Detailed information for compound 919479

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 919.084 | Formula: C44H66N14O8
  • H donors: 11 H acceptors: 8 LogP: -0.73 Rotable bonds: 35
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC(C[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CC(=O)N)CCCNC(=N)N)CCCNC(=N)N)c1ccccc1)NC(=O)CCc1ccccc1)C
  • InChi: 1S/C44H66N14O8/c1-26(2)24-32(53-35(60)20-19-27-12-5-3-6-13-27)39(63)57-36(28-14-7-4-8-15-28)41(65)55-30(17-10-22-52-44(49)50)42(66)58-23-11-18-33(58)40(64)54-29(16-9-21-51-43(47)48)38(62)56-31(37(46)61)25-34(45)59/h3-8,12-15,26,29-33,36H,9-11,16-25H2,1-2H3,(H2,45,59)(H2,46,61)(H,53,60)(H,54,64)(H,55,65)(H,56,62)(H,57,63)(H4,47,48,51)(H4,49,50,52)/t29-,30-,31-,32-,33-,36-/m0/s1
  • InChiKey: BJSQVSQGHOWWSG-MWSMAVIUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0625 0.0616
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Brugia malayi nuclear hormone receptor 0.0015 0.0367 0.0358
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0367 0.0358
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0061 0.0171
Loa Loa (eye worm) ACC-1 protein 0.002 0.0625 0.0616
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0367 0.0358
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0625 0.0616
Echinococcus granulosus protein kinase C gamma type 0.0048 0.2064 0.6847
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0625 0.2051
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0012 0.0202 0.0642
Loa Loa (eye worm) oxidoreductase 0.0012 0.0202 0.0193
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0066 0.301 0.3003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Onchocerca volvulus 0.002 0.0625 0.1913
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1992 0.6609
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0367 0.1193
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0367 0.1193
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0625 0.2051
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.1569 0.5197
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0061 0.0171
Loa Loa (eye worm) hypothetical protein 0.02 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0202 0.0202
Brugia malayi Dehydrogenases, short chain protein 30 0.0012 0.0202 0.0193
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.0202 0.0642
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0555 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Brugia malayi Protein kinase c protein 2 0.0046 0.1947 0.1939
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.02 1 1
Giardia lamblia Synaptic glycoprotein SC2 0.0066 0.301 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0625 0.0616
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0155 0.0484
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0367 0.0358
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0367 0.1193
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0061 0.0171
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0625 0.2051
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Onchocerca volvulus 0.0012 0.0202 0.0479
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0625 0.2051
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0625 0.2051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0142 0.0132
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0625 0.2051
Onchocerca volvulus 0.0012 0.0202 0.0479
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0367 0.1193
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0061 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0367 0.0358
Onchocerca volvulus 0.0011 0.0142 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0367 0.0358
Loa Loa (eye worm) hypothetical protein 0.0011 0.0142 0.0132
Echinococcus granulosus glutamate receptor 2 0.0011 0.0155 0.0484
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0625 0.2051
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.0202 0.0479
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0155 0.0484
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0625 0.2051
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0012 0.0202 0.0642
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0066 0.301 1
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Brugia malayi ecdysteroid receptor 0.0015 0.0367 0.0358
Loa Loa (eye worm) hypothetical protein 0.0011 0.0142 0.0132
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0015 0.0367 0.104
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Onchocerca volvulus Protein ultraspiracle homolog 0.0015 0.0367 0.104
Echinococcus multilocularis protein kinase c iota type 0.0014 0.0315 0.1017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0367 0.1193
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Onchocerca volvulus 0.002 0.0625 0.1913
Onchocerca volvulus 0.0066 0.301 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.0202 0.5
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.2064 0.6847
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.02 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Onchocerca volvulus 0.0011 0.0142 0.0275
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0061 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0625 0.2051
Echinococcus granulosus protein kinase c iota type 0.0014 0.0315 0.1017
Brugia malayi Cation transporter family protein 0.002 0.0625 0.0616
Loa Loa (eye worm) oxidoreductase 0.0012 0.0202 0.0193
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Loa Loa (eye worm) oxidoreductase 0.0012 0.0202 0.0193
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.0202 0.0642
Loa Loa (eye worm) hypothetical protein 0.0011 0.0142 0.0132
Loa Loa (eye worm) hypothetical protein 0.0015 0.0367 0.0358
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0625 0.0616
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0155 0.0484
Onchocerca volvulus 0.0012 0.0202 0.0479
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0061 0.0171
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0155 0.0484
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0625 0.2051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0367 0.0358
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0202 0.0642
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0061 0.0171
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0625 0.0616
Loa Loa (eye worm) hypothetical protein 0.0011 0.0142 0.0132
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0061 0.0051
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0367 0.1193
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0202 0.0193
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0155 0.0484
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1992 0.6609
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.1569 0.5197
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0012 0.0202 0.0202
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0625 0.2051
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0625 0.2051
Onchocerca volvulus 0.0012 0.0202 0.0479
