Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | LIM domain kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | dual specificity testis specific protein kinase | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Schistosoma japonicum | ko:K05743 LIM domain kinase 1, putative | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Schistosoma mansoni | protein kinase | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Schistosoma mansoni | protein kinase | Get druggable targets OG5_131191 | All targets in OG5_131191 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gliotactin | 0.0029 | 0.1427 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.9114 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0172 | 0.9114 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0029 | 0.1427 | 0.1427 |
Brugia malayi | Carboxylesterase family protein | 0.0172 | 0.9114 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0172 | 0.9114 | 0.9114 |
Echinococcus granulosus | neuroligin | 0.0029 | 0.1427 | 0.1427 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.9114 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0029 | 0.1427 | 0.1427 |
Echinococcus multilocularis | acetylcholinesterase | 0.0172 | 0.9114 | 0.9114 |
Onchocerca volvulus | 0.0029 | 0.1427 | 0.5 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0029 | 0.1427 | 0.1427 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0029 | 0.1427 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0172 | 0.9114 | 0.9114 |
Echinococcus granulosus | carboxylesterase 5A | 0.0172 | 0.9114 | 0.9114 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0172 | 0.9114 | 0.9114 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0029 | 0.1427 | 0.1427 |
Echinococcus granulosus | acetylcholinesterase | 0.0172 | 0.9114 | 0.9114 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0172 | 0.9114 | 0.9114 |
Schistosoma mansoni | protein kinase | 0.0188 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0029 | 0.1427 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0029 | 0.1427 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0029 | 0.1427 | 0.1427 |
Brugia malayi | Carboxylesterase family protein | 0.0172 | 0.9114 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0029 | 0.1427 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0029 | 0.1427 | 0.1427 |
Onchocerca volvulus | 0.0029 | 0.1427 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0029 | 0.1427 | 0.1427 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0029 | 0.1427 | 0.1427 |
Onchocerca volvulus | 0.0029 | 0.1427 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0029 | 0.1427 | 0.1427 |
Onchocerca volvulus | 0.0029 | 0.1427 | 0.5 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0029 | 0.1427 | 0.1427 |
Echinococcus multilocularis | neuroligin | 0.0029 | 0.1427 | 0.1427 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0172 | 0.9114 | 1 |
Schistosoma mansoni | protein kinase | 0.0188 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0029 | 0.1427 | 0.1427 |
Onchocerca volvulus | 0.0029 | 0.1427 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0029 | 0.1427 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0029 | 0.1427 | 0.1427 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0029 | 0.1427 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 145 nM | Inhibition of LIMK1 (unknown origin) assessed as ADP formation using cofilin-2 protein as substrate measured after 60 mins incubation with enzyme by Transcreener assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.