Detailed information for compound 918893

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.514 | Formula: C25H28N4O4
  • H donors: 2 H acceptors: 3 LogP: 3.2 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(N(C(=O)c1c[nH]c(=O)cn1)C)C(=O)Nc1ccc(cc1)C(C)(C)C
  • InChi: 1S/C25H28N4O4/c1-25(2,3)17-8-10-18(11-9-17)28-23(31)22(16-6-12-19(33-5)13-7-16)29(4)24(32)20-14-27-21(30)15-26-20/h6-15,22H,1-5H3,(H,27,30)(H,28,31)
  • InChiKey: OKQMLFBKCQXXFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0071 0.007
Entamoeba histolytica hypothetical protein 0.0011 0.0046 0.0116
Plasmodium falciparum DNA repair protein REV1, putative 0.0022 0.0323 0.0707
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0122 0.0302
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0024 0.0375 0.0774
Echinococcus multilocularis 0.0012 0.0071 0.007
Brugia malayi hypothetical protein 0.002 0.0262 0.0457
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0262 0.0261
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0709 0.39
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0488 0.0487
Loa Loa (eye worm) helicase 0.0011 0.0046 0.0079
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0087 0.0086
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0169 0.3998 0.9864
Echinococcus multilocularis hexokinase type 2 0.0079 0.1745 0.1744
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0829 0.0828
Echinococcus multilocularis dna polymerase kappa 0.0098 0.2234 0.2233
Loa Loa (eye worm) hypothetical protein 0.003 0.0524 0.0915
Schistosoma mansoni DNA helicase recq1 0.0019 0.0228 0.0227
Loa Loa (eye worm) hypothetical protein 0.002 0.0262 0.0457
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0069
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0012 0.0071 0.007
Brugia malayi nuclear hormone receptor 0.0018 0.0209 0.0363
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0024 0.0375 0.0774
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0123
Schistosoma mansoni DNA helicase recq5 0.0019 0.0228 0.0227
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Echinococcus multilocularis dnaJ subfamily B 0.0408 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.2067 0.2067
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0734 0.1835
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0209 0.0521
Echinococcus granulosus choline O acetyltransferase 0.0163 0.3864 0.3863
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0024 0.0375 0.0374
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0098 0.2234 0.5587
Schistosoma mansoni chromobox protein 0.0011 0.0046 0.0045
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.3998 1
Brugia malayi Hexokinase family protein 0.0024 0.0376 0.0655
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0365 0.0749
Echinococcus granulosus dna polymerase eta 0.0097 0.2202 0.2201
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0709 0.39
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0046 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.1733 0.4233
Trypanosoma cruzi hexokinase, putative 0.0079 0.1745 0.4262
Trichomonas vaginalis hypothetical protein 0.0011 0.0046 0.0113
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0709 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0113
Plasmodium vivax hexokinase, putative 0.0079 0.1745 0.4302
Trypanosoma brucei unspecified product 0.0092 0.2069 0.5087
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0709 0.1237
Loa Loa (eye worm) hypothetical protein 0.0097 0.2202 0.3848
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0169 0.0168
Brugia malayi jmjC domain containing protein 0.0037 0.0682 0.119
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0209 0.0363
Toxoplasma gondii hexokinase 0.0079 0.1745 0.4305
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0332
Loa Loa (eye worm) hypothetical protein 0.0049 0.0989 0.1726
Loa Loa (eye worm) hypothetical protein 0.0137 0.3193 0.558
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0024 0.0375 0.0774
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0046 0.0114
Trypanosoma brucei chrX additional, unordered contigs 0.0022 0.0323 0.0641
Loa Loa (eye worm) hypothetical protein 0.002 0.0262 0.0457
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0171 0.4053 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0071 0.0176
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0209 0.0208
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0772 0.0771
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0641 0.064
Brugia malayi ecdysone receptor 0.0018 0.0209 0.0363
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0891 0.089
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0709 0.0708
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0741 0.1763
Leishmania major phosphoglycerate kinase B, cytosolic 0.0169 0.3998 1
Trichomonas vaginalis dullard protein, putative 0.0012 0.0071 0.0176
Leishmania major phosphoglycerate kinase C, glycosomal 0.0169 0.3998 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0375 0.0774
Echinococcus granulosus chromobox protein 1 0.0069 0.1496 0.1495
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Loa Loa (eye worm) choline O-acetyltransferase 0.0163 0.3864 0.6753
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0262 0.0261
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0046 0.0007
Loa Loa (eye worm) hypothetical protein 0.0169 0.3998 0.6987
Loa Loa (eye worm) hypothetical protein 0.005 0.1006 0.1757
