Detailed information for compound 918501

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 527.566 | Formula: C27H33N3O8
  • H donors: 6 H acceptors: 8 LogP: 1.08 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 3
  • SMILES: CN([C@@H]1C(=C(C(=O)NCN2CCCC2)C(=O)[C@@]2([C@H]1C[C@H]1C(=C2O)C(=O)c2c([C@@]1(C)O)cccc2O)O)O)C
  • InChi: 1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14-,15-,20-,26+,27-/m0/s1
  • InChiKey: HMEYVGGHISAPJR-IAHYZSEUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0071 0.0493
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0084 0.0315 0.0436
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1013 0.105
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0113 0.0113
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0113 0.0113
Brugia malayi 6-phosphofructokinase 0.0131 0.051 0.0529
Brugia malayi nuclear hormone receptor family member nhr-6 0.0064 0.023 0.0238
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0136 0.0529 0.0548
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0326 0.1323 0.1323
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0136 0.0529 0.0548
Onchocerca volvulus 0.0064 0.023 0.1049
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0101 0.0105
Brugia malayi jmjC domain containing protein 0.0019 0.0042 0.0044
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0326 0.1323 0.3495
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0084 0.0315 0.0832
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0295 0.0295
Schistosoma mansoni glutaminase 0.033 0.1338 0.1338
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0113 0.0675
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0295 0.0295
Schistosoma mansoni lozenge 0.0067 0.0243 0.0243
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0692 0.0692
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0071 0.0071
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0101 0.0605
Schistosoma mansoni nuclear receptor 0.0064 0.023 0.023
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0295 0.1764
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0111 0.0323
Mycobacterium ulcerans DNA polymerase IV 0.005 0.017 0.0449
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0342 0.0355
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0101 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0342 0.0342
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0027 0.0028
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0326 0.1323 0.1323
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0042 0.0042
Brugia malayi Pre-SET motif family protein 0.0252 0.1013 0.105
Echinococcus multilocularis Biotin lipoyl attachment 0.0084 0.0315 0.0315
Schistosoma mansoni hypothetical protein 0.0398 0.162 0.162
Loa Loa (eye worm) nuclear receptor NHR-67 0.0064 0.023 0.0238
Loa Loa (eye worm) glutaminase 0.033 0.1338 0.1387
Brugia malayi nuclear receptor NHR-67 0.0064 0.023 0.0238
Schistosoma mansoni zinc finger protein 0.0064 0.023 0.023
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0008 0.0008
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.051 0.3558
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0483 0.0483
Schistosoma mansoni cpg binding protein 0.0028 0.008 0.008
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0084 0.0315 0.051
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0326 0.1323 0.3495
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0326 0.1323 0.3495
Leishmania major DNA polymerase kappa, putative 0.0025 0.0069 0.0069
Brugia malayi hypothetical protein 0.0072 0.0262 0.0272
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0101 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0136 0.0529 0.0548
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0101 0.0606
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.051 0.3558
Onchocerca volvulus Bile acid receptor homolog 0.0136 0.0529 0.2412
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0101 0.0268
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0111 0.0663
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0326 0.1323 0.3495
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0262 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0044
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0918 0.3786 0.613
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0047
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.051 0.1347
Onchocerca volvulus 0.0033 0.0099 0.0452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0342 0.0342
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0004 0.0005
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0207 0.0827 0.2185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1434 1
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.051 0.3558
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0165 0.0171
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0116 0.0116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.023 0.023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0165 0.0171
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0918 0.3786 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0243 0.0974 0.2573
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0069 0.0183
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0058 0.0404
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0136 0.0529 0.0548
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.051 0.3046
Brugia malayi ecdysone receptor 0.0064 0.023 0.0238
Schistosoma mansoni thyroid hormone receptor 0.0288 0.1162 0.1162
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0084 0.0315 0.0917
Mycobacterium ulcerans DNA polymerase IV 0.005 0.017 0.0449
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0084 0.0315 0.0832
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0008 0.0011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0069 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0069 0.0069
Brugia malayi Carboxyl transferase domain containing protein 0.2325 0.9648 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0178 0.0178
Brugia malayi 6-phosphofructokinase 0.0131 0.051 0.0529
