Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.1275 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.1275 | 0 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1275 | 0 | 0.5 |
Onchocerca volvulus | 0.1275 | 0 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1523 | 0.6722 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1523 | 0.6722 | 0.5 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1644 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1523 | 0.6722 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.1275 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.1275 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1523 | 0.6722 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1644 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1523 | 0.6722 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1523 | 0.6722 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 28.2 uM | Inhibition of BACE1 in human HEK293 cells transfected with pCDNA-neo-SEAP-APP assessed as secreted alkaline phosphatase after cleavage of beta-site of APP by fluorescence assay | ChEMBL. | 20303626 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.