Echinococcus multilocularis hexokinase 0.0079 0.1745 0.1744
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0228 0.04
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0046 0.0079
Schistosoma mansoni smad1 5 8 and 0.0016 0.0169 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1287 0.1286
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0709 0.0708
Echinococcus multilocularis chromobox protein 2 0.0011 0.0046 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0709 0.1237
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.039 0.0962
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0488 0.1204
Loa Loa (eye worm) hypothetical protein 0.0024 0.0375 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.2067 0.2067
Loa Loa (eye worm) hypothetical protein 0.0038 0.0709 0.1237
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0262 0.0261
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0709 0.1237
Brugia malayi steroid hormone receptor 0.0038 0.0709 0.1237
Echinococcus granulosus Chromobox protein 3 0.0011 0.0046 0.0045
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0087 0.0086
Echinococcus granulosus chromobox protein 2 0.0011 0.0046 0.0045
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0024 0.0375 0.0654
Echinococcus granulosus geminin 0.0168 0.3979 0.3979
Loa Loa (eye worm) RecQ helicase 0.0045 0.0891 0.1556
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0709 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0113
Plasmodium falciparum phd finger protein, putative 0.0029 0.0488 0.1124
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0209 0.0957
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0046 0.0113
Brugia malayi Smad1 0.0016 0.0169 0.0293
Trypanosoma cruzi hexokinase, putative 0.0079 0.1745 0.4262
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0046 0.0045
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0323 0.0641
Loa Loa (eye worm) hypothetical protein 0.0025 0.039 0.068
Brugia malayi PHD-finger family protein 0.0029 0.0488 0.0851
Schistosoma mansoni hypothetical protein 0.0168 0.3979 0.3979
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0024 0.0375 0.0774
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0024 0.0375 0.0774
Schistosoma mansoni smad1 5 8 and 0.0016 0.0169 0.0168
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0134 0.0332
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.2234 0.5508
Echinococcus multilocularis beta adrenergic receptor kinase 0.0092 0.2067 0.2067
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0375 0.0774
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0169 0.0168
Onchocerca volvulus 0.0018 0.0209 0.0957
Onchocerca volvulus 0.0024 0.0375 0.1936
Schistosoma mansoni cpg binding protein 0.003 0.0522 0.0521
Brugia malayi MH2 domain containing protein 0.0016 0.0169 0.0293
Onchocerca volvulus 0.0079 0.1745 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.1317 0.3173
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0829 0.2073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0209 0.0521
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0375 0.0774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0709 0.1237
Echinococcus granulosus dna polymerase kappa 0.0098 0.2234 0.2233
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0071 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0734 0.1835
Echinococcus granulosus Chromo domain 0.0011 0.0046 0.0045
Onchocerca volvulus 0.0024 0.0375 0.1936
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.3998 0.3997
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0046 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0709 0.0708
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0754 0.1797
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0209 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0709 0.1237
Echinococcus granulosus hexokinase 0.0079 0.1745 0.1744
Brugia malayi Choline O-acetyltransferase 0.0163 0.3864 0.6753
Brugia malayi hypothetical protein 0.0025 0.039 0.068
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.2139 0.2138
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0046 0.0045
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.1317 0.3173
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0741 0.1704
Giardia lamblia DNA damage repair protein 0.0022 0.0323 0.0641
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0046 0.0079
Onchocerca volvulus 0.0012 0.0062 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0901 0.09
Trichomonas vaginalis dullard protein, putative 0.0012 0.0071 0.0176
Entamoeba histolytica hypothetical protein 0.001 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.001 0.0001 0.0003
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0709 0.1237
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0176 0.4182 0.7309
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0734 0.4052
Loa Loa (eye worm) hypothetical protein 0.0054 0.1114 0.1946
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0682 0.0681
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.339 0.5925
Brugia malayi Phosphoglycerate kinase 0.0062 0.1317 0.2301
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0024 0.0375 0.0654
Brugia malayi nuclear receptor RXR 0.0018 0.0209 0.0363
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.001 0.0007 0.001
Echinococcus multilocularis chromobox protein 1 0.0069 0.1496 0.1495
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0209 0.0208