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0058 0.0153
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1434 0.8559
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0136 0.0529 0.0548
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0136 0.0529 0.0548
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0084 0.0315 0.051
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0084 0.0315 0.051
Loa Loa (eye worm) hypothetical protein 0.0136 0.0529 0.0548
Echinococcus granulosus GPCR family 2 0.0015 0.0027 0.0027
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0084 0.0315 0.051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0136 0.0529 0.0529
Mycobacterium ulcerans hypothetical protein 0.0084 0.0315 0.0832
Toxoplasma gondii thioredoxin reductase 0.0096 0.0362 0.0362
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0035 0.0035
Schistosoma mansoni intermediate filament proteins 0.0033 0.0099 0.0099
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0362 0.0956
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0295 0.0295
Plasmodium falciparum carbamoyl phosphate synthetase 0.0207 0.0827 0.1145
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.2409 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0136 0.0529 0.0529
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.023 0.023
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0101 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0188
Loa Loa (eye worm) glutathione reductase 0.0096 0.0362 0.0375
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0295 0.0295
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0207 0.0827 0.2185
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0207 0.0827 0.0827
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0065 0.0067
Trypanosoma brucei unspecified product 0.0012 0.0014 0.0014
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0918 0.3786 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0178 0.0178
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0144 0.0381
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0084 0.0315 0.0326
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0058 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0058 0.0094
Plasmodium falciparum thioredoxin reductase 0.0096 0.0362 0.0501
Loa Loa (eye worm) hypothetical protein 0.0072 0.0262 0.0272
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0207 0.0827 0.1145
Echinococcus multilocularis lamin dm0 0.0033 0.0099 0.0099
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.017 0.0275
Schistosoma mansoni hypothetical protein 0.0152 0.0597 0.0597
Schistosoma mansoni ap endonuclease 0.0023 0.0058 0.0058
Brugia malayi tailless protein 0.0064 0.023 0.0238
Brugia malayi orphan nuclear receptor NR2E1 0.0064 0.023 0.0238
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0326 0.1323 0.3495
Loa Loa (eye worm) phosphofructokinase 0.0131 0.051 0.0529
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0084 0.0315 0.0436
Loa Loa (eye worm) hypothetical protein 0.0136 0.0529 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.012 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0116 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0342 0.0342
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0918 0.3786 0.3786
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Schistosoma mansoni lamin 0.0033 0.0099 0.0099
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0207 0.0827 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0047
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0027 0.0028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.3248 0.3248
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0156 0.0156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0136 0.0529 0.0529
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0084 0.0315 0.051
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0136 0.0529 0.2412
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0111 0.0154
Schistosoma mansoni nuclear hormone receptor 0.0064 0.023 0.023
Schistosoma mansoni cpg binding protein 0.003 0.0086 0.0086
Schistosoma mansoni nuclear receptor 0.0064 0.023 0.023
Onchocerca volvulus 0.0287 0.1157 0.5282
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0116 0.0116
Echinococcus granulosus ecdysone induced protein 78C 0.0136 0.0529 0.0529
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0037 0.0116 0.012
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0295 0.0306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0136 0.0529 0.0529
Trypanosoma brucei acetyl-CoA carboxylase 0.2409 1 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0101 0.0268
Brugia malayi phosphofructokinase 0.0131 0.051 0.0529
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Plasmodium falciparum glutathione reductase 0.0033 0.0101 0.014
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0036 0.0037
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0692 0.0718
Trichomonas vaginalis glutaminase, putative 0.033 0.1338 0.9336
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0326 0.1323 0.3495
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0084 0.0315 0.0315
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0326 0.1323 0.3495
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0021 0.0033
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0243 0.0974 0.2573
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0058 0.0346
Trypanosoma brucei unspecified product 0.0012 0.0014 0.0014
Brugia malayi Cytochrome P450 family protein 0.0055 0.0191 0.0198
Echinococcus granulosus dna polymerase eta 0.0017 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.017 0.017
Brugia malayi nuclear hormone receptor 0.0136 0.0529 0.0548
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0058 0.0058
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0027 0.0027
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0113 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0136 0.0529 0.0548
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0918 0.3786 0.3786
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0116 0.0116
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0027 0.0188
