Detailed information for compound 917548

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.524 | Formula: C24H21FN6O5S
  • H donors: 3 H acceptors: 6 LogP: 1.81 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1c(cc(cc1C(=O)N)c1ccn2c(c1)nc(n2)NC(=O)C1CC1)NS(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C24H21FN6O5S/c1-36-21-18(22(26)32)10-15(11-19(21)30-37(34,35)17-6-4-16(25)5-7-17)14-8-9-31-20(12-14)27-24(29-31)28-23(33)13-2-3-13/h4-13,30H,2-3H2,1H3,(H2,26,32)(H,28,29,33)
  • InChiKey: FAMZMIUSZGOGOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Leishmania major hypothetical protein, conserved 0.0105 0.1029 0.4528
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.043 0.043
Brugia malayi hypothetical protein 0.0105 0.1029 0.1029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0213 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0396 0.4236 0.6229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0213 0.0213
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0035 0.0039
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0025 0.0145 0.0298
Brugia malayi tailless protein 0.0014 0.0035 0.0035
Brugia malayi nuclear receptor NHR-88 0.0014 0.0035 0.0035
Brugia malayi nuclear receptor RXR 0.0014 0.0035 0.0035
Echinococcus multilocularis GPCR, family 2 0.0291 0.3079 0.6707
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.043 0.0921
Loa Loa (eye worm) isocitrate dehydrogenase 0.0202 0.2097 0.2097
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0202 0.2097 0.4564
Loa Loa (eye worm) pax transcription factor protein 2 0.0265 0.2792 0.2792
Schistosoma mansoni tyrosine kinase 0.0422 0.4519 0.6644
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0202 0.2097 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0213 0.0448
Brugia malayi hypothetical protein 0.0016 0.0054 0.0054
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0213 0.0448
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0035 0.0057
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0035 0.0057
Brugia malayi ecdysone receptor 0.0014 0.0035 0.0035
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0035 0.0035
Brugia malayi nuclear receptor NHR-88 0.0031 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0008 0.0008
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0035 0.0057
Schistosoma mansoni tyrosine kinase 0.0014 0.0027 0.0028
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0291 0.3079 0.3079
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0202 0.2097 0.4564
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0213 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0105 0.1029 0.1029
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0213 0.0649
Loa Loa (eye worm) DR-78 0.0014 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0202 0.2097 1
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0213 0.0448
Brugia malayi nuclear receptor NHR-67 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Schistosoma mansoni zinc finger protein 0.0014 0.0035 0.0039
Brugia malayi SRC-1 0.0014 0.0027 0.0027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.092 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0213 0.0448
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Echinococcus multilocularis c src tyrosine kinase 0.0014 0.0027 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0213 0.0448
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0025 0.0145 0.0145
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0123 0.025
Echinococcus granulosus tar DNA binding protein 0.0396 0.4236 0.9236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0291 0.3079 0.6707
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0213 0.0213
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.043 0.0921
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0054 0.0067
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0025 0.0145 0.5
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0025 0.0145 0.0298
Entamoeba histolytica hypothetical protein 0.0038 0.029 1
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0035 0.0035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0213 0.0302
Schistosoma mansoni hypothetical protein 0.0291 0.3079 0.4523
Schistosoma mansoni unc-13 (munc13) 0.0025 0.0145 0.0201
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0304 0.3223 0.7023
Schistosoma mansoni smad 0.0023 0.0123 0.0169
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0202 0.2097 0.3078
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0213 0.0448
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0054
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0392 0.0839
Loa Loa (eye worm) TAR-binding protein 0.0396 0.4236 0.4236
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0213 0.0302
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0035 0.0057
Brugia malayi nuclear hormone receptor 0.0031 0.0213 0.0213
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0035 0.0035
Toxoplasma gondii isocitrate dehydrogenase 0.0202 0.2097 1
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0025 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Brugia malayi MH1 domain containing protein 0.005 0.043 0.043
Echinococcus granulosus tyrosine protein kinase Lyn 0.0014 0.0027 0.0041
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0012 0.0008 0.0008
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.1915 0.6821
Loa Loa (eye worm) hypothetical protein 0.0028 0.0182 0.0182
Echinococcus multilocularis tyrosine protein kinase Abl 0.0174 0.1795 0.3904
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0291 0.3079 0.3079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0213 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0396 0.4236 0.6229
Loa Loa (eye worm) hypothetical protein 0.0162 0.1662 0.1662
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0025 0.0145 0.0145
Schistosoma mansoni hypothetical protein 0.0629 0.6796 1
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0213 0.0302
Schistosoma mansoni tyrosine kinase 0.0014 0.0027 0.0028
Loa Loa (eye worm) nuclear hormone receptor 0.0288 0.3044 0.3044
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0035 0.0035
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0014 0.0027 0.0041
Brugia malayi MH2 domain containing protein 0.005 0.043 0.043
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0213 0.0302