Trypanosoma brucei hexokinase, putative 0.0079 0.1745 0.4262
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.3998 1
Brugia malayi chromobox protein homolog 3 0.0039 0.0734 0.1282
Echinococcus granulosus beta-adrenergic receptor kinase 0.0092 0.2067 0.2067
Loa Loa (eye worm) hypothetical protein 0.002 0.0262 0.0457
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0709 0.0708
Brugia malayi ImpB/MucB/SamB family protein 0.0097 0.2202 0.3848
Trypanosoma cruzi DNA damage repair protein, putative 0.0022 0.0323 0.0641
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0071 0.007
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0709 0.0708
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0169 0.0168
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.039 0.0811
Trypanosoma brucei DNA polymerase IV, putative 0.0098 0.2234 0.5508
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0113
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0169 0.0293
Loa Loa (eye worm) hypothetical protein 0.002 0.0262 0.0457
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0709 0.0708
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0516 0.1274
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0169 0.0168
Entamoeba histolytica hexokinase 1 0.0079 0.1745 0.4364
Brugia malayi jmjC domain containing protein 0.0095 0.2139 0.3737
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.1317 0.3173
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0829 0.2073
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0709 0.1237
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.2139 0.2138
Brugia malayi Choline O-acetyltransferase 0.0163 0.3864 0.6753
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0024 0.0375 0.0654
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Leishmania major hexokinase, putative 0.0079 0.1745 0.4262
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0709 0.1237
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0228 0.0397
Loa Loa (eye worm) hypothetical protein 0.0019 0.0228 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0113
Loa Loa (eye worm) hypothetical protein 0.0038 0.0709 0.1237
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0488 0.1204
Trypanosoma brucei DNA polymerase IV, putative 0.0092 0.2069 0.5087
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0709 0.0708
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0044 0.0043
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0113
Schistosoma mansoni hexokinase 0.0079 0.1745 0.1744
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.039 0.0876
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0365 0.0749
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0488 0.0487
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0262 0.0457
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0209 0.0363
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0038 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0709 0.1237
Brugia malayi hypothetical protein 0.0016 0.0168 0.0291
Loa Loa (eye worm) hypothetical protein 0.0038 0.0709 0.1237
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0228 0.0227
Schistosoma mansoni hypothetical protein 0.0012 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0709 0.0708
Leishmania major DNA polymerase eta, putative 0.0097 0.2202 0.5427
Trypanosoma cruzi DNA polymerase eta, putative 0.0097 0.2202 0.5427
Plasmodium falciparum hexokinase 0.0079 0.1745 0.4302
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0022 0.0323 0.0797
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0901 0.09
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0682 0.0681
Brugia malayi SET domain containing protein 0.0012 0.0062 0.0107
Echinococcus granulosus G protein coupled receptor kinase 1 0.0082 0.1829 0.1828
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0046 0.0113
Brugia malayi nuclear receptor RXR 0.002 0.0262 0.0457
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0209 0.0208
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.039 0.0811
Brugia malayi polk-prov protein 0.0049 0.0989 0.1726
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.5721 1
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0219 0.0381
Loa Loa (eye worm) hexokinase 0.005 0.1006 0.1757
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0209 0.0521
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1213 0.2994
Schistosoma mansoni smad1 5 8 and 0.0016 0.0169 0.0168
Schistosoma mansoni phosphoglycerate kinase 0.0169 0.3998 0.3997
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0169 0.3998 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0209 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1173 0.2806
Schistosoma mansoni DNA polymerase eta 0.0097 0.2202 0.2201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0901 0.09
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.3998 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.339 0.339
Echinococcus multilocularis traf and tnf receptor associated protein 0.0176 0.4182 0.4181
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0808 0.202
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0079 0.1733 0.068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1173 0.2806
Brugia malayi nuclear receptor NHR-67 0.0018 0.0209 0.0363
Brugia malayi Phosphoglycerate kinase 0.0169 0.3998 0.6987
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Schistosoma mansoni nuclear receptor 0.0018 0.0209 0.0208
