TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.529 | Formula: C22H33N5O3
H donors: 1 H acceptors: 3 LogP: 1.75 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)N1CCC(CC1)CN1CCC2(CC1)CN(c1c2cccn1)C(=O)NC
InChi: 1S/C22H33N5O3/c1-3-30-21(29)26-11-6-17(7-12-26)15-25-13-8-22(9-14-25)16-27(20(28)23-2)19-18(22)5-4-10-24-19/h4-5,10,17H,3,6-9,11-16H2,1-2H3,(H,23,28)
InChiKey: ZIXYMMYKROQVQH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	ubiquitin-activating enzyme E1, putative	0.0067	0.0361	0.0471
Schistosoma mansoni	opsin-like receptor	0.0434	0.2671	0.348
Entamoeba histolytica	ubiquitin-activating enzyme, putative	0.0067	0.0364	0.0341
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0434	0.2671	0.348
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0165	0.098	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Schistosoma mansoni	amine GPCR	0.0434	0.2671	0.348
Echinococcus granulosus	neuropeptide receptor A26	0.0434	0.2671	0.2671
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0479	0.2955	0.2955
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0479	0.2955	0.2953
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Brugia malayi	G-protein coupled receptor	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.0005
Trypanosoma brucei	nucleoside transporter 1, putative	0.0277	0.1688	0.2193
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0156	0.0152
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0022	0.0022
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0056	0.0056
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0434	0.2671	0.348
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0056	0.0056
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0434	0.2671	0.348
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0124	0.0155
Brugia malayi	hypothetical protein	0.0019	0.0059	0.0059
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0034	0.0156	0.0196
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0089	0.0502	0.0502
Entamoeba histolytica	phosphofructokinase, putative	0.0126	0.0736	0.0714
Onchocerca volvulus		0.0278	0.1692	0.1689
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0075	0.0415	0.0415
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0434	0.2671	0.348
Trypanosoma brucei	ribokinase, putative	0.014	0.0822	0.1064
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.0479	0.2955	0.3847
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0479	0.2955	0.2938
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.001	0.0006	0.0006
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0304	0.0304
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0024	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0314	0.1916	0.1916
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0479	0.2955	0.3851
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0205	0.0205
Schistosoma mansoni	ubiquitin-activating enzyme E1	0.0101	0.0577	0.0752
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0434	0.2671	0.2671
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0019	0.0058	0.0054
Trypanosoma brucei	adenosine transporter 2, putative	0.0277	0.1688	0.2193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0434	0.2671	0.348
Schistosoma mansoni	opsin-like receptor	0.0434	0.2671	0.348
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0434	0.2671	0.2671
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0277	0.1688	0.1685
Trypanosoma brucei	ribokinase, putative	0.014	0.0822	0.1064
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Loa Loa (eye worm)	RecQ helicase	0.0025	0.0097	0.0097
Schistosoma mansoni	adenoreceptor	0.0434	0.2671	0.348
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.033	0.2021	0.2021
Echinococcus multilocularis	fmrfamide receptor	0.0434	0.2671	0.2671
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0056	0.0064
Schistosoma mansoni	adenosine kinase	0.1228	0.7674	1
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.001	0.0006	0.0006
Mycobacterium leprae	Probable adenosine kinase adk	0.014	0.0822	0.821
Leishmania major	ubiquitin activating enzyme, putative	0.0026	0.0104	0.0127
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Toxoplasma gondii	ThiF family protein	0.0019	0.0058	0.0069
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0434	0.2671	0.2671
Echinococcus multilocularis	serotonin receptor	0.0434	0.2671	0.2671
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.001	0.0006	0.0006
Trypanosoma cruzi	NEDD8-activating enzyme E1 regulatory subunit, putative	0.0042	0.0205	0.0267
Trypanosoma brucei	adenosine transporter 2, putative	0.0277	0.1688	0.2193
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0304	0.0304
Entamoeba histolytica	ubiquitin-activating enzyme, putative	0.0126	0.0732	0.071
Leishmania major	inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040	0.0277	0.1688	0.2193
Onchocerca volvulus		0.0434	0.2671	0.2668
Schistosoma mansoni	hypothetical protein	0.0042	0.0203	0.0264
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.0479	0.2955	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0153	0.0903	0.0903
Onchocerca volvulus		0.1088	0.6793	0.6791
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.001	0.0006	0.0008
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.1598	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0434	0.2671	0.348
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0434	0.2671	0.348
Leishmania major	adenosine kinase, putative	0.1228	0.7674	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0434	0.2671	0.2671
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus multilocularis	g-protein coupled receptor	0.0434	0.2671	0.2671
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0124	0.0403
Toxoplasma gondii	endonuclease IV APN	0.0089	0.0502	0.0647
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0479	0.2955	0.2955
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Trypanosoma cruzi	nucleobase transporter, putative	0.0277	0.1688	0.2199
Echinococcus granulosus	neuropeptide Y receptor	0.0434	0.2671	0.2671
Echinococcus granulosus	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Brugia malayi	Melatonin receptor type 1A	0.0434	0.2671	0.2671
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0018	0.0056	0.0171
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Echinococcus granulosus	neuropeptide receptor	0.0434	0.2671	0.2671
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0078	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0277	0.1688	0.1688
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0434	0.2671	0.348
