Detailed information for compound 920600

Basic information

Technical information
  • TDR Targets ID: 920600
  • Name: 1-(3,4-dichlorophenyl)-2-imidazol-1-ylethanol
  • MW: 257.116 | Formula: C11H10Cl2N2O
  • H donors: 1 H acceptors: 2 LogP: 2.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1ccc(c(c1)Cl)Cl)Cn1cncc1
  • InChi: 1S/C11H10Cl2N2O/c12-9-2-1-8(5-10(9)13)11(16)6-15-4-3-14-7-15/h1-5,7,11,16H,6H2
  • InChiKey: XALAHDDITRYXTH-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-(3,4-dichlorophenyl)-2-imidazol-1-yl-ethanol
  • 1-(3,4-dichlorophenyl)-2-(1-imidazolyl)ethanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium falciparum exported lipase 2 0.0022 0.0057 0.0089
Giardia lamblia PHD finger protein 15 0.003 0.0116 1
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0022 0.0057 0.1114
Entamoeba histolytica hypothetical protein 0.0039 0.0196 0.0464
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0085
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0538 0.7929
Loa Loa (eye worm) hypothetical protein 0.1214 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0116 1
Schistosoma mansoni hypothetical protein 0.003 0.0116 0.2274
Brugia malayi hypothetical protein 0.0039 0.0196 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0094 0.0094
Plasmodium vivax PST-A protein 0.0022 0.0057 0.0089
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0094 0.0094
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0085 0.0092
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0094 0.184
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0094 0.1389
Plasmodium vivax unspecified product 0.0022 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.003
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0057 0.0089
Entamoeba histolytica hypothetical protein 0.0039 0.0196 0.0464
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0381 0.305 1
Plasmodium vivax lysophospholipase, putative 0.0022 0.0057 0.0089
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0094 0.1389
Plasmodium vivax lysophospholipase, putative 0.0022 0.0057 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0094 0.0094
Brugia malayi bZIP transcription factor family protein 0.0091 0.0631 0.0631
Entamoeba histolytica hypothetical protein 0.0039 0.0196 0.0464
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0094 0.0094
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0678 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0094
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0381 0.305 1
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0022 0.0057 0.0089
Schistosoma mansoni hypothetical protein 0.0039 0.0196 0.3828
Echinococcus multilocularis peregrin 0.003 0.0116 0.1717
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0094 0.0094
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0085 0.018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0094 0.0094
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0094 0.0094
Brugia malayi jmjC domain containing protein 0.0097 0.0678 0.0678
Plasmodium falciparum prodrug activation and resistance esterase 0.0022 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0085 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0094 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0085
Trypanosoma brucei monoglyceride lipase, putative 0.0381 0.305 1
Echinococcus granulosus jun protein 0.0091 0.0631 0.9312
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0085 0.0092
Echinococcus granulosus Phospholipase carboxylesterase 0.0022 0.0057 0.0841
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0000000075621 0.00000014773
Echinococcus multilocularis Phospholipase carboxylesterase 0.0022 0.0057 0.0841
Plasmodium vivax lysophospholipase, putative 0.0022 0.0057 0.0089
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0094 0.1389
Brugia malayi Uncoordinated protein 44 0.0016 0.0000000075621 0.0000000075621
Plasmodium vivax PST-A protein 0.0381 0.305 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0085 0.0092
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0512 1
Brugia malayi hypothetical protein 0.0072 0.0468 0.0468
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0094 0.1389
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0213 0.3143
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0091 0.0631 0.9312
Echinococcus granulosus abhydrolase domain containing 3 0.0022 0.0057 0.0841
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0085 0.018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0094 0.184
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0381 0.305 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0085 0.018
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0057
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0094 0.1389
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0091 0.0631 0.9312
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0057 0.0089
Mycobacterium ulcerans lysophospholipase 0.0381 0.305 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0168 0.2483
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0001 0.0022
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0381 0.305 1
Plasmodium vivax PST-A protein 0.0022 0.0057 0.0089
Mycobacterium ulcerans hypothetical protein 0.0022 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0094
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0085 0.0209
Plasmodium falciparum lysophospholipase, putative 0.0022 0.0057 0.0089
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0094 0.184
Brugia malayi PHD-finger family protein 0.003 0.0116 0.0116
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0213 0.3143
Schistosoma mansoni jun-related protein 0.0074 0.0489 0.9547
Brugia malayi Bromodomain containing protein 0.003 0.0116 0.0116
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0094 0.2014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0094
Plasmodium falciparum lysophospholipase, putative 0.0381 0.305 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0116 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0057 0.0089
Mycobacterium ulcerans hypothetical protein 0.0026 0.0085 0.018
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0085 0.018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0094 0.1389
Plasmodium falciparum epoxide hydrolase 2 0.0022 0.0057 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0094 0.1389
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0057
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0085 0.0092
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0085 0.018
Plasmodium vivax PST-A protein 0.0022 0.0057 0.0089
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0094 0.2014
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0085 0.0092
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0094 0.1389
Mycobacterium ulcerans hypothetical protein 0.0022 0.0057 0.0089
Mycobacterium ulcerans hypothetical protein 0.0381 0.305 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0094 0.0094
Echinococcus granulosus peregrin 0.003 0.0116 0.1717
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0085 0.018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0094 0.1389
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0094 0.184
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0196 0.289
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.003
Onchocerca volvulus 0.0027 0.0094 0.2014
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0381 0.305 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0085 0.0209
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0116 0.2274
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0381 0.305 1