Brugia malayi nuclear receptor NHR-88 0.0136 0.0529 0.0548
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0326 0.1323 0.3495
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1744 0.7227 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.017 0.0275
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0042 0.0042
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0918 0.3786 0.3786
Onchocerca volvulus 0.0015 0.0027 0.0123
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0136 0.0529 0.0529
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0005
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0326 0.1323 0.3495
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.2409 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0008 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0136 0.0529 0.0529
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0027 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1434 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0692 0.0692
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0111 0.0775
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0113 0.0113
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0326 0.1323 0.1323
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0084 0.0315 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.017 0.017
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0008 0.0008
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0058 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1434 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0529 0.0548
Brugia malayi hypoxia-induced factor 1 0.0182 0.0721 0.0747
Schistosoma mansoni cpg binding protein 0.003 0.0086 0.0086
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.051 0.051
Mycobacterium tuberculosis Probable dehydrogenase 0.0218 0.0873 0.2305
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0101 0.0101
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0101 0.0164
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.051 0.051
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0207 0.0827 0.1339
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0036 0.0036
Schistosoma mansoni single-minded 0.0059 0.0208 0.0208
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0042 0.0068
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0084 0.0315 0.0917
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0326 0.1323 0.1323
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0027 0.0044
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0058 0.0404
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0136 0.0529 0.0529
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.017 0.017
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0036 0.0037
Brugia malayi jmjC domain containing protein 0.0019 0.0042 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.017 0.0275
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0084 0.0315 0.0315
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0027 0.0188
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0084 0.0315 0.0315
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0136 0.0529 0.0529
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0101 0.0101
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0326 0.1323 0.1323
Echinococcus multilocularis Protein lozenge 0.0067 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Loa Loa (eye worm) histone methyltransferase 0.001 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0015 0.0027 0.0027
Brugia malayi nuclear receptor NHR-88 0.0064 0.023 0.0238
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0021 0.0021
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0101 0.0105
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1744 0.7227 1
Mycobacterium ulcerans pyruvate carboxylase 0.0918 0.3786 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0042 0.0042
Brugia malayi hypothetical protein 0.0197 0.0784 0.0813
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0111 0.0775
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0136 0.0529 0.0529
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0005
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0326 0.1323 0.1323
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0084 0.0315 0.0832
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Schistosoma mansoni lamin 0.0033 0.0099 0.0099
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0027 0.0044
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0027 0.0027
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0259 0.0259
Echinococcus multilocularis lamin 0.0033 0.0099 0.0099
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0027 0.0027
Brugia malayi Nuclear hormone receptor E75 0.0064 0.023 0.0238
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0111 0.0111
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0006 0.0006
Schistosoma mansoni nuclear receptor nhr-48 0.0064 0.023 0.023
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0483 0.0483
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0111 0.0111
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0036 0.0036
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0101 0.0164
Loa Loa (eye worm) hypothetical protein 0.0084 0.0315 0.0326
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.1434 1
Mycobacterium ulcerans glutaminase 0.033 0.1338 0.3535
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.023 0.023
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0101 0.0268
Schistosoma mansoni ap endonuclease 0.0023 0.0058 0.0058
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0232 0.0241
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0918 0.3786 0.3786
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0058 0.008
Brugia malayi jmjC domain containing protein 0.0071 0.0259 0.0269
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0326 0.1323 0.3495
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.017 0.017
Loa Loa (eye worm) runx1 0.0067 0.0243 0.0252
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0111 0.0154
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0111 0.0154
