0.0263
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0277 0.0574
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0579 0.1243
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0321 0.4538 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0173 0.0263
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0055 0.0084
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0213 0.0197

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 3 % Inhibition of DA reuptake at human DAT expressed in HEK293 cells at 0.1 uM after 15 mins by fluorescence neurotransmitter transporter assay ChEMBL. 24974340
Inhibition (binding) = 83 % Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells at 0.1 uM after 15 mins by fluorescence neurotransmitter transporter assay ChEMBL. 24974340
Inhibition (binding) = 100 % Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells at 0.1 uM after 15 mins by fluorescence neurotransmitter transporter assay ChEMBL. 24974340

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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