TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 475.321 | Formula: C23H20Cl2N2O5
H donors: 1 H acceptors: 3 LogP: 4.2 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1OC)OCC(=O)Nc1ccccc1)C(=O)Cc1c(Cl)cncc1Cl
InChi: 1S/C23H20Cl2N2O5/c1-30-20-9-8-15(19(28)10-16-17(24)11-26-12-18(16)25)22(23(20)31-2)32-13-21(29)27-14-6-4-3-5-7-14/h3-9,11-12H,10,13H2,1-2H3,(H,27,29)
InChiKey: HOMXWYBOLCQCME-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0507	0.0684	0.0603
Brugia malayi	hypothetical protein	0.0507	0.0684	0.2437
Echinococcus granulosus	jumonji domain containing 1A	0.0019	0.0005	0.0017
Brugia malayi	Carboxylesterase family protein	0.0344	0.0457	0.1627
Echinococcus granulosus	PHD finger protein rhinoceros	0.0058	0.006	0.0212
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0507	0.0684	0.2437
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0058	0.006	0.0212
Brugia malayi	jmjC domain containing protein	0.0019	0.0005	0.0017
Echinococcus granulosus	neuroligin	0.0344	0.0457	0.1627
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.0372	0.7922
Loa Loa (eye worm)	hypothetical protein	0.0507	0.0684	0.2437
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0023	0.008
Echinococcus granulosus	acetylcholinesterase	0.2035	0.2809	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0457	0.1627
Brugia malayi	jmjC domain containing protein	0.0019	0.0005	0.0017
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0019	0.0005	0.0071
Brugia malayi	AF-10 protein	0.0019	0.0005	0.0018
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0019	0.0005	0.0071
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0078	0.0087	0.1268
Echinococcus multilocularis	acetylcholinesterase	0.2035	0.2809	1
Echinococcus granulosus	jumonji domain containing protein	0.0081	0.0091	0.0325
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0019	0.0005	0.0071
Schistosoma mansoni	hypothetical protein	0.0031	0.0023	0.008
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0019	0.0005	0.0598
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0507	0.0684	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0138	0.0171	0.1563
Schistosoma mansoni	hypothetical protein	0.0031	0.0023	0.008
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0344	0.0457	0.0492
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.0115	0.041
Onchocerca volvulus		0.0507	0.0684	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0005	0.0017
Treponema pallidum	fructose-bisphosphate aldolase	0.0282	0.0372	0.5
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0048	0.0046	0.0163
Echinococcus multilocularis	peregrin	0.0058	0.006	0.0212
Giardia lamblia	Fructose-bisphosphate aldolase	0.0282	0.0372	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0344	0.0457	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0019	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0117	0.0417
Onchocerca volvulus		0.0344	0.0457	0.6582
Loa Loa (eye worm)	hypothetical protein	0.0507	0.0684	0.2437
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0344	0.0457	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0078	0.0087	0.1268
Brugia malayi	Carboxylesterase family protein	0.0344	0.0457	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0005	0.0017
Loa Loa (eye worm)	acetylcholinesterase 1	0.2035	0.2809	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.019	0.0244	0.0867
Schistosoma mansoni	protein phosphatase 2C	0.0019	0.0005	0.0017
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0507	0.0684	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0078	0.0087	0.0309
Schistosoma mansoni	phosphatidylserine receptor	0.0019	0.0005	0.0017
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0019	0.0067
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0344	0.0457	0.1627
Brugia malayi	intracellular kinase	0.0048	0.0046	0.0163
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0344	0.0457	0.1627
Brugia malayi	Bromodomain containing protein	0.0058	0.006	0.0212
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0507	0.0684	1
Mycobacterium ulcerans	monoamine oxidase	0.0507	0.0684	0.0603
Brugia malayi	Carboxylesterase family protein	0.0344	0.0457	0.1627
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0048	0.0046	0.0671
Brugia malayi	Carboxylesterase family protein	0.2035	0.2809	1
Schistosoma mansoni	inositol monophosphatase	0.0078	0.0087	0.0309
Mycobacterium tuberculosis	Possible oxidoreductase	0.0507	0.0684	0.0736
Schistosoma mansoni	jumonji domain containing protein	0.0019	0.0005	0.0017
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0282	0.0372	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0073	0.0261
