Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | ABC transporter, putative | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 611 aa | 557 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hexokinase | 0.0163 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0163 | 1 | 1 |
Onchocerca volvulus | 0.0163 | 1 | 1 | |
Trypanosoma brucei | hexokinase, putative | 0.0163 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2729 | 0.2729 |
Trypanosoma brucei | hexokinase | 0.0163 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0163 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0163 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0163 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0163 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0163 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0102 | 0.6028 | 0.6028 |
Loa Loa (eye worm) | hexokinase type II | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.6611 | 0.6611 |
Onchocerca volvulus | 0.0163 | 1 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.0163 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0163 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0163 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.005 | 0.2639 | 0.2639 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0012 | 0.0118 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0163 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0052 | 0.2729 | 0.2729 |
Brugia malayi | Hexokinase family protein | 0.0102 | 0.6028 | 0.6028 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0012 | 0.0118 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0163 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0163 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0163 | 1 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0012 | 0.0118 | 0.5 |
Onchocerca volvulus | 0.0163 | 1 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.005 | 0.2639 | 0.2639 |
Loa Loa (eye worm) | hexokinase | 0.0163 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0163 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0163 | 1 | 1 |
Giardia lamblia | ABC transporter | 0.0012 | 0.0109 | 0.5 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.0012 | 0.0118 | 0.0118 |
Echinococcus multilocularis | hexokinase | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2729 | 0.2729 |
Echinococcus granulosus | hexokinase | 0.0163 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.75 uM | Inhibition of human BCRP expressed in MDCK2 cells preincubated for 30 mins prior to Hoechst 33342 addition measured every 60 secs up to 120 mins by Hoechst 33342 accumulation assay | ChEMBL. | 23017888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.