Detailed information for compound 919082

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 353.282 | Formula: C17H9F2N5O2
  • H donors: 1 H acceptors: 5 LogP: 1.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc(F)cc(c1)C(=O)Nc1cncc(n1)Oc1cncc(c1)F
  • InChi: 1S/C17H9F2N5O2/c18-12-2-10(5-20)1-11(3-12)17(25)24-15-8-22-9-16(23-15)26-14-4-13(19)6-21-7-14/h1-4,6-9H,(H,23,24,25)
  • InChiKey: ITKIAAYGUOMIGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0578 0.0313
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.2384 0.2619
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0506 0.0556
Brugia malayi ShTK domain containing protein 0.0092 0.2695 0.2605
Loa Loa (eye worm) hypothetical protein 0.0035 0.0569 0.0454
Loa Loa (eye worm) hypothetical protein 0.0036 0.0578 0.0463
Loa Loa (eye worm) hypothetical protein 0.0028 0.0287 0.0168
Echinococcus multilocularis Squalene phytoene synthase 0.0082 0.2311 0.4047
Brugia malayi nuclear receptor NHR-88 0.0028 0.0287 0.0168
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0095 0.2812 0.5014
Onchocerca volvulus 0.0036 0.0578 0.1466
Loa Loa (eye worm) hypothetical protein 0.0028 0.0287 0.0168
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0095 0.2812 0.5014
Brugia malayi nuclear hormone receptor 0.0028 0.0287 0.0168
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0287 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0578 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.2384 0.2619
Trypanosoma brucei unspecified product 0.007 0.1878 0.2063
Brugia malayi intermediate filament protein 0.0026 0.0215 0.0095
Trypanosoma cruzi phytoene synthase, putative 0.0082 0.2311 0.2245
Brugia malayi bZIP transcription factor family protein 0.0088 0.2542 0.2451
Leishmania major fructose-1,6-bisphosphate aldolase 0.0095 0.2812 0.2816
Trichomonas vaginalis DNA polymerase eta, putative 0.0084 0.2384 0.1917
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0287 0.0074
Loa Loa (eye worm) glutaminase 2 0.0286 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0287 0.0139
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0084 0.2384 0.1917
Loa Loa (eye worm) hypothetical protein 0.0028 0.0287 0.0168
Onchocerca volvulus 0.0092 0.2695 1
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0095 0.2812 0.2816
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0851 0.0677
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0287 0.0074
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0095 0.2812 0.2816
Loa Loa (eye worm) hypothetical protein 0.0036 0.0578 0.0463
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0095 0.2812 0.2816
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0913 0.0355
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0287 0.0074
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0287 0.0291
Brugia malayi steroid hormone receptor 0.0028 0.0287 0.0168
Loa Loa (eye worm) ShTK domain-containing protein 0.0092 0.2695 0.2605
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0578 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.2384 0.2619
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0287 0.0074
Loa Loa (eye worm) hypothetical protein 0.003 0.0345 0.0227
Leishmania major squalene synthase, putative 0.0262 0.9105 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.2384 0.2328
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0092 0.2695 0.2605
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0287 0.0168
Trypanosoma cruzi squalene synthase, putative 0.0262 0.9105 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.4782 0.8818
Loa Loa (eye worm) tyrosinase 1 0.0092 0.2695 0.2605
Mycobacterium leprae Probable lipase LipE 0.0036 0.0578 0.5
Onchocerca volvulus 0.0092 0.2695 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0578 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0287 0.0168
Loa Loa (eye worm) hypothetical protein 0.0082 0.2311 0.2217
Echinococcus multilocularis dna polymerase eta 0.003 0.0345 0.0251
Schistosoma mansoni hypothetical protein 0.0164 0.5394 0.5293
Mycobacterium tuberculosis Conserved protein 0.0036 0.0578 0.0313
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0578 0.0313
Loa Loa (eye worm) hypothetical protein 0.0028 0.0287 0.0168
Schistosoma mansoni hypothetical protein 0.0082 0.2311 0.2142
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0578 0.0702
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0287 0.0291
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0287 0.0139
Loa Loa (eye worm) acetyltransferase 0.0152 0.4942 0.4881
Loa Loa (eye worm) hypothetical protein 0.0063 0.1619 0.1517
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0913 0.1498
Brugia malayi hypothetical protein 0.0038 0.0651 0.0537
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0095 0.2812 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0287 0.0168
Loa Loa (eye worm) hypothetical protein 0.0028 0.0287 0.0168
Onchocerca volvulus 0.0036 0.0578 0.1466
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0287 0.0074
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.003 0.0345 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.1619 0.1778
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0651 0.0843
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.4942 0.9127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0287 0.0168
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0913 0.3036
Mycobacterium ulcerans glutaminase 0.0286 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0287 0.0168
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0287 0.0139
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0287 0.0139
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0345 0.0227
Loa Loa (eye worm) hypothetical protein 0.0028 0.0287 0.0168
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.003 0.0345 0.0251