Echinococcus granulosus intermediate filament protein 0.0033 0.0099 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0216 0.0216
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0208 0.0208
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0027 0.0188
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.2409 1 1
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.051 0.051
Schistosoma mansoni thyroid hormone receptor 0.0288 0.1162 0.1162
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0124
Schistosoma mansoni hypothetical protein 0.0033 0.0101 0.0101
Schistosoma mansoni DNA polymerase eta 0.0017 0.0036 0.0036
Leishmania major carbamoyl-phosphate synthase, putative 0.0207 0.0827 0.0827
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0266 0.0266
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0064 0.023 0.0238
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0021 0.0144
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0084 0.0315 0.051
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0072 0.0262 0.0262
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0252 0.0665
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0535 0.2192 0.2271
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.051 0.3046
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0101 0.0164
Onchocerca volvulus 0.0535 0.2192 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0136 0.0529 0.0529
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0008 0.0008
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0084 0.0315 0.0315
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0113 0.0789
Echinococcus granulosus cpg binding protein 0.003 0.0086 0.0086
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0137 0.0137
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0008 0.0008
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0111 0.0323
Echinococcus multilocularis ecdysone induced protein 78C 0.0136 0.0529 0.0529
Toxoplasma gondii carbamoylphosphate synthetase 0.0207 0.0827 0.0827
Mycobacterium leprae Possible regulatory protein 0.0015 0.0027 0.0071
Loa Loa (eye worm) steroid hormone receptor 0.0136 0.0529 0.0548
Loa Loa (eye worm) DR-78 0.0064 0.023 0.0238
Brugia malayi Thioredoxin reductase 0.0096 0.0362 0.0375
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0171
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0021 0.0123
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0101 0.0101
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.051 0.051
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0042 0.0042
Brugia malayi intermediate filament protein 0.0033 0.0099 0.0103
Brugia malayi glutaminase DH11.1 0.033 0.1338 0.1387
Loa Loa (eye worm) hypothetical protein 0.0072 0.0262 0.0272
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0326 0.1323 0.2142
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0111 0.0775
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0326 0.1323 0.3853
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0113 0.0117
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0084 0.0315 0.0832
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0036 0.0059
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.016 0.0955
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0259 0.0259
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0101 0.0101
Brugia malayi nuclear hormone receptor family member odr-7 0.0064 0.023 0.0238
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0411 0.1675 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0058 0.0153
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0918 0.3786 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0027 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0136 0.0529 0.0529
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0113 0.0183
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0048 0.0048
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0218 0.0873 0.2305
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0101 0.0708
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0136 0.0529 0.0548
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.008 0.0083
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0362 0.0362
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0326 0.1323 0.2142
Schistosoma mansoni pyruvate carboxylase 0.0918 0.3786 0.3786
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0099 0.0103
Trypanosoma cruzi acetyl-CoA carboxylase 0.1492 0.6177 1
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.051 0.3046
Loa Loa (eye worm) hypothetical protein 0.0072 0.0262 0.0272
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0178 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.017 0.017
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0058 0.0153
Brugia malayi steroid hormone receptor 0.0136 0.0529 0.0548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0342 0.0342
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0036 0.0037
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0084 0.0315 0.0832
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0101 0.0101
Echinococcus multilocularis musashi 0.0033 0.0099 0.0099
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0252 0.0252
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0111 0.0775
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0483 0.1275
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0295 0.0478
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0262 0.0272
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0027 0.0188
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0084 0.0315 0.0315
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0027 0.0028
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0058 0.0058
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.023 0.1049
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0326 0.1323 0.3495
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0362 0.0501
Toxoplasma gondii exonuclease III APE 0.0023 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0136 0.0529 0.0548
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0362 0.0362
