Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0056 | 0.0741 | 0.0741 |
Schistosoma mansoni | thyroid hormone receptor | 0.0201 | 0.4776 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0056 | 0.0741 | 0.0741 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0169 | 0.3901 | 0.3901 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0056 | 0.0741 | 0.1552 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0056 | 0.0741 | 0.1552 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | nuclear hormone receptor | 0.0056 | 0.0741 | 0.1552 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0323 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0201 | 0.4776 | 0.4776 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0549 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0755 | 0.1086 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0056 | 0.0741 | 0.0741 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0056 | 0.0741 | 0.1065 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0323 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0056 | 0.0741 | 0.0741 |
Brugia malayi | nuclear receptor NHR-88 | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.2095 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0056 | 0.0741 | 0.1065 |
Onchocerca volvulus | 0.0057 | 0.0755 | 0.004 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0144 | 0.3205 | 0.3205 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0279 | 0.6956 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0056 | 0.0741 | 0.1552 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4554 | 0.1027 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0323 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0056 | 0.0741 | 0.1065 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4554 | 0.1027 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0056 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0549 | 0.115 |
Brugia malayi | steroid hormone receptor | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0056 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0549 | 0.0549 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0056 | 0.0741 | 0.0741 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0056 | 0.0741 | 0.1552 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0549 | 0.0789 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.1001 | 0.1001 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0056 | 0.0741 | 0.1065 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0323 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0056 | 0.0741 | 0.1552 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0056 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0323 | 0.0323 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0144 | 0.3205 | 0.3205 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0056 | 0.0741 | 0.0741 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0056 | 0.0741 | 0.1552 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0323 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0056 | 0.0741 | 0.0741 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0056 | 0.0741 | 0.0741 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0183 | 0.4279 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0279 | 0.6956 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0056 | 0.0741 | 0.0741 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0323 | 0.0465 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0056 | 0.0741 | 0.0741 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0056 | 0.0741 | 0.1552 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0056 | 0.0741 | 0.1552 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0549 | 0.0549 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0388 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.014 | 0.3071 | 0.3071 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.1001 | 0.1001 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0549 | 0.0789 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0549 | 0.0549 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0549 | 0.115 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | ecdysteroid receptor | 0.0056 | 0.0741 | 0.1065 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0056 | 0.0741 | 0.0741 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0323 | 0.0677 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.1001 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0056 | 0.0741 | 0.0741 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0056 | 0.0741 | 0.1552 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0056 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | thyroid hormone receptor | 0.0201 | 0.4776 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0323 | 0.0323 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.0755 | 0.1581 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.2095 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0169 | 0.3901 | 0.8167 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0549 | 0.115 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.3205 | 0.6711 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | nuclear hormone receptor | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0056 | 0.0741 | 0.1065 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.