TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 570.761 | Formula: C36H46N2O4
H donors: 2 H acceptors: 3 LogP: 7.94 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CCCOc1ccc(cc1CNC(=O)c1ccc(cc1)N1CC(C)(C)CC(C1)(C)C)C[C@H](C(=O)O)Cc1ccccc1
InChi: 1S/C36H46N2O4/c1-6-18-42-32-17-12-27(20-29(34(40)41)19-26-10-8-7-9-11-26)21-30(32)22-37-33(39)28-13-15-31(16-14-28)38-24-35(2,3)23-36(4,5)25-38/h7-17,21,29H,6,18-20,22-25H2,1-5H3,(H,37,39)(H,40,41)/t29-/m1/s1
InChiKey: CTTGJGHAKDHCCV-GDLZYMKVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peroxisome proliferator-activated receptor gamma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	ecdysone induced protein 78C	peroxisome proliferator-activated receptor gamma	477 aa	447 aa	28.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0089	0.5	0.5
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Onchocerca volvulus	Sepiapterin reductase homolog	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0089	0.5	0.5
Giardia lamblia	Short-chain dehydrogenase, putative	0.0089	0.5	0.5
Leishmania major	short chain dehydrogenase, putative	0.0089	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0089	0.5	0.5
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0089	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0089	0.5	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0089	0.5	0.5
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0089	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0089	0.5	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0089	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0089	0.5	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0089	0.5	0.5
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0089	0.5	0.5
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0089	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0089	0.5	0.5
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0089	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0089	0.5	0.5
Brugia malayi	dehydrogenases, short chain protein 9	0.0089	0.5	0.5
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0089	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0089	0.5	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0089	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Mycobacterium ulcerans	dehydrogenase	0.0089	0.5	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0089	0.5	0.5
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Leishmania major	oxidoreductase-like protein	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0089	0.5	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0089	0.5	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0089	0.5	0.5
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0089	0.5	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Echinococcus multilocularis	retinol dehydrogenase 13	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Schistosoma mansoni	carbonyl reductase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0089	0.5	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0089	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0089	0.5	0.5
Brugia malayi	hypothetical protein	0.0089	0.5	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Leishmania major	short chain dehydrogenase-like protein	0.0089	0.5	0.5
Loa Loa (eye worm)	dehydrogenase	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0089	0.5	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0089	0.5	0.5
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0089	0.5	0.5
Leishmania major	short chain dehydrogenase, putative	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0089	0.5	0.5
Echinococcus granulosus	oxidoreductase	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0089	0.5	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Leishmania major	dehydrogenase-like protein	0.0089	0.5	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0089	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0089	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0089	0.5	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0089	0.5	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0089	0.5	0.5
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0089	0.5	0.5
Schistosoma mansoni	carbonyl reductase	0.0089	0.5	0.5
Echinococcus granulosus	WW domain containing oxidoreductase	0.0089	0.5	0.5
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0089	0.5	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0089	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0089	0.5	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0089	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0089	0.5	0.5
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0089	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0089	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0089	0.5	0.5
Brugia malayi	Retinol dehydrogenase 12	0.0089	0.5	0.5
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0089	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0089	0.5	0.5
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0089	0.5	0.5
Leishmania major	pteridine reductase 1	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0089	0.5	0.5
Echinococcus multilocularis	conserved hypothetical protein	0.0089	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0089	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Echinococcus granulosus	hypothetical protein	0.0089	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Brugia malayi	dehydrogenases, short chain protein 2	0.0089	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Schistosoma mansoni	carbonyl reductase	0.0089	0.5	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0089	0.5	0.5
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0089	0.5	0.5
Plasmodium falciparum	steroid dehydrogenase, putative	0.0089	0.5	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0089	0.5	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0089	0.5	0.5
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0089	0.5	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0089	0.5	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	oxidoreductase	0.0089	0.5	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0089	0.5	0.5
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0089	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0089	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0089	0.5	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0089	0.5	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0089	0.5	0.5
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0089	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0089	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0089	0.5	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0089	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0089	0.5	0.5
Mycobacterium ulcerans	oxidoreductase	0.0089	0.5	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Echinococcus granulosus	steroid dehydrogenase	0.0089	0.5	0.5
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0089	0.5	0.5
Brugia malayi	hypothetical protein	0.0089	0.5	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0089	0.5	0.5
Brugia malayi	oxidoreductase	0.0089	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0089	0.5	0.5
Giardia lamblia	Hypothetical protein	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0089	0.5	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0089	0.5	0.5
Schistosoma mansoni	retinal dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0089	0.5	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Brugia malayi	Dehydrogenases, short chain protein 2	0.0089	0.5	0.5
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0089	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0089	0.5	0.5
Toxoplasma gondii	carbonyl reductase 1, putative	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0089	0.5	0.5
Giardia lamblia	Reductase, putative	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Loa Loa (eye worm)	dehydrogenase	0.0089	0.5	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0089	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0089	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0089	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0089	0.5	0.5
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0089	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Echinococcus granulosus	hypothetical protein	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0089	0.5	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0089	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Onchocerca volvulus		0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0089	0.5	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0089	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0089	0.5	0.5
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0089	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0089	0.5	0.5
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0089	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0089	0.5	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0089	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0089	0.5	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0089	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0089	0.5	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0089	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0089	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.5	0.5
Echinococcus multilocularis	oxidoreductase	0.0089	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0089	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0089	0.5	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 2.2 nM	Agonist activity at human PPARgamma	ChEMBL.	25017035
Kd (binding)	= 0.4 nM	Binding affinity to human His-tagged PPARgamma LBD by SPR method	ChEMBL.	25017035

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3317863

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 920776