Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.5 | 0.5 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 76 % | Agonist activity at glucocorticoid receptor in human HeLa cells assessed as NP-1 transactivation by luciferase reporter gene assay relative to dexamethasone | ChEMBL. | 24980053 |
Activity (binding) | = 90 % | Agonist activity at glucocorticoid receptor in human A549 cells assessed as E-selectin transrepression by luciferase reporter gene assay relative to dexamethasone | ChEMBL. | 24980053 |
Activity (binding) | = 91 % | Agonist activity at glucocorticoid receptor in human A549 cells assessed as AP-1 transrepression by luciferase reporter gene assay relative to dexamethasone | ChEMBL. | 24980053 |
Activity (binding) | = 99 % | Agonist activity at glucocorticoid receptor in human whole blood assessed as inhibition of LPS-induced TNF production incubated for 20 hrs prior to LPS challenge measured after 5 hrs by ELISA relative to dexamethasone | ChEMBL. | 24980053 |
EC50 (binding) | = 3.2 nM | Agonist activity at glucocorticoid receptor in human A549 cells assessed as E-selectin transrepression by luciferase reporter gene assay | ChEMBL. | 24980053 |
EC50 (binding) | = 5 nM | Agonist activity at glucocorticoid receptor in human A549 cells assessed as AP-1 transrepression by luciferase reporter gene assay | ChEMBL. | 24980053 |
EC50 (binding) | = 14 nM | Agonist activity at glucocorticoid receptor in human HeLa cells assessed as NP-1 transactivation by luciferase reporter gene assay | ChEMBL. | 24980053 |
EC50 (binding) | = 88 nM | Agonist activity at glucocorticoid receptor in human whole blood assessed as inhibition of LPS-induced TNF production incubated for 20 hrs prior to LPS challenge measured after 5 hrs by ELISA | ChEMBL. | 24980053 |
Ki (binding) | = 5.9 nM | Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assay | ChEMBL. | 24980053 |
Ki (binding) | = 268 nM | Binding affinity to progesterone receptor (unknown origin) by fluorescence polarization assay | ChEMBL. | 24980053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.