Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0056 | 0.0741 | 0.0741 |
Brugia malayi | ecdysteroid receptor | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0056 | 0.0741 | 0.1065 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0056 | 0.0741 | 0.0741 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0056 | 0.0741 | 0.1552 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0549 | 0.115 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0056 | 0.0741 | 0.1065 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.1001 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0144 | 0.3205 | 0.3205 |
Brugia malayi | nuclear receptor NHR-88 | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | thyroid hormone receptor | 0.0201 | 0.4776 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0056 | 0.0741 | 0.0741 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0323 | 0.0677 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0169 | 0.3901 | 0.3901 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0056 | 0.0741 | 0.0741 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0549 | 0.115 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0056 | 0.0741 | 0.0741 |
Schistosoma mansoni | nuclear hormone receptor | 0.0056 | 0.0741 | 0.1552 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.1001 | 0.1001 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0056 | 0.0741 | 0.0741 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0323 | 0.0323 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0323 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0201 | 0.4776 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.1001 | 0.1001 |
Onchocerca volvulus | 0.0057 | 0.0755 | 0.004 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | coup transcription factor | 0.0056 | 0.0741 | 0.1552 |
Echinococcus granulosus | FTZ F1 alpha | 0.0056 | 0.0741 | 0.0741 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0056 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0056 | 0.0741 | 0.1552 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0323 | 0.0465 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0056 | 0.0741 | 0.1552 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0323 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0323 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4554 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0549 | 0.0549 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0323 | 0.0677 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.0755 | 0.1581 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0056 | 0.0741 | 0.1065 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0549 | 0.0549 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | tumor protein p63 | 0.0388 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0056 | 0.0741 | 0.0741 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0056 | 0.0741 | 0.1552 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0056 | 0.0741 | 0.1065 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0549 | 0.0549 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0056 | 0.0741 | 0.1552 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4554 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | nuclear hormone receptor | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0549 | 0.115 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0323 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0144 | 0.3205 | 0.3205 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0056 | 0.0741 | 0.0741 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0056 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0755 | 0.1086 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0056 | 0.0741 | 0.0741 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0549 | 0.0789 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0549 | 0.0789 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0323 | 0.0323 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.014 | 0.3071 | 0.3071 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0056 | 0.0741 | 0.1065 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0056 | 0.0741 | 0.0741 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0056 | 0.0741 | 0.1065 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0279 | 0.6956 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0056 | 0.0741 | 0.1552 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0056 | 0.0741 | 0.1065 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0183 | 0.4279 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0056 | 0.0741 | 0.1552 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.3205 | 0.6711 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0201 | 0.4776 | 0.4776 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.2095 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0279 | 0.6956 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1001 | 0.2095 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0056 | 0.0741 | 0.0741 |
Brugia malayi | steroid hormone receptor | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0741 | 0.1065 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0279 | 0.6956 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0056 | 0.0741 | 0.1552 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0056 | 0.0741 | 0.0741 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0169 | 0.3901 | 0.8167 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0056 | 0.0741 | 0.0741 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0549 | 0.0549 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0056 | 0.0741 | 0.1065 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 8 % | Activation of PXR (unknown origin) at 10 uM by reporter gene assay relative to rifampicin | ChEMBL. | 24986660 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.