TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 463.736 | Formula: C29H53NO3
H donors: 1 H acceptors: 2 LogP: 6.88 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCCCCOC(=O)C[C@H](CC[C@H]1C(=CC[C@@H]2[C@]1(C)CCCC2(C)C)CO)C)CC
InChi: 1S/C29H53NO3/c1-7-30(8-2)19-10-9-11-20-33-27(32)21-23(3)13-15-25-24(22-31)14-16-26-28(4,5)17-12-18-29(25,26)6/h14,23,25-26,31H,7-13,15-22H2,1-6H3/t23-,25-,26-,29+/m0/s1
InChiKey: OIQUQGHWRGMUNL-UEQJIGKFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Torpedo californica	Acetylcholinesterase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	acetylcholinesterase 1	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	carboxylesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	ko:K01049 acetylcholinesterase [EC3.1.1.7], putative	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	Acetylcholinesterase 1 precursor, putative	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K01050 cholinesterase [EC3.1.1.8], putative	Acetylcholinesterase	586 aa	577 aa	33.6 %
Onchocerca volvulus	Putative nuclear protein	Acetylcholinesterase	586 aa	551 aa	40.7 %
Echinococcus granulosus	BC026374 protein S09 family	Acetylcholinesterase	586 aa	648 aa	32.6 %
Onchocerca volvulus	Molybdopterin synthase catalytic subunit homolog	Acetylcholinesterase	586 aa	588 aa	28.1 %
Onchocerca volvulus	Carnitine O-palmitoyltransferase 2, mitochondrial homolog	Acetylcholinesterase	586 aa	552 aa	37.7 %
Onchocerca volvulus		Acetylcholinesterase	586 aa	612 aa	25.5 %
Schistosoma mansoni	gliotactin	Acetylcholinesterase	586 aa	474 aa	31.6 %
Echinococcus granulosus	neuroligin	Acetylcholinesterase	586 aa	493 aa	21.5 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	586 aa	546 aa	29.3 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	586 aa	480 aa	24.6 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	586 aa	571 aa	25.0 %
Echinococcus multilocularis	neuroligin	Acetylcholinesterase	586 aa	487 aa	23.0 %
Onchocerca volvulus		Acetylcholinesterase	586 aa	564 aa	29.4 %
Brugia malayi	Carboxylesterase family protein	Acetylcholinesterase	586 aa	592 aa	28.0 %
Onchocerca volvulus		Acetylcholinesterase	586 aa	562 aa	25.1 %
Loa Loa (eye worm)	hypothetical protein	Acetylcholinesterase	586 aa	509 aa	24.8 %
Echinococcus multilocularis	BC026374 protein (S09 family)	Acetylcholinesterase	586 aa	643 aa	32.2 %
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Acetylcholinesterase	586 aa	602 aa	24.4 %
Drosophila melanogaster	CG10175 gene product from transcript CG10175-RE	Acetylcholinesterase	586 aa	535 aa	31.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0519	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0021	0.0376	0.0376
Echinococcus granulosus	acetylcholinesterase	0.0123	0.2819	0.2819
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.028	0.028
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0021	0.0376	0.0376
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0041	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0041	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0158	0.3667	0.5519
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0056	0.0056
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0041	0.0062
Loa Loa (eye worm)	carboxylesterase	0.0021	0.0376	0.0567
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0774	0.1165
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.01	0.01
Trichomonas vaginalis	glutaminase, putative	0.0283	0.6643	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.1039	0.1039
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0774	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0041	0.0062
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.028	0.028
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0345	0.052
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0744	0.112
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0376	0.0567
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0774	0.0681
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.028	0.028
Brugia malayi	hypothetical protein	0.0017	0.0292	0.044
Schistosoma mansoni	hypothetical protein	0.0362	0.8555	0.8555
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0774	1
Brugia malayi	Carboxylesterase family protein	0.0123	0.2819	0.4243
Leishmania major	hypothetical protein, conserved	0.0027	0.0519	0.6703
Onchocerca volvulus		0.0021	0.0376	0.6376
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0166	0.0166
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.1039	0.1039
Schistosoma mansoni	ap endonuclease	0.0019	0.0345	0.0345
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.1039	0.1039
Echinococcus multilocularis	muscleblind protein 1	0.0158	0.3667	0.3667
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0774	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0021	0.0376	0.0933
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0041	0.0062