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0479	0.2955	0.3851
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0314	0.1916	0.1916
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.0479	0.2955	0.3846
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0126	0.0736	0.7249
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0277	0.1688	0.1685
Echinococcus granulosus	dro:myosuppressin receptor	0.0434	0.2671	0.2671
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Echinococcus multilocularis	neuropeptide Y receptor	0.0434	0.2671	0.2671
Trichomonas vaginalis	ribokinase, putative	0.014	0.0822	0.0819
Schistosoma mansoni	opsin-like receptor	0.0434	0.2671	0.348
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0434	0.2671	0.348
Brugia malayi	putative neuropeptide receptor	0.0434	0.2671	0.2671
Trichomonas vaginalis	molybdopterin biosynthesis moeb protein, putative	0.0026	0.0104	0.01
Echinococcus multilocularis	ubiquitin modifier activating enzyme 1	0.0126	0.0732	0.0732
Leishmania major	ATP-dependent phosphofructokinase	0.0126	0.0736	0.0952
Echinococcus multilocularis	neuropeptide receptor A26	0.0434	0.2671	0.2671
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0056	0.0056
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.001	0.0006	0.0008
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Leishmania major	hypothetical protein, conserved	0.0029	0.0124	0.0154
Entamoeba histolytica	ubiquitin-activating enzyme E1 1, putative	0.0097	0.0552	0.053
Echinococcus granulosus	fmrfamide receptor	0.0434	0.2671	0.2671
Trypanosoma cruzi	adenosine kinase, putative	0.1228	0.7674	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0434	0.2671	0.2671
Plasmodium falciparum	ubiquitin-activating enzyme	0.0019	0.0058	0.0178
Trichomonas vaginalis	phosphofructokinase, putative	0.0126	0.0736	0.0733
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Mycobacterium ulcerans	epimerase	0.0023	0.0088	0.0287
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Brugia malayi	Ectopic membrane ruffles in embryo protein 1	0.0067	0.0364	0.0364
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0046	0.0046
Chlamydia trachomatis	endonuclease IV	0.0089	0.0502	0.1236
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0006	0.0008
Trypanosoma brucei	purine nucleoside transporter	0.0277	0.1688	0.2193
Trypanosoma cruzi	ribokinase, putative	0.014	0.0822	0.1071
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.001	0.0006	0.0006
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0434	0.2671	0.2671
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0314	0.1916	0.1916
Schistosoma mansoni	amine GPCR	0.0434	0.2671	0.348
Onchocerca volvulus		0.0434	0.2671	0.2668
Echinococcus granulosus	sex peptide receptor	0.0434	0.2671	0.2671
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0006	0.0008
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0148	0.0875	0.114
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0434	0.2671	0.348
Onchocerca volvulus		0.0434	0.2671	0.2668
Schistosoma mansoni	app binding protein	0.0042	0.0205	0.0267
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0056	0.0056
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0056	0.0056
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0156	0.0152
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.001	0.0006	0.0008
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0126	0.0736	0.2073
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0124	0.0403
Entamoeba histolytica	hypothetical protein	0.0042	0.0203	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0086	0.048	0.048
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0056	0.0056
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.001	0.0006	0.0004
Echinococcus multilocularis	dro:myosuppressin receptor	0.0434	0.2671	0.2671
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0005	0.000000000038276
Brugia malayi	Adenosine kinase-like	0.1228	0.7674	0.7674
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0042	0.0205	0.0201
Echinococcus granulosus	equilibrative nucleoside transporter	0.1598	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0434	0.2671	0.2671
Leishmania major	ubiquitin-activating enzyme e1, putative	0.0067	0.0361	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0479	0.2955	0.3851
Trichomonas vaginalis	ubiquitin-activating enzyme E1 X, putative	0.0043	0.0213	0.0209
Trichomonas vaginalis	phosphofructokinase, putative	0.0126	0.0736	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Schistosoma mansoni	amine GPCR	0.0434	0.2671	0.348
Loa Loa (eye worm)	G-protein coupled receptor	0.0434	0.2671	0.2671
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.001	0.0006	0.0006
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0313	0.1914	0.2494
Brugia malayi	sulfakinin receptor protein	0.0434	0.2671	0.2671
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0086	0.048	0.048
Trypanosoma cruzi	ubiquitin-activating enzyme E1, putative	0.0038	0.0178	0.0232
Trypanosoma brucei	adenosine transporter 2, putative	0.0277	0.1688	0.2193
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0056	0.0056
Echinococcus granulosus	orexin receptor type 2	0.0434	0.2671	0.2671
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.001	0.0006	0.0008
Trypanosoma brucei	adenosine transporter 2	0.0277	0.1688	0.2193
Brugia malayi	Dopamine receptor protein 1	0.0434	0.2671	0.2671
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0006	0.0003
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.0089	0.0502	0.4625
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0479	0.2955	0.3851
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Echinococcus granulosus	7TM GPCR rhodopsin	0.0434	0.2671	0.2671
Schistosoma mansoni	DNA helicase recq1	0.001	0.0005	0.0007
Entamoeba histolytica	fructokinase, putative	0.014	0.0822	0.08
Trypanosoma brucei	unspecified product	0.0277	0.1688	0.2193
Leishmania major	adenosine kinase-like protein	0.014	0.0822	0.1064
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0434	0.2671	0.348
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.0045	0.0052
Toxoplasma gondii	6-phosphofructokinase	0.0034	0.0156	0.0196
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0051	0.0259	0.0255
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0479	0.2955	0.2955
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0434	0.2671	0.348
Brugia malayi	RE15519p	0.0434	0.2671	0.2671
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0203	0.0203
Echinococcus granulosus	bloom syndrome protein	0.0025	0.0097	0.0097
Echinococcus multilocularis	geminin	0.0393	0.2414	0.2414
