Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAR-related orphan receptor C | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.9048 | 0.9527 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0268 | 0.9497 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0268 | 0.9497 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 33 nM | Inverse agonist activity at human RoRc-LBD expressed in cells assessed as SRC1 to 2 coactivator peptide recruitment | ChEMBL. | 24502334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.