Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | DNA topoisomerase II, putative | 0.013 | 0.0396 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.013 | 0.0396 | 0.0332 |
Loa Loa (eye worm) | carboxylesterase | 0.038 | 0.1528 | 0.1471 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.1528 | 0.1471 |
Onchocerca volvulus | 0.038 | 0.1528 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.038 | 0.1528 | 0.1179 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.038 | 0.1528 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2246 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.038 | 0.1528 | 0.1179 |
Echinococcus multilocularis | acetylcholinesterase | 0.2246 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.038 | 0.1528 | 0.1179 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.038 | 0.1528 | 1 |
Onchocerca volvulus | 0.038 | 0.1528 | 1 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.038 | 0.1528 | 0.1179 |
Echinococcus multilocularis | neuroligin | 0.038 | 0.1528 | 0.1179 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2246 | 1 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0117 | 0.0337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0202 | 0.0136 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.038 | 0.1528 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.1528 | 0.1471 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2246 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2246 | 1 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.013 | 0.0396 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2246 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0117 | 0.0337 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.038 | 0.1528 | 0.1471 |
Echinococcus multilocularis | acetylcholinesterase | 0.2246 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.038 | 0.1528 | 0.1179 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.038 | 0.1528 | 0.1179 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.1528 | 0.1471 |
Giardia lamblia | DNA topoisomerase II | 0.0124 | 0.037 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.038 | 0.1528 | 0.1179 |
Schistosoma mansoni | gliotactin | 0.038 | 0.1528 | 0.1179 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0071 | 0.0126 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.038 | 0.1528 | 0.1179 |
Brugia malayi | Carboxylesterase family protein | 0.038 | 0.1528 | 0.1179 |
Schistosoma mansoni | acetylcholinesterase | 0.038 | 0.1528 | 0.1179 |
Loa Loa (eye worm) | hypothetical protein | 0.2246 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.038 | 0.1528 | 0.1179 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.013 | 0.0396 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0117 | 0.0337 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.038 | 0.1528 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.038 | 0.1528 | 1 |
Onchocerca volvulus | 0.038 | 0.1528 | 1 | |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0117 | 0.0337 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.038 | 0.1528 | 0.1179 |
Brugia malayi | Carboxylesterase family protein | 0.038 | 0.1528 | 0.1179 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.1528 | 0.1471 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.038 | 0.1528 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2246 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.1528 | 0.1471 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0117 | 0.0337 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.1528 | 0.1471 |
Onchocerca volvulus | 0.038 | 0.1528 | 1 | |
Brugia malayi | hypothetical protein | 0.038 | 0.1528 | 0.1179 |
Echinococcus granulosus | BC026374 protein S09 family | 0.038 | 0.1528 | 0.1179 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0202 | 0.0136 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.013 | 0.0396 | 0.5 |
Onchocerca volvulus | 0.038 | 0.1528 | 1 | |
Echinococcus granulosus | carboxylesterase 5A | 0.2246 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.038 | 0.1528 | 0.1179 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.1528 | 0.1471 |
Brugia malayi | Carboxylesterase family protein | 0.038 | 0.1528 | 0.1179 |
Echinococcus granulosus | acetylcholinesterase | 0.2246 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.038 | 0.1528 | 0.1179 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 5.5 | Agonist activity at human cannabinoid CB1 receptor expressed in CHO cells co-expressing AP-1 response element after 5 hrs by luciferase reporter gene assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.