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0095 0.2812 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0215 0.0095
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0287 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0506 0.0556
Plasmodium falciparum fructose-bisphosphate aldolase 0.0095 0.2812 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0913 0.0355
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0578 0.0635
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1187 0.108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0287 0.0168
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0088 0.2542 0.4492
Echinococcus granulosus dna polymerase kappa 0.0084 0.2384 0.4189
Schistosoma mansoni hypothetical protein 0.0038 0.0651 0.0446
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.2384 0.2619
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0095 0.2812 0.2654
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0773 1
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0095 0.2812 0.2724
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0287 0.0168
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0287 0.0168
Brugia malayi polk-prov protein 0.0063 0.1619 0.1517
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0095 0.2812 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0851 0.0578
Entamoeba histolytica hypothetical protein 0.0038 0.0651 0.7155
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0651 0.0446
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.2384 0.2328
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0092 0.2695 0.2605
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.2384 0.2619
Echinococcus granulosus dna polymerase eta 0.003 0.0345 0.0251
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0578 0.0702
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0345 0.0227
Trypanosoma brucei DNA polymerase eta, putative 0.003 0.0345 0.0378
Brugia malayi beta-lactamase family protein 0.0036 0.0578 0.0463
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0088 0.2542 0.4492
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0506 0.0556
Loa Loa (eye worm) glutaminase 0.0286 1 1
Entamoeba histolytica hypothetical protein 0.0038 0.0651 0.7155
Schistosoma mansoni hypothetical protein 0.0035 0.0569 0.0362
Mycobacterium ulcerans phytoene synthase, CrtB 0.0082 0.2311 0.1839
Echinococcus multilocularis dna polymerase kappa 0.0084 0.2384 0.4189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0287 0.0139
Loa Loa (eye worm) beta-lactamase 0.0036 0.0578 0.0463
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.8307 0.8287
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0095 0.2812 0.2816
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0578 0.5
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0095 0.2812 0.5014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0287 0.0168
Onchocerca volvulus 0.0036 0.0578 0.1466
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0287 0.0074
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.2384 0.1917
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0287 0.0139
Trypanosoma brucei squalene synthase, putative 0.0262 0.9105 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0287 0.0168
Schistosoma mansoni tyrosinase precursor 0.0092 0.2695 0.2534
Echinococcus granulosus geminin 0.0164 0.5394 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.003 0.0345 0.0227
Leishmania major hypothetical protein, conserved 0.0082 0.2311 0.2245
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1187 0.108
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0082 0.2311 0.263
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0215 0.0095
Loa Loa (eye worm) hypothetical protein 0.0036 0.0578 0.0463
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0578 0.0313
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0578 0.0313
Schistosoma mansoni jun-related protein 0.0071 0.1922 0.1745
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0287 0.0168
Leishmania major DNA polymerase kappa, putative 0.0043 0.0851 0.0578
Trypanosoma brucei DNA polymerase IV, putative 0.007 0.1878 0.2063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0287 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.2384 0.2619
Loa Loa (eye worm) hypothetical protein 0.0052 0.1187 0.108
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0287 0.0074
Entamoeba histolytica hypothetical protein 0.0038 0.0651 0.7155
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.2384 0.2619
Schistosoma mansoni tyrosinase precursor 0.0092 0.2695 0.2534
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0569 0.0454
Onchocerca volvulus 0.0092 0.2695 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0287 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0287 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.2384 0.2619
Echinococcus granulosus Squalene phytoene synthase 0.0082 0.2311 0.4047
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0287 0.0168
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0095 0.2812 1
Echinococcus multilocularis jun protein 0.0088 0.2542 0.4492
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0095 0.2812 0.5014
Brugia malayi follicle stimulating hormone receptor 0.0241 0.8307 0.8287
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0287 0.0139
Trypanosoma cruzi squalene synthase, putative 0.0262 0.9105 1
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0082 0.2311 0.8453
Brugia malayi beta-lactamase 0.0036 0.0578 0.0463
Loa Loa (eye worm) hypothetical protein 0.0036 0.0578 0.0463
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0287 0.0168
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0578 0.0313
Schistosoma mansoni terminal deoxycytidyl transferase 0.003 0.0345 0.0133