Trypanosoma brucei hexokinase 0.0079 0.1745 0.4262
Brugia malayi Hexokinase family protein 0.0079 0.1745 0.3048
Onchocerca volvulus 0.003 0.0524 0.2815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0709 0.1237
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0024 0.0375 0.0374
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0682 0.0681
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0488 0.0487
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0901 0.1573
Echinococcus multilocularis peregrin 0.0032 0.0577 0.0576
Onchocerca volvulus 0.0038 0.0709 0.39
Echinococcus granulosus chromobox protein 1 0.0069 0.1496 0.1495
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0262 0.0261
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0071 0.0176
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.039 0.0811
Loa Loa (eye worm) hypothetical protein 0.0038 0.0709 0.1237
Echinococcus granulosus hexokinase type 2 0.0079 0.1745 0.1744
Echinococcus granulosus jumonji domain containing protein 0.004 0.0772 0.0771
Schistosoma mansoni hypothetical protein 0.0408 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0709 0.0708
Onchocerca volvulus 0.0029 0.0481 0.2562
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0038 0.0037
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0709 0.0708
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0709 0.0708
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0209 0.0363
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0209 0.0363
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0709 0.1237
Mycobacterium ulcerans phosphoglycerate kinase 0.0169 0.3998 1
Leishmania major DNA polymerase kappa, putative 0.0022 0.0323 0.0641
Echinococcus granulosus bloom syndrome protein 0.0045 0.0891 0.089
Echinococcus granulosus hexokinase 0.0079 0.1745 0.1744
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0071 0.0176
Schistosoma mansoni nuclear receptor 0.0018 0.0209 0.0208
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0169 0.3998 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0957 0.2255
Brugia malayi Protein cec-1. 0.0011 0.0046 0.0079
Giardia lamblia DINP protein human, muc B family 0.0079 0.1733 0.4233
Loa Loa (eye worm) DR-78 0.0018 0.0209 0.0363
Schistosoma mansoni terminal deoxycytidyl transferase 0.0072 0.1568 0.1567
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0323 0.0641
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0024 0.0375 0.0374
Schistosoma mansoni choline o-acyltransferase 0.0024 0.0375 0.0374
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0323 0.0641
Echinococcus multilocularis phosphoglycerate kinase 1 0.0169 0.3998 0.3997
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0169 0.0168
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0709 0.0708
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0709 0.1237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0709 0.1237
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.1317 0.3173
Loa Loa (eye worm) hypothetical protein 0.0025 0.0393 0.0685
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0741 0.1852
Echinococcus granulosus hexokinase 0.0079 0.1745 0.1744
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0209 0.0521
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0209 0.0208
Schistosoma mansoni chromobox protein 0.0011 0.0046 0.0045
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0046 0.0007
Brugia malayi Bromodomain containing protein 0.0032 0.0577 0.1007
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0169 0.3998 0.9864
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0228 0.0563
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0072 0.1568 0.274
Brugia malayi hexokinase type II 0.0025 0.0393 0.0685
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0209 0.0208
Schistosoma mansoni hypothetical protein 0.0168 0.3979 0.3979
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0046 0.0113
Schistosoma mansoni cpg binding protein 0.003 0.0522 0.0521
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0024 0.0375 0.0774
Onchocerca volvulus 0.0018 0.0209 0.0957
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0709 0.0708
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0046 0.0007
Entamoeba histolytica hypothetical protein 0.0011 0.0046 0.0116
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0891 0.2226
Schistosoma mansoni chromobox protein 0.0069 0.1496 0.1495
Brugia malayi conserved hypotetical protein 0.0018 0.0209 0.0363
Loa Loa (eye worm) hypothetical protein 0.0039 0.0734 0.1282
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0262 0.0457
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0709 0.0708
Giardia lamblia PHD finger protein 15 0.0029 0.0488 0.1061
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0046 0.0045
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0024 0.0375 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0451 0.1125
Brugia malayi hexokinase 0.0079 0.1745 0.3048
Echinococcus multilocularis chromobox protein 1 0.0069 0.1496 0.1495
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0709 0.0708
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0209 0.0363
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0079
Onchocerca volvulus 0.0024 0.0375 0.1936
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0228 0.0227
Brugia malayi hypothetical protein 0.0018 0.0209 0.0363
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0169 0.0293
