Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cytochrome P450 reductase | 0.00465612 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.00465612 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.00465612 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.00465612 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.00465612 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.00465612 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.00465612 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.00465612 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.00203271 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00465612 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.00465612 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.00465612 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.00203271 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.00465612 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.00465612 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.00465612 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.00465612 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.00300781 | 0.371693 | 0.371693 |
Brugia malayi | FAD binding domain containing protein | 0.00465612 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.00465612 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0042717 | 0.853467 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0026234 | 0.22516 | 0.22516 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.00465612 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.00465612 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.00300781 | 0.371693 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0042717 | 0.853467 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.00465612 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.00465612 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.00465612 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.00465612 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 59 uM | Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by XTT assay | ChEMBL. | 24594524 |
IC50 (functional) | = 840 nM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis | ChEMBL. | 24594524 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 24594524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.