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0012 0.0202 0.0193
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0012 0.0202 0.0193
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0625 0.2051
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0012 0.0202 0.0193
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0367 0.1193
Echinococcus granulosus oxidoreductase 0.0012 0.0202 0.0642
Onchocerca volvulus 0.0012 0.0202 0.0479
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0367 0.0358
Schistosoma mansoni nAChR subunit 0.002 0.0625 0.2051
Toxoplasma gondii carbonyl reductase 1, putative 0.0012 0.0202 0.0193
Onchocerca volvulus Sepiapterin reductase homolog 0.0012 0.0202 0.0479
Onchocerca volvulus 0.0012 0.0202 0.0479
Brugia malayi Synaptic glycoprotein SC2 0.0066 0.301 0.3003
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.0202 0.0479
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0367 0.1193
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0367 0.1193
Schistosoma mansoni coup transcription factor 0.0015 0.0367 0.1193
Loa Loa (eye worm) dehydrogenase 0.0012 0.0202 0.0193
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0061 0.0051
Entamoeba histolytica hypothetical protein 0.0012 0.0202 0.0193
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0012 0.0202 0.0193
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0625 0.0616
Schistosoma mansoni neurotransmitter gated ion channel 0.0011 0.0142 0.0441
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0012 0.0202 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0367 0.0358
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0625 0.0616
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0625 0.0616
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0367 0.0358
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0066 0.301 0.301
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0625 0.0616
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0011 0.0142 0.0132
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0012 0.0202 0.0642
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0202 0.0202
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0202 0.0642
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0625 0.2051
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Toxoplasma gondii oxidoreductase, putative 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0367 0.0358
Loa Loa (eye worm) hypothetical protein 0.0044 0.1874 0.1866
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0012 0.0202 0.0193
Loa Loa (eye worm) oxidoreductase 0.0012 0.0202 0.0193
Onchocerca volvulus 0.002 0.0625 0.1913
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Brugia malayi Cation transporter family protein 0.002 0.0625 0.0616
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0625 0.2051
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.0202 0.0642
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0625 0.2051
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0202 0.0642
Onchocerca volvulus 0.0012 0.0202 0.0479
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0061 0.0051
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0202 0.0642
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.02 1 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.2369 0.7864
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0155 0.0484
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0066 0.301 0.301
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0155 0.0484
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1992 0.6609
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0367 0.1193
Brugia malayi protein kinase C II. 0.0015 0.0378 0.0369
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Loa Loa (eye worm) oxidoreductase 0.0012 0.0202 0.0193
Schistosoma mansoni retinal dehydrogenase 0.0012 0.0202 0.0642
Schistosoma mansoni nAChR subunit 0.002 0.0625 0.2051
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0625 0.2051
Onchocerca volvulus 0.002 0.0625 0.1913
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0625 0.2051
Onchocerca volvulus 0.002 0.0625 0.1913
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0555 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0012 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0142 0.0132
Entamoeba histolytica short chain dehydrogenase family protein 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.0202 0.0642
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0012 0.0202 0.0642
Echinococcus granulosus nAChR subunit 0.0011 0.0142 0.0441
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Brugia malayi hypothetical protein 0.0009 0.0061 0.0051
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0012 0.0202 0.0642
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0625 0.0616
Plasmodium vivax polyprenol reductase, putative 0.0066 0.301 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0367 0.0358
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0625 0.0616
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Brugia malayi hypothetical protein 0.0009 0.0061 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Echinococcus multilocularis transient receptor potential cation channel 0.0012 0.0202 0.0642
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0625 0.2051
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0625 0.0616
Echinococcus multilocularis oxidoreductase 0.0012 0.0202 0.0642
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0012 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0367 0.0358
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.0202 0.0642
Onchocerca volvulus Bile acid receptor homolog 0.0015 0.0367 0.104
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.0202 0.0642
Brugia malayi hypothetical protein 0.0012 0.0202 0.0193
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0061 0.0051
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0202 0.0642
Brugia malayi dehydrogenases, short chain protein 9 0.0012 0.0202 0.0193
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0066 0.301 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0367 0.1193
Loa Loa (eye worm) LGC-31 protein 0.002 0.0625 0.0616
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0555 0.5
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0937 0.3091
Echinococcus granulosus nAChR subunit 0.002 0.0625 0.2051
Plasmodium falciparum polyprenol reductase, putative 0.0066 0.301 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0367 0.0358
Schistosoma mansoni nAChR subunit 0.002 0.0625 0.2051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0367 0.0358
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Echinococcus multilocularis nAChR subunit 0.0011 0.0142 0.0441
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0012 0.0202 0.0193
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0012 0.0202 0.0193
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0066 0.301 0.2866
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Brugia malayi hypothetical protein 0.0009 0.0061 0.0051
