Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0056 | 0.0959 | 0.0959 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0056 | 0.0959 | 0.2698 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0056 | 0.0959 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.2825 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.0056 | 0.0959 | 1 | |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.0959 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0959 | 0.0959 |
Trypanosoma brucei | glucose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0959 | 0.0959 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0035 | 0.0269 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0112 | 0.2825 | 0.2825 |
Echinococcus multilocularis | General substrate transporter | 0.0097 | 0.2304 | 0.2304 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0056 | 0.0959 | 0.0959 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0056 | 0.0959 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0056 | 0.0959 | 0.0959 |
Brugia malayi | Carboxylesterase family protein | 0.0056 | 0.0959 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0959 | 0.0959 |
Brugia malayi | Sugar transporter family protein | 0.0112 | 0.2825 | 0.2825 |
Trypanosoma cruzi | hexose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.0056 | 0.0959 | 1 | |
Trypanosoma brucei | glucose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.033 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.033 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0056 | 0.0959 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0959 | 0.0959 |
Brugia malayi | Carboxylesterase family protein | 0.0056 | 0.0959 | 0.0959 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0112 | 0.2825 | 0.2825 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0056 | 0.0959 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0056 | 0.0959 | 0.0959 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0056 | 0.0959 | 0.0959 |
Trypanosoma brucei | glucose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Trypanosoma brucei | glucose transporter 1E | 0.0035 | 0.0269 | 0.5 |
Leishmania major | glucose transporter, lmgt2 | 0.0035 | 0.0269 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0056 | 0.0959 | 0.0959 |
Leishmania major | glucose transporter, lmgt1 | 0.0035 | 0.0269 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0056 | 0.0959 | 0.0959 |
Echinococcus granulosus | neuroligin | 0.0056 | 0.0959 | 0.0959 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0056 | 0.0959 | 0.0959 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0056 | 0.0959 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0056 | 0.0959 | 0.0959 |
Schistosoma mansoni | glucose transport protein | 0.0112 | 0.2825 | 0.2825 |
Schistosoma mansoni | glucose transport protein | 0.0112 | 0.2825 | 0.2825 |
Onchocerca volvulus | 0.0056 | 0.0959 | 1 | |
Plasmodium vivax | hexose transporter | 0.0112 | 0.2825 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0959 | 0.0959 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0112 | 0.2825 | 0.2825 |
Brugia malayi | Carboxylesterase family protein | 0.0056 | 0.0959 | 0.0959 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0056 | 0.0959 | 0.0959 |
Echinococcus multilocularis | neuroligin | 0.0056 | 0.0959 | 0.0959 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0112 | 0.2825 | 0.2825 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0112 | 0.2825 | 0.2825 |
Trypanosoma brucei | glucose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0056 | 0.0959 | 0.2698 |
Loa Loa (eye worm) | carboxylesterase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0112 | 0.2825 | 0.2825 |
Loa Loa (eye worm) | carboxylesterase | 0.0056 | 0.0959 | 0.0959 |
Echinococcus multilocularis | acetylcholinesterase | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.0056 | 0.0959 | 1 | |
Trypanosoma brucei | glucose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Echinococcus granulosus | General substrate transporter | 0.0097 | 0.2304 | 0.2304 |
Trypanosoma brucei | glucose transporter 2A | 0.0035 | 0.0269 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0112 | 0.2825 | 0.2825 |
Schistosoma mansoni | glucose transport protein | 0.0112 | 0.2825 | 0.2825 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0056 | 0.0959 | 0.0959 |
Trypanosoma cruzi | hexose transporter | 0.0035 | 0.0269 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0056 | 0.0959 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0959 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0959 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0056 | 0.0959 | 0.0959 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0035 | 0.0269 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.2825 | 0.2825 |
Echinococcus multilocularis | carboxylesterase 5A | 0.033 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0056 | 0.0959 | 0.0959 |
Plasmodium falciparum | hexose transporter | 0.0112 | 0.2825 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.033 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0112 | 0.2825 | 0.2825 |
Leishmania major | glucose transporter, lmgt3 | 0.0035 | 0.0269 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.033 | 1 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0112 | 0.2825 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0959 | 0.0959 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0112 | 0.2825 | 0.2825 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Cytotoxicity against human K562 cells | ChEMBL. | 24967847 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.