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0411 0.1675 1
Brugia malayi hypothetical protein 0.0064 0.023 0.0238
Trypanosoma brucei unspecified product 0.0603 0.2477 0.2477
Brugia malayi nuclear receptor RXR 0.0064 0.023 0.0238
Brugia malayi jmjC domain containing protein 0.0073 0.0266 0.0276
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0042 0.0068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0117
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0218 0.0873 0.2305
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0191 0.0198
Trypanosoma brucei trypanothione reductase 0.0096 0.0362 0.0362
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0027 0.0188
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0116 0.0116
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0136 0.0529 0.0529
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0136 0.0529 0.0529
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0058 0.0094
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0113 0.0113
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0027 0.0188
Plasmodium vivax JmjC domain containing protein 0.0019 0.0042 0.0058
Brugia malayi photoreceptor-specific nuclear receptor 0.0136 0.0529 0.0548
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0042 0.0042
Brugia malayi conserved hypotetical protein 0.0064 0.023 0.0238
Trypanosoma brucei unspecified product 0.0042 0.0137 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0342 0.0342
Onchocerca volvulus 0.0043 0.0144 0.0659
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0029 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0136 0.0529 0.0548
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0918 0.3786 1
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0036 0.0037
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0084 0.0315 0.0917
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0165 0.0171
Brugia malayi jmjC domain containing protein 0.0019 0.0042 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1434 1
Brugia malayi jmjC domain containing protein 0.0019 0.0042 0.0044
Giardia lamblia DINP protein human, muc B family 0.0025 0.0069 0.0414
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0111 0.0154
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0113 0.0113
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0101 0.0708
Brugia malayi CXXC zinc finger family protein 0.0028 0.008 0.0083
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0036 0.0036
Leishmania major acetyl-CoA carboxylase, putative 0.2409 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0108 0.0108
Brugia malayi nuclear hormone receptor 0.0064 0.023 0.0238
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0028
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0362 0.0586
Loa Loa (eye worm) nuclear hormone receptor 0.0064 0.023 0.0238
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0337 0.1366 0.1366
Onchocerca volvulus 0.0064 0.023 0.1049
Leishmania major hypothetical protein, conserved 0.0019 0.0042 0.0042
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.2189 0.9082 0.9082
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0111 0.0663
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0136 0.0529 0.0548
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0084 0.0315 0.0315
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0259 0.0259
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0042 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1434 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0252 0.0252
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0027 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0101 0.0164
Loa Loa (eye worm) hypothetical protein 0.0072 0.0262 0.0272
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0101 0.0101
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0136 0.0529 0.0548
Plasmodium vivax glutathione reductase, putative 0.0096 0.0362 0.0501
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0064 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0136 0.0529 0.0548
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0101 0.014
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0049 0.0049
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0042 0.0042
Onchocerca volvulus 0.0028 0.008 0.0363
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Onchocerca volvulus 0.0136 0.0529 0.2412
Echinococcus multilocularis expressed protein 0.0034 0.0105 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0111 0.0775
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0116 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1434 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0099 0.0103
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0113 0.0675
Echinococcus granulosus single minded 2 0.0043 0.0144 0.0144
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0918 0.3786 1
Brugia malayi Pre-SET motif family protein 0.0037 0.0116 0.012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.023 0.023
Echinococcus granulosus expressed protein 0.0034 0.0105 0.0105
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0266 0.0276
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0218 0.0873 0.2305
Echinococcus multilocularis dna polymerase kappa 0.005 0.017 0.017
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0597 0.0597
Onchocerca volvulus 0.0037 0.0116 0.0529
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.017 0.017
Plasmodium falciparum glutathione reductase 0.0096 0.0362 0.0501
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0027 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0099 0.0103
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0008 0.0008
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0064 0.023 0.0238
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0042 0.0042
Toxoplasma gondii pyruvate carboxylase 0.0918 0.3786 0.3786
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0071 0.0493
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0099 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0188
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0036 0.0095
