Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0263 | 0.2707 | 0.2656 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0057 |
Mycobacterium tuberculosis | Probable reductase | 0.0119 | 0.1067 | 0.1295 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0047 | 0.0237 | 0.0373 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0685 | 0.7533 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0161 | 0.0101 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0273 | 0.0273 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0035 | 0.0105 | 0.0057 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0035 | 0.0105 | 0.0036 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0273 | 0.0205 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.0317 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.3268 | 0.4286 |
Echinococcus multilocularis | serotonin receptor | 0.0142 | 0.1328 | 0.1268 |
Brugia malayi | isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0048 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0133 | 0.1219 | 0.15 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0338 | 0.036 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.0302 | 0.0265 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.059 | 0.647 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0582 | 0.6353 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0106 | 0.0912 | 0.1087 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0582 | 0.6353 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0142 | 0.1328 | 0.1378 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0137 | 0.0092 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.2707 | 0.3534 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0161 | 0.0124 |
Echinococcus multilocularis | transcription factor btf3 | 0.0078 | 0.059 | 0.0525 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0078 | 0.059 | 0.083 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0832 | 0.9205 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0035 | 0.0105 | 0.0057 |
Leishmania major | trypanothione reductase | 0.0052 | 0.0302 | 0.0475 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0033 | 0.0079 | 0.0124 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0273 | 0.0223 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0317 | 0.0333 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.0302 | 0.0475 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0273 | 0.0273 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.0302 | 0.0312 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.0302 | 0.0371 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.0302 | 0.0255 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0273 | 0.0273 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.074 | 0.09 |
Schistosoma mansoni | transcription factor btf3 | 0.0078 | 0.059 | 0.0698 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0832 | 0.9205 | 0.9199 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.0302 | 0.0235 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0161 | 0.0093 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.0302 | 0.0371 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0119 | 0.1067 | 0.1295 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0222 | 0.2243 | 0.1819 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0137 | 0.0092 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0078 | 0.059 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.034 | 0.3593 | 0.4721 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0078 | 0.059 | 0.083 |
Brugia malayi | thymidylate synthase | 0.0222 | 0.2243 | 0.2913 |
Onchocerca volvulus | 0.0222 | 0.2243 | 1 | |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.0302 | 0.0371 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.0302 | 0.0371 |
Schistosoma mansoni | DNA polymerase eta | 0.0047 | 0.0237 | 0.0225 |
Brugia malayi | glutathione reductase | 0.0052 | 0.0302 | 0.0312 |
Echinococcus granulosus | snurportin 1 | 0.034 | 0.3593 | 0.3857 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0119 | 0.1067 | 0.1295 |
Brugia malayi | hypothetical protein | 0.0263 | 0.2707 | 0.3534 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0142 | 0.1328 | 0.1687 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.0317 | 0.0333 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0161 | 0.2736 |
Leishmania major | DNA polymerase eta, putative | 0.0047 | 0.0237 | 0.0373 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0033 | 0.0079 | 0.0016 |
Brugia malayi | Isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0048 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0119 | 0.1067 | 0.1295 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0035 | 0.0105 | 0.0057 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0582 | 0.6353 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0048 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0312 | 0.3268 | 0.4286 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0035 | 0.0105 | 0.0057 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0263 | 0.2707 | 0.2888 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1328 | 0.1687 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0036 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0391 | 0.4167 | 0.4486 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0161 | 0.2736 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0582 | 0.6353 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0273 | 0.0273 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0137 | 0.0092 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0161 | 0.2736 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.0302 | 0.0312 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.059 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0273 | 0.0223 |
Schistosoma mansoni | dihydrofolate reductase | 0.0685 | 0.7533 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0685 | 0.7533 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0685 | 0.7533 | 0.7516 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0685 | 0.7533 | 1 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0078 | 0.059 | 0.083 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.0302 | 0.0371 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0685 | 0.7533 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0039 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0912 | 0.113 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.0302 | 0.0371 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0078 | 0.059 | 0.0929 |
Echinococcus granulosus | transcription factor btf3 | 0.0078 | 0.059 | 0.0571 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0035 | 0.0105 | 0.0165 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0048 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0273 | 0.0205 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0106 | 0.0912 | 0.1436 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0391 | 0.4167 | 0.5491 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0047 | 0.0237 | 0.0225 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0222 | 0.2243 | 0.2878 |
Brugia malayi | Serotonin receptor | 0.0472 | 0.51 | 0.6741 |
Echinococcus granulosus | dna polymerase eta | 0.0047 | 0.0237 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.3268 | 0.4286 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0036 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0391 | 0.4167 | 0.4127 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.059 | 0.647 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0273 | 0.0273 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0036 |
Brugia malayi | beta-NAC-like protein | 0.0078 | 0.059 | 0.0698 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0133 | 0.1219 | 0.15 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0237 | 0.0225 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0222 | 0.2243 | 0.2913 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0685 | 0.7533 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0133 | 0.1219 | 0.0235 |
Loa Loa (eye worm) | thymidylate synthase | 0.0222 | 0.2243 | 0.2913 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0133 | 0.1219 | 0.15 |
Brugia malayi | dihydrofolate reductase family protein | 0.0685 | 0.7533 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0047 | 0.0237 | 0.0169 |
Brugia malayi | hypothetical protein | 0.004 | 0.0161 | 0.0124 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0674 | 0.7401 | 0.7382 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0161 | 0.2736 |
Toxoplasma gondii | NAC domain-containing protein | 0.0078 | 0.059 | 0.083 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0582 | 0.6353 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0035 | 0.0105 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0338 | 0.036 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0119 | 0.1067 | 0.1295 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.2856 | 0.3734 |
Echinococcus granulosus | dihydrofolate reductase | 0.0685 | 0.7533 | 0.817 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0338 | 0.036 |
Echinococcus multilocularis | snurportin 1 | 0.034 | 0.3593 | 0.3548 |
Echinococcus granulosus | hypothetical protein | 0.0697 | 0.7666 | 0.8315 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0035 | 0.0105 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1328 | 0.1687 |
Loa Loa (eye worm) | ICD-1 protein | 0.0078 | 0.059 | 0.0698 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.059 | 0.647 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0338 | 0.036 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0312 | 0.3268 | 0.4286 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0047 | 0.0237 | 0.0267 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0119 | 0.1067 | 0.1295 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0078 | 0.059 | 0.0929 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0582 | 0.6353 | 1 |
Schistosoma mansoni | hypothetical protein | 0.034 | 0.3593 | 0.4721 |
Echinococcus multilocularis | thymidylate synthase | 0.0222 | 0.2243 | 0.2189 |
Leishmania major | DNA polymerase eta, putative | 0.0033 | 0.0079 | 0.0124 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0106 | 0.0912 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0685 | 0.7533 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0161 | 0.0124 |
Leishmania major | basic transcription factor 3a, putative | 0.0078 | 0.059 | 0.0929 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.0302 | 0.0312 |
Echinococcus granulosus | thymidylate synthase | 0.0222 | 0.2243 | 0.238 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0035 | 0.0105 | 0.0165 |
Echinococcus multilocularis | serotonin receptor | 0.0142 | 0.1328 | 0.1268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.