Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 0.5653 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.5653 | 0.5653 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0.5653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.5653 | 0.5653 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.5653 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 0.5653 | 0.5653 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.5653 | 0.5653 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 0.5653 | 0.5653 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 0.5653 | 0.5653 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0.5653 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.5653 | 0.5653 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0.5653 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0.5653 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.5653 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.5653 | 0.5653 |
Brugia malayi | ecdysteroid receptor | 0.0018 | 0.5653 | 0.5653 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.5653 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0.5653 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.5653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5653 | 0.5653 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.5653 | 0.5653 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0.5653 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0.5653 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.5653 | 0.5653 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0.5653 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5653 | 0.5653 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.5653 | 0.5653 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0.5653 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5653 | 0.5653 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.5653 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.5653 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.5653 | 0.5653 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0.5653 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0.5653 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.5653 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 0.5653 | 0.5653 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5653 | 0.5653 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.5653 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0.5653 | 1 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.5653 | 0.5653 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0.5653 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0.5653 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.5653 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0.5653 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.5653 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 0.5653 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.5653 | 0.5653 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.5653 | 0.5653 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 0.5653 | 0.5653 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.5653 | 0.5653 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.5653 | 0.5653 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0.5653 | 1 |
Onchocerca volvulus | 0.0018 | 0.5653 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5653 | 0.5653 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.5653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5653 | 0.5653 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0.5653 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0.5653 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.5653 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0.5653 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.5653 | 0.5653 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.5653 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 55 % | Agonist activity at glucocorticoid receptor in human HeLa cells assessed as NP-1 transactivation by luciferase reporter gene assay relative to dexamethasone | ChEMBL. | 24980053 |
Activity (binding) | = 56 % | Agonist activity at glucocorticoid receptor in human A549 cells assessed as E-selectin transrepression by luciferase reporter gene assay relative to dexamethasone | ChEMBL. | 24980053 |
Activity (binding) | = 72 % | Agonist activity at glucocorticoid receptor in human A549 cells assessed as AP-1 transrepression by luciferase reporter gene assay relative to dexamethasone | ChEMBL. | 24980053 |
EC50 (binding) | = 203.2 nM | Agonist activity at glucocorticoid receptor in human A549 cells assessed as E-selectin transrepression by luciferase reporter gene assay | ChEMBL. | 24980053 |
EC50 (binding) | = 907 nM | Agonist activity at glucocorticoid receptor in human A549 cells assessed as AP-1 transrepression by luciferase reporter gene assay | ChEMBL. | 24980053 |
EC50 (binding) | = 8912 nM | Agonist activity at glucocorticoid receptor in human HeLa cells assessed as NP-1 transactivation by luciferase reporter gene assay | ChEMBL. | 24980053 |
Ki (binding) | = 110.5 nM | Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assay | ChEMBL. | 24980053 |
Ki (binding) | = 10630 nM | Binding affinity to progesterone receptor (unknown origin) by fluorescence polarization assay | ChEMBL. | 24980053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.