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0012 0.0202 0.0642
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0367 0.1193
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0367 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0367 0.0358
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0066 0.301 0.3003
Brugia malayi Dehydrogenases, short chain protein 2 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Onchocerca volvulus 0.0012 0.0202 0.0479
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0202 0.0202
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0155 0.0484
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0625 0.2051
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0367 0.1193
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.02 1 1
Loa Loa (eye worm) oxidoreductase 0.0012 0.0202 0.0193
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.02 1 1
Entamoeba histolytica hypothetical protein 0.0066 0.301 0.3003
Echinococcus granulosus hypothetical protein 0.0012 0.0202 0.0642
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0367 0.0358
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0367 0.1193
Onchocerca volvulus 0.0012 0.0202 0.0479
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0155 0.0484
Loa Loa (eye worm) oxidoreductase 0.0012 0.0202 0.0193
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0625 0.2051
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0012 0.0202 0.0642
Onchocerca volvulus 0.0012 0.0202 0.0479
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.0202 0.0193
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0625 0.0616
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0367 0.1193
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0625 0.2051
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0555 0.0361
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.0202 0.0642
Loa Loa (eye worm) dehydrogenase 0.0012 0.0202 0.0193
Brugia malayi hypothetical protein 0.0009 0.0061 0.0051
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0625 0.2051
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.02 1 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0012 0.0202 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.0012 0.0202 0.0193
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0367 0.1193
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0061 0.0171
Brugia malayi Retinol dehydrogenase 12 0.0012 0.0202 0.0193
Schistosoma mansoni carbonyl reductase 0.0012 0.0202 0.0642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0367 0.0358
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Echinococcus granulosus steroid dehydrogenase 0.0012 0.0202 0.0642
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0367 0.1193
Schistosoma mansoni carbonyl reductase 0.0012 0.0202 0.0642
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0012 0.0202 0.0479
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Schistosoma mansoni nAChR subunit 0.002 0.0625 0.2051
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0202 0.0642
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0625 0.2051
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0625 0.2051
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0066 0.301 0.3003
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0625 0.2051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1992 0.6609
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.0202 0.5
Schistosoma mansoni nAChR subunit 0.0009 0.0061 0.0171
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0367 0.0358
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0011 0.0142 0.0441
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.1569 0.5197
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0937 0.3091
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.0202 0.0193
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0012 0.0202 0.0642
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.1641 0.1634
Loa Loa (eye worm) hypothetical protein 0.0011 0.0142 0.0132
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0367 0.1193
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0011 0.0142 0.0441
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1992 0.1985
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0012 0.0202 0.0642
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0625 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0367 0.0358
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0012 0.0202 0.0193
Onchocerca volvulus Putative nachr subunit 0.002 0.0625 0.1913
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0625 0.2051
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0555 0.5
Loa Loa (eye worm) ACC-1 protein 0.002 0.0625 0.0616
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0937 0.3091
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0367 0.0358
Onchocerca volvulus 0.0015 0.0367 0.104
Entamoeba histolytica steroid 5-alpha reductase, putative 0.02 1 1
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.02 1 1
Schistosoma mansoni nAChR subunit 0.002 0.0625 0.2051
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0625 0.2051
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0066 0.301 1
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0066 0.301 0.301
Schistosoma mansoni nAChR subunit 0.002 0.0625 0.2051
Echinococcus multilocularis retinol dehydrogenase 13 0.0012 0.0202 0.0642
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0061 0.0171
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.0202 0.0193
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0625 0.0616
Loa Loa (eye worm) hypothetical protein 0.0011 0.0142 0.0132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0142 0.0132
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0011 0.0142 0.0132
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0367 0.1193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0367 0.0358
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0367 0.1193
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0625 0.2051
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0012 0.0202 0.0642
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0367 0.0358
Loa Loa (eye worm) hypothetical protein 0.0011 0.0142 0.0132
Entamoeba histolytica hypothetical protein 0.0011 0.0142 0.0132
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0066 0.301 0.301
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Loa Loa (eye worm) oxidoreductase 0.0012 0.0202 0.0193
Brugia malayi steroid hormone receptor 0.0015 0.0367 0.0358
Chlamydia trachomatis glutamine binding protein 0.0019 0.0555 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0367 0.1193
Echinococcus multilocularis protein kinase c epsilon type 0.0015 0.0378 0.1228
Brugia malayi oxidoreductase 0.0012 0.0202 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0367 0.0358
Onchocerca volvulus 0.0012 0.0202 0.0479
Entamoeba histolytica short chain dehydrogenase family protein 0.0012 0.0202 0.0193