Echinococcus multilocularis	g protein coupled receptor	0.0434	0.2671	0.2671
Toxoplasma gondii	NEDD8-activating enzyme E1 catalytic subunit	0.0067	0.0364	0.0468
Onchocerca volvulus	Putative hydroxypyruvate isomerase	0.0023	0.0088	0.0085
Onchocerca volvulus		0.014	0.0822	0.0819
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.001	0.0006	0.0006
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0005	0.0005
Loa Loa (eye worm)	ectopic membrane ruffles in embryo protein 1	0.0067	0.0364	0.0364
Schistosoma mansoni	amine GPCR	0.0434	0.2671	0.348
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0479	0.2955	0.2955
Brugia malayi	Uncoordinated protein 44	0.0017	0.0046	0.0046
Brugia malayi	AKH receptor	0.0434	0.2671	0.2671
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.1598	1	1
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0313	0.1914	0.1911
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0434	0.2671	0.2671
Echinococcus multilocularis	orexin receptor type 2	0.0434	0.2671	0.2671
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0434	0.2671	0.2671
Schistosoma mansoni	neuropeptide f receptor 76f	0.0434	0.2671	0.348
Leishmania major	putative PfkB family sugar kinase	0.014	0.0822	0.1064
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0479	0.2955	0.2953
Loa Loa (eye worm)	neuropeptide F receptor	0.0434	0.2671	0.2671
Mycobacterium leprae	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0165	0.0982	1
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0019	0.0058	0.0054
Echinococcus granulosus	Ankyrin	0.0017	0.0047	0.0047
Entamoeba histolytica	tagatose-6-phosphate kinase, putative	0.014	0.0822	0.08
Onchocerca volvulus	Netrin receptor homolog	0.0017	0.0046	0.0042
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0434	0.2671	0.2671
Brugia malayi	Serotonin receptor	0.0434	0.2671	0.2671
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.001	0.0006	0.0008
Echinococcus multilocularis	bloom syndrome protein	0.0025	0.0097	0.0097
Schistosoma mansoni	neuropeptide receptor	0.0434	0.2671	0.348
Leishmania major	hypothetical protein, conserved	0.0042	0.0205	0.0259
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.001	0.0006	0.0006
Brugia malayi	G protein-coupled receptor F59B2.13	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0056	0.0056
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0056	0.0073
Echinococcus granulosus	ubiquitin modifier activating enzyme 6	0.0126	0.0732	0.0732
Loa Loa (eye worm)	phosphofructokinase	0.0126	0.0736	0.0736
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.014	0.0822	0.0822
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0203	0.0199
Schistosoma mansoni	biogenic amine receptor	0.0434	0.2671	0.348
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0086	0.048	0.048
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0479	0.2955	0.3851
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Leishmania major	ubiquitin-activating enzyme e1, putative	0.0047	0.0238	0.0301
Brugia malayi	GnHR receptor homolog	0.0434	0.2671	0.2671
Schistosoma mansoni	ubiquitin-activating enzyme E1C	0.0067	0.0364	0.0474
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0056	0.0056
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0156	0.0506
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0434	0.2671	0.348
Echinococcus granulosus	neuropeptide s receptor	0.0434	0.2671	0.2671
Trypanosoma cruzi	adenosine kinase, putative	0.014	0.0822	0.1071
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0434	0.2671	0.348
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0156	0.0152
Onchocerca volvulus		0.0434	0.2671	0.2668
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0006	0.0008
Plasmodium falciparum	phosphodiesterase delta, putative	0.001	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0047	0.0047
Entamoeba histolytica	phosphofructokinase, putative	0.0126	0.0736	0.0714
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0005	0.0005
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0434	0.2671	0.2671
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.001	0.0006	0.0006
Leishmania major	nucleoside transporter 1, putative	0.0277	0.1688	0.2193
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0247	0.0322
Schistosoma mansoni	6-phosphofructokinase	0.0126	0.0736	0.0959
Schistosoma mansoni	netrin receptor unc5	0.0017	0.0046	0.006
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0148	0.0875	0.114
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0017	0.0046	0.0046
Brugia malayi	Bloom's syndrome protein homolog	0.0025	0.0097	0.0097
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0277	0.1688	0.1685
Onchocerca volvulus		0.0434	0.2671	0.2668
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0097	0.0552	0.0549
Loa Loa (eye worm)	hypothetical protein	0.002	0.0065	0.0065
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0277	0.1688	0.2193
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0314	0.1916	0.1916
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0479	0.2955	0.2955
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0165	0.098	0.098
Plasmodium falciparum	phosphodiesterase gamma, putative	0.001	0.0006	0.0004
Plasmodium falciparum	ubiquitin-activating enzyme E1	0.0126	0.0732	0.2464
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Echinococcus multilocularis	neuropeptide receptor	0.0434	0.2671	0.2671
Loa Loa (eye worm)	ube1-prov protein	0.0126	0.0732	0.0732
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Echinococcus multilocularis	neuropeptides capa receptor	0.0434	0.2671	0.2671
Echinococcus multilocularis	somatostatin receptor	0.0434	0.2671	0.2671
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0022	0.0022
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0018	0.0056	0.0167
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.001	0.0006	0.0003
Echinococcus granulosus	neuropeptide Y receptor	0.0434	0.2671	0.2671
Echinococcus multilocularis	neuropeptide s receptor	0.0434	0.2671	0.2671
Echinococcus granulosus	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0434	0.2671	0.2671
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Leishmania major	nucleobase transporter	0.0277	0.1688	0.2193
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0005	0.0005
Entamoeba histolytica	nucleoside transporter, putative	0.1598	1	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.001	0.0006	0.0006
Schistosoma mansoni	neuropeptide receptor	0.0434	0.2671	0.348
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0124	0.0154
Mycobacterium tuberculosis	Ribokinase RbsK	0.014	0.0822	0.3193
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma cruzi	ubiquitin-activating enzyme E1, putative	0.0067	0.0361	0.0471
