Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | hexokinase | 0.0054 | 0.2728 | 0.2728 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0246 | 0.0246 |
Trypanosoma brucei | hexokinase | 0.0175 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0175 | 1 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.2147 | 0.2147 |
Schistosoma mansoni | hexokinase | 0.0175 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0175 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.2147 | 0.2147 |
Brugia malayi | Hexokinase family protein | 0.011 | 0.6076 | 0.6076 |
Loa Loa (eye worm) | hexokinase type II | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0246 | 0.0246 |
Echinococcus granulosus | hexokinase | 0.0175 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6652 | 0.6652 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2393 | 0.2393 |
Plasmodium vivax | hexokinase, putative | 0.0175 | 1 | 0.5 |
Onchocerca volvulus | 0.0175 | 1 | 1 | |
Entamoeba histolytica | hexokinase 2 | 0.0175 | 1 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0246 | 0.0246 |
Echinococcus granulosus | hexokinase | 0.0175 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0175 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0054 | 0.2728 | 0.2728 |
Trypanosoma brucei | hexokinase, putative | 0.0175 | 1 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.2147 | 0.2147 |
Brugia malayi | Hexokinase family protein | 0.0175 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0246 | 0.0246 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0246 | 0.0246 |
Trypanosoma cruzi | hexokinase, putative | 0.0175 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2818 | 0.2818 |
Onchocerca volvulus | 0.0175 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.0175 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1971 | 1 |
Toxoplasma gondii | hexokinase | 0.0175 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.1971 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1794 | 0.1794 |
Brugia malayi | hexokinase type II | 0.0056 | 0.2818 | 0.2818 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0246 | 0.0246 |
Onchocerca volvulus | 0.0175 | 1 | 1 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hexokinase | 0.0175 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.2147 | 0.2147 |
Treponema pallidum | hexokinase (hxk) | 0.0175 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0246 | 0.0246 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2393 | 0.2393 |
Loa Loa (eye worm) | hexokinase | 0.011 | 0.6076 | 0.6076 |
Echinococcus granulosus | hexokinase | 0.0175 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0175 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0175 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0175 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0175 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0175 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0175 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0175 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 | Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs by TopCount analysis | ChEMBL. | 23021991 |
Ki (binding) | = 7.2 | Binding affinity to histamine H1 receptor | ChEMBL. | 23021991 |
Ki (binding) | = 7.6 | Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay | ChEMBL. | 23021991 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.