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.002	0.0007	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0457	0.1627
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0023	0.008
Onchocerca volvulus		0.0229	0.0297	0.418
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0078	0.0087	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0507	0.0684	0.0736
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0048	0.0046	0.0163
Plasmodium vivax	hypothetical protein, conserved	0.0507	0.0684	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0019	0.0067
Toxoplasma gondii	PHD-finger domain-containing protein	0.0058	0.006	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0457	0.1627
Echinococcus multilocularis	lysine specific demethylase 6a	0.0019	0.0005	0.0017
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0282	0.0372	1
Loa Loa (eye worm)	hypothetical protein	0.0507	0.0684	0.2437
Echinococcus multilocularis	jumonji domain containing 1A	0.0019	0.0005	0.0017
Loa Loa (eye worm)	jmjC domain-containing protein	0.007	0.0077	0.0273
Brugia malayi	PHD-finger family protein	0.0058	0.006	0.0212
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0019	0.0005	0.0017
Echinococcus granulosus	para nitrobenzyl esterase	0.0344	0.0457	0.1627
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0048	0.0046	0.0671
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0078	0.0087	0.1256
Onchocerca volvulus		0.0344	0.0457	0.6582
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.0115	0.041
Leishmania major	hypothetical protein, conserved	0.0019	0.0005	0.0071
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0344	0.0457	0.1627
Schistosoma mansoni	jumonji domain containing protein	0.0151	0.0189	0.0673
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0019	0.0005	0.0017
Brugia malayi	jmjC domain containing protein	0.0019	0.0005	0.0017
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.7203	1	1
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0019	0.0005	0.056
Loa Loa (eye worm)	inositol-1	0.0078	0.0087	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0134	0.0477
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0048	0.0046	0.0671
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0023	0.008
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0507	0.0684	0.2437
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0507	0.0684	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.007	0.0077	0.0273
Brugia malayi	Carboxylesterase family protein	0.0344	0.0457	0.1627
Onchocerca volvulus		0.0048	0.0046	0.0406
Brugia malayi	F/Y-rich N-terminus family protein	0.002	0.0007	0.0024
Echinococcus multilocularis	carboxylesterase 5A	0.2035	0.2809	1
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0507	0.0684	0.5
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0138	0.0171	0.0085
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0019	0.0276
Echinococcus multilocularis	geminin	0.0164	0.0207	0.0735
Echinococcus granulosus	JmjC domain containing protein 4	0.0019	0.0005	0.0017
Echinococcus granulosus	phd:f box containing protein	0.0019	0.0005	0.0017
Plasmodium vivax	hypothetical protein, conserved	0.0019	0.0005	0.0076
Onchocerca volvulus	Alhambra homolog	0.0058	0.006	0.0612
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0019	0.0005	0.0071
Brugia malayi	amine oxidase, flavin-containing family protein	0.0507	0.0684	0.2437
Loa Loa (eye worm)	carboxylesterase	0.0344	0.0457	0.1627
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.0115	0.041
Schistosoma mansoni	hypothetical protein	0.0068	0.0073	0.0261
Onchocerca volvulus		0.0344	0.0457	0.6582
Schistosoma mansoni	hypothetical protein	0.0019	0.0005	0.0018
Echinococcus multilocularis	para nitrobenzyl esterase	0.0344	0.0457	0.1627
Brugia malayi	hypothetical protein	0.0344	0.0457	0.1627
Onchocerca volvulus		0.0344	0.0457	0.6582
Loa Loa (eye worm)	hypothetical protein	0.0507	0.0684	0.2437
Echinococcus granulosus	peregrin	0.0058	0.006	0.0212
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.0117	0.0417
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0048	0.0046	0.0163
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0005	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0005	0.0018
Mycobacterium ulcerans	oxidoreductase	0.0507	0.0684	0.0603
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.0372	0.7922
Schistosoma mansoni	acetylcholinesterase	0.0344	0.0457	0.1627
Schistosoma mansoni	gliotactin	0.0344	0.0457	0.1627
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0507	0.0684	0.2437
Echinococcus granulosus	protein kinase shaggy	0.0048	0.0046	0.0163