Schistosoma mansoni	protein kinase	0.0277	0.1688	0.2199
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0221	0.0221
Entamoeba histolytica	Hypothetical protein T24C12.3, putative	0.014	0.0822	0.08
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0479	0.2955	0.3851
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0124	0.0162
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0056	0.0056
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0022	0.0022
Schistosoma mansoni	neuropeptide F-like receptor	0.0434	0.2671	0.348
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Trypanosoma brucei	adenosine transporter 2	0.0277	0.1688	0.2193
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0434	0.2671	0.2671
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0434	0.2671	0.2671
Schistosoma mansoni	hypothetical protein	0.0434	0.2671	0.348
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0067	0.0361	0.0463
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.033	0.2021	0.2021
Schistosoma mansoni	hypothetical protein	0.0018	0.0056	0.0072
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0434	0.2671	0.348
Echinococcus granulosus	neuropeptide receptor	0.0434	0.2671	0.2671
Leishmania major	nucleobase transporter	0.0277	0.1688	0.2193
Trypanosoma brucei	NEDD8 activating enzyme subunit, putative	0.0026	0.0104	0.0127
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0124	0.0162
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Leishmania major	glyceraldehyde-3-phosphate dehydrogenase-like protein	0.0313	0.1914	0.2488
Echinococcus granulosus	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0479	0.2955	0.3846
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.0479	0.2955	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0056	0.0073
Echinococcus granulosus	neuropeptides capa receptor	0.0434	0.2671	0.2671
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Entamoeba histolytica	hypothetical protein	0.0042	0.0203	0.0179
Schistosoma mansoni	hypothetical protein	0.0039	0.0189	0.0246
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma brucei	adenosine kinase, putative	0.1228	0.7674	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.001	0.0006	0.0008
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0075	0.0415	0.0415
Schistosoma mansoni	clathrin coat associated protein ap-50	0.0078	0.0429	0.0559
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0434	0.2671	0.348
Echinococcus granulosus	neuropeptide FF receptor 2	0.0434	0.2671	0.2671
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.001	0.0006	0.0006
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Trypanosoma cruzi	hypothetical protein	0.0263	0.1596	0.208
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.004	0.019	0.0186
Loa Loa (eye worm)	hypothetical protein	0.1598	1	1
Trypanosoma brucei	purine nucleoside transporter	0.0277	0.1688	0.2193
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0042	0.0205	0.0201
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0006	0.0008
Entamoeba histolytica	ribokinase, putative	0.014	0.0822	0.08
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Onchocerca volvulus		0.0434	0.2671	0.2668
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0086	0.048	0.048
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0434	0.2671	0.348
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Brugia malayi	putative neuropeptide receptor NPR1	0.0434	0.2671	0.2671
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0006	0.0008
Giardia lamblia	Hypothetical protein	0.1598	1	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0046	0.006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Giardia lamblia	Ubiquitin-conjugating enzyme E1	0.0067	0.0361	0.0358
Echinococcus granulosus	serotonin receptor	0.0434	0.2671	0.2671
Schistosoma mansoni	equilibrative nucleoside transporter	0.0277	0.1688	0.2199
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.0434	0.2671	0.2671
Leishmania major	nucleoside transporter 1, putative	0.0277	0.1688	0.2193
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0479	0.2955	0.2953
Echinococcus multilocularis	netrin receptor unc 5	0.0017	0.0046	0.0046
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0017	0.0046	0.0046
Schistosoma mansoni	hypothetical protein	0.0393	0.2414	0.3146
Mycobacterium tuberculosis	Adenosine kinase	0.014	0.0822	0.3193
Trichomonas vaginalis	DNA helicase recq1, putative	0.0025	0.0097	0.0093
Trypanosoma cruzi	nucleoside transporter 1, putative	0.0277	0.1688	0.2199
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0277	0.1688	0.2193
Schistosoma mansoni	hypothetical protein	0.0393	0.2414	0.3146
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma brucei	adenosine transporter 2, putative	0.0277	0.1688	0.2193
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0434	0.2671	0.2668
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0434	0.2671	0.2671
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0126	0.0736	0.0952
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0304	0.0304
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.1598	1	1
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0479	0.2955	0.2953
Brugia malayi	ORL1-like opioid receptor	0.0434	0.2671	0.2671
Brugia malayi	larval opioid receptor	0.0434	0.2671	0.2671
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0434	0.2671	0.2671
Loa Loa (eye worm)	neuropeptide F receptor	0.0434	0.2671	0.2671
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0041	0.0198	0.0258
Trichomonas vaginalis	ribokinase, putative	0.014	0.0822	0.0819
Echinococcus granulosus	g protein coupled receptor	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Brugia malayi	Serotonin receptor	0.0434	0.2671	0.2671
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0023	0.0023
Plasmodium falciparum	NEDD8-activating enzyme E1 catalytic subunit, putative	0.0026	0.0104	0.0334
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0417	0.2567	1
Brugia malayi	Hypothetical 29.7 kDa protein C05D11.5 in chromosome III	0.0023	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.1598	1	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0156	0.051
Schistosoma mansoni	histamine h1 receptor	0.0434	0.2671	0.348
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0434	0.2671	0.348
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0089	0.0502	0.1943
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Entamoeba histolytica	kinase, PfkB family	0.014	0.0822	0.08
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0088	0.0287
