Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0821 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0102 | 0.0413 | 0.0292 |
Brugia malayi | Protein kinase domain containing protein | 0.0362 | 0.3872 | 0.3688 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0507 | 0.581 | 0.581 |
Giardia lamblia | Pyruvate kinase | 0.0102 | 0.0413 | 0.0143 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0124 | 0.0698 | 0.0418 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0407 | 0.4482 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0102 | 0.0413 | 0.0125 |
Plasmodium falciparum | pyruvate kinase | 0.0102 | 0.0413 | 0.0125 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0362 | 0.3872 | 0.3688 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0314 | 0.3237 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0407 | 0.4482 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0314 | 0.3237 | 0.3033 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0821 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0314 | 0.3237 | 0.3033 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0102 | 0.0413 | 0.0125 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0821 | 1 | 1 |
Trypanosoma brucei | wee1-like protein kinase | 0.0124 | 0.0698 | 0.0418 |
Giardia lamblia | Hypothetical protein | 0.0727 | 0.8755 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0314 | 0.3237 | 0.3033 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0093 | 0.0292 | 0.0169 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0102 | 0.0413 | 0.0125 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0314 | 0.3237 | 0.3033 |
Loa Loa (eye worm) | pyruvate kinase | 0.0102 | 0.0413 | 0.0413 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0102 | 0.0413 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0102 | 0.0413 | 0.0125 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0102 | 0.0413 | 1 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0093 | 0.0292 | 0.0292 |
Chlamydia trachomatis | pyruvate kinase | 0.0102 | 0.0413 | 0.022 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0413 | 0.4565 | 0.4402 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0314 | 0.3237 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0821 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0821 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0314 | 0.3237 | 0.2945 |
Echinococcus granulosus | methionine synthase reductase | 0.0507 | 0.581 | 0.5684 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0821 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.0102 | 0.0413 | 0.0125 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0102 | 0.0413 | 1 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0124 | 0.0698 | 0.0418 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0124 | 0.0698 | 0.0418 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0727 | 0.8755 | 0.8701 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0102 | 0.0413 | 0.0125 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0727 | 0.8755 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0314 | 0.3237 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0507 | 0.581 | 0.5757 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0821 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0821 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0407 | 0.4482 | 0.4316 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0821 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0314 | 0.3237 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0507 | 0.581 | 0.5684 |
Plasmodium vivax | pyruvate kinase, putative | 0.0102 | 0.0413 | 0.0125 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0124 | 0.0698 | 0.0418 |
Schistosoma mansoni | pyruvate kinase | 0.0102 | 0.0413 | 0.0125 |
Brugia malayi | flavodoxin family protein | 0.0314 | 0.3237 | 0.3033 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0314 | 0.3237 | 0.2945 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0821 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0821 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0314 | 0.3237 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0102 | 0.0413 | 0.0289 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0821 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0821 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0821 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0102 | 0.0413 | 0.0413 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0102 | 0.0413 | 1 |
Leishmania major | pyruvate kinase | 0.0102 | 0.0413 | 0.0125 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0314 | 0.3237 | 0.2945 |
Echinococcus granulosus | pyruvate kinase | 0.0102 | 0.0413 | 0.0125 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0102 | 0.0413 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0314 | 0.3237 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0362 | 0.3872 | 0.3872 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0821 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0507 | 0.581 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0821 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0102 | 0.0413 | 0.0292 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0821 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0314 | 0.3237 | 0.3033 |
Leishmania major | cytochrome P450 reductase, putative | 0.0727 | 0.8755 | 0.8717 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0727 | 0.8755 | 0.8717 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0314 | 0.3237 | 0.3237 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0314 | 0.3237 | 0.2945 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0821 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0102 | 0.0413 | 0.0125 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0102 | 0.0413 | 0.0125 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0314 | 0.3237 | 0.3033 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0102 | 0.0413 | 0.0125 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0314 | 0.3237 | 0.3033 |
Leishmania major | p450 reductase, putative | 0.0821 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0821 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0821 | 1 | 1 |
Loa Loa (eye worm) | diaphorase | 0.0093 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0413 | 0.0413 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0124 | 0.0698 | 0.0418 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0314 | 0.3237 | 1 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0093 | 0.0292 | 0.0169 |
Echinococcus granulosus | pyruvate kinase | 0.0102 | 0.0413 | 0.0125 |
Brugia malayi | FAD binding domain containing protein | 0.0507 | 0.581 | 0.5684 |
Loa Loa (eye worm) | pyruvate kinase | 0.0102 | 0.0413 | 0.0413 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0821 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 47 % | Inhibition of mouse GAT1-mediated [3H]GABA uptake stably transfected in HEK293 cells assessed as residual uptake at 100 uM relative to control | ChEMBL. | 23859778 |
Activity (binding) | = 73 % | Inhibition of mouse GAT2-mediated [3H]GABA uptake stably transfected in HEK293 cells assessed as residual uptake at 100 uM relative to control | ChEMBL. | 23859778 |
Activity (binding) | = 95 % | Binding affinity to mouse GAT1 stably transfected in HEK293 cells assessed as residual binding at 100 uM relative to control | ChEMBL. | 23859778 |
IC50 (binding) | = 4.54 | Inhibition of mouse GAT3-mediated [3H]GABA uptake stably transfected in HEK293 cells | ChEMBL. | 23859778 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.