Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | formyl peptide receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | AKH receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 1 | 1 |
Brugia malayi | Dopamine receptor protein 2 | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0254 | 0.3494 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0254 | 0.3494 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0254 | 0.3494 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0254 | 0.3494 | 1 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0675 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0254 | 0.3494 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0254 | 0.3494 | 1 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0254 | 0.3494 | 1 |
Brugia malayi | RE15519p | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0028 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0254 | 0.3494 | 1 |
Brugia malayi | Serotonin receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0254 | 0.3494 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0254 | 0.3494 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Echinococcus multilocularis | serotonin receptor | 0.0675 | 1 | 1 |
Brugia malayi | G protein-coupled receptor | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0254 | 0.3494 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0028 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0254 | 0.3494 | 1 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0254 | 0.3494 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0254 | 0.3494 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0254 | 0.3494 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0254 | 0.3494 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0028 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0254 | 0.3494 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0254 | 0.3494 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0254 | 0.3494 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0254 | 0.3494 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0675 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0254 | 0.3494 | 1 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.059 | 0.8693 | 0.8693 |
Brugia malayi | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 150 nM | Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method | ChEMBL. | 25035262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.