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0113 0.0113
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0672 0.0672
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0101 0.0101
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0144 0.0144
Echinococcus multilocularis nuclear receptor nhr 48 0.0064 0.023 0.023
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0064 0.023 0.023
Echinococcus granulosus lamin dm0 0.0033 0.0099 0.0099
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.017 0.0275
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0071 0.0073
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0042 0.0042
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0918 0.3786 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0136 0.0529 0.0529
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.051 0.1347
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0027 0.0188
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0084 0.0315 0.0315
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0006 0.001
Leishmania major protein kinase, putative 0.0015 0.0027 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0342 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.017 0.017
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.017 0.017
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0006 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0111 0.0775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0136 0.0529 0.0548
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0084 0.0315 0.051
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0113 0.0113
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0036 0.0216
Schistosoma mansoni rotamase 0.0034 0.0105 0.0105
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0084 0.0315 0.0315
Loa Loa (eye worm) glutaminase 2 0.033 0.1338 0.1387
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0027 0.0027
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0042 0.0058
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0084 0.0315 0.0315
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0113 0.0789
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.017 0.1185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0136 0.0529 0.0548
Schistosoma mansoni hypothetical protein 0.0015 0.0027 0.0027
Echinococcus granulosus FTZ F1 alpha 0.0136 0.0529 0.0529
Schistosoma mansoni steroid hormone receptor ad4bp 0.0136 0.0529 0.0529
Echinococcus multilocularis FTZ F1 alpha 0.0136 0.0529 0.0529
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0042 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.017 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.017 0.017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0136 0.0529 0.0529
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0326 0.1323 0.2142
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0027 0.0044
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.023 0.023
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0682 0.18
Brugia malayi hypothetical protein 0.0535 0.2192 0.2271
Chlamydia trachomatis biotin carboxylase 0.0833 0.3435 1
Loa Loa (eye worm) acetyltransferase 0.0175 0.0692 0.0718
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0207 0.0827 0.0827
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0483 0.1275
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0072 0.0262 0.0262
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0326 0.1323 0.3495
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0084 0.0315 0.0832
Brugia malayi nuclear receptor RXR 0.0072 0.0262 0.0272
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0084 0.0315 0.0326
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0262 0.0262
Leishmania major carboxylase, putative 0.0918 0.3786 0.3786
Schistosoma mansoni hypothetical protein 0.0015 0.0027 0.0027
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0084 0.0315 0.0326
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0682 0.18
Loa Loa (eye worm) hypothetical protein 0.0197 0.0784 0.0813
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0051
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0101 0.014
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0207 0.0827 0.1339
Echinococcus multilocularis thyroid hormone receptor alpha 0.0288 0.1162 0.1162
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0027 0.0027
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0295 0.0306
Echinococcus granulosus dna polymerase kappa 0.005 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0097 0.01
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0178 0.124
Treponema pallidum pyruvate carboxylase subunit B 0.0084 0.0315 0.2196
Schistosoma mansoni nuclear hormone receptor 0.0136 0.0529 0.0529
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0342 0.0342
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0015 0.0027 0.0078
Schistosoma mansoni DNA helicase recq5 0.0011 0.0008 0.0008
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.051 0.0826
Schistosoma mansoni nuclear hormone receptor 0.0064 0.023 0.023
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0021 0.0021
Echinococcus granulosus thyroid hormone receptor alpha 0.0064 0.023 0.023
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0027 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0136 0.0529 0.0548
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0918 0.3786 0.3786
Onchocerca volvulus 0.0033 0.0099 0.0452
Echinococcus granulosus bloom syndrome protein 0.0026 0.0071 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0101 0.0164
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0084 0.0315 0.0315
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0064 0.023 0.023
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0084 0.0315 0.0436
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.051 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0136 0.0529 0.0548
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0027 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0136 0.0529 0.0529
Schistosoma mansoni hypothetical protein 0.0062 0.0223 0.0223