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0071 0.0178
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.2234 0.52
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0228 0.0397
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0709 0.1237
Loa Loa (eye worm) hypothetical protein 0.0163 0.3864 0.6753
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0375 0.0774
Onchocerca volvulus 0.0079 0.1745 1
Trypanosoma brucei DNA polymerase eta, putative 0.0097 0.2202 0.5427
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0709 0.0708
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0709 0.0708
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0709 0.1237
Brugia malayi nuclear hormone receptor 0.0038 0.0709 0.1237
Schistosoma mansoni choline o-acyltransferase 0.0163 0.3864 0.3863
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.1317 0.3173
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.1317 0.3173
Leishmania major hypothetical protein, conserved 0.0025 0.039 0.0811
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0082 0.1829 0.1828
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0071 0.0176
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0024 0.0375 0.0654
Echinococcus granulosus traf and tnf receptor associated protein 0.0176 0.4182 0.4181
Schistosoma mansoni cpg binding protein 0.0029 0.0481 0.048
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0209 0.0208
Loa Loa (eye worm) Smad1 0.0016 0.0169 0.0293
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0488 0.0851
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0901 0.1573
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0228 0.0397
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.1496 0.2614
Brugia malayi MH1 domain containing protein 0.0016 0.0169 0.0293
Brugia malayi MH2 domain containing protein 0.0237 0.5721 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0829 0.1987
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0007 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.1173 0.2806
Echinococcus multilocularis choline O acetyltransferase 0.0163 0.3864 0.3863
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0323 0.0641
Loa Loa (eye worm) hypothetical protein 0.0038 0.0709 0.1237
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0488 0.1204
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0046 0.0114
Brugia malayi nuclear receptor NHR-88 0.0038 0.0709 0.1237
Mycobacterium ulcerans DNA polymerase IV 0.0098 0.2234 0.52
Loa Loa (eye worm) hexokinase type II 0.0079 0.1745 0.3048
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0046 0.0079
Schistosoma mansoni zinc finger protein 0.0018 0.0209 0.0208
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0046 0.0045
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0046 0.0045
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0046 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0709 0.1237
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0046 0.0007
Trichomonas vaginalis dullard protein, putative 0.0012 0.0071 0.0176
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0709 0.0708
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Loa Loa (eye worm) hexokinase 0.0024 0.0376 0.0655
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0526 0.1219
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0169 0.3998 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0808 0.202
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0209 0.0363
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0365 0.0912
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0071 0.0123
Trypanosoma brucei hexokinase 0.0079 0.1745 0.4262
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.1317 0.3173
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0116
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0071 0.007
Schistosoma mansoni coup transcription factor 0.0038 0.0709 0.0708
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0024 0.0375 0.0774
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0365 0.0749
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0709 0.1237
Trypanosoma brucei unspecified product 0.005 0.1008 0.2385
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0209 0.0208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0901 0.09
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0891 0.1556
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0169 0.3998 0.5
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0046 0.0113
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1261 0.2202
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0113
Schistosoma mansoni hypothetical protein 0.0029 0.0488 0.0487
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0046 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0709 0.1237
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0079
Loa Loa (eye worm) acetyltransferase 0.0144 0.339 0.5925
Loa Loa (eye worm) hypothetical protein 0.0038 0.0709 0.1237
Entamoeba histolytica hexokinase 2 0.0079 0.1745 0.4364
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0228 0.0227
Onchocerca volvulus 0.0079 0.1745 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0709 0.39
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0481 0.084
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0654 0.0653
Leishmania major DNA polymerase kappa, putative 0.0079 0.1733 0.4233
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0709 0.0708