Entamoeba histolytica	ubiquitin-activating enzyme, putative	0.0019	0.0058	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.0056	0.0064
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.001	0.0006	0.0006
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0004
Echinococcus granulosus	pseudouridine metabolizing bifunctional protein	0.014	0.0822	0.0822
Echinococcus multilocularis	g protein coupled receptor	0.0434	0.2671	0.2671
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0022	0.0022
Echinococcus multilocularis	equilibrative nucleoside transporter protein	0.1598	1	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0479	0.2955	0.3851
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0434	0.2671	0.348
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0221	0.0221
Echinococcus granulosus	GPCR family 2	0.0018	0.0056	0.0056
Toxoplasma gondii	kinase, pfkB family protein	0.014	0.0822	0.1065
Echinococcus multilocularis	g protein coupled receptor	0.0434	0.2671	0.2671
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Schistosoma mansoni	hypothetical protein	0.0434	0.2671	0.348
Brugia malayi	Death domain containing protein	0.0017	0.0046	0.0046
Loa Loa (eye worm)	transcription factor SMAD2	0.0138	0.081	0.081
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0097	0.0552	0.0549
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0034	0.0156	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus granulosus	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.0479	0.2955	0.5
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0156	0.0152
Onchocerca volvulus		0.0434	0.2671	0.2668
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.001	0.0006	0.0006
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.0064	0.0084
Giardia lamblia	hypothetical protein	0.001	0.0006	0.0003
Schistosoma mansoni	growth hormone secretagogue receptor	0.0434	0.2671	0.348
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0013	0.0025	0.0026
Schistosoma mansoni	clathrin coat associated protein ap-50	0.0078	0.0429	0.0559
Brugia malayi	hypothetical protein	0.0141	0.0831	0.0831
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Mycobacterium ulcerans	fructokinase, PfkB	0.014	0.0822	0.2773
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0434	0.2671	0.2671
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.001	0.0006	0.0006
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0479	0.2955	0.2953
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Loa Loa (eye worm)	STAT protein	0.0153	0.0903	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0124	0.0124
Echinococcus multilocularis	serotonin receptor	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0434	0.2671	0.348
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0434	0.2671	0.2671
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0017	0.0046	0.0135
Echinococcus granulosus	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma cruzi	nucleoside transporter-like, putative	0.0277	0.1688	0.2199
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Entamoeba histolytica	hypothetical protein	0.0042	0.0203	0.0179
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.005	0.0256	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0086	0.048	0.048
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.001	0.0006	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma cruzi	nucleoside transporter 1, putative	0.0277	0.1688	0.2199
Brugia malayi	hypothetical protein	0.001	0.0004	0.0004
Trypanosoma cruzi	nucleoside transporter 1, putative	0.0277	0.1688	0.2199
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0023	0.0023
Trichomonas vaginalis	ubiquitin-activating enzyme E1c, putative	0.0097	0.0552	0.0549
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0056	0.0056
Trypanosoma brucei	NEDD8-activating enzyme E1 regulatory subunit, putative	0.0042	0.0205	0.0259
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0434	0.2671	0.2671
Trypanosoma cruzi	nucleobase transporter, putative	0.0277	0.1688	0.2199
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0263	0.1596	0.1593
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.001	0.0006	0.0008
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0124	0.0399
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0086	0.048	0.048
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0314	0.1916	0.1913
Echinococcus granulosus	adenosine kinase	0.1228	0.7674	0.7674
Toxoplasma gondii	ThiF family protein	0.0042	0.0205	0.026
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0203	0.0199
Schistosoma mansoni	hypothetical protein	0.0434	0.2671	0.348
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Plasmodium vivax	ubiquitin activating enzyme, putative	0.005	0.0256	0.0846
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.0024	0.0021
Plasmodium vivax	ubiquitin-activating enzyme, putative	0.0019	0.0058	0.0174
Echinococcus granulosus	NEDD8 activating enzyme E1 regulatory subunit	0.0042	0.0205	0.0205
Toxoplasma gondii	kinase, pfkB family protein	0.1228	0.7674	1
Plasmodium vivax	SUMO-activating enzyme subunit 2, putative	0.0019	0.0058	0.0174
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0018	0.0056	0.0072
Loa Loa (eye worm)	6-phosphofructokinase	0.0126	0.0736	0.0736
Loa Loa (eye worm)	pax transcription factor protein 2	0.0278	0.1692	0.1692
Loa Loa (eye worm)	MH2 domain-containing protein	0.0138	0.081	0.081
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0047	0.0238	0.0301
Schistosoma mansoni	neuropeptide receptor	0.0434	0.2671	0.348
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.001	0.0006	0.0006
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0314	0.1916	0.1913
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0277	0.1688	0.1685
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.001	0.0006	0.0006
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0277	0.1688	0.2193
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.1598	1	1
Echinococcus multilocularis	ribokinase	0.014	0.0822	0.0822
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.001	0.0006	0.0008
Entamoeba histolytica	hypothetical protein	0.0042	0.0203	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0088	0.0088
Echinococcus granulosus	ubiquitin modifier activating enzyme 1	0.0126	0.0732	0.0732
Echinococcus granulosus	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Mycobacterium tuberculosis	6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase)	0.014	0.0822	0.3193
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0479	0.2955	0.3846
Brugia malayi	hypothetical protein	0.0029	0.0124	0.0124