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0042 0.0044
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0105 0.0108
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0111 0.0775
Brugia malayi polk-prov protein 0.0038 0.012 0.0124
Echinococcus multilocularis geminin 0.0337 0.1366 0.1366
Brugia malayi PAS domain containing protein 0.0059 0.0208 0.0216
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0101 0.0101
Brugia malayi hypothetical protein 0.0064 0.023 0.0238
Schistosoma mansoni DNA helicase recq1 0.0011 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0136 0.0529 0.0529
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0058 0.008
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0295 0.0478
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0218 0.0873 0.2305
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0362 0.0375
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0207 0.0207
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0101 0.0295
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0252 0.0665
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1157 0.8074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0058 0.006
Brugia malayi hypothetical protein 0.0072 0.0262 0.0272
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.2325 0.9648 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0105 0.0108
Brugia malayi Nuclear hormone receptor-like 1 0.0136 0.0529 0.0548
Schistosoma mansoni coup transcription factor 0.0136 0.0529 0.0529
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0266 0.0266
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0111 0.0775
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0008 0.0008
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0084 0.0315 0.0436
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0144 0.015
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0084 0.0315 0.0832
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0136 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Schistosoma mansoni hypothetical protein 0.0015 0.0027 0.0027
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0136 0.0529 0.0548
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0243 0.0974 0.2573
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0326 0.1323 0.1323
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.051 0.051
Echinococcus granulosus dnaJ subfamily B 0.0398 0.162 0.162
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0252 0.0665
Brugia malayi glutathione reductase 0.0096 0.0362 0.0375
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0483 0.1275
Loa Loa (eye worm) hypothetical protein 0.0084 0.0315 0.0326
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0084 0.0315 0.0917
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0049 0.0049
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.1434 0.8559
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.017 0.1185
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.012 0.012
Treponema pallidum NADH oxidase 0.0033 0.0101 0.0708
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0101 0.0101
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0084 0.0315 0.0832
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0218 0.0873 0.2305
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0918 0.3786 0.3786
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0136 0.0529 0.0548
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0064 0.023 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0047 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0042 0.0044
Loa Loa (eye worm) hypothetical protein 0.0535 0.2192 0.2271
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.016 0.0221
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0042 0.0042
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0027
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0101 0.0164
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0084 0.0315 0.0315
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0072 0.0262 0.0272
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0483 0.0483
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0918 0.3786 0.3786
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0113 0.0113
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0084 0.0315 0.0315
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0342 0.0355
Loa Loa (eye worm) hypothetical protein 0.0136 0.0529 0.0548
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0266 0.0266
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.051 0.3558
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0006 0.0006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.023 0.1049
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0042 0.0042
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0101 0.0101
Onchocerca volvulus Protein ultraspiracle homolog 0.0136 0.0529 0.2412
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0116 0.0116
Schistosoma mansoni RAR-like nuclear receptor 0.0136 0.0529 0.0529
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.051 0.3558
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0027 0.0044
Leishmania major trypanothione reductase 0.0096 0.0362 0.0362
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0027 0.0027
Echinococcus granulosus Biotin lipoyl attachment 0.0084 0.0315 0.0315
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0156 0.0156
Brugia malayi Nuclear hormone receptor E75 0.0064 0.023 0.0238
Echinococcus granulosus geminin 0.0337 0.1366 0.1366
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.051 0.051
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0101 0.0101
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1434 0.8559
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0483 0.0483
Trichomonas vaginalis rotamase, putative 0.0033 0.0101 0.0706
Loa Loa (eye worm) hypothetical protein 0.0064 0.023 0.0238
Schistosoma mansoni aspartate carbamoyltransferase 0.0207 0.0827 0.0827
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.0721 0.0747
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0483 0.0483
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0008 0.0046
