Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1032 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1032 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1032 | 1 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1032 | 1 | 0.5 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0321 | 0.1898 | 0.1898 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1032 | 1 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.0154 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.1032 | 1 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1032 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1032 | 1 | 0.5 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0321 | 0.1898 | 0.1898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.