Schistosoma mansoni	hypothetical protein	0.0164	0.0207	0.0735
Echinococcus granulosus	lysine specific demethylase 5A	0.007	0.0077	0.0273
Trichomonas vaginalis	inositol monophosphatase, putative	0.0078	0.0087	0.0995
Echinococcus multilocularis	JmjC domain containing protein 4	0.0019	0.0005	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0507	0.0684	0.2437
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.0372	0.7922
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.0115	0.041
Onchocerca volvulus		0.0344	0.0457	0.6582
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0019	0.0005	0.0071
Plasmodium vivax	hypothetical protein, conserved	0.0507	0.0684	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0019	0.0005	0.0076
Loa Loa (eye worm)	jmjC domain-containing protein	0.012	0.0146	0.0519
Toxoplasma gondii	PHD-finger domain-containing protein	0.0058	0.006	0.0871
Trichomonas vaginalis	spcc417.12 protein, putative	0.0344	0.0457	1
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0507	0.0684	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0507	0.0684	0.2437
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0134	0.0477
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0507	0.0684	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0344	0.0457	0.0492
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0019	0.0067
Plasmodium vivax	SET domain protein, putative	0.0029	0.0019	0.0276
Schistosoma mansoni	hypothetical protein	0.0058	0.006	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0073	0.0261
Echinococcus granulosus	lysine specific demethylase 6a	0.0019	0.0005	0.0017
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0507	0.0684	0.2437
Mycobacterium ulcerans	carboxylesterase, LipT	0.0344	0.0457	0.0373
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0019	0.0067
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0019	0.0067
Brugia malayi	jmjC domain containing protein	0.019	0.0244	0.0867
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.0117	0.0417
Brugia malayi	Pre-SET motif family protein	0.0201	0.0258	0.092
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0507	0.0684	0.2437
Brugia malayi	SWIRM domain containing protein	0.0507	0.0684	0.2437
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0134	0.0477
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0344	0.0457	0.1627
Leishmania major	UDP-galactopyranose mutase	0.0507	0.0684	1
Plasmodium falciparum	protoporphyrinogen oxidase	0.0507	0.0684	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0112	0.0134	0.0477
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.0372	0.7922
Brugia malayi	jmjC domain containing protein	0.0019	0.0005	0.0017
Echinococcus multilocularis	phd:f box containing protein	0.0019	0.0005	0.0017
Echinococcus multilocularis	jumonji domain containing protein	0.0081	0.0091	0.0325
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0048	0.0046	0.0163
Schistosoma mansoni	amine oxidase	0.0507	0.0684	0.2437
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0112	0.0134	0.0477
Loa Loa (eye worm)	hypothetical protein	0.2035	0.2809	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0344	0.0457	0.0492
Brugia malayi	jmjC domain containing protein	0.007	0.0077	0.0273
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.006	0.0871
Schistosoma mansoni	phd/f-box containing protein	0.0019	0.0005	0.0017
Plasmodium falciparum	glycogen synthase kinase 3	0.0048	0.0046	0.0671
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0078	0.0087	0.0995
Toxoplasma gondii	histone lysine-specific demethylase	0.0507	0.0684	1
Echinococcus multilocularis	protein kinase shaggy	0.0048	0.0046	0.0163
Loa Loa (eye worm)	carboxylesterase	0.0344	0.0457	0.1627
Schistosoma mansoni	jumonji/arid domain-containing protein	0.007	0.0077	0.0273
Loa Loa (eye worm)	hypothetical protein	0.01	0.0117	0.0418
Echinococcus multilocularis		0.0507	0.0684	0.2437
Loa Loa (eye worm)	hypothetical protein	0.2035	0.2809	1
Trypanosoma brucei	protein kinase, putative	0.0048	0.0046	0.529
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0078	0.0087	0.1268
Echinococcus granulosus	inositol monophosphatase 1	0.0078	0.0087	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0457	0.1627
Brugia malayi	Carboxylesterase family protein	0.2035	0.2809	1
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0023	0.008
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0507	0.0684	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0078	0.0087	0.1268
Schistosoma mansoni	hypothetical protein	0.0031	0.0023	0.008
Brugia malayi	Pre-SET motif family protein	0.0029	0.0019	0.0067