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0304	0.0304
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0022	0.0029
Schistosoma mansoni	6-phosphofructokinase	0.0126	0.0736	0.0959
Brugia malayi	Dopamine receptor protein 2	0.0434	0.2671	0.2671
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0277	0.1688	0.2193
Brugia malayi	neuropeptide F receptor	0.0434	0.2671	0.2671
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0126	0.0736	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0005	0.0005
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Brugia malayi	hypothetical protein	0.014	0.0822	0.0822
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0056	0.0056
Echinococcus granulosus	somatostatin receptor	0.0434	0.2671	0.2671
Loa Loa (eye worm)	PDE1B protein	0.001	0.0006	0.0006
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0006	0.0008
Brugia malayi	neuropeptide F receptor	0.0434	0.2671	0.2671
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0156	0.0506
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.001	0.0006	0.0004
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.001	0.0006	0.0008
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0434	0.2671	0.2671
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.001	0.0006	0.0008
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0221	0.0221
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0126	0.0736	0.2858
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0247	0.0322
Mycobacterium ulcerans	sugar phosphate isomerases/epimerases	0.0023	0.0088	0.0287
Trichomonas vaginalis	ubiquitin-activating enzyme E1, putative	0.0019	0.0058	0.0054
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0024	0.0023
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0056	0.0056
Entamoeba histolytica	phosphofructokinase, putative	0.0126	0.0736	0.0714
Brugia malayi	Pax transcription factor protein 2	0.0278	0.1692	0.1692
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0203	0.0203
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0006	0.0003
Schistosoma mansoni	hypothetical protein	0.0013	0.0023	0.003
Leishmania major	adenosine kinase-like protein	0.014	0.0822	0.1064
Echinococcus granulosus	SUMO activating enzyme subunit 1	0.005	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.001	0.0006	0.0008
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0018	0.0056	0.0204
Brugia malayi	phosphofructokinase	0.0126	0.0736	0.0736
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Echinococcus granulosus	6 phosphofructokinase	0.0126	0.0736	0.0736
Trichomonas vaginalis	DNA helicase recq, putative	0.0025	0.0097	0.0093
Echinococcus multilocularis	NEDD8 activating enzyme E1 catalytic subunit	0.0067	0.0364	0.0364
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1	0.0277	0.1688	0.2193
Trypanosoma brucei	unspecified product	0.0277	0.1688	0.2193
Onchocerca volvulus		0.0434	0.2671	0.2668
Echinococcus granulosus	NEDD8 activating enzyme E1 catalytic subunit	0.0067	0.0364	0.0364
Toxoplasma gondii	nucleoside transporter protein	0.0277	0.1688	0.2194
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0434	0.2671	0.2671
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0034	0.0156	0.0152
Echinococcus granulosus	tm gpcr rhodopsin	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0479	0.2955	0.3851
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.001	0.0006	0.0006
Echinococcus granulosus	equilibrative nucleoside transporter 3	0.1598	1	1
Onchocerca volvulus	Putative pyridoxal kinase	0.014	0.0822	0.0819
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0148	0.0875	0.0875
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.001	0.0006	0.0002
Onchocerca volvulus		0.0434	0.2671	0.2668
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0024	0.0032
Leishmania major	tagatose-6-phosphate kinase-like protein	0.014	0.0822	0.1064
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0148	0.0875	0.114
Brugia malayi	ube1-prov protein	0.0126	0.0732	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Schistosoma mansoni	myosin xvIII	0.0434	0.2671	0.348
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0434	0.2671	0.2671
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0434	0.2671	0.2671
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.1598	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0434	0.2671	0.348
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0277	0.1688	0.1685
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.001	0.0006	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0022	0.0029
Schistosoma mansoni	biogenic amine receptor	0.0434	0.2671	0.348
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0502	0.0502
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.001	0.0006	0.0003
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0075	0.0415	0.0415
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0434	0.2671	0.2671
Schistosoma mansoni	biogenic amine receptor	0.0434	0.2671	0.348
Brugia malayi	hypothetical protein	0.1598	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0022	0.0022
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0165	0.0982	0.3817
Loa Loa (eye worm)	6-phosphofructokinase	0.0126	0.0736	0.0736
Trypanosoma cruzi	hypothetical protein	0.0263	0.1596	0.208
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0479	0.2955	0.3851
Trichomonas vaginalis	conserved hypothetical protein	0.014	0.0822	0.0819
Trypanosoma cruzi	adenosine kinase, putative	0.1228	0.7674	1
Brugia malayi	G protein-coupled receptor	0.0434	0.2671	0.2671
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.001	0.0006	0.0008
Trichomonas vaginalis	phosphofructokinase, putative	0.0126	0.0736	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus granulosus	biogenic amine 5HT receptor	0.0434	0.2671	0.2671
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0434	0.2671	0.348
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.0479	0.2955	1
Trypanosoma brucei	nucleoside transporter 1, putative	0.0277	0.1688	0.2193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0089	0.0502	0.1679
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0221	0.0221
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0086	0.048	0.048
Toxoplasma gondii	phosphofructokinase PFKII	0.0034	0.0156	0.0196
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0022	0.0022
Leishmania major	ribokinase, putative	0.014	0.0822	0.1064
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Loa Loa (eye worm)	hypothetical protein	0.014	0.0822	0.0822
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0056	0.0066
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Brugia malayi	ThiF family protein	0.005	0.0256	0.0256