Leishmania major carnitine palmitoyltransferase-like protein 0.0024 0.0375 0.0774
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0365 0.0914
Loa Loa (eye worm) hypothetical protein 0.0038 0.0709 0.1237
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0024 0.0375 0.0654
Brugia malayi CXXC zinc finger family protein 0.0029 0.0481 0.084
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0046 0.0045
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0116
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0072 0.1568 0.1567
Entamoeba histolytica deoxycytidyl transferase, putative 0.0072 0.1568 0.3923
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0087 0.0086
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0087 0.0151
Trypanosoma brucei unspecified product 0.005 0.1008 0.2385
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0709 0.1237
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0024 0.0375 0.0374
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0375 0.0774
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0079
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.3289 0.3288
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0024 0.0375 0.0774
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0044 0.0043
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0709 0.0708
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0209 0.0208
Brugia malayi hypothetical protein 0.002 0.0262 0.0457
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0228 0.0227
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0173 0.4116 0.7193
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0046 0.0114
Trypanosoma cruzi DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0209 0.0363
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0209 0.0208
Echinococcus multilocularis smad 0.0016 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0116
Plasmodium vivax DNA repair protein REV1, putative 0.0022 0.0323 0.0707
Treponema pallidum phosphoglycerate kinase 0.0169 0.3998 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0209 0.0521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0393 0.0685
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0024 0.0375 0.0774
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0709 0.0708
Brugia malayi Heterochromatin protein 1 0.0069 0.1496 0.2614
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0901 0.09
Echinococcus multilocularis Chromo domain 0.0011 0.0046 0.0045
Leishmania major DNA damage repair protein, putative 0.0022 0.0323 0.0641
Brugia malayi Hexokinase family protein 0.005 0.1006 0.1757
Schistosoma mansoni hypothetical protein 0.0011 0.0046 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0062 0.0061
Brugia malayi MH1 domain containing protein 0.0016 0.0169 0.0293
Leishmania major DNA polymerase eta, putative 0.0048 0.0957 0.2255
Schistosoma mansoni smad 0.0016 0.0169 0.0168
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1496 0.3741
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0709 0.1237
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0209 0.0208
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0323 0.0641
Onchocerca volvulus 0.005 0.1006 0.5651
Brugia malayi hypothetical protein 0.0018 0.0209 0.0363
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0209 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0989 0.2336
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0024 0.0375 0.0774
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1496 0.3741
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0709 0.0708
Echinococcus multilocularis geminin 0.0168 0.3979 0.3979
Echinococcus granulosus phosphoglycerate kinase 1 0.0169 0.3998 0.3997
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.039 0.0876
Brugia malayi MH2 domain containing protein 0.0016 0.0169 0.0293
Leishmania major hexokinase, putative 0.0079 0.1745 0.4262
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0228 0.0563
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0209 0.0363
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0209 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0709 0.0708
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0079
Echinococcus multilocularis Smad4 0.0016 0.0169 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0113
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0071 0.007
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0024 0.0375 0.0774
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.5721 1
Trypanosoma brucei DNA damage repair protein, putative 0.0022 0.0323 0.0641
Plasmodium falciparum phosphoglycerate kinase 0.0169 0.3998 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0209 0.0208
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.339 0.339
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0709 0.0708
Brugia malayi CHD4 protein 0.0013 0.0087 0.0151
Loa Loa (eye worm) hexokinase 0.0079 0.1745 0.3048
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0709 0.0708
Trypanosoma brucei phosphoglycerate kinase 0.0169 0.3998 1
Echinococcus multilocularis hexokinase 0.0079 0.1745 0.1744
Plasmodium vivax phosphoglycerate kinase, putative 0.0169 0.3998 1
Brugia malayi ecdysteroid receptor 0.0038 0.0709 0.1237
Leishmania major carnitine/choline acetyltransferase, putative 0.0024 0.0375 0.0774
Echinococcus multilocularis dna polymerase eta 0.0097 0.2202 0.2201
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.039 0.0876