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0287 0.0139
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0095 0.2812 0.5014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0287 0.0168
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0287 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.0578 0.0463
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0287 0.0139
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0578 0.0313
Echinococcus multilocularis geminin 0.0164 0.5394 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0287 0.0074
Giardia lamblia DINP protein human, muc B family 0.0043 0.0851 1
Brugia malayi fructose-bisphosphate aldolase 2 0.0095 0.2812 0.2724
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.1619 0.1778
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0095 0.2812 0.5014
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.2384 0.2619
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0287 0.0291
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.2384 0.2328
Schistosoma mansoni glutaminase 0.0286 1 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0092 0.2695 0.2605
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0287 0.0168
Echinococcus granulosus jun protein 0.0088 0.2542 0.4492
Brugia malayi Common central domain of tyrosinase family protein 0.0092 0.2695 0.2605
Leishmania major hypothetical protein, conserved 0.0036 0.0578 0.0267
Onchocerca volvulus 0.0028 0.0287 0.0291
Schistosoma mansoni DNA polymerase eta 0.003 0.0345 0.0133
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.2384 0.2619
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0287 0.0139
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.4942 0.4881
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0287 0.0168
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.003 0.0345 0.0133
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0095 0.2812 0.5014
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0578 0.0463
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1187 0.108
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0287 0.0139
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0092 0.2695 0.2605
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0913 0.1348
Schistosoma mansoni coup transcription factor 0.0028 0.0287 0.0074
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0095 0.2812 0.5014
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0851 0.0934
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0287 0.0168
Schistosoma mansoni hypothetical protein 0.0071 0.1922 0.1745
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.2384 0.2328
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.2384 0.1917
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0287 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0578 0.0267
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0913 0.3036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0287 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0287 0.0168
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0092 0.2695 0.2605
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0287 0.0074
Entamoeba histolytica hypothetical protein 0.0038 0.0651 0.7155
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0578 0.0463
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0287 0.0168
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0095 0.2812 0.2724
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.782 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0287 0.0139
Mycobacterium tuberculosis Conserved protein 0.0036 0.0578 0.0313
Trichomonas vaginalis glutaminase, putative 0.0286 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.4942 0.4831
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0287 0.0168
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0651 0.0843
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0578 0.0313
Onchocerca volvulus 0.0092 0.2695 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0215 0.0095
Brugia malayi beta-lactamase family protein 0.0036 0.0578 0.0463
Schistosoma mansoni hypothetical protein 0.0164 0.5394 0.5293
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0095 0.2812 0.3088
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0287 0.0074
Mycobacterium tuberculosis Conserved protein 0.0036 0.0578 0.0313
Loa Loa (eye worm) hypothetical protein 0.0085 0.2451 0.2359
Loa Loa (eye worm) hypothetical protein 0.0092 0.2695 0.2605
Brugia malayi hypothetical protein 0.0069 0.1831 0.1732
Onchocerca volvulus 0.0069 0.1831 0.6519
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0287 0.0139
Brugia malayi fructose-bisphosphate aldolase 1 0.0095 0.2812 0.2724
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0287 0.0074
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0287 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.2384 0.2619
Loa Loa (eye worm) hypothetical protein 0.0092 0.2695 0.2605
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0287 0.0168
Toxoplasma gondii ABC1 family protein 0.0036 0.0578 0.1809
Loa Loa (eye worm) hypothetical protein 0.0036 0.0578 0.0463
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0077
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0215 0.0095
Brugia malayi ecdysteroid receptor 0.0028 0.0287 0.0168
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0095 0.2812 0.2654
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0287 0.0139
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0287 0.0168

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 4.5 Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilization ChEMBL. 24969015
IC50 (binding) > 30000 nM Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilization ChEMBL. 24969015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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