Onchocerca volvulus		0.0434	0.2671	0.2668
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0086	0.048	0.0626
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1, putative	0.0277	0.1688	0.2193
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0434	0.2671	0.348
Echinococcus multilocularis	SUMO activating enzyme subunit 1	0.005	0.0256	0.0256
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0479	0.2955	0.3846
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0005	0.0005
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0203	0.0264
Trichomonas vaginalis	ribokinase, putative	0.014	0.0822	0.0819
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0434	0.2671	0.2671
Mycobacterium ulcerans	carbohydrate kinase CbhK	0.014	0.0822	0.2773
Giardia lamblia	Hypothetical protein	0.001	0.0006	0.0003
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0434	0.2671	0.2671
Schistosoma mansoni	hypothetical protein	0.0018	0.0056	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Brugia malayi	6-phosphofructokinase	0.0126	0.0736	0.0736
Brugia malayi	MH2 domain containing protein	0.0138	0.081	0.081
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0942	0.5874	0.5874
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0479	0.2955	0.3851
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0156	0.051
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.0056	0.0066
Brugia malayi	G-protein coupled receptor	0.0434	0.2671	0.2671
Onchocerca volvulus		0.0434	0.2671	0.2668
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.0479	0.2955	1
Echinococcus granulosus	allatostatin A receptor	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0075	0.0415	0.0415
Loa Loa (eye worm)	TYRA-2 protein	0.0434	0.2671	0.2671
Schistosoma mansoni	adenosine kinase	0.1228	0.7674	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0434	0.2671	0.2671
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.001	0.0004	0.0004
Echinococcus granulosus	7tm_1 domain containing protein	0.0434	0.2671	0.2671
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0434	0.2671	0.2671
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0313	0.1914	0.2488
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0434	0.2671	0.2671
Echinococcus granulosus	death domain containing protein	0.0017	0.0046	0.0046
Echinococcus granulosus	G protein coupled receptor 139	0.0434	0.2671	0.2671
Echinococcus granulosus	biogenic amine 5HT receptor	0.0434	0.2671	0.2671
Entamoeba histolytica	ThiF family protein	0.0042	0.0205	0.0181
Toxoplasma gondii	hypothetical protein	0.005	0.0256	0.0327
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0479	0.2955	0.2953
Schistosoma mansoni	DNA helicase recq5	0.001	0.0005	0.0007
Echinococcus multilocularis	neuropeptides capa receptor	0.0434	0.2671	0.2671
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0056	0.0056
Onchocerca volvulus		0.0434	0.2671	0.2668
Brugia malayi	hypothetical protein	0.0042	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0369	0.2262	0.2262
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0434	0.2671	0.348
Brugia malayi	hypothetical protein	0.0277	0.1688	0.1688
Toxoplasma gondii	nucleoside transporter protein	0.0277	0.1688	0.2194
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0189	0.0189
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0046	0.0046
Toxoplasma gondii	nucleoside transporter protein	0.0277	0.1688	0.2194
Brugia malayi	Sulfatase family protein	0.001	0.0004	0.0004
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.0479	0.2955	0.3847
Trypanosoma cruzi	adenosine kinase, putative	0.014	0.0822	0.1071
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0156	0.0152
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Leishmania major	hypothetical protein, conserved	0.0263	0.1596	0.2073
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Brugia malayi	follicle stimulating hormone receptor	0.0701	0.4354	0.4354
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0148	0.0875	0.114
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.1598	1	1
Plasmodium vivax	ubiquitin-activating enzyme E1C, putative	0.0026	0.0104	0.033
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0184	0.0184
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0089	0.0499	0.0644
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.001	0.0006	0.0008
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.001	0.0006	0.0008
Echinococcus granulosus	neuropeptides capa receptor	0.0434	0.2671	0.2671
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0701	0.4354	0.4354
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0088	0.033
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0434	0.2671	0.2671
Trypanosoma cruzi	ubiquitin activating enzyme, putative	0.0026	0.0104	0.0135
Echinococcus multilocularis	sex peptide receptor	0.0434	0.2671	0.2671
Echinococcus granulosus	ribokinase	0.014	0.0822	0.0822
Echinococcus multilocularis	ubiquitin modifier activating enzyme 6	0.0126	0.0732	0.0732
Entamoeba histolytica	nucleoside transporter, putative	0.0277	0.1688	0.1667
Onchocerca volvulus		0.0434	0.2671	0.2668
Brugia malayi	Dopamine receptor	0.0434	0.2671	0.2671
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0056	0.0056
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0479	0.2955	0.2938
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Onchocerca volvulus	Ribokinase homolog	0.014	0.0822	0.0819
Entamoeba histolytica	nucleoside transporter, putative	0.0277	0.1688	0.1667
Trypanosoma cruzi	ubiquitin activating enzyme, putative	0.0026	0.0104	0.0135
Plasmodium falciparum	SUMO-activating enzyme subunit 1	0.005	0.0256	0.0849
Echinococcus multilocularis	6 phosphofructokinase	0.0126	0.0736	0.0736
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0314	0.1916	0.1916
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Loa Loa (eye worm)	hypothetical protein	0.1598	1	1
Schistosoma mansoni	ribokinase	0.014	0.0822	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus multilocularis	neuropeptide receptor	0.0434	0.2671	0.2671
Brugia malayi	Ribokinase	0.014	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus multilocularis	adenosine kinase	0.1228	0.7674	0.7674
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.001	0.0006	0.0008
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0017	0.0047	0.0061
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Mycobacterium ulcerans	6-phosphofructokinase	0.0126	0.0736	0.2482
Loa Loa (eye worm)	hypothetical protein	0.005	0.0256	0.0256
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Giardia lamblia	Ribokinase	0.014	0.0822	0.0819