Onchocerca volvulus 0.0012 0.0202 0.0479
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0012 0.0202 0.0193
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0066 0.301 1
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.02 1 1
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0061 0.0171
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0012 0.0202 0.0202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1992 0.6609
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Brugia malayi nuclear receptor NHR-88 0.0015 0.0367 0.0358
Loa Loa (eye worm) GABA receptor subunit 0.0011 0.0142 0.0132
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.0202 0.0193
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0012 0.0202 0.0202
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0155 0.0484
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0367 0.0358
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0066 0.301 0.3003
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0367 0.1193
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0202 0.0193
Schistosoma mansoni nAChR subunit 0.002 0.0625 0.2051
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0625 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0378 0.1228
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1992 0.6609
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0367 0.1193
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0625 0.0616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0367 0.0358
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1992 0.1985
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0202 0.0193
Mycobacterium leprae Probable oxidoreductase 0.0012 0.0202 0.5
Schistosoma mansoni nAChR subunit 0.0009 0.0061 0.0171
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0202 0.0193
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0625 0.0616
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0061 0.0051
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0066 0.301 1
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0066 0.301 0.3003
Echinococcus granulosus WW domain containing oxidoreductase 0.0012 0.0202 0.0642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0367 0.0358
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0012 0.0202 0.0642
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0202 0.0202
Echinococcus multilocularis conserved hypothetical protein 0.0012 0.0202 0.0642
Brugia malayi hypothetical protein 0.0012 0.0202 0.0193
Echinococcus granulosus synaptic glycoprotein sc2 0.0066 0.301 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0202 0.0202
Brugia malayi hypothetical protein 0.0009 0.0061 0.0051
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0367 0.0358
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0625 0.2051
Onchocerca volvulus 0.002 0.0625 0.1913
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0061 0.0171
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.2369 0.7864
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0202 0.0193
Echinococcus granulosus hypothetical protein 0.0012 0.0202 0.0642
Schistosoma mansoni carbonyl reductase 0.0012 0.0202 0.0642
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0015 0.0378 0.0369
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0625 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.301 0.301
Loa Loa (eye worm) oxidoreductase 0.0012 0.0202 0.0193
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.0202 0.0642
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Echinococcus multilocularis nAChR subunit 0.002 0.0625 0.2051
Trichomonas vaginalis steroid dehydrogenase, putative 0.0012 0.0202 0.0202
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0625 0.0616
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0202 0.0642
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0066 0.301 0.3003
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0625 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.2369 0.7864
Loa Loa (eye worm) hypothetical protein 0.002 0.0625 0.0616
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Loa Loa (eye worm) hypothetical protein 0.0012 0.0202 0.0193
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0367 0.1193
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0367 0.1193
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0142 0.0132
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0061 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0367 0.0358
Toxoplasma gondii oxidoreductase, putative 0.0012 0.0202 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.301 0.301
Onchocerca volvulus 0.0012 0.0202 0.0479
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0367 0.1193
Mycobacterium ulcerans hypothetical protein 0.02 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0625 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.2369 0.7864
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0625 0.2051
Brugia malayi Cation transporter family protein 0.002 0.0625 0.0616
Schistosoma mansoni atypical protein kinase C 0.0014 0.0315 0.1017
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0009 0.0009
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0202 0.0642
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0202 0.0202
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0202 0.0642
Echinococcus granulosus protein kinase c epsilon type 0.0015 0.0378 0.1228
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0061 0.0051
Echinococcus multilocularis synaptic glycoprotein sc2 0.0066 0.301 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.301 0.3003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0367 0.1193
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0367 0.0358
Loa Loa (eye worm) hypothetical protein 0.0038 0.1569 0.1561
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0202 0.0642
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0367 0.1193
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0202 0.0202
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0367 0.1193
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0367 0.1193
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0202 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1992 0.6609
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0367 0.0358
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0012 0.0202 0.5
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0066 0.301 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0051
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0625 0.0616

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Agonist activity at human NMUR2 expressed in HEK293 cells at 1 to 100 nM by calcium mobilization assay relative to NMU ChEMBL. 24999562
Activity (functional) Agonist activity at human NMUR1 expressed in HEK293 cells at 1 to 100 nM by calcium mobilization assay relative to NMU ChEMBL. 24999562

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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