Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Zinc finger, C2H2 type family protein | 0.3446 | 0.3828 | 0.3771 |
Echinococcus multilocularis | geminin | 0.0197 | 0.01 | 0.0023 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3446 | 0.3828 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.8824 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3446 | 0.3828 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.8824 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0566 | 0.0524 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.8824 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3446 | 0.3828 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.3446 | 0.3828 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.01 | 0.0039 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3446 | 0.3828 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8824 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3446 | 0.3828 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.8824 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.8824 | 1 | 1 |
Brugia malayi | small heat shock protein | 0.0566 | 0.0524 | 0.0436 |
Echinococcus granulosus | geminin | 0.0197 | 0.01 | 0.0023 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8824 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3446 | 0.3828 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.01 | 0.0039 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.8824 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8824 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8824 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.8824 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3446 | 0.3828 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3446 | 0.3828 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.3446 | 0.3828 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.8824 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.8824 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.8824 | 1 | 0.5 |
Onchocerca volvulus | 0.011 | 0 | 0.5 | |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3446 | 0.3828 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T1/2 (ADMET) | = 34 min | Half life in human plasma at 5 mM by HPLC analysis | ChEMBL. | 23845282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.