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Trypanosoma cruzi	nucleoside transporter-like, putative	0.0277	0.1688	0.2199
Giardia lamblia	Sgs1 DNA helicase, putative	0.001	0.0005	0.0002
Trypanosoma brucei	adenosine transporter 2, putative	0.0277	0.1688	0.2193
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0434	0.2671	0.2668
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0086	0.048	0.0477
Echinococcus multilocularis	G protein coupled receptor 139	0.0434	0.2671	0.2671
Schistosoma mansoni	ankyrin 23/unc44	0.0017	0.0046	0.006
Echinococcus granulosus	tm gpcr rhodopsin	0.0434	0.2671	0.2671
Brugia malayi	ThiF family protein	0.0042	0.0205	0.0205
Trypanosoma brucei	nucleoside 2-deoxyribosyltransferase	0.0263	0.1596	0.2073
Trypanosoma cruzi	hypothetical protein, conserved	0.0263	0.1596	0.208
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0434	0.2671	0.348
Echinococcus multilocularis	neuropeptide Y receptor	0.0434	0.2671	0.2671
Schistosoma mansoni	amine GPCR	0.0434	0.2671	0.348
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0006
Echinococcus granulosus	netrin receptor unc 5	0.0017	0.0046	0.0046
Echinococcus granulosus	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Onchocerca volvulus		0.0434	0.2671	0.2668
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.001	0.0006	0.0003
Trypanosoma brucei	nucleobase/nucleoside transporter 8.1	0.0277	0.1688	0.2193
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.001	0.0006	0.0006
Onchocerca volvulus		0.0434	0.2671	0.2668
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Trypanosoma cruzi	hypothetical protein, conserved	0.0263	0.1596	0.208
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0018	0.0056	0.0073
Loa Loa (eye worm)	hypothetical protein	0.1228	0.7674	0.7674
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0434	0.2671	0.2671
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0156	0.0152
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0018	0.0056	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0006	0.0003
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.001	0.0006	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Leishmania major	tagatose-6-phosphate kinase-like protein	0.014	0.0822	0.1064
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0434	0.2671	0.2671
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0434	0.2671	0.2671
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.1598	1	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0479	0.2955	0.3851
Schistosoma mansoni	hypothetical protein	0.0018	0.0056	0.0072
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0313	0.1914	0.2494
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0479	0.2955	0.2938
Echinococcus multilocularis	fmrfamide receptor	0.0434	0.2671	0.2671
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Schistosoma mansoni	neuropeptide receptor	0.0434	0.2671	0.348
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0148	0.0875	0.114
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0046	0.0046
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0434	0.2671	0.348
Echinococcus multilocularis	NEDD8 activating enzyme E1 regulatory subunit	0.0042	0.0205	0.0205
Trypanosoma brucei	adenosine kinase, putative	0.1228	0.7674	1
Echinococcus granulosus	g-protein coupled receptor	0.0434	0.2671	0.2671
Echinococcus granulosus	g protein coupled receptor	0.0434	0.2671	0.2671
Echinococcus granulosus	geminin	0.0393	0.2414	0.2414
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0434	0.2671	0.2671
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0434	0.2671	0.2671
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0479	0.2955	0.3846
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0434	0.2671	0.2671
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0056	0.0056
Echinococcus granulosus	rhodopsin orphan GPCR	0.0434	0.2671	0.2671
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.001	0.0006	0.0008
Trypanosoma cruzi	hypothetical protein, conserved	0.0263	0.1596	0.208
Trichomonas vaginalis	phosphofructokinase, putative	0.0126	0.0736	0.0733
Trypanosoma brucei	adenosine transporter, putative	0.0277	0.1688	0.2193
Echinococcus multilocularis	allatostatin A receptor	0.0434	0.2671	0.2671
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0417	0.2567	0.8683
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.001	0.0006	0.0003
Brugia malayi	6-phosphofructokinase	0.0126	0.0736	0.0736
Mycobacterium ulcerans	endonuclease IV	0.0089	0.0502	0.1687
Trypanosoma brucei	adenosine transporter, putative	0.0277	0.1688	0.2193
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.132	0.8253	0.8253
Trypanosoma cruzi	nucleobase transporter, putative	0.0277	0.1688	0.2199
Schistosoma mansoni	neuropeptide F-like receptor	0.0434	0.2671	0.348
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0089	0.0502	0.1683
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.001	0.0006	0.0006
Onchocerca volvulus		0.0434	0.2671	0.2668
Echinococcus multilocularis	Ankyrin	0.0017	0.0047	0.0047
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0034	0.0156	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Onchocerca volvulus		0.0434	0.2671	0.2668
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671
Echinococcus granulosus	g protein coupled receptor	0.0434	0.2671	0.2671
Echinococcus multilocularis	pseudouridine metabolizing bifunctional protein	0.014	0.0822	0.0822
Loa Loa (eye worm)	ThiF family protein	0.0019	0.0058	0.0058
Brugia malayi	hypothetical protein	0.0434	0.2671	0.2671
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0479	0.2955	1
Loa Loa (eye worm)	hypothetical protein	0.0434	0.2671	0.2671

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 7 %	Agonist activity at muscarinic M2 receptor (unknown origin) at 0.3 uM by calcium mobilization assay	ChEMBL.	24856064
Activity (functional)	= 8 %	Agonist activity at muscarinic M3 receptor (unknown origin) at 0.3 uM by calcium mobilization assay	ChEMBL.	24856064
Activity (functional)	= 17 %	Agonist activity at muscarinic M5 receptor (unknown origin) at 10 uM by calcium mobilization assay	ChEMBL.	24856064
Activity (functional)	= 74 %	Agonist activity at muscarinic M1 receptor (unknown origin) at 0.3 uM by calcium mobilization assay	ChEMBL.	24856064
Activity (functional)	= 98 %	Agonist activity at muscarinic M4 receptor (unknown origin) at 0.3 uM by calcium mobilization assay	ChEMBL.	24856064
IC50 (binding)	= 0.3 uM	Inhibition of human ERG channel	ChEMBL.	24856064

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3310800

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 917378