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0023	0.008
Schistosoma mansoni	hypothetical protein	0.0031	0.0023	0.008
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0017	0.0062
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0078	0.0087	0.0995
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.0117	0.0417
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0023	0.008
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.0372	0.7922
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.6696	0.9294	1
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0457	0.1627
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.0372	0.7922
Mycobacterium ulcerans	dehydrogenase	0.0507	0.0684	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0058	0.006	0.0212
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0112	0.0134	0.1959
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0023	0.008
Echinococcus multilocularis	neuroligin	0.0344	0.0457	0.1627
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0138	0.0171	0.0184
Loa Loa (eye worm)	carboxylesterase	0.2035	0.2809	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.0372	0.7922
Loa Loa (eye worm)	PHD-finger family protein	0.0058	0.006	0.0212
Schistosoma mansoni	BC026374 protein (S09 family)	0.0344	0.0457	0.1627
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.0297	0.6111
Echinococcus granulosus	carboxylesterase 5A	0.2035	0.2809	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.2035	0.2809	1
Brugia malayi	PHD-finger family protein	0.0019	0.0005	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0457	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0457	0.1627
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0112	0.0134	0.2706
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0019	0.0005	0.0076
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0344	0.0457	0.1627
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0019	0.0005	0.0017
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0507	0.0684	1
Echinococcus granulosus	acetylcholinesterase	0.2035	0.2809	1
Plasmodium falciparum	phd finger protein, putative	0.0058	0.006	0.0871
Echinococcus granulosus	geminin	0.0164	0.0207	0.0735
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0058	0.006	0.0212
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0023	0.008
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.0372	0.7922
Brugia malayi	Inositol-1	0.0078	0.0087	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0507	0.0684	0.2437
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0023	0.008
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0019	0.0005	0.0076
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0078	0.0087	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0005	0.0017
Giardia lamblia	PHD finger protein 15	0.0058	0.006	0.042
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0019	0.0005	0.0598
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.0258	0.092
Schistosoma mansoni	hypothetical protein	0.0164	0.0207	0.0735
Echinococcus granulosus	BC026374 protein S09 family	0.0344	0.0457	0.1627
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.007	0.0075	0.0081
Schistosoma mansoni	inositol monophosphatase	0.0078	0.0087	0.0309
Plasmodium vivax	JmjC domain containing protein	0.0019	0.0005	0.0071
Echinococcus multilocularis	acetylcholinesterase	0.2035	0.2809	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0005	0.0017
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0019	0.0067
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0019	0.0067
Echinococcus granulosus	GPCR family 2	0.0031	0.0023	0.008
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0344	0.0457	0.1627
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0048	0.0046	0.0671
Schistosoma mansoni	amine oxidase	0.0507	0.0684	0.2437
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.019	0.0244	0.0867
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0112	0.0134	0.0477
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0048	0.0046	0.0163
Echinococcus multilocularis	lysine specific demethylase 5A	0.007	0.0077	0.0273

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 nM	Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP	ChEMBL.	24984230
IC50 (functional)	= 4 nM	Inhibition of LPS-induced TNFalpha release in human PBMC preincubated for 30 mins before LPS stimulation measured after 18 hrs by TR-FRET assay	ChEMBL.	24984230

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24984230

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3315084

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 919256