Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | formyl peptide receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0072 | 0.0432 | 0.5 | |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0072 | 0.0432 | 0.0858 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0354 | 1 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.0072 | 0.0432 | 0.5 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0072 | 0.0432 | 0.0858 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0354 | 1 | 1 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0354 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.0072 | 0.0432 | 0.0858 |
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0207 | 0.5034 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0207 | 0.5034 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0207 | 0.5034 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0207 | 0.5034 | 1 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0072 | 0.0432 | 0.0858 |
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Echinococcus granulosus | hormone sensitive lipase | 0.0207 | 0.5034 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0072 | 0.0432 | 0.0858 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0354 | 1 | 1 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0072 | 0.0432 | 0.0858 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0354 | 1 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0072 | 0.0432 | 0.5 |
Onchocerca volvulus | 0.0072 | 0.0432 | 0.5 | |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0354 | 1 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0072 | 0.0432 | 0.0858 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0072 | 0.0432 | 0.0858 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0072 | 0.0432 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0354 | 1 | 1 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0354 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Trypanosoma brucei | Fatty acid elongase | 0.0354 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0354 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0354 | 1 | 1 |
Toxoplasma gondii | fatty acid elongase | 0.0072 | 0.0432 | 0.0432 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0354 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0354 | 1 | 1 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0354 | 1 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0072 | 0.0432 | 0.0858 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0354 | 1 | 1 |
Brugia malayi | GNS1/SUR4 family protein | 0.0354 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0072 | 0.0432 | 0.0432 |
Leishmania major | long chain polyunsaturated fatty acid elongation enzyme-like protein | 0.0072 | 0.0432 | 0.0432 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5034 | 0.481 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 200 nM | Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method | ChEMBL. | 25035262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.