Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0368 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0368 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0368 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0368 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0368 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0368 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0368 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0368 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0368 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0368 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0368 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0368 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0368 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0368 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0368 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0368 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0368 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0368 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2188 mM | Inhibition of Schizosaccharomyces pombe HMG-CoA reductase by spectrophotometry | ChEMBL. | 20576575 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.