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0041	0.0062
Schistosoma mansoni	hypothetical protein	0.0036	0.0744	0.0744
Echinococcus multilocularis	acetylcholinesterase	0.0123	0.2819	0.2819
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0041	0.0062
Echinococcus multilocularis	geminin	0.0362	0.8555	0.8555
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1144	0.1721
Echinococcus granulosus	BC026374 protein S09 family	0.0021	0.0376	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0017	0.028	0.0421
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0041	0.0062
Echinococcus multilocularis	dnaJ subfamily B	0.0423	1	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0376	0.0567
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0774	0.0774
Echinococcus granulosus	geminin	0.0362	0.8555	0.8555
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.028	0.0421
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.1144	0.1721
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0345	0.052
Echinococcus multilocularis	carboxylesterase 5A	0.0123	0.2819	0.2819
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0345	0.4459
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0774	0.0774
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0017	0.028	0.028
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0774	0.0774
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0519	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0183	0.4268	0.6425
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0041	0.0062
Brugia malayi	Carboxylesterase family protein	0.0021	0.0376	0.0567
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0345	0.0345
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0774	0.6314
Onchocerca volvulus		0.0021	0.0376	0.6376
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0774	0.0774
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0056	0.0056
Echinococcus granulosus	acetylcholinesterase	0.0123	0.2819	0.2819
Schistosoma mansoni	hypothetical protein	0.0362	0.8555	0.8555
Brugia malayi	Carboxylesterase family protein	0.0123	0.2819	0.4243
Loa Loa (eye worm)	acetylcholinesterase 1	0.0123	0.2819	0.4243
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.01	0.015
Brugia malayi	Muscleblind-like protein	0.0158	0.3667	0.5519
Schistosoma mansoni	glutaminase	0.0283	0.6643	0.6643
Echinococcus granulosus	neuroligin	0.0021	0.0376	0.0376
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.1039	0.1565
Brugia malayi	hypothetical protein	0.0021	0.0376	0.0567
Brugia malayi	Inositol-1	0.0037	0.0774	0.1165
Brugia malayi	Carboxylesterase family protein	0.0021	0.0376	0.0567
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.1039	0.1039
Echinococcus granulosus	muscleblind protein	0.0158	0.3667	0.3667
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0774	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.1039	0.1039
Onchocerca volvulus		0.0021	0.0376	0.6376
Mycobacterium ulcerans	carboxylesterase, LipT	0.0021	0.0376	0.005
Echinococcus granulosus	para nitrobenzyl esterase	0.0021	0.0376	0.0376
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0041	0.0062
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0021	0.0376	0.0376
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0123	0.2819	0.2819
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0376	0.0567
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0345	0.052
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0345	0.5
Loa Loa (eye worm)	hypothetical protein	0.0158	0.3667	0.5519
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0519	0.6703
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0376	0.0567
Schistosoma mansoni	cpg binding protein	0.0031	0.0631	0.0631
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0519	0.6703
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.028	0.028
Loa Loa (eye worm)	glutaminase	0.0283	0.6643	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0631	0.0631
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0744	0.112
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0166	0.0166
Schistosoma mansoni	hypothetical protein	0.0012	0.0166	0.0166
Trichomonas vaginalis	conserved hypothetical protein	0.0178	0.4148	0.6244
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0056	0.0056
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0041	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0041	0.0062
Echinococcus multilocularis	GPCR, family 2	0.0017	0.028	0.028
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0519	0.6703
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0345	0.0345
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0519	1
Echinococcus granulosus	carboxylesterase 5A	0.0123	0.2819	0.2819
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0345	0.4459
Brugia malayi	Carboxylesterase family protein	0.0021	0.0376	0.0567
Brugia malayi	CXXC zinc finger family protein	0.003	0.059	0.0889