Trypanosoma brucei monoglyceride lipase, putative 0.0381 0.305 1
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0094 0.184
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0168 0.3289
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0196 0.289
Plasmodium falciparum esterase, putative 0.0381 0.305 1
Plasmodium vivax PST-A protein 0.0022 0.0057 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0094 0.0094
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0094 0.184
Echinococcus multilocularis Ankyrin 0.0016 0.0001 0.0016
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0116 0.1717
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0381 0.305 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0538 0.7929
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0022 0.0057 0.0841
Loa Loa (eye worm) hypothetical protein 0.0051 0.0293 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0057
Echinococcus granulosus Ankyrin 0.0016 0.0001 0.0016
Echinococcus granulosus abhydrolase domain containing protein 13 0.0022 0.0057 0.0841
Plasmodium falciparum lysophospholipase, putative 0.0381 0.305 1
Plasmodium falciparum BEM46-like protein, putative 0.0022 0.0057 0.0089
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0022 0.0057 0.1114
Plasmodium falciparum lysophospholipase, putative 0.0022 0.0057 0.0089
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0094 0.2014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0094
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0094 0.1389
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0116
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0381 0.305 1
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0094 0.1389
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0094 0.0094
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0094 0.184
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0094 0.1389
Echinococcus multilocularis jun protein 0.0091 0.0631 0.9312
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0094 0.184
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0057 0.0089
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0057 0.0089
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0094 0.184
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0022 0.0057 0.0841
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0094 0.1389
Brugia malayi nuclear receptor NHR-88 0.0027 0.0094 0.0094
Trypanosoma cruzi monoglyceride lipase, putative 0.0381 0.305 1
Plasmodium vivax PST-A protein 0.0022 0.0057 0.0089
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0094 0.0094
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0094 0.1389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0094
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0094 0.184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0094 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0094 0.0094
Chlamydia trachomatis acyltransferase family protein 0.0022 0.0057 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0196 0.3828
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0057 0.0089
Echinococcus multilocularis abhydrolase domain containing 3 0.0022 0.0057 0.0841
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0094 0.184
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0094 0.1389
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0094 0.1389
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0000000075621 0.00000011153
Plasmodium vivax alpha/beta hydrolase, putative 0.0022 0.0057 0.0089
Plasmodium falciparum exported lipase 1 0.0022 0.0057 0.0089
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0168 0.2483
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0089 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0094
Onchocerca volvulus 0.0072 0.0468 1
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0116 0.1717
Brugia malayi Protein kinase domain containing protein 0.0016 0.0000000075621 0.0000000075621
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0381 0.305 1
Mycobacterium ulcerans hydrolase 0.0022 0.0057 0.0089
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0057 0.0089
Brugia malayi nuclear hormone receptor 0.0027 0.0094 0.0094
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0379 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0094 0.0094
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0057 0.0089
Brugia malayi steroid hormone receptor 0.0027 0.0094 0.0094
Onchocerca volvulus 0.0026 0.0085 0.181
Schistosoma mansoni coup transcription factor 0.0027 0.0094 0.184
Trichomonas vaginalis conserved hypothetical protein 0.0381 0.305 1
Brugia malayi jmjC domain containing protein 0.0036 0.0168 0.0168
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0094 0.0094
Mycobacterium tuberculosis Possible lysophospholipase 0.0381 0.305 1
Brugia malayi MGC83647 protein 0.0022 0.0057 0.0057
Leishmania major hypothetical protein, conserved 0.0022 0.0057 0.000000025268
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0094 0.1389
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0000000075621 0.00000011153
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0116 0.0116
Brugia malayi Protein C20orf22 0.0022 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0057
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0094 0.184
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0094 0.1389
Trichomonas vaginalis conserved hypothetical protein 0.0381 0.305 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0085 0.0092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0057
Plasmodium falciparum phd finger protein, putative 0.003 0.0116 0.0285
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0085 0.0085
Brugia malayi ecdysteroid receptor 0.0027 0.0094 0.0094
Chlamydia trachomatis hydrolase 0.0022 0.0057 1
Plasmodium falciparum esterase, putative 0.0022 0.0057 0.0089
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0168 0.0168
Onchocerca volvulus Alhambra homolog 0.003 0.0116 0.2489
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0094 0.0094
Plasmodium vivax hypothetical protein, conserved 0.003 0.0116 0.0285
Leishmania major monoglyceride lipase, putative 0.0381 0.305 1
Plasmodium vivax unspecified product 0.0022 0.0057 0.0089
Schistosoma mansoni hypothetical protein 0.0074 0.0489 0.9547
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0168 0.3289
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0022 0.0057 0.0089
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0057 0.0117
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0678 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0085 0.0085
Brugia malayi Death domain containing protein 0.0016 0.0000000075621 0.0000000075621
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0094 0.0094
Plasmodium falciparum esterase, putative 0.0022 0.0057 0.0089
Brugia malayi MGC79044 protein 0.0022 0.0057 0.0057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.003 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0094 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0085 0.0085
Entamoeba histolytica hypothetical protein 0.0039 0.0196 0.0464
Plasmodium falciparum lysophospholipase, putative 0.0381 0.305 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0094
Schistosoma mansoni peptidase 0.0022 0.0057 0.1114
Plasmodium vivax alpha/beta hydrolase, putative 0.0022 0.0057 0.0089

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 830 uM Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 mins in presence of 0.01% Triton-X by HPLC ChEMBL. 25036789

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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