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0202 0.2097 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0054
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0035 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.043 0.043
Brugia malayi MH1 domain containing protein 0.0028 0.0182 0.0182
Schistosoma mansoni tyrosine kinase 0.0014 0.0027 0.0028
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0213 0.0302
Brugia malayi Smad1 0.005 0.043 0.043
Echinococcus multilocularis isocitrate dehydrogenase 0.0202 0.2097 0.4564
Brugia malayi nuclear receptor RXR 0.0016 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0035 0.0039
Schistosoma mansoni smad 0.005 0.043 0.0621
Brugia malayi Steroid receptor seven-up type 2 0.0304 0.3223 0.3223
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0014 0.0027 0.0028
Brugia malayi isocitrate dehydrogenase 0.0202 0.2097 0.2097
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.043 0.0621
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0213 0.0302
Schistosoma mansoni tar DNA-binding protein 0.0396 0.4236 0.6229
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.029 0.0415
Echinococcus granulosus tyrosine protein kinase Src64B 0.0014 0.0027 0.0041
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0202 0.2097 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0213 0.0213
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0035 0.0035
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0014 0.0027 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0054
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0014 0.0027 0.0041
Schistosoma mansoni tyrosine kinase 0.0014 0.0027 0.0028
Brugia malayi hypothetical protein 0.0014 0.0035 0.0035
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0035 0.0057
Brugia malayi steroid hormone receptor 0.0031 0.0213 0.0213
Brugia malayi MH2 domain containing protein 0.074 0.8019 0.8019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0213 0.0448
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0123 0.0123
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0014 0.0027 0.0041
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0014 0.0027 0.0041
Loa Loa (eye worm) latrophilin receptor protein 2 0.0291 0.3079 0.3079
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0213 0.0649
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0035 0.0035
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0123 0.025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0213 0.0213
Loa Loa (eye worm) Smad1 0.005 0.043 0.043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0291 0.3079 0.6707
Brugia malayi hypothetical protein 0.0014 0.0035 0.0035
Echinococcus multilocularis tar DNA binding protein 0.0396 0.4236 0.9236
Echinococcus granulosus GPCR family 2 0.0291 0.3079 0.6707
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0014 0.0027 0.0041
Schistosoma mansoni nuclear receptor 0.0014 0.0035 0.0039
Schistosoma mansoni Smad4 0.005 0.043 0.0621
Schistosoma mansoni coup transcription factor 0.0031 0.0213 0.0302
Echinococcus granulosus tyrosine protein kinase Fyn 0.0014 0.0027 0.0041
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0202 0.2097 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0213 0.0302
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0014 0.0027 0.0041
Brugia malayi nuclear hormone receptor 0.0014 0.0035 0.0035
Toxoplasma gondii isocitrate dehydrogenase 0.0202 0.2097 1
Entamoeba histolytica hypothetical protein 0.0038 0.029 1
Brugia malayi Latrophilin receptor protein 2 0.0291 0.3079 0.3079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0629 0.6796 0.6796
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.043 0.0921
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0035 0.0057
Brugia malayi hypothetical protein 0.0038 0.029 0.029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0213 0.0448
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0202 0.2097 0.4564
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0213 0.0213
Loa Loa (eye worm) SRC-1 0.0014 0.0027 0.0027
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0035 0.0057
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0428 0.4586 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0008 0.0008
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0123 0.0123
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0014 0.0027 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0054
Schistosoma mansoni Smad4 0.0023 0.0123 0.0169
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0025 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0185 0.1915 0.1915
Loa Loa (eye worm) RNA binding protein 0.0396 0.4236 0.4236
Schistosoma mansoni hypothetical protein 0.0038 0.029 0.0415
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0213 0.0448
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0025 0.0145 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0213 0.0213
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0054 0.0067
Echinococcus granulosus tyrosine protein kinase Fyn 0.0014 0.0027 0.0041
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0035 0.0057
Echinococcus granulosus smad 0.005 0.043 0.0921
Brugia malayi Pax transcription factor protein 2 0.0265 0.2792 0.2792
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0035 0.0039
Loa Loa (eye worm) transcription factor SMAD2 0.074 0.8019 0.8019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0213 0.0213
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0213 0.0649
Brugia malayi ecdysteroid receptor 0.0031 0.0213 0.0213
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0123 0.025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0291 0.3079 0.6707
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0213 0.0213
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.043 0.0921
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0025 0.0145 0.0298
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Echinococcus granulosus tyrosine protein kinase Src42A 0.0014 0.0027 0.0041
Brugia malayi Sex muscle abnormal protein 5 0.0012 0.0008 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0213 0.0213
Echinococcus granulosus tyrosine protein kinase Fyn 0.0014 0.0027 0.0041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0213 0.0448
Schistosoma mansoni isocitrate dehydrogenase 0.0025 0.0145 0.0201