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0709 0.1237
Schistosoma mansoni jumonji domain containing protein 0.0075 0.165 0.1649
Schistosoma mansoni hypothetical protein 0.0011 0.0044 0.0043
Loa Loa (eye worm) hexokinase 0.0079 0.1745 0.3048
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0375 0.0774
Echinococcus granulosus cpg binding protein 0.003 0.0522 0.0521
Chlamydia trachomatis phosphoglycerate kinase 0.0169 0.3998 0.5
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0891 0.2226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0901 0.09
Onchocerca volvulus Hexokinase homolog 0.005 0.1006 0.5651
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0209 0.0521
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0072 0.1568 0.1567
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.2234 0.5508
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0957 0.2361
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0024 0.0375 0.0774
Loa Loa (eye worm) hypothetical protein 0.002 0.0262 0.0457
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0709 0.0708
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0228 0.0467
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0169 0.3998 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0113
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0808 0.4486
Schistosoma mansoni DNA polymerase IV / kappa 0.0022 0.0323 0.0322
Onchocerca volvulus Alhambra homolog 0.0029 0.0488 0.2601
Brugia malayi hypothetical protein 0.0011 0.0046 0.0079
Loa Loa (eye worm) hypothetical protein 0.0029 0.0488 0.0851
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0829 0.2046
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0709 0.0708
Schistosoma mansoni chromobox protein 0.0069 0.1496 0.1495
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0451 0.1125
Echinococcus multilocularis hexokinase 0.0079 0.1745 0.1744
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0092 0.2067 0.3612
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0682 0.119
Brugia malayi nuclear receptor NHR-88 0.0018 0.0209 0.0363
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0113
Brugia malayi tailless protein 0.0018 0.0209 0.0363
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.1317 0.3173
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0709 0.1237
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0072 0.1568 0.1567
Entamoeba histolytica hypothetical protein 0.0011 0.0046 0.0116
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0071 0.007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0178 0.0177
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.001 0.0007 0.001
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0829 0.2046
Entamoeba histolytica phosphoglycerate kinase, putative 0.0169 0.3998 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0262 0.0457
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0209 0.0957
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0323 0.0641
Brugia malayi PHD-finger family protein 0.0011 0.0041 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0709 0.1237
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0709 0.1237
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.1568 0.274
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0209 0.0208
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0079 0.1733 0.4233
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0209 0.0208
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0209 0.0521
Onchocerca volvulus 0.0024 0.0375 0.1936
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0116
Loa Loa (eye worm) hypothetical protein 0.0038 0.0709 0.1237
Entamoeba histolytica hypothetical protein 0.001 0.0001 0.0003
Giardia lamblia Phosphoglycerate kinase 0.0169 0.3998 1
Schistosoma mansoni Smad4 0.0016 0.0169 0.0168
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0488 0.1124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0901 0.09
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0209 0.0521
Loa Loa (eye worm) hypothetical protein 0.0018 0.0209 0.0363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0709 0.0708
Echinococcus granulosus smad 0.0016 0.0169 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0989 0.2336
Echinococcus multilocularis cpg binding protein 0.003 0.0522 0.0521
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0209 0.0208
Echinococcus granulosus Smad4 0.0016 0.0169 0.0168
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0071 0.007
Echinococcus granulosus peregrin 0.0032 0.0577 0.0576
Trichomonas vaginalis DNA polymerase eta, putative 0.0098 0.2234 0.5587

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 79 % Agonist activity at human RoRc-LBD in human PBMC cells assessed as inhibition of IL-17A production at 10 uM by luciferase assay ChEMBL. 24502334
Inhibition (binding) = 85 % Inverse agonist activity at human RoRc-LBD fusion protein with GST expressed in BL-21 (BL3) cells assessed as SRC1 coactivator peptide recruitment at 1 uM relative to control ChEMBL. 24502334
Inhibition (binding) = 93 % Inverse agonist activity at human RoRc in human Jurkat cells with RORE construct assessed as inhibition of IL-17 promoter at 3 uM relative to control ChEMBL. 24502334
Inhibition (binding) = 95 % Activity at RoRc in mouse CD4+ T cells assessed as inhibition of IL-17 production at 10 uM ChEMBL. 24502334

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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