Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NPC1-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.9749 | 0.9744 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.2869 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0167 | 0.5121 | 0.3471 |
Leishmania major | cytochrome P450 reductase, putative | 0.0239 | 0.855 | 0.8159 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.027 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.5282 | 0.3686 |
Brugia malayi | FAD binding domain containing protein | 0.0167 | 0.5121 | 0.3805 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.027 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.027 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0167 | 0.5121 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0239 | 0.855 | 0.8159 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0134 | 0.3574 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.027 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0134 | 0.3574 | 0.0878 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.2528 | 0.2528 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0167 | 0.5121 | 0.3074 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.027 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.027 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.027 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.5282 | 0.5282 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0239 | 0.855 | 0.8159 |
Treponema pallidum | flavodoxin | 0.0103 | 0.2125 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.027 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0239 | 0.855 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0167 | 0.5121 | 0.5021 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.2869 | 0.0456 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0103 | 0.2125 | 0.1962 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.027 | 1 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.2869 | 0.0945 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.027 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0167 | 0.5121 | 0.5121 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.027 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0239 | 0.855 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.027 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0134 | 0.3574 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.027 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.027 | 1 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.2869 | 0.2869 |
Brugia malayi | FAD binding domain containing protein | 0.027 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2869 | 0.2722 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0136 | 0.3671 | 0.1016 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.84 uM | Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy | ChEMBL. | 24928400 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.