Echinococcus multilocularis Smad4 0.005 0.043 0.0921
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0213 0.0448
Brugia malayi Calcitonin receptor-like protein seb-1 0.092 1 1
Brugia malayi MH2 domain containing protein 0.005 0.043 0.043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0213 0.0213
Brugia malayi conserved hypotetical protein 0.0014 0.0035 0.0035
Brugia malayi Isocitrate dehydrogenase 0.0202 0.2097 0.2097
Entamoeba histolytica hypothetical protein 0.0038 0.029 1
Brugia malayi RNA binding protein 0.0396 0.4236 0.4236
Brugia malayi latrophilin 2 splice variant baaae 0.0629 0.6796 0.6796
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0014 0.0027 0.0041
Echinococcus granulosus Smad4 0.005 0.043 0.0921
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0202 0.2097 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Loa Loa (eye worm) TK/ABL protein kinase 0.0428 0.4586 0.4586
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0025 0.0145 0.5
Schistosoma mansoni tar DNA-binding protein 0.0396 0.4236 0.6229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0213 0.0213
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0123 0.0123
Brugia malayi MH2 domain containing protein 0.0023 0.0123 0.0123
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0025 0.0145 0.0145
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0213 0.0213
Schistosoma mansoni Smad4 0.0023 0.0123 0.0169
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0054 0.0054
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0213 0.0213
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0123 0.025
Brugia malayi MH1 domain containing protein 0.005 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.092 1 1
Schistosoma mansoni smad1 5 8 and 0.005 0.043 0.0621
Entamoeba histolytica hypothetical protein 0.0038 0.029 1
Brugia malayi RNA recognition motif domain containing protein 0.0396 0.4236 0.4236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0213 0.0302
Echinococcus granulosus c src tyrosine kinase 0.0014 0.0027 0.0041
Schistosoma mansoni hypothetical protein 0.0291 0.3079 0.4523
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0035 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0213 0.0213
Loa Loa (eye worm) MH2 domain-containing protein 0.074 0.8019 0.8019
Brugia malayi Tyrosine-protein kinase abl-1 0.0174 0.1795 0.1795
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0213 0.0213
Brugia malayi MH1 domain containing protein 0.0028 0.0182 0.0182
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0025 0.0145 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0213 0.0302
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0054 0.0099
Brugia malayi Tyrosine-protein kinase abl-1 0.0259 0.2731 0.2731
Brugia malayi Probable isocitrate dehydrogenase 0.0025 0.0145 0.0145
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0202 0.2097 0.4564
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0213 0.0302
Schistosoma mansoni nuclear receptor 0.0014 0.0035 0.0039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0291 0.3079 0.6707
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0213 0.0448
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0025 0.0145 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0428 0.4586 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0008 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0202 0.2097 0.4564
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0396 0.4236 0.4236
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0202 0.2097 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0213 0.0448
Schistosoma mansoni smad1 5 8 and 0.005 0.043 0.0621
Schistosoma mansoni hypothetical protein 0.0291 0.3079 0.4523
Onchocerca volvulus 0.0265 0.2792 1
Schistosoma mansoni hypothetical protein 0.0047 0.0392 0.0566
Onchocerca volvulus 0.0031 0.0213 0.0649
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0014 0.0027 0.0041
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0035 0.0039
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0035 0.0057
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0035 0.0035
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0035 0.0039
Brugia malayi Probable isocitrate dehydrogenase 0.0025 0.0145 0.0145
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0213 0.0448
Schistosoma mansoni smad1 5 8 and 0.005 0.043 0.0621
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0054 0.0099
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0054 0.0054
Loa Loa (eye worm) nuclear factor I 0.0028 0.0182 0.0182
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0014 0.0027 0.0041
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0213 0.0302
Loa Loa (eye worm) hypothetical protein 0.029 0.3064 0.3064
Echinococcus multilocularis smad 0.005 0.043 0.0921
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.0123 0.032
Brugia malayi hypothetical protein 0.0016 0.0054 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.029 0.0616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0213 0.0213
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.029 0.0616
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0025 0.0145 0.0298
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0213 0.0448
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0213 0.0302
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0035 0.0057
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0392 0.0839
Schistosoma mansoni tar DNA-binding protein 0.0396 0.4236 0.6229
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Brugia malayi hypothetical protein 0.0068 0.062 0.062
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0014 0.0027 0.0041
Brugia malayi TAR-binding protein 0.0396 0.4236 0.4236
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0014 0.0027 0.0041
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0213 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0213 0.0213
Brugia malayi N-terminal motif family protein 0.0185 0.1915 0.1915
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0304 0.3223 0.7023
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0202 0.2097 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0213
Schistosoma mansoni hypothetical protein 0.0291 0.3079 0.4523

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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