Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.033 | 0.2673 | 0.1674 |
Brugia malayi | Dihydrofolate reductase | 0.1191 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1191 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1191 | 1 | 1 |
Onchocerca volvulus | 0.033 | 0.2673 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0025 | 0.0075 | 0.0075 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1191 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0157 | 0.12 | 0.5 |
Brugia malayi | thymidylate synthase | 0.033 | 0.2673 | 0.2673 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0868 | 0.7257 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0868 | 0.7257 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1191 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0868 | 0.7257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.015 | 0.0075 |
Echinococcus granulosus | dihydrofolate reductase | 0.1191 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1191 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0868 | 0.7257 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0282 | 0.0282 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0868 | 0.7257 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1191 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0157 | 0.12 | 0.1566 |
Loa Loa (eye worm) | thymidylate synthase | 0.033 | 0.2673 | 0.2618 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.033 | 0.2673 | 0.2562 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0868 | 0.7257 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0282 | 0.0209 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0282 | 0.0209 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1191 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0282 | 0.0282 |
Brugia malayi | hypothetical protein | 0.0157 | 0.12 | 0.12 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 7 % | Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP level at 1 uM by scintillation counting analysis | ChEMBL. | 25063944 |
Inhibition (binding) | = 21 % | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells at 1 uM by scintillation counting analysis relative to control | ChEMBL. | 25063944 |
Inhibition (binding) | = 25 % | Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cells at 1 uM by scintillation counting analysis relative to control | ChEMBL. | 25063944 |
Ki (binding) | = 480 nM | Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in CHO cells by scintillation counting analysis | ChEMBL. | 25063944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.