Loa Loa (eye worm)	carboxylesterase	0.0021	0.0376	0.0567
Mycobacterium ulcerans	glutaminase	0.0283	0.6643	1
Loa Loa (eye worm)	carboxylesterase	0.0123	0.2819	0.4243
Trichomonas vaginalis	helicase, putative	0.0007	0.0041	0.0062
Echinococcus multilocularis	cpg binding protein	0.0031	0.0631	0.0631
Echinococcus multilocularis	acetylcholinesterase	0.0123	0.2819	0.2819
Loa Loa (eye worm)	glutaminase 2	0.0283	0.6643	1
Schistosoma mansoni	hypothetical protein	0.0423	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.1144	0.1721
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0519	0.0781
Schistosoma mansoni	BC026374 protein (S09 family)	0.0021	0.0376	0.0376
Echinococcus multilocularis	para nitrobenzyl esterase	0.0021	0.0376	0.0376
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0021	0.0376	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0376	0.0567
Brugia malayi	hypothetical protein	0.0027	0.0519	0.0781
Schistosoma mansoni	hypothetical protein	0.0017	0.028	0.028
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0345	0.052
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1387	0.1387
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0021	0.0376	0.0933
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.1039	0.1039
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0041	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0041	0.0062
Echinococcus granulosus	GPCR family 2	0.0017	0.028	0.028
Onchocerca volvulus		0.0021	0.0376	0.6376
Schistosoma mansoni	acetylcholinesterase	0.0021	0.0376	0.0376
Schistosoma mansoni	gliotactin	0.0021	0.0376	0.0376
Loa Loa (eye worm)	inositol-1	0.0037	0.0774	0.1165
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0345	0.4459
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0774	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.059	0.0889
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0519	0.4232
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0376	0.0567
Schistosoma mansoni	cpg binding protein	0.003	0.059	0.059
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.068	1
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0183	0.4268	0.6425
Onchocerca volvulus		0.003	0.059	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0774	0.1165
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0021	0.0376	0.0376
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0021	0.0376	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2819	0.4243
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0041	0.0062
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.068	0.5
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0097	0.0146
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0345	0.4459
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.1039	0.1039
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.028	0.0421
Brugia malayi	Carboxylesterase family protein	0.0021	0.0376	0.0567
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0021	0.0376	0.0376
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1226	1
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.028	0.0421
Brugia malayi	glutaminase DH11.1	0.0283	0.6643	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.1039	0.1565
Echinococcus granulosus	cpg binding protein	0.0031	0.0631	0.0631
Schistosoma mansoni	hypothetical protein	0.0017	0.028	0.028
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0041	0.0062
Schistosoma mansoni	hypothetical protein	0.0017	0.028	0.028
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0021	0.0376	0.0933
Schistosoma mansoni	ap endonuclease	0.0019	0.0345	0.0345
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0774	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0041	0.0062
Echinococcus multilocularis	neuroligin	0.0021	0.0376	0.0376
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0345	0.5
Echinococcus multilocularis	muscleblind protein	0.0158	0.3667	0.3667
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2819	0.4243
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0376	0.0567
Toxoplasma gondii	exonuclease III APE	0.0019	0.0345	0.2816
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.1144	0.1721
Trichomonas vaginalis	spcc417.12 protein, putative	0.0021	0.0376	0.0567
Onchocerca volvulus		0.0021	0.0376	0.6376
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0021	0.0376	0.0376
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0774	0.1165

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13.8 uM	Inhibition of Torpedo californica AChE by spectrophotometry based Ellman's method	ChEMBL.	25017625
IC50 (binding)	= 27.2 uM	Inhibition of horse serum BChE by spectrophotometry based Ellman's method	ChEMBL.	25017625

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3311545

Bibliographic References

No literature references available for this target.

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Detailed information for compound 918130