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0019 0.0019
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0084 0.0315 0.0315
Plasmodium falciparum thioredoxin reductase 0.0033 0.0101 0.014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0136 0.0529 0.0548
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0037
Leishmania major DNA polymerase eta, putative 0.0017 0.0036 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0101 0.0164
Leishmania major protein kinase, putative 0.0015 0.0027 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0101 0.0164
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0084 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0105
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0101 0.0268
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0008 0.0008
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0084 0.0315 0.0315
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0252 0.0252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.023 0.023
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0483 0.0483
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0058 0.0346
Brugia malayi Steroid receptor seven-up type 2 0.0136 0.0529 0.0548
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0597 0.0597
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0178 0.124
Echinococcus multilocularis cpg binding protein 0.003 0.0086 0.0086
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0084 0.0315 0.0315
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0243 0.0974 0.2573
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0483 0.1275
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0084 0.0315 0.0326
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0058 0.006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0072 0.0262 0.0262
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0101 0.0101
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0042 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0101 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0105 0.073
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0084 0.0315 0.0315
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0101 0.014
Echinococcus granulosus lamin 0.0033 0.0099 0.0099
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0084 0.0315 0.0315
Echinococcus multilocularis dna polymerase eta 0.0017 0.0036 0.0036
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0029 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1434 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0252 0.0261
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0084 0.0315 0.0832
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0058 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0028
Schistosoma mansoni acetyl-CoA carboxylase 0.2409 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0136 0.0529 0.0548
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.162 0.162
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0136 0.0529 0.0548
Loa Loa (eye worm) RecQ helicase 0.0026 0.0071 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0113 0.0789
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0084 0.0315 0.0315
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0101 0.0101
Echinococcus granulosus nuclear receptor nhr 48 0.0064 0.023 0.023
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.051 0.1347
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0084 0.0315 0.0315
Schistosoma mansoni hypothetical protein 0.0337 0.1366 0.1366
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0036 0.005
Plasmodium vivax SET domain protein, putative 0.0037 0.0116 0.0161
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0101 0.0164
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0006 0.0006
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0682 0.18
Loa Loa (eye worm) hypothetical protein 0.0072 0.0262 0.0272
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0136 0.0529 0.0529
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.016 0.0955
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0084 0.0315 0.0436
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0136 0.0529 0.0529
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0065 0.0067
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0136 0.0529 0.0548
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0101 0.0101
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0918 0.3786 1
Brugia malayi ecdysteroid receptor 0.0136 0.0529 0.0548
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0918 0.3786 0.613
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0178 0.0246
Mycobacterium tuberculosis Probable reductase 0.0218 0.0873 0.2305
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0259 0.0259
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0101 0.0268
Loa Loa (eye worm) hypothetical protein 0.0136 0.0529 0.0548
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0058 0.0058
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0252 0.0252
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0101 0.014
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.051 0.0529
Trichomonas vaginalis rotamase, putative 0.0034 0.0105 0.073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1434 1
Echinococcus granulosus phd:f box containing protein 0.0019 0.0042 0.0042

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = -6.65 Beta-blocking activity measured by applying the stepwise linear discriminate analysis; Inactive ChEMBL. No reference
CC50 (ADMET) = 45.5 uM Cytotoxicity against CEM cells after 5 days by MTT method ChEMBL. 17376679
IC50 (functional) = 21 uM Antimicrobial activity against Plasmodium falciparum ChEMBL. 20185316
IC50 (binding) = 28 uM Inhibition of HIV1 recombinant integrase 3'-processing activity ChEMBL. 17376679
IC50 (binding) = 34 uM Inhibition of HIV1 recombinant integrase strand transfer activity ChEMBL. 17376679
MIC (functional) > 6.25 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis by agar dilution method ChEMBL. 17376679

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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