Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RAR-like nuclear receptor | 0.0058 | 0.0383 | 0.0152 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0207 | 0.4574 | 0.4358 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.7963 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0058 | 0.0383 | 0.7963 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0058 | 0.0383 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0399 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0149 | 0.2942 | 0.2661 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0174 | 0.3665 | 0.3413 |
Schistosoma mansoni | thyroid hormone receptor | 0.0207 | 0.4574 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0058 | 0.0383 | 0.0152 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0058 | 0.0383 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0058 | 0.0383 | 0.7963 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0058 | 0.0383 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0058 | 0.0383 | 0.0152 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0058 | 0.0383 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0058 | 0.0383 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0058 | 0.0383 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0144 | 0.2803 | 0.2516 |
Schistosoma mansoni | nuclear hormone receptor | 0.0058 | 0.0383 | 0.0152 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0058 | 0.0383 | 0.0152 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0058 | 0.0383 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0058 | 0.0383 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0058 | 0.0383 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0448 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0058 | 0.0383 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0058 | 0.0383 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0149 | 0.2942 | 0.2661 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0058 | 0.0383 | 0.7963 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0058 | 0.0383 | 0.7963 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0058 | 0.0383 | 0.7963 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0058 | 0.0383 | 0.7963 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.013 | 0.3382 |
Onchocerca volvulus | 0.0058 | 0.0398 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0058 | 0.0383 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.0398 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.7963 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0058 | 0.0383 | 0.0152 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0448 | 0.0067 |
Brugia malayi | nuclear hormone receptor | 0.0058 | 0.0383 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.7963 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0448 | 0.0067 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0058 | 0.0383 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.7963 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0174 | 0.3665 | 0.7864 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0058 | 0.0383 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0058 | 0.0383 | 0.0152 |
Brugia malayi | steroid hormone receptor | 0.0058 | 0.0383 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0058 | 0.0383 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.7963 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.7963 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.7963 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0058 | 0.0383 | 0.7963 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.2942 | 0.6166 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0058 | 0.0383 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0058 | 0.0383 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0383 | 0.7963 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0058 | 0.0383 | 0.0152 |
Brugia malayi | nuclear receptor NHR-88 | 0.0058 | 0.0383 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0398 | 0.8424 |
Schistosoma mansoni | thyroid hormone receptor | 0.0207 | 0.4574 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0058 | 0.0383 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0058 | 0.0383 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0058 | 0.0383 | 0.7963 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 48 % | Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in 100 uM glutamate-induced calcium mobilization at 30 uM | ChEMBL. | 24969015 |
IC50 (binding) | > 5 | Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilization | ChEMBL. | 24969015 |
IC50 (binding) | > 10000 nM | Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilization | ChEMBL. | 24969015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.